Conserved Protein Domain Family
denti_PrcA
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NF033597: denti_PrcA 
dentilisin complex subunit PrcA
PrcA is a lipoprotein that, together with PrcB and the serine proteinase subunit PrtP, form a chymotrypsin-like surface complex that is also known as dentilisin, after its discovery and characterization in Treponema denticola. Dentilisin is an important virulence factor in periodontal disease.
Links
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Statistics
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PSSM-Id: 411219
Aligned: 12 rows
Threshold Bit Score: 874.047
Created: 19-Oct-2021
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_010956812   8 AAALWCILLLAFLFGSCPQQ-KSASEPekdpypiPADAVSVEITVSDSVSGTLVDG-TKLVVFDSADGKQVTNQLPVRKG 85  Treponema denti...
AAQ73569       9 YAAPCIVCVLVCLFSACPNAgISSQNG-------YSNIAGIHITILDSVGGTPVREaTALTVYRAGTKTLMYAPTLVVNG 81  Treponema sp. O...
WP_021687459   9 YTAFCFLCALVCFFTSCPNG--AQQNGi------YASGTAVTVNILDSVGGTPQMEsTILSAYKAGTKSAACQPVTVSGG 80  Treponema lecit...
AAQ72848      13 AAALCCIGTLACLFAACPNG----QTR--------KNQATVIVNVLDSVGGVPITEpAALTVYKVDTERSLYSQVQVING 80  Treponema vince...
WP_016523485  13 AATLCCIGVLISLFTACPNG----QTP--------KKGVAVTVNVLDSVSGVPITEsSVLTVYTVGTSRSLYDQVRIVNG 80  Treponema medium
WP_016521177  11 ITGTFCIAAIIGLFFACAMT-----GTa------DESYSSVSVNILDSIGGTLITEpTTLTVYKTGTQIPFYR-FTVYNG 78  Treponema socra...
AFV33673       8 AAALWCILLLAFLFGSCPQQ-KSASEPekdpypiPADAVSVEITVSDSVSGTVVDG-TKLVVFDS-DGKQVTNQLTVRKG 84  Treponema denti...
WP_010698770   8 AAALWCILLLAFLFGSCPQQ-KSASEPekdpypiPADAVSVEITVSDSVSGTLVDG-TKLVVFDSVDGKQVTNQLPVRKG 85  Treponema denti...
WP_024465453   8 AITLFCIIVLALVFASCPQS-GRAGi--------LQNGVSVEVLVADSVSGSTVDG-TELKVFYS-KTKSLAAQVDIKNG 76  Treponema pedis
WP_051169911   9 ACTAVCLCALIISMTGCAQSsDSGDEPffp-detPAEFSTIRIQVTDSIGGTVVSG-TTLKVYKSGTTEQIGSGYTVTDG 86  Treponema socra...
WP_021686482   8 ACSALCLCALLVWVTSCPQSaGNGGa--------STDFTTLYVSVTDSIGGTAVDG-TTLRVYESGNTLQFQSDFRVTNG 78  Treponema lecit...
AAQ73567       8 AALPLFFIALVL-LAGCPQSiGGGGSSggfidepYADFSTVHVQVTDSIGGTFVSG-TTLKMYKSGTTEQIGT-YTVTDG 84  Treponema sp. O...

WP_010956812  86 KVTAK-VSPKKKYDFVLLGKKGSWAGSMLQDYYVPEGGLNGdksLMMLQFEHgQITRDVTPPRIDKVTIEN---ASGVDI 161 Treponema denti...
AAQ73569      82 SVRLY-LPKNECYDLYLSGKKDRLAASVIENYWVKDADEQS---LTMFQRAV-QIGAQTQSPSITSVKLNG---FDFADG 153 Treponema sp. O...
WP_021687459  81 SAQLY-LPEGQCYDLYLSGEKNKLAASVIENYWVKSANAQT---VTMFQRTP-QQGAATEAPSVQSVKLNG---VPFEDS 152 Treponema lecit...
