1706001 1 MSAHTYKKFENSTSGDLPDKMTIYQDCMnTFNESPVNSKRCRLLISRLLRLLAQGETFPQNEATALFFSISKLFQHQNDP 80 baker's yeast 7302058 6 REKDDEEDAGPSNAYQNLEKTSVLQETR-TFNETPVNPRKCIHILTKILYLINQGEQLVAREATDCFFAMTKLFQSKDVV 84 fruit fly 15226705 -------------------------------------------------------------------------------- thale cress 15236120 7 KKDDDHDDELEYSPFMGIEKGAVLQEAR-VFNDPQVDPRRCSQVITKLLYLLNQGESFTKVEATEVFFSVTKLFQSKDTG 85 thale cress 2492685 3 TNKKDEETGG--NVYAHLDKTSVLQEAR-AFNETPINARKCCFILSKLIYIIQQGESIGRTEATEAFFGVTKLWQSKDVS 79 Caenorhabditis ele... 19172987 1 ---------MKTKVFTTLTERQLLEEMNeSLTKSPVSTRSAVKALNNLFYMLSTR-KLSEATVRNVYVALLKGFQSKDLY 70 Encephalitozoon cu... 12229771 5 FDKKDEESGGGSNPFQHLEKSAVLQEAR-VFNETPINPRKCAHILTKILYLINQGEHLGTTEATEAFFAMTKLFQSNDPT 83 human 13124090 5 FDKKDEESGSGSNPFQHLEKSAVLQEAR-IFNETPINPRRCLHILTKILYLLNQGEHFGTTEATEAFFAMTRLFQSNDQT 83 human 13124090 1 ---------------------------------------------------------------------------mikkf 5 human 3182972 1 MSYSKKDDDGDESIFANVNQVTVTQDAR-AFNSSSISPRKSRRLLSKIAYLIYTGEHFQEKQATELFFGITKLFQHKDPS 79 fission yeast
1706001 81 LRQAVYLAIKELSGISEDVLMATSSIMKD-VQNGSDLIKPDAIRSLTYVLDESTAFSAERLLKSAVVSRHPSISSAALCT 159 baker's yeast 7302058 85 LRRMVYLGIKELSSIAEDVIIVTSSLTKD-MTGKEDLYRAAAIRALCSITDNTMLQAVERYMKQCIVDKNAAVSCAALVS 163 fruit fly 15226705 -------------------------------------------------------------------------------- thale cress 15236120 86 LRRMVYLIIKELSPSSDEVIIVTSSLMKD-MNSKIDMYRANAIRVLCRIIDGTLLTQIERYLKQAIVDKNPVVSSAALVS 164 thale cress 2492685 80 LRRMVYLAVKELAEVSDDVIIVTSSLTKD-MTGREDLYRAAAIRALCKITDTGMLQTIERYMKQAIVDRNSAISSSAIVS 158 Caenorhabditis ele... 19172987 71 LKLCIYSAIEKMSKLTDEGLVGINILMNDlNGKVPDDVKAMALRTLFSIIPGEMVYDFGKYVNQAFISTSMARRDMSVVV 150 Encephalitozoon cu... 12229771 84 LRRMCYLTIKEMSCIAEDVIIVTSSLTKD-MTGKEDNYRGPAVRALCQITDSTMLQAIERYMKQAIVDKVPSVSSSALVS 162 human 13124090 84 LRRMCYLTIKEMATISEDVIIVTSSLTKD-MTGKEDVYRGPAIRALCRITDGTMLQAIERYMKQAIVDKVSSVSSSALVS 162 human 13124090 6 dkkdeesgsgsnpfqhleksavlqearifnetpinprrclhiltkilyllnqgehfgtteateaffamtrlfqsndqtlr 85 human 3182972 80 LRQFVYIIIKELSVVAEDVIMITSSIMKDtATGRETIYRPNAIRSLIRVIDANTVPAIERILTTGIVDPISAVASAALVS 159 fission yeast
1706001 160 SYHLLPISEVTIRRFTNETQEAVLDLKQfpnqhgns------eyypnstyISQYHALGLLYQLKKTDKMALLKLVRHFSE 233 baker's yeast 7302058 164 SLRLANTAGDVVKRWANEAQEALNSDNI----------------------MVQYHALGLLYHIRKSDRLAVSKLVNKLTR 221 fruit fly 15226705 -------------------------------------------------------------------------------- thale cress 15236120 165 GLHLLKTNPEIVKRWSNEVQEGIQSRSA----------------------LVQFHALALLHQIRQNDRLAVSKLVGSLTR 222 thale cress 2492685 159 