17017991 1 MGK-KGKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRF-QFLQKARALLDLCAAPGGWLQVAAKFMP---VSSLIVGV 75 human 7293173 1 MGK-KTKVGKTRKDKFYQLAKETGLRSRAAFKLIQLNRKF-GFLQQSQVCLDLCAAPGGWMQVAKQNMP---VSSIVIGV 75 fruit fly 4539291 1 MGK---VKGKHRLDKYYRLAKERGFRSRASYKLLQLDAKY-SLLHSAHAVLDLCAAPGGWMQVAVEKVP---VGSLVLGI 73 thale cress 15240727 1 ------MSGAGVPDFFYREAQRLGYVARSAFKLLQIQKQY-KLIKPGSSVLDLGCAPGAWLQVACQSLGplrSGGIVVGM 73 thale cress 17553860 1 MGK-KVKIGKQRRDKYYKLAKEAGYRSRAAFKLVQLNKRF-EFLEKSRATVDLCAAPGGWMQVASQFMP---VSSLIVGV 75 Caenorhabditis elegans 17553858 1 MGK-KVKIGKQRRDKYYKLAKEAGYRSRAAFKLVQLNKRF-EFLEKSRATVDLCAAPGGWMQVASQFMP---VSSLIVGV 75 Caenorhabditis elegans 19074557 24 MGK-SKSTGKTRLDKYYSLAKEKGYRARSAFKLLQMNRKY-GFLEDAHVLIDLCAAPGSWSQVAAQEMP---LRRKIVAI 98 Encephalitozoon cun... 9910811 1 MGKsQKKTAKGRLDKWYKLAKEQGYRSRAAFKLVQLNQKY-SFLEKAKVIIDLCAAPGGWLQVASKTCK---PGSLIVGV 76 fission yeast 6226708 1 MGKtQKKNSKGRLDRYYYLAKEKGYRARSSFKIIQINEKYgHFLEKSKVVIDLCAAPGSWCQVASKLCP---VNSLIIGV 77 baker's yeast
17017991 76 DLVPIKPLPNVVTLQEDITTERCRQALRKELKTWKV----DVVLNDGAPNVGASWVHDAYSQAHLTLMALRLACDFLARG 151 human 7293173 76 DLFPIRPIAGCIGLVEDITTEKCRQSLTKELQSWKA----DVVLHDGAPNVGRNWLYDAYQQICLTLNALKLSTQFLRNG 151 fruit fly 4539291 74 DLVPILPVRGCVTMTQDITRTECKSKIKQVMEQHGVsa-fNLVLHDGSPNVGGAWAQEAMSQNALVIDSVRLATEFLARN 152 thale cress 15240727 74 DIKKVKVPPQCDSRVQTIAADVLNFPRQKIRELSPQqlgfSVILSDMCHSVSGITTRDAALSAELGMRALDLAVGQAAIS 153 thale cress 17553860 76 DLAPIKPIKNCIALQGDITTNETRAAIKKELKTWSA----DCVLHDGAPNVGLNWVHDAFQQNCLTLSALKLATQILRKG 151 Caenorhabditis elegans 17553858 76 DLAPIKPIKNCIALQGDITTNETRAAIKKELKTWSA----DCVLHDGAPNVGLNWVHDAFQQNCLTLSALKLATQILRKG 151 Caenorhabditis elegans 19074557 99 DLEPIKFIGDVDTIVEDITTDECRLKLREILGTHKA----DVVLHDGAPNVGTSWENDAFNQNLLVLHSARLAAEFLRKG 174 Encephalitozoon cun... 9910811 77 DLAPIKPIPNCHTFVEDITSDKCRSQLRGYLKTWKA----DVVLHDGAPNVGSAWLQDAYGQAQLVLMSMKLACEFLVAG 152 fission yeast 6226708 78 DIVPMKPMPNVITFQSDITTEDCRSKLRGYMKTWKA----DTVLHDGAPNVGLGWVQDAFTQSQLTLQALKLAVENLVVN 153 baker's yeast