AAQ72848      81 TAQLS-LQKNERYDFSLSGTENGRAASAIENYWIRSADIQT---VTMIQRMI-QKGARPEAPSIQSVTLNG---KSFEDG 152 Treponema vince...
WP_016523485  81 SALLY-LPKNQRYDFNLSGTENGRAASVIENYWIRTADMQT---VTMIQRMI-QKGAQAEAPSIQSVTLNG---QPFEDG 152 Treponema medium
WP_016521177  79 KTSFG-LRKGECYDFYLSGEKNKLAESVIENYCVKDTDAQT---VMMIQREI-QKGAEPEAPAVTSVKLNG---ENFTDG 150 Treponema socra...
AFV33673      85 KVTAK-VSPKKKYDFVLLGKKGTWAGSRLQDYYVPEEGLKG---VMMLQFAHgQITRDVTPPHIDKVTIEN---ASGVDI 157 Treponema denti...
WP_010698770  86 KVTAK-VSPKKKYDFVLLGKKGSWAGSRLQDYYVPEEGLKG---VMMLQFEHgQITRDVTPPHIDKVTIGN---ASGAVI 158 Treponema denti...
WP_024465453  77 KGYVN-LIPNQTYDFELLGKKGVRAGSVIYDYFIG--GGQS---LTMLQFQHgQITRGIETPKITAVKADS---ETGADI 147 Treponema pedis
WP_051169911  87 KVMLYdIATDQRYDFELIGEKEKWAGSRLENWKPLSIAKQN---LSLIQPVHgTITRGITPPKITSAQSGN---GSFTDI 160 Treponema socra...
WP_021686482  79 KVRVSgISTNKRYDFELIGIKGKWAGSRLENYSPLKKAEQT---LSIIQSEHaMITRGITPPKITSIQSGN---GTFTDI 152 Treponema lecit...
AAQ73567      85 KVKLEnLATEARYDFELIGIQGEWAGSRLENYKLPPRAEQT---LSLIQPVHgMITRGITPPKIDSIKKAKtllDTFTDL 161 Treponema sp. O...

WP_010956812 162 TDNYDIGNAEKKVYVEFTSKVGAVEDVAWNG-FGAKLGFGMMPTSYEGIDGVYTPDNTPGDGIFTSKYVFDIEHAAMPDD 240 Treponema denti...
AAQ73569     154 GVWAGAKNQPMKLAIVFHSPSRAIQSVPSNGnFGCAVAVGASASSRNNIASVSPLCVRMPDGSWQCTAEFSFDKISFPNE 233 Treponema sp. O...
WP_021687459 153 GVWAGAVDKPMVLEIVLRAPSRAIQAVPTNGnFGCAVAVGSSPSSRNKIASVSPECVRNGDGSWTCTARFNFDKISFPNK 232 Treponema lecit...
AAQ72848     153 GVWAGAAGQTMKLQIVFKAPSRAIQARSTDTnFGCAIGVGTAPSFYNNIASASPDCERNADGSWKCTANFALQKISFPDE 232 Treponema vince...
WP_016523485 153 SVWSSAVGQTMKLEIVFTSRSRAIQAIPDNGnFGCAVGIGTSPSSHNNIATVSPVCKRDIDGSWKCTANFSFDKISFPNE 232 Treponema medium
WP_016521177 151 SVWKSTMYQQMKLEIVFKAPSRPVAAT-NGGnFGCAIAVGSSPSSQNNIASVSPICKRENDGSWTCTAAFTFDRISFPSE 229 Treponema socra...
AFV33673     158 TDNYDIGNAEKKVYVEFTSKVGAVEDVAWNG-FGAKLGFGMMPTSYEGIDGVYTPDNTPGDGIFTSKYVFDIEHAAMPDD 236 Treponema denti...
WP_010698770 159 NDDHVIDTAVKKIYVEFSSKAGAVEDVAWSG-FGAKLGIGMMPTSYAGIYGEYTPDNTPDDGIFTSKYVFDIEHAAMPDG 237 Treponema denti...
