Conserved Protein Domain Family
flagella_HExxH

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NF033876: flagella_HExxH 
flagellinolysin
Flagellinolysin is a variant form of bacterial flagellin in with the normally hypervariable central region contains an M9 (MEROPS classification) family metalloprotease domain, with its signature HExxH motif. The founding member of the family, from the pathogen Clostridium haemolyticum, shows EDTA-sensitive metalloprotease activity. The large count of flagellin subunits in a complete flagellum means the capacity of flagellinolysin to perform as a protease may have implications for host-pathogen relationships.
Statistics
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PSSM-Id: 411440
Aligned: 65 rows
Threshold Bit Score: 199.027
Created: 19-Oct-2021
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_026509870 110 INNEIVQLKNEIDAiTSKTKFNELNVFLKEGPepp--------kvQDVPTS-PDIPDEIK---NPLVDVAEKISEEYYpn 177 Butyrivibrio sp...
WP_015263259 110 LQDEMVQILSNIEMiANDTEFNTKKLLNQSGSv-----------vSQYTGIsQAALDELTsklPGWLNDSMVAIYTRL-- 176 Desulfitobacter...
WP_094768477 110 LNDEIVQLKEQISAtANNTEFNTKKLLNKGSV---------------SSAS-ATLIPALKdklEYWIDDALNTINTNL-- 171 Bacillus sp. OG2
WP_132848258 110 INDEIAQLRQEVDRiANNTEFNTQKLMNYGASlq----------aDGFPGIsQEVINTLNtkiPEWINDSLEAIRGRF-- 177 Serpentinicella...
WP_026657293 110 INNEIVALKKEIDSiTSRTKFNETSVFVKGGVvpekptsnipekvKTSLEL---LANKVT---NEYYPNAIEQIMNSFss 183 Butyrivibrio sp...
WP_028235328 110 INEEILKIKDEINSiTKKTKFNELNVFTEDGYmpnlksisatagsEGAVNT---LAGKIK---DEFFPNAVSQILESFsp 183 Pseudobutyrivib...
WP_033152383 110 INAEIIKLKDEINSiTARTKFNDIPIFSKDGYvpklksitasssqATAVEK---LATKIS---DEYFPNAVSQILSAFps 183 Pseudobutyrivib...
WP_051665872 110 VNTEFNQLKEALDQiGTNTKFNELEVFPPNGSst----------tEATPAQ-LELTNIIA---TEYIPTAVSQIVSKLsg 175 Lachnospiraceae...
WP_049973154 110 LNEELKSIKDEINGiHSRTLFNELRIFPEHGSsl----------sEATPAQ-KALTEKIA---NEYIPTAMSQIMSSLsg 175 Lachnospiraceae...
WP_004602238 110 IDLEIQELKTEINRiSENTDFNGIKLLQGTRYpfa--------idKANAVD-PAMLKTLK----NTIGNAGEAILNTF-- 174 [Eubacterium] c...
WP_026509870 178 aieqiingiGSVGSklrelASTEGTSqFDtalivnylDGPGNTLAQMga---sfVMPGQGFESNSLSMKVDSDD-Y-PSI 252 Butyrivibrio sp...
WP_015263259 177 ---------GIDYPds-piKRPMRVE-YYy-------NDITSTGASM----------GTADGGATLTLRVNTAKvFdGSG 228 Desulfitobacter...
WP_094768477 172 ---------GVTSAf----GSPKTMN-VEf------yESPTGAAASM----------GTADGGNTLTLRLNMQQ-IsSVM 220 Bacillus sp. OG2
WP_132848258 178 ---------GIELNa---tKRDLTVV-YEt-------DVSYGA------------AVATSDLGASLELRINLDAfTdSNG 225 Serpentinicella...
WP_026657293 184 ig---nklsELAKGdtskyNTKLKVDy---------iDGVGNTLARMwa---afSIPGQGFYSGSLQMDVDNDD-F-PSL 246 Butyrivibrio sp...
WP_028235328 184 lg---ntinTLAAPdkspyYTTLSVDy---------iDGVSNKLAYMqas--fsMGSPVTFAASSLLMKVDKDD-F-PSV 247 Pseudobutyrivib...