17017991 152 GS-FITKVFRSRDYQPLLWIFQQLFRRVQATKPQASRHESAEIFVVCQGFLAPDKVDSKFFDPKFAFKEVEVQAK----- 225 human 7293173 152 GW-FVTKVFRSKDYNALLWVLKQLFKKVHATKPSASRKESAEIFVVCQGYLAPDHIDPRLLDSKYVFEELDLDAK----- 225 fruit fly 4539291 153 GN-LVTKMCVPEPFFLLAFLLVQLFEKVEVFKPPASRSASAETYLVGLKYLAPAKIDPRLLDYRHLFKESAEPTR----- 226 thale cress 15240727 154 QSpNDDDGGPNESRPGVLRHGGHLVIKLLESEDAQDFARICKPIFNKASWLRPKATRPSSREIYLICQGFR--------- 224 thale cress 17553860 152 GT-FVTKVFRSNDYSCLIRVFEKLFKRVHVWKPAASRLESAEIFVVCEVYQKPDKVGAEYLDPKKVFAN-PDGSEgtkpn 229 Caenorhabditis elegans 17553858 152 GT-FVTKVFRSNDYSCLIRVFEKLFKRVHVWKPAASRLESAEIFVVCEVYQKPDKVGAEYLDPKKVFAN-PDGSEgtkpn 229 Caenorhabditis elegans 19074557 175 GV-FVTKVFRSQDYFSLLNVLSQLFGSVETSKPLSSRSQSAEIFLVCLGFIGEEDVDYSILEASAVFEE-MKGAG----- 247 Encephalitozoon cun... 9910811 153 GT-FVTKVFRSRDYNNLLWVFKQLFNKVEATKPPSSRNVSAEIFVVCRGYKAPKKLDPRFTDPRTVFEEVQEPVTn---- 227 fission yeast 6226708 154 GT-FVTKIFRSKDYNKLIWVFQQLFEKVEATKPPASRNVSAEIFVVCKGFKAPKRLDPRLLDPKEVFEELPDGQQn---- 228 baker's yeast
17017991 226 T-VTELVTKKKPKA--EGYAEGDLTLYHRTSVTDFLRAANPV---DFLSKASEIMVD--DEELA---QHPATTEDIRVCC 294 human 7293173 226 KkSSLLHPEKQKRIkaEGYTAQDIALRNDLAATEFLKAENAL---AALQGIGSIRID--DQRIA---NHKKTTPEILECC 297 fruit fly 4539291 227 KvVDVLGGSKQKRNr-DGYEDGESILRRVASAADFIWSENPL---DVLGTTTSISFD--DQASLplkEHDLTTEEIKILC 300 thale cress 15240727 -------------------------------------------------------------------------------- thale cress 17553860 230 PqNLLIGKQKKAKA--EGYDTDSLAIHSTINATDFIKSSGYL---DILGTANVITLD--DEKWK---NHEKTTEEVIEYM 299 Caenorhabditis elegans 17553858 230 PqNLLIGKQKKAKA--EGYDTDSLAIHSTINATDFIKSSGYL---DILGTANVITLD--DEKWK---NHEKTTEEVIEYM 299 Caenorhabditis elegans 19074557 248 -----------------GY--DDFNFHKTLKLTEFLREDDPVvlsEMLLKYSEIEIDi-DPGDV----CKVLEPEFLDLF 303 Encephalitozoon cun... 9910811 228 VdAKVFHPEKRKRSr-EGYADDDYTLHKTVLASEFVTANDPI---QILGTSAEIVFPkdDEECQrlyNLDVTTEEILLCC 303 fission yeast 6226708 229 MeSKIYNPEKKVRKr-QGYEEGDNLLYHETSILDFVRTEDPI---SMLGEMNKFTIDenDHEWKilkKLKQTTDEFRSCI 304 baker's yeast
17017991 295 QDIRVLGRKELRSLLNWRtklrryvaKKLKEQAKALDiSLSSGEEDEGDEEDstagttkqPSKEEeeeeeeeQLNQTLAE 374 human 7293173 298 KDLKVLGRKDIKGLVQWW--------KDVRELFVEKEtPLVVGNAADEKPKP--------LTQAEiedmedaELQTQIET 361 fruit fly 4539291 301 DDLPVLGKNDFKHILKWR--------MQIRKALTPEKkEVAKPEPDVGKE-----------DEEN-------EDDKLLNE 354 thale cress 15240727 -------------------------------------------------------------------------------- thale cress 17553860 300 NDVKVLGPRELRVLLRWR--------KSMLETLEEQR-KAVEGEAKEVEIEEn-------LTEEQledramaEIDELIAK 363 Caenorhabditis elegans 17553858 300 NDVKVLGPRELRVLLRWR--------KSMLETLEEQR-KAVEGEAKEVEIEEn-------LTEEQledramaEIDELIAK 363 Caenorhabditis elegans 19074557 304 KDLQLLGKGDIRKILRKR-------------------------------------------------------------- 321 Encephalitozoon cun... 9910811 304 SDLQVLGKKEFRDILRWR--------LKIRDEMGIGK-KVEDEQKTVVEEIPe-------MDEEE-------RLDQELQD 360 fission yeast 6226708 305 EDLKVLGKKDFKMILRWR--------KIAREILGI---EVKDDAKTEIEVVP--------LTEEE-------QIEKDLQG 358 baker's yeast