WP_024465453 148 TENTEIDGKINKIYVEFTSSVGAVEEVAWNG-YGAKLSIGGSPGSSTGISGEYTPD-TVSDNIFISKYKFDIRDVKLPDG 225 Treponema pedis
WP_051169911 161 DESTVIS-TSDKVRIVFESAVGAVEETASGA-FGAKLGIGKAPNQMSGISGSCAVSKSGSE--FTSTYTFNLEEVPD--G 234 Treponema socra...
WP_021686482 153 DESTVIS-SSDKVRVVFDSDVGAVEETASGA-FGAKLGIDKAPNNLSGIHGRYSVSQAGGV--IKSTYTFSFSEVPN--G 226 Treponema lecit...
AAQ73567     162 SENSFVN-APVYIKVVFSSDVGAVKETDGGG-FGAKLGIGKSPNVFTGIDGSIKVEKENDS--FISTGIFRIETLFK--G 235 Treponema sp. O...

WP_010956812 241 KTELIIVGYDVANNRVEKRIP-VKFS-KTSAAAPLSNAIFGRVFVIMERVPFTNNTFSAEPGQGLVqlgsg-hevmPQAL 317 Treponema denti...
AAQ73569     234 INDFIITAYDVAGNRVERHINsIEFKeRRPGLKSMTGARIKKFRVEMHRFPHSLKLFNMPEKSPLK----------PFAV 303 Treponema sp. O...
WP_021687459 233 TDDFIISAYDTAGNRVERHINsIEFKeRRPALTDISGSSVKDFRIEMHRFPHSLKLFSLPDQSAIS----------PFGI 302 Treponema lecit...
AAQ72848     233 FNNFIITAYDVAGNRVERHINsIQFKeRRPALKTIEGASIQEFRVEMRRYPHSLKIFNTQQQSELR----------PRSI 302 Treponema vince...
WP_016523485 233 FNNFVITAYDVAGNRVERHINsIEFQeRRPGLKTIEGASIRGFRVEMHRYPHSLKLFNNPGQSGTR----------PFGV 302 Treponema medium
WP_016521177 230 INDLIIAAYDVAGNRVERHINsIEFReRRVGLTTTQNATIKNFRVEMHRFPHSLGLFNLSERQTVR----------PFAI 299 Treponema socra...
AFV33673     237 KTELIIVGYDVANNRVEKRIP-VKFS-KTSAAAPLSNAKFGSAFMIIERVPFTNNTFSTEPGQGLVqldsg-hevmPQAL 313 Treponema denti...
WP_010698770 238 NTELIMVGYDVANNRVEKHIP-VKLN-KAPAAAPLLNAKFEDPFMIIERVPFTNNTFSTEPGQGLVqlgsg-hevmPQAL 314 Treponema denti...
WP_024465453 226 ETELVIVGYDVANNRVEKHIP-VRLK-KGFNANPLANAQFKNPFIIVERVPFSNNTFSANGDIQIEtlktasdftaPAVL 303 Treponema pedis
WP_051169911 235 KDTLIVVGYDIANNRIEKHIP-VTFSaSAASASDLSTCKFEDIAVIAKRLPYSENLYS---------------------L 292 Treponema socra...
WP_021686482 227 TGELIAVGYDVAHNRIEKHIP-VTFQsSSAAASDLSTCTFDKLSVNTERLPFSENLFS---------------------L 284 Treponema lecit...
AAQ73567     236 NDDLVITGYDVANNRIERHMP-LKFE-NNNSTLDLSSCSFRNLSAFAERLPYSEGILS---------------------L 292 Treponema sp. O...

WP_010956812 318 NPIEGHNSSYVAAFVFSVVDNAS--TPIPIMGFNLLRREK-DIGEFKPVSRTHYDRPKTETRPGW----GVHQGFDTSSE 390 Treponema denti...
AAQ73569     304 KPHNGESNTYEVQLWFQIKDSAS--QDLPIRGFNIYRRVQgQADWIFVGRKQYANDYIGEHNPQFpaynGFHLGYDTDSA 381 Treponema sp. O...
