Conserved Protein Domain Family
pheromone_VP1

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NF033772: pheromone_VP1 
peptide pheromone VP1
VP1 (virulence peptide 1), as characterized in Streptococcus pneumoniae (a.k.a. pneumococcus), is part of a large panel of secreted regulatory peptides with paralogous leader domains, typically ending with the cleavage site GlyGly, but with highly variable core regions. VP1, along with other pneumococcal peptide pheromones such as BriC, participate to cell-cell communication to regulate pathogenic processes such as biofilm formation.
Statistics
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PSSM-Id: 411356
Aligned: 16 rows
Threshold Bit Score: 84.1251
Created: 20-Oct-2021
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_084972152  1 MLNLQFAETMELTEVELEAVYGGDLVNVANIPGGGnWGGwggLGTPWSITNFWKKYFN-HDSSTVNRRR 68  Streptococcus oralis
WP_000933464  1 MLNLQFAETMELTEAELEIVYGGEFGNNAVIPAGA-WGG---FGTPWSITNFWKKNFNdRPDFDSDRRR 65  Streptococcus pneumoniae
WP_000933472  1 MLNLQFAETMELTEAELETVYGGELGYNAVIPGGS-WGG---LGTSWSITNFWKKNFNdRPDFDSDRRR 65  Streptococcus pneumoniae
WP_049538072  1 MLNLQFAETMELTEMELEAVYGGDLVYAAVIPGGGgWGG---FGTPWSITNFWQKYFNdKPDSDYDRRR 66  Streptococcus
WP_061419080  1 MLNLQFAETMELTEDELEKVYGGNLVYVANIPGGGnWGG---LGTPRSITNFWKKYFNdKPDSNSDRRR 66  Streptococcus oralis
WP_119942731  1 MLNLQFAETMELTEAELETVYGG-RASPPLIHIGGdYGGg--FGTPWSITNFWKKYFNdKPESDSDRRR 66  Streptococcus pseudopneumoniae
WP_044813862  1 MLNLQFAETMELTEAELETVYGGEFGNNAVIPAGA-WGG---FGTPWSITNFWKKYFN-HDSSTVNRRH 64  Streptococcus pneumoniae
WP_050235351  1 MLNLQFAETMELTEAELETVYGGELGYNAVIPGGS-WGG---LGTSWSITNFWEKYFN-HDSSTVNRRR 64  Streptococcus pneumoniae
WP_033605726  1 MLNLQFAETMELTEMELEAVYGGDLVYAAVIPGGG---GwggFGTPWSITNFWEKYFN-HDSSTVNRRR 65  Streptococcus sp. CM6
WP_061863716  1 MLNLQFAETMELTEAELQEVSGGDLVYNANIPGGGnWGG---IGSFWRNSNFADHFFYfIKGSDPDRRR 66  Streptococcus infantis
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