17017991 375 MKAQEVAELKRKKKKLLREQRKQRERVELKMDLPG-VSIADEg--ETGMFSLCTIRGHQLLEEVTQGDMs---AADTFLS 448 human 7293173 362 IVEEEKKDLKRKRKKTLKTKAKLHEKMNLNMVIKGdDGPVEEm--EHEIFDLKNIRTSAELDELLDVQPd--fAVDESQP 437 fruit fly 4539291 355 LEELTN-TVDRKKKQAKKILAKRRAKDKARKATGPqMDVLEDgfvDNELFSLNAIKGKKDLMAVDNDEDdngnAVDSENE 433 thale cress 15240727 -------------------------------------------------------------------------------- thale cress 17553860 364 ASEDEKAALKKKKKKMLKAKARVLKRRELKMIIDGdEGPQAE---DQEVFQLKKIRKAKELAEITKDTQ----APDFDMM 436 Caenorhabditis elegans 17553858 364 ASEDEKAALKKKKKKMLKAKARVLKRRELKMIIDGdEGPQAE---DQEVFQLKKIRKAKELAEITKDTQ----APDFDMM 436 Caenorhabditis elegans 19074557 322 -------------SKIVKGVQ----R--------G----------EIDVAELAFLRNSS--------------DVP---- 348 Encephalitozoon cun... 9910811 361 LSEAERVKLKRERRKANQRKQREIVRMQMGMLAPMdIGLEHEamgEDSLFGLATAEKHG-LKELENGTLpvteSVDEEVS 439 fission yeast 6226708 359 LQEKQRLNVKRERRRKNEMKQKELQRMQMNMITPTdIGIEAAslgKESLFNLKTAEKTGILNDLAKGKKrm-iFTDDELA 437 baker's yeast
17017991 449 DLPRDDIYVS-DvEDDGd---dTSLDSDLDPEELAgvrgHQGLRDQKRMRLTEVQDDKEEEEEEnplLVPLEEKav-lqE 523 human 7293173 438 EETKLPKYKYfD-KDEG------NINDDLN---------YDDDNDEEQSE--ASDDEDQINDKQ---GLGLSDD-----D 491 fruit fly 4539291 434 DHGEGASDDSkD-SDRDsdeerQKYTEQMEEIFEQa---YERYMVKKEGSAKQRKRARQAHAEK------LEEG-----D 498 thale cress 15240727 -------------------------------------------------------------------------------- thale cress 17553860 437 EDGDSDEEEGlG-EGEWethgeEGENSDEDENELI----HTEKSGMSKMEKRNARTESWFEKEE---ISGLVSDe---dD 505 Caenorhabditis elegans 17553858 437 EDGDSDEEEGlG-EGEWethgeEGENSDEDENELI----HTEKSGMSKMEKRNARTESWFEKEE---ISGLVSDe---dD 505 Caenorhabditis elegans 19074557 349 ---------------------------------------------ETEMK--AKSVEEKIEEIQ---------------M 366 Encephalitozoon cun... 9910811 440 TDNEVEYDS----DDER-----DRLEADLDSMYSD----YTKRKAESDVKYRVKKARGDLDDEE---WNGIDNGt----E 499 fission yeast 6226708 438 KDNDIYIDENiMiKDKDsaadaDDLESELNAMYSD----YKTRRSERDAKFRAKQARGGDNEEE---WTGFNEGslekkE 510 baker's yeast
