19113349 19 GSSPSKASSLNw--nEPHTLNEQNTYCYCGKDRNLRFPDLQCSVCLNMFH--LSCLSPPCT--S-MMGFSTNYQFVCKHC 91 fission yeast 7301188 30 SSSEVNFTAEEd---KSQETRSAAGVCYCGKERNLNIVELLCATCSRWVHe-TCVSYQLGK--GkLLPFITNYVFVCKNC 103 fruit fly 15223851 1 ------------------MESLQSNSKIEEAEQNPKIEEAQVSVSLPEEPtgVLLPSELVD--D-SAPPESSDAVEESIE 59 thale cress 17536921 1 MRSSKGGRGRQ----AAP-KTAPTTVCYCDGKRELGSVEVVCSTCLKWFHgrCLKEFHELN--SnGVPFMICYTFTCKQC 73 Caenorhabditis elegans 17536919 1 MRSSKGGRGRQ----AAP-KTAPTTVCYCDGKRELGSVEVVCSTCLKWFHgrCLKEFHEFSrnSnGVPFMICYTFTCKQC 75 Caenorhabditis elegans 17536923 1 MRSSKGGRGRQ----AAP-KTAPTTVCYCDGKRELGSVEVVCSTCLKWFHgrCLKEFHELN--SnGVPFMICYTFTCKQC 73 Caenorhabditis elegans 4009336 76 TESSNGKDTLEgagdTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWF---TADTFGIDT--SsCLPFMTNYSFHCNVC 150 human 4009336 29 egemkpvaagaaappgegisaaptvepssgeaeggeanlvdvsggletessngkdtlegagdtsevmdtqagsvdeengr 108 human 4757790 76 TESSNGKDTLEgagdTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWF---TADTFGIDT--SsCLPFMTNYSFHCNVC 150 human 2506766 1 --------------------MKLGIIPYQEGTDIVYKNALQGQQEGKRPNlpQMEATHQIK----SSVQGTSYEFVRTED 56 baker's yeast
19113349 92 TEDGFERFERGVSAWKAITATAMANLvvkryveTNPDVPVDSFNAEkmrnfqanTYFFKKKEdLIPFIEEHWQLLCPDRE 171 fission yeast 7301188 104 SASGLESFRKSQATISQMCHCAIAN--------MQQAASRDGRRQ---------IQFSKDKE-IIPYIEQYWEAMTTMPR 165 fruit fly 15223851 60 TAS---EAEVSIS---LLEGTTTGTA-------LLPSEENDLAPLE--------SSGIIEEP-IDTDLEKLDVVAMDVDQ 117 thale cress 17536921 74 RPT-AEDWKAKKADLVQMCVTVLATL-------SAERLKADGKLSAehvp-edfTYLSLKDE-IVPYMNENWYMLTAIKQ 143 Caenorhabditis elegans 17536919 76 RPT-AEDWKAKKADLVQMCVTVLATL-------SAERLKADGKLSAehvp-edfTYLSLKDE-IVPYMNENWYMLTAIKQ 145 Caenorhabditis elegans 17536923 74 RPT-AEDWKAKKADLVQMCVTVLATL-------SAERLKADGKLSAehvp-edfTYLSLKDE-IVPYMNENWYMLTAIKQ 143 Caenorhabditis elegans 4009336 151 HHSGNTYFLRKQANLKEMCLSALANL-------TWQSRTQDEHPK---------TMFSKDKD-IIPFIDKYWECMTTRQR 213 human 4009336 109 qlgevelqcgictkwftadtfgidtssclpfmtnysfhcnvchhsgntyflrkqanlkemclsalanltwqsrtqdehpk 188 human 4757790 151 HHSGNTYFLRKQANLKEMCLSALANL-------TWQSRTQDEHPK---------TMFSKDKD-IIPFIDKYWECMTTRHR 213 human 2506766 57 IPLNRRHFVYRPCS--ANPFFTILGY-------GCTEYPFDHSGMS----------VMDRSE--GLSISRDGNDLVSVPD 115 baker's yeast
