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nickel-binding protein HpnL The Hpn-like protein HpnL, or Hpn-2, including founding member HP1432, is a histidine and glutamine-rich metal-binding polypeptide that binds nickel, among other metals, any may help deliver sequestered nickel for the biosynthesis of urease, which is critical to the survival of Helicobacter pylori during exposures to strongly acidic conditions. This protein is a paralog to the histidine-rich nickel storage protein Hpn (e.g. HP1427). Both nickel-binding proteins are expressed in response to nickel, under control of the regulator NikR. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",