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bifunctional dihydropteridine reductase/dihydrofolate reductase TmpR Members of this family are SDR family oxidoreductases, unrelated to previously known families of dihydrofolate reductase (DHFR), one of which was demonstrated to be a bifunctional dihydropteridine reductase/dihydrofolate reductase. The DHFR activity can give a heterologously expressed protein the ability to confer resistance to trimethoprim, an inhibitor of most forms of DHFR. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",