19113349 172 k-VQTWQATLGSCLVANRDTYRAKDETMRNQn-------SEYALNNPNLFDFRSGYIFPFQRVGATVPKKRl---vETET 240 fission yeast 7301188 166 rlTQSWYSTVQRSLVKDVQTLFTYEEHAEHG--------AMYGLFHQDLRIIKPNYES-MSKSGALRLT-------DDGY 229 fruit fly 15223851 118 --PGSDLKIESDSFSEEAPTTSSSDNPKSPK---------LDSVANQNGSAMEEDEGDEEQDDPPHKKLKQ-----LDCL 181 thale cress 17536921 144 --KKEWHQNLAPTLLKEKN---IFVQHNDDD--------DLFALAEKNLSLLGPLHEA-VKLIGKRPIEREnreprHIEL 209 Caenorhabditis elegans 17536919 146 --KKEWHQNLAPTLLKEKN---IFVQHNDDD--------DLFALAEKNLSLLGPLHEA-VKLIGKRPIEREnreprHIEL 211 Caenorhabditis elegans 17536923 144 --KKEWHQNLAPTLLKEKN---IFVQHNDDD--------DLFALAEKNLSLLGPLHEA-VKLIGKRPIEREnreprHIEL 209 Caenorhabditis elegans 4009336 214 pgKMTWPNNIVKTMSKERD-VFLVKEHPDPGskdpeedyPKFGLLDQDLSNIGPAYDN-QKQSSAVSTSGNl----NGGI 287 human 4009336 189 tmfskdkdiipfidkywecmttrqrpgkmtwpnnivktmskerdvflvkehpdpgskdpeedypkfglldqdlsnigpay 268 human 4757790 214 pgKTTWPNNIVKTMSKERD-VFLVKEHPDPGskdpeedyPKFGLLDQDLSNIGPAYDN-QKQSSAVSTSGNl----NGGI 287 human 2506766 116 --QYGWRTARSDVCIKEGMTYWEVEVIRGGN--------KKFADGVNNKENADDSVDEVQSGIYEKMHK-Q-----VNDT 179 baker's yeast
19113349 241 PPPSSSKLkedyKDSKREMKrSNTPWSNASIKKNEVpTVPIRYKPPPWrdsdfetvpKLPIFYPNSSSPNFFSLSEI-P- 318 fission yeast 7301188 230 TQASLSKN----NRQKRKFPgTDSGPTGKKGRPSSD-ITANVKLPPHG----------YPLEHPFNKDGYRYILAEPdPh 294 fruit fly 15223851 182 TSVAVKEE----EEPEQVLP-SEAMVVEEAATLVASaAKKSKSKKKNN---------NVWVTKSTRKGKKKSKANTPnPa 247 thale cress 17536921 210 PPIEGPKT----RGASKRRH-AEAPVTGKKQKLAAD---YSSTAAPNG----------VQIDIPFSKDNYRYYLTEVdPn 271 Caenorhabditis elegans 17536919 212 PPIEGPKT----RGASKRRH-AEAPVTGKKQKLAAD---YSSTAAPNG----------VQIDIPFSKDNYRYYLTEVdPn 273 Caenorhabditis elegans 17536923 210 PPIEGPKT----RGASKRRH-AEAPVTGKKQKLAAD---YSSTAAPNG----------VQIDIPFSKDNYRYYLTEVdPn 271 Caenorhabditis elegans 4009336 288 AAGSSGKG----RGAKRKQQ--DGGTTGTTKKARSDpLFSAQRLPPHG----------YPLEHPFNKDGYRYILAEPdPh 351 human 4009336 269 dnqkqssavstsgnlnggiaagssgkgrgakrkqqdggttgttkkarsdplfsaqrlpphgyplehpfnkdgyryilaep 348 human 4757790 288 AAGSSGKG----RGAKRKQQ--DGGTTGTTKKARSDpLFSAQRLPPHG----------YPLEHPFNKDGYRYILAEPdPq 351 human 2506766 180 PHLRFGVCr---REASLEAP-VGFDVYGYGIRDISL---ESIHEGKLN---------CVLENGSPLKEGDKIGFLLSlPs 243 baker's yeast