WP_033152383 184 ig---skvnELAATdktpyDTKLSIEy---------iDGVYGTLAYMgar-friYGSKQEFVSGSLGMTVDEAD-F-PSL 248 Pseudobutyrivib...
WP_051665872 176 slg--nkltSLASAnpeayAMDLDMGy---------iDGPSGTLAYMqssfygyDNMADKFAEGMLLMKVDSAD-F-SSS 242 Lachnospiraceae...
WP_049973154 176 svg--selnTLDANktnenAYAIDLN-LSy------iDGKSGTLAYMqgsfyaaNGHPDSFAEESLFMKCDSAD-F-SSD 244 Lachnospiraceae...
WP_004602238 175 ---------DKLTElieskGASPSVV-NGkl-----aKLSENVLAQAk------GWVPFRGGSGLIEVDVDTSK-FgDSA 232 [Eubacterium] c...
WP_026509870 253 N-VSEQELGKLESTIAHETMHAVMDVVFpRR-------MATegga----edfPEWFIEGAAQLAGG----GFAagWNSPL 316 Butyrivibrio sp...
WP_015263259 229 NlRPEG---ILDTLLAHEMVHAFQFTEM-PF-------SRdgvd-----taeENWFIEGLAMTIQG----GNL------- 281 Desulfitobacter...
WP_094768477 221 D-ASDDGWGQVDALVAHEIVHALQFTKMpET---------Lng-------giPTWFTEGLATSIQG-----------GVP 272 Bacillus sp. OG2
WP_132848258 226 NlISEG---QLDTLVAHEVMHALQYTEM-TD-------LLlgtpa---lsdeEIWFMEGLSMAVQG----ANS--WI-AS 284 Serpentinicella...
WP_026657293 247 D-LgsyKMQQLESTIAHETMHGVMDVVFpSRmhsdsgaEDF-----------PKWFKEGTAQLVGG----GYTtgW-NDE 309 Butyrivibrio sp...
WP_028235328 248 N-MSEQQQTLLESTIAHETMHGVMDVAFpERmsqsnpsTSF-----------PLWFVEGTAQLAGG----GFTtgWNNSL 311 Pseudobutyrivib...
WP_033152383 249 N-LTESQIQELESTIAHETMHGVMDVVMpSG-------MYGrdgs---asdmPKWFVEGTAQLAGG----GFTtgWNDSL 313 Pseudobutyrivib...
WP_051665872 243 S-LSDADKQILQSTIAHELMHGVMDILLpEG-------MFRndsadqnrgnfPKWFVEGAAQLVGG----GYTtgWNDTL 310 Lachnospiraceae...
WP_049973154 245 N-LSASDTQKLQSTIAHELMHGVMDVILpEG-------MWNddtgdnsrgnlPDWFIEGTAQLIGG----GYTtgWNDSL 312 Lachnospiraceae...
WP_004602238 233 D-ASTG----IQATIAHEMMHGVMGIVYnSL-------VTsgthp---lhatPTWFIEGTAQVAGGifnaGWN--WNLRG 295 [Eubacterium] c...
WP_026509870 317 QsiasqLSSESDNRGDS-----V-ITEylsqgGEFTVDKSPYGHGYLAAAYASYLa---aDGndvt-mnnlRNGSSNLFQ 386 Butyrivibrio sp...
WP_015263259 282 ------FGVTDHHVSMG-----YpFDG-------------DYRSAYEAVKVLHEVt---------------DDGINAIID 322 Desulfitobacter...
WP_094768477 273 F-----LGSLGSNSSAA-------ITP------AWTG---DYGSAYAAVMTLHEAt---------------TGGIQAIVD 316 Bacillus sp. OG2
WP_132848258 285 I-----TGGITNADISG-------VFG---------NTYEDYASAFVAIKTLHEIt---------------EGGINAIIN 328 Serpentinicella...
WP_026657293 310 L-----SGIVKGLEGEDdnskdSeIVNy---lGQYTVDDREYGHGYLAAAYASYLa---aDGnevt-tanlQNGASKMFQ 377 Butyrivibrio sp...