SIHLMRKSSEVVRRWANEVQEAVSSDNH----------------------MVQYHALALLYQIRANDRLAVNKLVQKFSK 216 Caenorhabditis ele... 19172987 151 AYKLLCNNFNQTKKWLEGIEPTGNPLMD-------------------------YHVVGFLAQS-K--RLQLSSVEHFRGP 202 Encephalitozoon cu... 12229771 163 SLHLLKCSFDVVKRWVNEAQEAASSDNI----------------------MVQYHALGLLYHVRKNDRLAVNKMISKVTR 220 human 13124090 163 SLHMMKISYDVVKRWINEAQEAASSDNI----------------------MVQYHALGVLYHLRKNDRLAVSKMLNKFTK 220 human 13124090 86 rmcyltikematisedviivtssltkdmtgkedvyrgpairalcritdgtmlqaierymkqaivdkvssvsssalvsslh 165 human 3182972 160 AYHLYPVAKDIVSRWNNEVQDAVTSHNVgrkvasspfftstlgytpnasgISQYHALGLLYRIRRHDSIAMNKLLQLLVS 239 fission yeast
1706001 234 n-NSMKNQLAKVELVKIVNDLIYRD-----PQLFSQFRPLLSDWLSNKFESVQLETAKLITSFATRNSRLVAPelyaaAI 307 baker's yeast 7302058 222 --GSLKSPYAVCMLIRIACKLIEEEdipseELSDSPLFTFIESCLRHKSEMVIYEAAHAIVNLKNTNPRMLSP-----AF 294 fruit fly 15226705 -------------------------------------------------------------------------------- thale cress 15236120 223 --GSVRSPLAQCLLI---------------QR---PFYEFLESCLRHKAEMVILEAARAITELDGVTSRELTP-----AI 277 thale cress 2492685 217 --NALRSPYAVCYLIRIATRCLVDDd----QP-DSSVFTFIESCLRHKSEMVVYEAARAIVSLPQTTPSEIQP-----AI 284 Caenorhabditis ele... 19172987 203 ---------AGILGVRATVEALKEN-----SDALLILRKFLNSKYS--DEMVFMEAARAVCALSEEYGSQFVDq----TV 262 Encephalitozoon cu... 12229771 221 --HGLKSPFAYCMMIRVASKQLEEEd----GSRDSPLFDFIESCLRNKHEMVVYEAASAIVNLPGCSAKELAP-----AV 289 human 13124090 221 --SGLKSQFAYCMLIRIASRLLKETe----DGHESPLFDFIESCLRNKHEMVIYEAASAIIHLPNCTARELAP-----AV 289 human 13124090 166 mmkisydvvkrwineaqeaassdnimvqyhalgvlyhlrkndrlavskmlnkftksglksqfaycmliriasrllketed 245 human 3182972 240 nlGTVSNSHAFVMLIRYISSLMDQN-----TQFRDQMVPFLHGWLKSKGDMVNLEVARNMVRLKNISDDDLQP-----VV 309 fission yeast
1706001 308 SALQSLLTVPRVSSRFAALRILNRISMVSPEKIVVCNPELESLINDSNRNISTYAITTLLKTGTSKNISSLISTITNFIH 387 baker's yeast 7302058 295 SILQLFCSSPKATLRFAAVRTLNKVAMTHPAAVTTCNLDLEGLITDSNRSVATLAITTLLKTGAESSVERLMKQISTFVA 374 fruit fly 15226705 -------------------------------------------------------------------------------- thale cress 15236120 278 TVLQLFLSSPRPVLRFAAVRTLNKVAMTHPMAVTNCNIDMESLISDQNRSIATLAITTLLKTGNESSVERLMKQITNFMS 357 thale cress 2492685 285 TALQMCCTSPKAAVRFAAVRTLNKVAMAHPNAVMSCNVDLEKFITDPNRSIATLAITTLLKTGAESSVERLMQQIAGFVN 364 Caenorhabditis ele... 19172987 263 QSLRTFLKSTNVVLQFSAMRIISQLAQKYPQKVSVANKEVEDLVSSENKTISMFAITSLLKTGTEETIDRLVNLIPSMVH 342 Encephalitozoon cu... 12229771 290 SVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSNRSIATLAITTLLKTGSESSIDRLMKQISSFMS 369 human 13124090 290 SVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTACNLDLENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISSFVS 369 human 13124090 246 ghesplfdfiesclrnkhemviyeaasaiihlpnctarelapavsvlqlfcsspkpalryaavrtlnkvamkhpsavtac 325 human 3182972 310 SVLKIFLSSHRSATRFSAIRTLNELAMTRPHLVHSCNLNIESLITDVNRSIATYAITTLLKTGNDESVDRLMKQIVTFMS 389 fission yeast
