Conserved Protein Domain Family
helico_Hpn_like

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NF033704: helico_Hpn_like 
nickel-binding protein HpnL
The Hpn-like protein HpnL, or Hpn-2, including founding member HP1432, is a histidine and glutamine-rich metal-binding polypeptide that binds nickel, among other metals, any may help deliver sequestered nickel for the biosynthesis of urease, which is critical to the survival of Helicobacter pylori during exposures to strongly acidic conditions. This protein is a paralog to the histidine-rich nickel storage protein Hpn (e.g. HP1427). Both nickel-binding proteins are expressed in response to nickel, under control of the regulator NikR.
Statistics
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PSSM-Id: 411293
Aligned: 9 rows
Threshold Bit Score: 83.9936
Created: 20-Oct-2021
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_001947846  1 MAHHEQQHQAQqqqqQQANSQHHHHHHAHHHHYYGGEHHHHNAQQHAEQQAEQKAQQQQQqqahqqqqqQQAHQQNQQY 79  Helicobacter pylori
WP_002207810  1 MAHHEQQHQAQ----QQQQQANSHHHHVHHHHYYGGEHHHHNAQQHAEQQAEQHAQQQQQ---------QQAHQQNQQY 66  Helicobacter pylori
WP_014534490  1 MAHHEQQ--------QQANSQHHHHH-AHHHHYYGGEHHHHNAQQHAEQQAEQQAQQQQQqqah-qqqqQKAQQQNQQY 69  Helicobacter pylori
WP_014537402  1 MAHHEQQq-------QQANSQHHHHHHAHHHHYYGGEHHHHNAQQHAEQQAEQHAQQQQQqqah-qqqqQKAQQQNQQY 71  Helicobacter pylori
WP_001954762  1 MAHHEQQHQAQqq-qQQANSQHHHHHHAHHHHYYGGEHHHHNAQQHAEQQAEQQVQQQQQ---------QKAQQQNQQY 69  Helicobacter pylori
WP_001963267  1 MAHHEQQHQAQqqqqQQANSQHHHHHHAHHHHYYGGEHHHHNAQQHAEQQAEQHVQQQQQqahq--qqqQKAQQQNQQY 77  Helicobacter pylori
WP_001945965  1 MAHHEQQHQAQqqqqQQANSQHHHHHHEHHHHYYGGEHHHHNAQQHAEQQAEQHAQQQQQq-------qQKAQQQNQQY 72  Helicobacter pylori
WP_001872221  1 MAHHEQQ--------QQANSQHHHHHHVHHHHYYGGEHHHHNAQQHAEQQAEQQAQQQQQ---------QKAQQQNQQY 62  Helicobacter pylori
WP_001925933  1 MAHHEQQHQAQqqqqQQANSQHHHHHHAHHHHYYGGEHHHHNAQQHAEQQAEQHAQQQQQ---------QQAHQQNQQY 70  Helicobacter pylori
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