WP_028235328 312 SntvknLSNANDTSSDS-----A-ISNy---lKSKTVETNEYGHGYLAAAYASYLa---aDGndvs-assiASGASKIFQ 378 Pseudobutyrivib...
WP_033152383 314 InraksLTSATDTSQDS-----A-IAAylsqgGDYTVDSRPYGHGYLASAYASYLa---aDGnevs-agnlRSGADKIFG 383 Pseudobutyrivib...
WP_051665872 311 Mr----IADLSVPDSVK-------LSNvsnylKNYTVDERPYGHGYLACAYLCQLasgspLGsvtq--nslITGANKIFN 377 Lachnospiraceae...
WP_049973154 313 MtiaksSLITDKQAAVS-----SyLSQ-------FTVAGRPYGHGYLACAYLCQLa----SGqsdvtlgnlRTGANNIFN 376 Lachnospiraceae...
WP_004602238 296 V-----TSSTSTADVKA-------LLS-----RHQDPENEPYGMGALAVAYMGQKa----SGettvsaenvVKGLNNIFE 354 [Eubacterium] c...
WP_026509870 387 KFLDGdr--------ggRNDSFTDV-IKTATG----------------------LTEQQLKDAI---NSGsnvsp--gng 430 Butyrivibrio sp...
WP_015263259 323 RLE--------------AGDTLDQA-LLNTTQnftgteld------gaigaadlTTATEFINWF---NANss-------s 371 Desulfitobacter...
WP_094768477 317 RLE--------------AGDTLDQA-LAATTQaatgdl----------agvtdfADTASFVSWF---NSS---------- 358 Bacillus sp. OG2
WP_132848258 329 ELE--------------AGNSLDVAiLNTVQRnqgevsgagidhtdyaggdtgyHSWSEFVADF---NGGq--------- 382 Serpentinicella...
WP_026657293 378 GFIDGds--------ngRNDSFDDV-IKATTG----------------------LTEAQLKAEI---NGGstts----pi 419 Butyrivibrio sp...
WP_028235328 379 SFLND------------KTSSFNSV-MNSAVG----------------------VSADSLVDQI---NNGsittl--kpg 418 Pseudobutyrivib...
WP_033152383 384 ALIEK------------QDDSFSSV-VASQTG----------------------VDVSSIVNAI---NTGstaafgekpd 425 Pseudobutyrivib...
WP_051665872 378 ALMTNennyr--nggtgNVSSFNDV-INSTISn---------------------LTLTDVINNI---NSGe--------- 421 Lachnospiraceae...
WP_049973154 377 ALIQNeknyrnngtaksFSDVIDSV-LSSAGSt---------------------HTTNNVIANInsgEVN---------- 424 Lachnospiraceae...
WP_004602238 355 QM---------------KEKSFEDA-VKAATGs---------------------YYPNDILDAFtpsNVT---------- 387 [Eubacterium] c...
WP_026509870 431 kYSPv--eFIR----R-LAYNSL---GGVGSFVADklnTGGTQVL-GSTAIKDEQ-----PFk----iTS--QSIK--YV 486 Butyrivibrio sp...
WP_015263259 372 aGVLn--tYLMgs-aDfTQGSGV---ITIGGAKGS----SSDLTL-DQTIPNATG--------------V--ATLNthFT 424 Desulfitobacter...
WP_094768477 359 -ADVd--sYLD----GaTDFADGi--GSIAPSQGT----ARTLSSiNDVIANDTT-------------ID--NPDQ--FN 408 Bacillus sp. OG2
WP_132848258 383 -FDT----YLSss-tDfTLGTGAiveGDVAGSSSN-------LTLdQTITNDTGL-----------------ATAYtvYN 432 Serpentinicella...
WP_026657293 420 aGKYsaveFVR----R-LTYNSL---GGAGSLITP-----SLSTGgTSILADTADkdaqpFKi---------TSQSvkYV 477 Butyrivibrio sp...