1706001 388 DVSDDFKIIIIDAVRTLSLNFPQEWKSILNFLIDVLKNsEGGFKFKNSIVEALIDIVSFVPQSKELALENLCDFIEDCEF 467 baker's yeast 7302058 375 EISDEFKVVVVQAICALCTKYPRKHTVLMNFLSGMLRE-EGGLEYKTSIVDTIITIIEENADAKESGLSHLCEFIEDCEH 453 fruit fly 15226705 -------------------------------------------------------------------------------- thale cress 15236120 358 DIADEFKIVVVDAIRSLCVKFPLKYRSLMTFLSNILRE-EGGFEYKRAIVDSIVTIIRDIPDAKESGLLHLCEFIEDCEF 436 thale cress 2492685 365 EISDEFKIVVVDAIRSLCSRYPRKHTVMMPFLAKMLRS-DGSYDYKKAIVETIIAIIEENPDAKVAGLAHLCEFIEDCEH 443 Caenorhabditis ele... 19172987 343 DMSDGFKKVAIETLESLSNLFESKKLLYIDFLGSSLLQ-KGELEFKKYMIDVISRAME-NDDMRERILEVLCTYIEDSQY 420 Encephalitozoon cu... 12229771 370 EISDEFKVVVVQAISALCQKYPRKHAVLMNFLFTMLRE-EGGFEYKRAIVDCIISIIEENSESKETGLSHLCEFIEDCEF 448 human 13124090 370 EISDEFKVVVVQAISALCQKYPRKHSVMMTFLSNMLRD-DGGFEYKRAIVDCIISIVEENPESKEAGLAHLCEFIEDCEH 448 human 13124090 326 nldlenlitdsnrsiatlaittllktgsessvdrlmkqissfvseisdefkvvvvqaisalcqkyprkhsvmmtflsnml 405 human 3182972 390 DISDNFKIIVVDAIRSLCLKFPRKQDSMLTFLSNILCD-EGGYEFKRAAVDAISDMIKYIPESKERALAELCEFIEDCEY 468 fission yeast
1706001 468 NEILVRILHLLGKEGPSAPNPSLYVRHIYNRVVLENSIIRSAAVVALSKFAltKNDPTLYESIISLLKRIANDKDDEVRD 547 baker's yeast 7302058 454 VSLAVRILHLLGKEGPFAATPSKYIRFIYNRVILESPIVRAAAVTAMAQFG--ASCPALLSNILVLLGRCQMDPDDEVRD 531 fruit fly 15226705 -------------------------------------------------------------------------------- thale cress 15236120 437 TYLSTQILHFLGIEGPNTSDPSKYIRYIYNRVHLENATVRAAAVSTLAKFG--FMVESLKPRITVLLKRCIYDSDDEVRD 514 thale cress 2492685 444 DNLSTRVLHLLGREAPKTPNPSSYIRFIYNRVILESTKVRAAAVTALAKFG--AQCVDLRPSIQVLLKRCLLDSDDEVRD 521 Caenorhabditis ele... 19172987 421 HQITLDILGILGREIPRSKTPGKYVVHVLNRLILENNHVRAGALQCLYNIS----SVVSPQTVENAMKRCLNDQDESIRE 496 Encephalitozoon cu... 12229771 449 TVLATRILHLLGQEGPKTTNPSKYIRFIYNRVVLEHEEVRAGAVSALAKFG--AQNEEMLPSILVLLKRCVMDDDNEVRD 526 human 13124090 449 TVLATKILHLLGKEGPRTPVPSKYIRFIFNRVVLENEAVRAAAVSALAKFG--AQNESLLPSILVLLQRCMMDTDDEVRD 526 human 13124090 406 rddggfeykraivdciisiveenpeskeaglahlcefiedcehtvlatkilhllgkegprtpvpskyirfifnrvvlene 485 human 3182972 469 PKIAVRILSILGEEGPKASEPTRFIRYIYNRIMLENAIVRSAAVSALTKFGlnAEDKFVQRSVKVILTRCLEDADDEVRD 548 fission yeast