17017991 524 EQANLWFSKGsfaGIEDDADEALEISQaqllFEN-RRKGRQQq----qKQQLPQTPPSCLKtEimsp-lyqdEAPKGTEA 597 human 7293173 492 NDEGNAKGKN---KRKKRSENPLIKSNd---FRD-KNTKREQ------RVQLWYEKDVLQNiQs--------DDDEETYD 550 fruit fly 4539291 499 GDEEMKIDYDs-dMNEEKDEANPLVVP----LDDgVVQTKEE------ISNQWFSQNIFAEaVe--------EGDLGKDD 559 thale cress 15240727 -------------------------------------------------------------------------------- thale cress 17553860 506 DDEMNAIEKHigkNRSKKTENYENTVS----FDD-SKGKKKGk----kGGKGG-EDDGFNT-N---------DADEQASE 565 Caenorhabditis elegans 17553858 506 DDEMNAIEKHigkNRSKKTENYENTVS----FDD-SKGKKKGk----kGGKGG-EDDGFNT-N---------DADEQASE 565 Caenorhabditis elegans 19074557 367 LLEKK---------RKKESRGDRMAKS----------GKEIG---------CFFKDSIFDR------------------- 399 Encephalitozoon cun... 9910811 500 SDDSQIAETN-----FATPDKDRLTTS----LLD-KGSTKDGls---rKARMFFDQDIFDGiE---------DADADVEI 557 fission yeast 6226708 511 EEGKDYIEDNddeGVEGDSDDDEAITN----LIS-KLKGQEGdhklssKARMIFNDPIFNNvEpdlpvntvnDGIMSSES 585 baker's yeast
17017991 598 SSGTEAATGLEGEEKDGISDSDSSTSSE-------EE-ESWEPLRGKKRSRGP----KS-DDDGFEIVPIEdp----aKH 660 human 7293173 551 LNNLAKEFKAKGVAVLGESTLTPDANEEvvqgkkaKRrARHETATKDSSSESSesedDA-NEDSDGEQPAAgt---naKK 626 fruit fly 4539291 560 SE--DEIANKKKSKNLSKPDKSKQKASK-------ASvLSDQSLPNSSKKEDEfevvPApATDSDSDSSSE-------DD 623 thale cress 15240727 -------------------------------------------------------------------------------- thale cress 17553860 566 SESSDAEMDEVAKEKLSRFDAQIDLDDD-------DEeERYEDEGRRAAKRKC----DK-KIIGEDLKPVA-------KK 626 Caenorhabditis elegans 17553858 566 SESSDAEMDEVAKEKLSRFDAQIDLDDD-------DEeERYEDEGRRAAKRKC----DK-KIIGEDLKPVA-------KK 626 Caenorhabditis elegans 19074557 400 ------LKMVGEDEEVGKEN-------E-------QT------IEVSSCSDS--------------LDLDE--------- 430 Encephalitozoon cun... 9910811 558 MSMNRAAIKKREAELASQNNDDGSKGDQs-----eDSnDHIEVVPVASAHDE-----DD-DWNSDSDNDEN-------NV 619 fission yeast 6226708 586 VGDISKLNKKRKHEEMHQKQDEADSSDEs-----sSDdSDFEIVANDNASEEF----DS-DYDSEEEKNQTkkekhsrDI 655 baker's yeast