WP_028235328 419 kASPt--eFVR----R-LAYNSL---GGAGSVIT-----GDLKTGgSSILGETAV-----ND------DQ--PIMInnVE 470 Pseudobutyrivib...
WP_033152383 426 kLSAv--eFVR----Q-LAYNSL---GGAGSLIAD-----DLKIGgTAILGDTAD-----KD-------T--QPIRi-TN 475 Pseudobutyrivib...
WP_051665872 422 -TNAs--kFVL----AlTEASKS---SSTSGLNGS---G-------SIVAPSLNS-----PYv----fGS--TVTSqqAM 470 Lachnospiraceae...
WP_049973154 425 -ASA----FVLalttKcISNDGS---GLNGAGSII----ADNLNS-TSVFGSTVT-----SKqvlfvrGTtsSSASg--- 483 Lachnospiraceae...
WP_004602238 388 -DDVa--nFVK----E-ICDQAG---GDGGGSFLK----GLGLSK---KVSEYGF-------------NG--EYSGtkFT 434 [Eubacterium] c...
WP_026509870 487 EISEEIPeelakeIEEkgqeYTVDLHLGADADLVnkVNIMRYDMSTKALLLEDTNVLTSerATSAIDDFGNAILTVSAVR 566 Butyrivibrio sp...
WP_015263259 425 LDFVN--------SAGsvglGEIVFHVGANSGQN--IPFQSFDLRTSALELVGTNIKTQsgANAAIGTINKALGLVSNAR 494 Desulfitobacter...
WP_094768477 409 YVFQDTS------AAG----EQLVFQVGANEGQT--VSMSTYDLTTEGLALGSADISTRigAEQAIDMFDSAIGRVSAVR 476 Bacillus sp. OG2
WP_132848258 433 ISFTTDSastvasDTP----EKVILQIGANNGQT--IEIDAFDATANGLRIDTVNATTQenADNSISLLDAALTSVSNFR 506 Serpentinicella...
WP_026657293 478 EATEEVDeeekarGHY----YTVDLHVGTDADMNnkVSIKRYDMSTKALFLEDTNVLNEerATDAIDAFGDAIIMVSSVR 553 Butyrivibrio sp...
WP_028235328 471 TSYNEV-------AVEgdsaANVVLQIGSDRQDEnkLEIKLFNMNCDALSVGNTDVLTEkrATSAIDEFGKAIKLVSGVR 543 Pseudobutyrivib...
WP_033152383 476 VEKKYSKlentmpGGT----ANVALHLGTDADQTnkLEIRLYNMSCQALTIDTTEVLTEdtATSAIDEFGNAIRLVSGVR 551 Pseudobutyrivib...
WP_051665872 471 YVKNTDTsaysdaANA----TAFKLQVGADSNDSnvIEIKRFAMSQSALNLSNSTVLTQdeAVASISTVKNALVIVNTIR 546 Lachnospiraceae...
WP_049973154 484 -------------GDE----AAIYLQVGADALPSnrVELKRFSINSAALGISSASVSTQasATESIRSMGGAINTVSAMR 546 Lachnospiraceae...
WP_004602238 435 VNFDAGD------GASdgesSDVVLQIGATKNET--LNLYRVNMSTKGLGITDTNVLTQdeAKSALESFQNAIDSTSTVR 506 [Eubacterium] c...
WP_026509870 567 SYF 569 Butyrivibrio sp. LC3010
WP_015263259 495 SYF 497 Desulfitobacterium dichloroeliminans
WP_094768477 477 GSL 479 Bacillus sp. OG2
WP_132848258 507 SSL 509 Serpentinicella alkaliphila
WP_026657293 554 SYF 556 Butyrivibrio sp. AC2005
WP_028235328 544 SYF 546 Pseudobutyrivibrio sp. MD2005
WP_033152383 552 SYF 554 Pseudobutyrivibrio ruminis
WP_051665872 547 TYY 549 Lachnospiraceae bacterium ND2006
WP_049973154 547 AYY 549 Lachnospiraceae bacterium MC2017
WP_004602238 507 GYY 509 [Eubacterium] cellulosolvens
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