19113349 319 -FNRRGFryspceaAKDLPNVMYREIELPPFTSRINWHDISTPVFIDHSALCATVEKGFRMARSNVFMTSGEWYFEIKIE 397 fission yeast 7301188 295 aPFRQEFdessdwaGKPIPGWLYRILVPH--SVLLALHDRAPQLKISEDRLAVTGERGYCMVRATHSVNRGCWYFEVTIE 372 fruit fly 15223851 248 aVEDKVL-------ITPVPRFPDKGDDTPDLEICLSKVYKAEKVEISEDRLTAGSSKGYRMVRATRGVVEGAWYFEIKVL 320 thale cress 17536921 272 vPEDPAWnqn-qssAYVIPSFHYRELLNP--TVNVSSNDRAFQLSINGN--SITGFEGYSMARASHGVSKGTWYFEVNFD 346 Caenorhabditis elegans 17536919 274 vPEDPAWnqn-qssAYVIPSFHYRELLNP--TVNVSSNDRAFQLSINGN--SITGFEGYSMARASHGVSKGTWYFEVNFD 348 Caenorhabditis elegans 17536923 272 vPEEPIFp------IFLAFSLFY-----------------------------IE-------------------------- 290 Caenorhabditis elegans 4009336 352 aPDPEKLeld-cwaGKPIPGDLYRACLYE--RVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVD 428 human 4009336 349 dphapdpekleldcwagkpipgdlyraclyervllalhdrapqlkisddrltvvgekgysMVRASHGVRKGAWYFEITVD 428 human 4757790 352 aPDPEKLeid-cwaGKPISGDLYRACLYE--RVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVD 428 human 2506766 244 iHTQIKQ-------AKEFTKRRIFALNSHMDTMNEPWREDAENGPSRKKLKQETTNKEFQR-----ALLEDIEYNDVVR- 310 baker's yeast
19113349 398 KGggDDGAHVRIGVSRREAPLDAPVGYDAYSYGLRDLGGQKVHMSRPRNFM-DSFGTGDIIGLHISLPKPSFAq------ 470 fission yeast 7301188 373 EM--PDGAATRLGWGREYGNLQAPLGYDKFGYSWRSRKGTKFTESHGKHYS-DAYVEGDTLGFLIELPEEAS-------- 441 fruit fly 15223851 321 SLg--ETGHTRLGWSTDKGDLQAPVGYDGNSFGFRDIDGCKIHKALRETYAeEGYKEGDVIGFYINLPDGES-------- 390 thale cress 17536921 347 DQ--PDDSHIRIGWSQSYASLQACVGYNKFSYGWRSKHGTKFHEAKGKKYHfGGFKQGDVLGCLIHLPVDKKLqipanlp 424 Caenorhabditis elegans 17536919 349 DQ--PDDSHIRIGWSQSYASLQACVGYNKFSYGWRSKHGTKFHEAKGKKYHfGGFKQGDVLGCLIHLPVDKKLqipanlp 426 Caenorhabditis elegans 17536923 291 ---------IF---------------------------------------------QGDVLGCLIHLPVDKKLqipanlp 316 Caenorhabditis elegans 4009336 429 EM--PPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYS-SGYGQGDVLGFYINLPEDTET------- 498 human 4009336 429 EM--PPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYS-SGYGQGDVLGFYINLPEDTET------- 498 human 4757790 429 EM--PPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYS-SGYGQGDVLGFYINLPEDTET------- 498 human 2506766 311 -----DQIAIRYK-NQLFFEATDYVKTTKPEYYSSDKRERQDYYQLEDSYL-AIFQNGKYLGKAFENLKPLLP------- 376 baker's yeast
19113349 471 -HTTLPSCH-DRIPIRYKGQLYFEQPDYVpSKMMDELMIpskhnryidlpyIPGSFIKVYKNGSYMGTAFENLLDfnppn 548 fission yeast 7301188 442 -LDYLPNTFkDRPLVKFKSHLYYEDKDKI-TETLKNLHI------------LQGSRIEFFKNGQSQGVAFEDIY------ 501 fruit fly 15223851 391 --FAPKPPH----YVFYKGQRYICAPDAK----EEPPKV------------VPGSEISFFKNGVCQGAAFTDIVG----- 443 thale cress 17536921 425 sEKYLPVSHkGFNLISFKANYFFEVQEES-ADIAKTLVE------------MPGSYIEFFHNGKSCGKAYENIY------ 