WP_021687459 303 RSHNGESNTYEVLLYFRVKDASS--QDLPIRGYDIYRRLQgQTEWTHIGQRQYVADYAGENNPNWpsykGYHLGYDTDTS 380 Treponema lecit...
AAQ72848     303 SPHNGESTSYEALLWFQIKGLAS--QDLPIRGFDIYRRVQgQSAWTLVGRKQYAADYTGEQDSRYstymGFHNGYDTDPS 380 Treponema vince...
WP_016523485 303 TAHNGESTTSEVLLWFQIKDLAS--QDLPIRGFYIYRRIQgQAEWTLVGRQQYAADYTGEQDYRYpsyiGFHLGYDTDPS 380 Treponema medium
WP_016521177 300 EGRNGESNTHEALLWFRIKDFSS--NDLSIRGFDIYRRKQgERTWIHVGRRQYANDYTGEQDIRYpsykGFHIGYDTDVS 377 Treponema socra...
AFV33673     314 NPVEGHNSSYMAVFVFGVVDKTTptTSVPIMGFDVFRKEKgSTDTPKFVSRTHYDEPKTETNPGW----GAHQGFDTSSE 389 Treponema denti...
WP_010698770 315 NPVEGHNSSYMAAFVFSVVDNAS--TPVPIMGFNLLRREK-DIGEFKPVSRTHYDRPKTETNPGW----GAHQGFDTSSE 387 Treponema denti...
WP_024465453 304 DPYNGESSSYRAIVVFDIVDKTSgkTKIPISGFDLYRRDMgSIGEFKFVSRTLYDKPKVETGAGW----GLHQGFDNSSE 379 Treponema pedis
WP_051169911 293 KPVGGRRSSYRMLVRFEFT-KFG--SHKKILGFDLYRREKgRPQDFLFVSRTLYDDLKTETYSGQ----GFHVGIDGDSL 365 Treponema socra...
WP_021686482 285 NPVENRRSSYRVLVRFTLK-KFG--IDEKILGFDLYRKKNgYAQDFRFVSRTLYNELKNETQSGW----GFHVGIDSDSL 357 Treponema lecit...
AAQ73567     293 QPVGGRRSSYKMTVIFEFVNSYG--TDKEILGFDLYRRKKgSARKFRFVSRTLYNDLETET-SGL----GFHAGFDTDSQ 365 Treponema sp. O...

WP_010956812 391 LEEGKEYEYEIEAFTAT-DTLKSPVLTGKVMEAFTYSLKAPENRKKISAAEAANMSYSCTISNKKLLTTEQADWCDLGLL 469 Treponema denti...
AAQ73569     382 LQEGVTYEYKVSPFIDStHSLDSPTATARLLPACTIELENPSDNGFVKKSELNDLSFSFRITNPDMWNKKQADTFSFGLF 461 Treponema sp. O...
WP_021687459 381 LEENVTYEYQVRPFNGSgKNLVSPTATARLLPANTIELQSPADNGFVKKSKLNNLSFSFRLTNPDIWEHKLADSFSFGLF 460 Treponema lecit...
AAQ72848     381 LEEGVTYEYKVEPFTDGtHRLVSPTATARLLPASTIELINPADNGVVKKSELDKLSFSFRITNPAIWDNRLADSFMFGLL 460 Treponema vince...
WP_016523485 381 LEEGVTYEYKVRPFIDGsHYLDSPTATARLLPASTIELINPADNGVVKKSELDNLSFSFKITNPALWDNRLADAFSFGLL 460 Treponema medium
WP_016521177 378 LEENVTYEYKISAFTDStHRVDSPIATARLLPANTIQLESPADNGSVKFSELDNLRLSFRLTNRDIWEKGYADFFTFGLV 457 Treponema socra...
AFV33673     390 LEEGKEYVYTIKAFTAT-DTLESPVFTGKVMEAFTYSLKAPENRKKISAADAANMSYSCTISNKKLLTKEEADWCDLGLL 468 Treponema denti...
