Conserved Protein Domain Family
mCpol

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NF033576: mCpol 
mCpol domain
The mCpol domain (minimal CRISPR polymerase) is named for its homology relationship to catalytic domain of the CRISPR polymerases (often called Cmr2 or Cas10). It is predicted to generate cyclic nucleotides, potentially sensed by CARF domains which in turn activate various effector domain including HEPN RNases, CARF sensor and effectors are found in conserved genome contexts. It is part of a broader class of conflict systems reliant on the production of second messenger nucleotide or nucleotide derivatives. The putative function of the mCpol domain implies that CRISPR polymerases of the type III CRISPR/Cas systems have a nucleotide synthetase functional role.
Statistics
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PSSM-Id: 411201
Aligned: 9 rows
Threshold Bit Score: 151.352
Created: 19-Oct-2021
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_008275317 364 LYYGLDGDDTGKILEELFLACsDEAKFRKSSKQITKAISKIAGFIRKtlNQNSIIFEAGDDLLFKgnlGKEiLLEIQAMY 443 Crocosphaera ch...
WP_010995662 364 LYYGLDGDDTGKILEELFLSCsDESSFRKLSKDVANAISKISKFVTDklGKNAVVFEAGDDLLFKgnlQEDmLFEMQAMY 443 Nostocaceae
WP_012197014   2 EYITIDGDDVGRKITACYLSN-DEVGLRLISNELEAATIKVSNLLKS--FGFDVIFCAADGVVAS---CEG-VVDFSDVF 74  Shewanella baltica
WP_004960911   1 MYIAIDGDDVGRKITSSYLSN-SEERLKYISNKLNDTTIRISKMLLS--NGFEIIFQAADGVTAK---TDN-EVNLNFVF 73  Serratia odorifera
WP_005418912   2 KYISIDGDDVGRKITSCYLSN-DQHGLEKLSNSLKASTEAISIKLQD--HGFDIIFCAADGVVAF---TKK-DIDMRFIF 74  Aliivibrio fisc...
WP_016140051   4 LYLTIDGDDIGQMITSSYLKN-DIYELSRINRVVNEKTHLISIFLRE--QGFNIIFCAADGVAGY---IDRsAIDKKFIF 77  Acinetobacter
WP_015648376   2 IYLTIDGDDIGHKITSAYLIN-STTELVRINDLVQEKTRCIAEYLRK--ENFIIHFCAADGVAAS---IEY-ELDMRRIF 74  Pseudomonas aer...
WP_017256018   5 RYLTIDGDDIGQKIAAAYLTN-NTAELIRVNNLVQESTHFIADFLRL--EGFAIHFCAADGVAAS---IAH-DFDLKQIS 77  Pseudomonas tol...
WP_017679350   2 NYITIDGDDIGQKITSAYLGN-NVKELIGVNNLVQDKTRQIAAYLKS--QGFEIIFCAADGVAGT---TKS-EIDAEYIY 74  Pseudomonas che...
WP_008275317 444 SQLTSgittsGLTCSIGYGRSFQEVYLALKLAKTQpGKNAIVGIELC 490 Crocosphaera chwakensis
WP_010995662 444 SQLTP-----GLTCSIGYGRSFQEVYLALKLAKTQpGKNAIVGIELC 485 Nostocaceae
WP_012197014  75 AHIQEla-pnSISFSAGVGSNLKDAYVALLDAKSN-GKNKLCNHSKI 119 Shewanella baltica
WP_004960911  74 DKIKSys-fdEITFSAGVGANLREAYVALLNSKSN-GKNMISIYKDI 118 Serratia odorifera
WP_005418912  75 SEIRKis-sgEVTFSAGSGSSLRESYIALTSAKSN-GKNCLHDYSAL 119 Aliivibrio fischeri
WP_016140051  78 DSIESla-epELHFSAGIGSTLQEAYIALLSAKSS-GKRCIHDFSQI 122 Acinetobacter
WP_015648376  75 SQIEKia-ggEITFSAGVGASLREAYVALLYAKNT-GKKRLCDFRDI 119 Pseudomonas aeruginosa
WP_017256018  78 AEIEKia-dsEITFSAGVGNSLREAYIALLFAKSS-GKNKFCDFREI 122 Pseudomonas tolaasii
WP_017679350  75 SQIQRis-dnELSFSAGVGKSLREAYVALLSAKSS-GKGKLQSFEGM 119 Pseudomonas chengduensis
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