1706001 548 RATIALEFIDsarNKDDVIAQNLieSKYFYDIPSLESKLSSYIssnTDSFATAFDVNQVRKFTEDEMKAINLKRKQeqif 627 baker's yeast 7302058 532 RATYYLSILN---SERPELYKNYiiERENCSLALLEKSLVEHL---NGDVDTRFDISIVP-KAAIVKPVIANDVML---- 600 fruit fly 15226705 -------------------------------------------------------------------------------- thale cress 15236120 515 RATLYLSEPS---EEAFDINS-----------------------------------VPKEVKSQPLAEKKAQGKKP---- 552 thale cress 2492685 522 RATFYLKMLT---EAAEGLIHNFilDGLQVSPSGLERSILDYLr--SGSYSSPFDLRVVPVTQQALSQPEKRVP------ 590 Caenorhabditis ele... 19172987 497 TASFLLRNMR-------------------------------------------------L--SRACEPFSFDELG----- 520 Encephalitozoon cu... 12229771 527 RATFYLNVLE---QKQKALNAGYilNGLTVSIPGLERALQQYT---LEPSEKPFDLKSVPLATAPMAEQRTESTPI---- 596 human 13124090 527 RATFYLNVLQ---QRQMALNATYifNGLTVSVPGMEKALHQYT---LEPSEKPFDMKSIPLAMAPVFEQKAEIT------ 594 human 13124090 486 avraaavsalakfgaqnesllpsilvllqrcmmdtddevrdratfylnvlqqrqmalnatyifngltvsvpgmekalhqy 565 human 3182972 549 RAAFSVKALE---DRDAFLPVVK--SDKIPSLPALERSLVIYIs--ERKFGQGFDIKSVPVLSQEEIDAENLRIKK---- 617 fission yeast
1706001 628 nqksetTLDTTPEAESVPEKRadansfagpnlddhqedllatKYADELLSIEQIKPFGQLVNSS-RAISLTEPEAEFVVR 706 baker's yeast 7302058 601 ------VTSSAPRPPKITREE---------------------ESAARLAQLPGIQVLGPIHRST-APIQLTESETEYTVQ 652 fruit fly 15226705 -------------------------------------------------------------------------------- thale cress 15236120 553 ------TGLGAPPAAPASGFD---------------------GYERLLSSIPEFAAFGKLFKSS-LPVELTEAETEYAVN 604 thale cress 2492685 591 ------QLVEEEEKPKAPKVE---------------------PYAAQLAAIPQFAALGPVFKSS-TRIALTESIAEYTVH 642 Caenorhabditis ele... 19172987 521 -------DIKSGVLERIGKVD-------------------------EDKES---K-MDPLIKSC-RELILTEPSADVQIK 563 Encephalitozoon cu... 12229771 597 ------TAVKQPEKVAATRQE---------------------IFQEQLAAVPEFRGLGPLFKSSpEPVALTESETEYVIR 649 human 13124090 595 ------LVATKPEKLAPSRQD---------------------IFQEQLAAIPEFLNIGPLFKSS-EPVQLTEAETEYFVR 646 human 13124090 566 tlepsekpfdmksiplamapvfeqkaeitlvatkpeklapsrqdifqeqlaaipeflnigplfkssepvqlteaeteyfv 645 human 3182972 618 ------ATTEVEFTEVTPAEDqnalas----------snietEFLNALESVSEFNEYGPVLKSSpSPIELTEQETEFVVK 681 fission yeast
1706001 707 GVKHLFKDNVVLQFNITNTLTDIALDNVSVVCTPEISdEAELEELFTLQVDRLLPSEEAACYVAFKKLDEIVMEGFLNNL 786 baker's yeast 7302058 653 CIKHIFGQHVVFQFDCLNTLSDQILENVRVELTLPEG-FTTRAVIPCPKLPYNDLQTTFVIVEFPPDAANSIA-TFGATL 730 fruit fly 15226705 -------------------------------------------------------------------------------- thale cress 15236120 605 VVKHIFDSHVVFQYNCTNTIPEQLLERVLNIEAEEFS---EVTSKALNSLPYDSPGQAFVVFEKPAGVPAVGKFSNTLTF 681 thale cress 2492685 643 MIKHTFANAMVLQFECKNTMNDQLLLDVSVELEDPDGeWETGNTVQIDKLPYGEVHSAFSLLEFP--DSGAISGSLGAIL 720 Caenorhabditis ele... 19172987 564 VTKNVYEDRLVLVFLLENKLEGIQISDGILGLVGTGG----VKKS--MSIKVDQIDSLGTLSIER---EWDIEEGYVVNG 634 Encephalitozoon