WP_010698770 388 LEEGKEYEYKIEAFTAT-DKLESPILTGKVMEAFTYSLKTPENRKKISAADAANMSYSCTISNKKLLTKEESDWCDLGLL 466 Treponema denti...
WP_024465453 380 LKENGEYEYKIKAFNEA-GTIESPVMAGKLMEAFTYTLETPINREEIPLSLAADIAYSCKISNPGLLTEQAADWCDLGLL 458 Treponema pedis
WP_051169911 366 LEENKEYEYKIRAFNAK-SEKYSPVITTKLLESFTYELTSPANNVLVTSANAANFTYKCKISNTNMFGSAQSDYMRLGLL 444 Treponema socra...
WP_021686482 358 LEEDTEYEYKIRVFNKL-NEKYSPVIKTKVLKSFTYDLTAPAQNAFVSFANAANLTYKCKMSNTHLLDAGQSDYMICGLL 436 Treponema lecit...
AAQ73567     366 LEENTEYEYKIRAFNEK-YEKFSPVITVKLLESFTYELTEPVNNAYVLLADTANLAYKCKISNANMFSPAQSDYISLGLL 444 Treponema sp. O...

WP_010956812 470 ILDGQGQP--VFGSKLRYVFDgvtv-giggGSTTGPDLLIdTIGFAPGNKPRRFSYKQHLAATprisaylqshginNLND 546 Treponema denti...
AAQ73569     462 IAEKTSDQkiLFAGKAAFSLK---------APAGERLSLQ-ALSSSPRMLSLKELKQRNLIDS-------------SVTE 518 Treponema sp. O...
WP_021687459 461 VTEKTSNQkiIFAGKATFYLK---------KNGGEKLALQyAISGTPQEYSFKELQTRGVIAS-------------NLTE 518 Treponema lecit...
AAQ72848     461 VTDKTSSEnvIFAGKISVYLK---------RSAGRRLGLQyAVSGNPKEYSFAELQERGYIPA-------------DATE 518 Treponema vince...
WP_016523485 461 ITEKASTEnvVFAGKVSVALK---------ATAGNRLKLQyAVSGNPKEYSFKELQERGFISG-------------SAVE 518 Treponema medium
WP_016521177 458 IADKTTAEnvVFAGKVSVDLK---------KPQGERLTLKfAQGNQFLDLTLAELKQRGFIGY-------------AVTE 515 Treponema socra...
AFV33673     469 ILDGQGQP--VFGSKFRYVFDgvtvgiggaNTTTGPDLLIdTIGFGSG--VKRFSYKKQLATPlqty-----yninKLED 539 Treponema denti...
WP_010698770 467 ILDGQGQP--VFGSKFRYVFDrv-----vgPSSIGPDLLIdTIGFGSG--VKRFSYKQQLATPlqty-----yninKLED 532 Treponema denti...
WP_024465453 459 ILDGQGQP--LFGSKLRYVFD---------SGDGTPDILVdTAAGTPK--PVRRSYKQHLKSKlqsl------ginNLED 519 Treponema pedis
WP_051169911 445 INDFRGIP--RFGAKLLYVFD----------YGGRPEILIeVCNPTTGILVGRKK-VSDLITAgilrr----ygvrSLDD 507 Treponema socra...
WP_021686482 437 IKDFRGIP--LFGAKLIYVFN----------AGGNPDILIeVCDRVTGMLQSQLKRGSELIATgklns----ydiySLDD 500 Treponema lecit...
AAQ73567     445 INKFDGNP--VFGARFFYLLN----------GSGSPDMLIfLCDAVSGNLQ-DPEWVSDLIAAgklsa----ygitSVND 507 Treponema sp. O...

WP_010956812 547 LITVNSSTGIITITDKFLKIAQFNVVAGT-------PMEYQAGVSYQWDIQDWGDNAYGLNDDRALRIVKMYGSSQ---- 615 Treponema denti...