485 Caenorhabditis elegans 17536919 427 sEKYLPVSHkGFNLISFKANYFFEVQEES-ADIAKTLVE------------MPGSYIEFFHNGKSCGKAYENIY------ 487 Caenorhabditis elegans 17536923 317 sEKYLPVSHkGFNLISFKANYFFEVQEES-ADIAKTLVE------------MPGSYIEFFHNGKSCGKAYENIY------ 377 Caenorhabditis elegans 4009336 499 -AKSLPDTYkDKALIKFKSYLYFEEKDFV-DKAEKSLKQ------------TPHSEIIFYKNGVNQGVAYKDIF------ 558 human 4009336 499 -AKSLPDTYkDKALIKFKSYLYFEEKDFV-DKAEKSLKQ------------TPHSEIIFYKNGVNQGVAYKDIF------ 558 human 4757790 499 -AKSLPDTYkDKALIKFKSYLYFEEKDFV-DKAEKSLKQ------------TPHSEIIFYKNGVNQGVAYKDIF------ 558 human 2506766 377 --PFSELQYnEKFYLGYWQHGEARDESND----KNTTSA------------KKKKQQQKKKKGLILRNKYVNNNK----- 433 baker's yeast
19113349 549 sinsnhysfdDGslGYYPSISMYGG-------GIARFQFGPQFSHRPLVLGSNVR-PVSERYNEQIAEDVLCDILDEIDY 620 fission yeast 7301188 502 ----------AG--SYFPAISIHKS-------ATVSVNFGPAFKYPEVLVEHKAK-GMHDRVEELITEQCLADTLYLTEH 561 fruit fly 15223851 444 -----------G--RYYPAASMYTLpdq--snCLVKFNFGPSFEFFPEDFGGRA---TPRP-MWEVPYHGFNGRLETNGS 504 thale cress 17536921 486 ----------AG--AYYPSISIFKS-------ATATMNLGPKFRN----LPRGAT-GIHARADEQQHEQTLSDMLYLVSK 541 Caenorhabditis elegans 17536919 488 ----------AG--AYYPSISIFKS-------ATATMNLGPKFRN----LPRGAT-GIHARADEQQHEQTLSDMLYLVSK 543 Caenorhabditis elegans 17536923 378 ----------AG--AYYPSISIFKS-------ATATMNLGPKFRN----LPRGAT-GIHARADEQQHEQTLSDMLYLVSK 433 Caenorhabditis elegans 4009336 559 ----------EG--VYFPAISLYKS-------CTVSINFGPCFKYPPKDLTYRP---MSDMGWGAVVEHTLADVLYHVET 616 human 4009336 559 ----------EG--VYFPAISLYKS-------CTVSINFGPCFKYPPKDLTYRP---MSDMGWGAVVEHTLADVLYHVET 616 human 4757790 559 ----------EG--VYFPAISLYKS-------CTVSINFGPCFKYPPKDLTYRP---MSDMGWGAVVEHTLADVLYHVET 616 human 2506766 434 ----------LG---YYPTISCFNGgtariisEEDKLEYLDQIRSAYCVDGNSKVnTLDTLYKEQIAEDIVWDIIDELEQ 500 baker's yeast
19113349 621 AEDPNts--svTIDVPQEP 637 fission yeast 7301188 562 DGRL-------RLDNMGL- 572 fruit fly 15223851 505 EDMKS-------------- 509 thale cress 17536921 542 EVNLDhpprvkREDDDDVK 560 Caenorhabditis elegans 17536919 544 EVNLDhpprvkREDDDDVK 562 Caenorhabditis elegans 17536923 434 EVNLDhpprvkREDDDDVK 452 Caenorhabditis elegans 4009336 617 EVDG-------RRSPPWEP 628 human 4009336 617 EVDG-------RRSPPWEP 628 human 4757790 617 EVDG-------RRSPPWEP 628 human 2506766 501 IALQQ-------------- 505 baker's yeast
Jiyao W et al.(2023). "The conserved domain database in 2023.",