cu... 12229771 650 CTKHTFTNHMVFQFDCTNTLNDQTLENVTVQMEPTEA-YEVLCYVPARSLPYNQPGTCYTLVALPKEDPTAVACTFSCMM 728 human 13124090 647 CIKHMFTNHIVFQFDCTNTLNDQLLEKVTVQMEPSDS-YEVLSCIPAPSLPYNQPGICYTLVRLPDDDPTAVAGSFSCTM 725 human 13124090 646 rcikhmftnhivfqfdctntlndqllekvtvqmepsdsyevlscipapslpynqpgicytlvrlpdddptavagsfsctM 725 human 3182972 682 VVKHVFKDHLVVQFQLHNTLSEVILENAVVVSTPSTD-DLVEECVVPAAIVSGEPVSIFVSFKFNDSVPYPLT-TLTNTL 759 fission yeast
1706001 787 TFTTKEINPDTNEPFdgDEGFQDEYEIDSIFLNAGDYVKSSFTGNFSATFDELP----CEEVAVFNIQEDLSIQEVVDKI 862 baker's yeast 7302058 731 RFVVKDCDPNTGEPEs-EEGYDDEYMLEDLELTVADQIQKTRKNNFQVSWDAADseewLQAEDTFVLSAVTTLQDAVNTI 809 fruit fly 15226705 -------------------------------------------------------------------------------- thale cress 15236120 682 VVKEVHVDPSTGEAE--DDGVEDEYQLEDLEVVAGDYMVKVGVSNFRNAWESMDe--eDERVDEYGLGQRESLGEAVKAV 757 thale cress 2492685 721 KFKVMDVDPTSGEPDs-DDTYEQTYVLEEVDVNVSDSVQGVAKSSFGSAWEALGd--dATREETFQLSTVENIPDAVKKI 797 Caenorhabditis ele... 19172987 635 AFDYTVCVEGDISDT-----ETDSISLEPFQITTLDFVRPVRIKQTPRNKREIT----------FNLQG--DIYAAGKKI 697 Encephalitozoon cu... 12229771 729 KFTVKDCDPTTGETD--DEGYEDEYVLEDLEVTVADHIQKVMKLNFEAAWDEVGd--eFEKEETFTLSTIKTLEEAVGNI 804 human 13124090 726 KFTVRDCDPNTGVPD--EDGYDDEYVLEDLEVTVSDHIQKVLKPNFAAAWEEVGd--tFEKEETFALSSTKTLEEAVNNI 801 human 13124090 726 KFTVRDCDPNTGVPD--EDGYDDEYVLEDLEVTVSDHIQKVLKPNFAAAWEEVGd--tFEKEETFALSSTKTLEEAVNNI 801 human 3182972 760 QFTTKEIDIHTGEPE--EEGYEDEYKIDDLDVSAGDFISPAYESNFDGLFDSLE----HEASEVYVLSLLDSFRSTCSRV 833 fission yeast
1706001 863 ILNSSCLPVESTQFAPSDSNSHTLKLFGkSALTGSKVALQIKMIKSSKG--LALKVHGKGEDSLLCSDLVNGLM 934 baker's yeast 7302058 810 VKILGLGAANLSENVPEGTHLHTLLCSG-TFRGGAEILVRAKLALSEG---VTLNLTVRSTDQDVAELITAAIG 879 fruit fly 15226705 1 -----MQSCKGTETVASNARSHTCLPSG-LYIGNVKVLVKAQFGMDSSKe-IVMKLAVRAEDPSVSDAIHALVA 67 thale cress 15236120 758 MDLLGMQTCEGTETIPLNARSHTCLLSG-VYIGNVKVLVRAQFGMDSSKd-IAMKLTVRAEDVSVAEAIHEIVA 829 thale cress 2492685 798 SEILGLVPCERSDRVPEGKTQHTVFLSG-VFRGGYDVLSKATVAVDPNDnsIAMNIIIKSNEPLVADLVISAVV 870 Caenorhabditis elegans 19172987 698 LDLLNMKIVTQET---ETN-TMVMTLNG--EYHGTPISIRVNMVYSMA---CRCTVGVYCDNEYVTQKIVRLFD 762 Encephalitozoon cuniculi 12229771 805 VKFLGMHPCERSDKVPDNKNTHTLLLAG-VFRGGHDILVRSRLLLLDT---VTMQVTARSLEELPVDIILASVG 874 human 13124090 802 ITFLGMQPCERSDKVPENKNSHSLYLAG-IFRGGYDLLVRSRLALADG---VTMQVTVRSKERTPVDVILASVG 871 human 13124090 802 ITFLGMQPCERSDKVPENKNSHSLYLAG-IFRGGYDLLVRSRLALADG---VTMQVTVRSKERTPVDVILASVG 871 human 3182972 834 AELLQMQPLEGTE-NPTDKPVHVMKLSG-KLVNGEKVLALVKMAHSKDGegITIKVIARGESDSSVELVVGGIA 905 fission yeast
Jiyao W et al.(2023). "The conserved domain database in 2023.",