AAQ73569     519 DDLISYSNGVVTIKPGYLKTKEFNHPHFK-------DKVFQTGYTYAWDIFDWGKDPQSVYDDEPAAFKSTWQSKDadgn 591 Treponema sp. O...
WP_021687459 519 DDFISYKDGVITIKPAYLITEGFNHPQCK-------DEKFQTGVTYAWDIFDWGKRLKETYDDEPAAFSAAWKSKDvdgn 591 Treponema lecit...
AAQ72848     519 DDFISYSNGIVTIKPRYLTTAGFNHPLFR-------DTAFKTGYTYSWDILDWGKDAKEILDNEPAEFTAVWQSKDiegh 591 Treponema vince...
WP_016523485 519 DDFISYRNGIVTIHPRYLKTAAFNHPLFK-------DAKFTTGCTYGWDILDWGEDAKNISDNEPAAFTAVWLSKDadgn 591 Treponema medium
WP_016521177 516 DDLVSYNDGVVTLQPAYLRTPGFCHPKYQ-------ANKFWKGYTYGWDIFDWGKDAVRTTDDEPAAFTSVWRCKDndgn 588 Treponema socra...
AFV33673     540 LITVDSSTGIITITDKFVKIAQFNVAAGT-------PMEYQSGVNYQWDIQDWGKSAISLRDDRALRIVKMYDSNQ---- 608 Treponema denti...
WP_010698770 533 LITVDSSTGIITITDKFVKIAQFNVAAGT-------PMEYQSGVNYQWDIQDWGKSAISLRDDRALRIVKMYDSNQ---- 601 Treponema denti...
WP_024465453 520 IVKLDAGSGIITFTPKFMKIPYFNVAASG-------AMEYKAGVNYQWDIQDWGESPYRLTDDRALRIVKMYGGAQ---- 588 Treponema pedis
WP_051169911 508 LVKVDKRTGIIEFTETFVRVPFFNVIPMGsgkglnlPMSYEKGTSYQWDIQDWGNDDVSLDDDTALYFVKEYTYTGddgn 587 Treponema socra...
WP_021686482 501 LVKVDKATGVIEFTEKLVKVPFFNVIPISggkglnlPMIYEKGTSYQWDIQDWGSNSVSLNDDTALNFVKMYSYIDenaq 580 Treponema lecit...
AAQ73567     508 LVKVDKTTGIVEFTKKFVQVPFFNVIPIGsdkglnrAMNYETGVAYQWDIQDWGLNPYDLYDDEALSFVKNYPYTSagst 587 Treponema sp. O...

WP_010956812 616 -----SRTMGNNSSSG-----SNAVNGRFTFVI 638 Treponema denticola
AAQ73569     592 eipypTEPLSSSESFAnglryAGSLNGQYYFKV 624 Treponema sp. OMZ 839
WP_021687459 592 eigtdIEPLSSSESFAnairyASSSNGQYFFRV 624 Treponema lecithinolyticum
AAQ72848     592 eipypTEPLSSSESFVshlryPGSLNGQCYFKV 624 Treponema vincentii
WP_016523485 592 eipypTEPLSSSESFVshlryPGSLNGQCYFKV 624 Treponema medium
WP_016521177 589 eiappTEDLSSSESFAnrlsvAGSLNGQYYFKI 621 Treponema socranskii
AFV33673     609 -----SRTMGNNSSSG-----SNAVNGRFTFVI 631 Treponema denticola ASLM
WP_010698770 602 -----SRTMGNNSSSG-----SNAVNGRFTFVI 624 Treponema denticola
WP_024465453 589 -----SRTMGNNSPSG-----SNAVNGRFTFTV 611 Treponema pedis
WP_051169911 588 egfcpAISYGNNDSNG-----ANAVNGRFTFTI 615 Treponema socranskii
WP_021686482 581 ikycrAASYGNNSSSG-----ANAVNGCFTFTV 608 Treponema lecithinolyticum
AAQ73567     588 -tyckSISRGNNSMNG-----ANAINGRFTFTV 614 Treponema sp. OMZ 840
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