17017991 661 RILDPEGLALGAVIASSKKAKRDLIDNSFNRYTFNEdeGELPEWFVQEEKQHRIRQLPVGKKEVEHYRKRWREINARPIK 740 human 7293173 627 VRLSENEMALGALLTRSKKTRRDLIDAAWNRYAFND--ENVPVWFKLDEDEHMTKPTPVPKELTAEYQRKLQEVNVRPIK 704 fruit fly 4539291 624 VHTKAEILACAKKMLR-KKQREQMLDDAYNKHMFVD--EGLPKWFVDDEKQHRQPMKPVTKDEVNAMKAQFKEINARPAK 700 thale cress 15240727 -------------------------------------------------------------------------------- thale cress 17553860 627 RKLTPEQLAIGEQMIYSAKAARNLEDEAWNRYANND--EDLPDWFADDEKKHYFKQTPVTKEQVALYRERMREFNARPSK 704 Caenorhabditis elegans 17553858 627 RKLTPEQLAIGEQMIYSAKAARNLEDEAWNRYANND--EDLPDWFADDEKKHYFKQTPVTKEQVALYRERMREFNARPSK 704 Caenorhabditis elegans 19074557 431 -----EEMMC---VAKLKENREEFIEDTIDRYARDPn-EKLPNYLREDQEAFYSR--PPKNE------ER------RLSK 487 Encephalitozoon cun... 9910811 620 EIVTAEAMTLAQDIASRRKSKADLIDEGYNRWSFQSk-EGLPDWFLDEETTVNKPNKPITKEAVLALREKMKALNARPIK 698 fission yeast 6226708 656 DIATVEAMTLAHQLALGQKNKHDLVDEGFNRYTFRDt-ENLPDWFLEDEKEHSKINKPITKEAAMAIKEKIKAMNARPIK 734 baker's yeast
17017991 741 KVAEAKARKKRRMLKRLEQTRKKAEAVVNTVDISEREKVAQLRSLYKKAGLgKEKRHV--TYVVAKKGvgrKVRRPAGvR 818 human 7293173 705 KVMEAKARKHRRATKRLAKAKKMAEKIMENSDATNHEKSKQLKKVYKKAQE--KKKEVt-YVVAKKQTaarRARRPAGvK 781 fruit fly 4539291 701 KVAEAKARKKRAAQKRLEKVRKKANTISDTADISDRSKDKMIDKLYKKAAE-PRKPRK--ELVVSKKG----VGVKVG-K 772 thale cress 15240727 -------------------------------------------------------------------------------- thale cress 17553860 705 KVAEAKARKQKKMQRKLESAKKKAEGILENDQMEHSEKVREMKKVYANATR-KEKKKV--ELVRMTKGkkgKTGRPN--- 778 Caenorhabditis elegans 17553858 705 KVAEAKARKQKKLKI----------------------------------------------------------------- 719 Caenorhabditis elegans 19074557 488 KEREALSRRKSRAERRAEIFMK--DLVIDDSE----EEGKVAKKIYRSSFK-KTKAKP--RIVFPKKG---TCGVPHG-K 554 Encephalitozoon cun... 9910811 699 KVLEAQGRKKMRTIKRLQRVAKKAEGISESGDMTESEKAKEISRLVSRATKsKPKAKP--TLVVAKGPnkgLKSRPKGvK 776 fission yeast 6226708 735 KVAEAKARKRMRAVARLEKIKKKAGLINDDSDKTEKDKAEEISRLMRKVTK-KPKTKPkvTLVVASGRnkgLAGRPKGvK 813 baker's yeast
17017991 819 GHFKVVDSRMKKDQRAQQR-------KEQKKKHK 845 human 7293173 782 GRYKVVDPREKKDKRSMDAkkrrekgSKGRKGKG 815 fruit fly 4539291 773 GQ-KRVDRRMKSDDRKRGGgk---pgRNGQKGTG 802 thale cress 15240727 ---------------------------------- thale cress 17553860 779 GQYKLVDSRMKKDLRAAKAkek-tkgRGGKRGIP 811 Caenorhabditis elegans 17553858 ---------------------------------- Caenorhabditis elegans 19074557 555 GKLVMLDKRLKKDKRGRKA--------------- 573 Encephalitozoon cuniculi 9910811 777 GKYKMVDSRMKKDLRAQK--------RLAKKGRR 802 fission yeast 6226708 814 GKYKMVDGVMKNEQRALR--------RIAKKHHK 839 baker's yeast
Jiyao W et al.(2023). "The conserved domain database in 2023.",