GUMAP (Giant Ureaplasma Membrane-Anchored Protein) is a very large protein found in several species of the genus Ureaplasma, a lineage that resembles Gram-positive bacteria by ancestry but that lacks a peptidoglycan cell wall. GUMAP proteins average about 5000 amino acids in length. Near the C-terminus, these proteins have a strongly hydrophobic segment followed immediately by a cluster of basic residues, as is characteristic of proteins with a C-terminal membrane anchor. Because of the potentially large computation cost of performing database searches with a protein profile HMM that is thousands of residues long, this HMM models only about 750 amino acids of the C-terminal region of GUMAP proteins.
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