2506138 4 LSSQPAYTLVFDPSP-SMETYSSTDFQKALEKGSDEQKIDTMKSILVTMLEGNPMPE-LLMHIIRFVMPSKNKELKKLLY 81 baker's yeast 22832491 1 MTS-QVPCYTIINSP-DLEVTNEMQLKRDLEKGDTNVKIETLKRVIKLLLNGERYPG-LIMTIIRFVLPVQNHTIKKLLL 77 fruit fly 15235964 21 PEKMDKSSTMLVHYD-KGTPAVANEIKEALEGNDVEAKVDAMKKAIMLLLNGETIPQ-LFITIIRYVLPSEDHTIQKLLL 98 thale cress 7447851 1 ---MDKSSTMLVHYD-KGTPAVANEIKEALEGNDVEAKVDAMKKAIMLLLNGETIPQ-LFITIIRYVLPSEDHTIQKLLL 75 thale cress 17536967 1 MSSGEQPCYTLIHVPsDAELPSEAQLKEKFEKGGDKERIEALKKLIYMILNGEKTSQsMLMYVIRFCLPSNEHTLKKVLL 80 Caenorhabditis ele... 19173437 1 -----MQASLYLNTS---MRMRKDEIMQKLRSSSEQDKIEGMKQMIAQMSQGEDFSS-LTHKITKETLVVRSNELKRLFY 71 Encephalitozoon cu... 19112195 1 MSCWTLVQQDFLEAP-SVDALKTS-----LESKNDYVKISAMKTILRVVINGDSLPS-ILMHVIRFVMPSRNKELKKLLY 73 fission yeast 13124070 1 MTAAENVCYTLINVPmDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPG-LLMTIIRFVLPLQDHTIKKLLL 79 house mouse
2506138 82 FYWEIVPKLAEDGKLRHEMILVCNAIQHDLQHPNEYIRGNTLRFLTKLREAELLEQMVPSVLACLEYRHAYVRKYAILAV 161 baker's yeast 22832491 78 IFWEIVPKTSADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMPAIRACLDHRHSYVRRNAVLAI 157 fruit fly 15235964 99 LYLELIEKTDSKGKVLPEMILICQNLRNNLQHPNEYIRGVTLRFLCRMKETEIVEPLTPSVLQNLEHRHPFVRRNAILAI 178 thale cress 7447851 76 LYLELIEKTDSKGKVLPEMILICQNLRNNLQHPNEYIRGVTLRFLCRMKETEIVEPLTPSVLQNLEHRHPFVRRNAILAI 155 thale cress 17536967 81 IFWECVPKTDSNGKLLHEMILVCDAYRKDLQHPNEFVRGSTLRFLCKLREPELLEPLMPAIRACLEHRHSYVRRNAVCAI 160 Caenorhabditis ele... 19173437 72 YYLELLPKARG-TQSFEEMLLLSNQVRKDLEHPNEYVRGFVMRFVSTLDDQELVGNFYKLIKDNFNHPNTYVRRNAYFCL 150 Encephalitozoon cu... 19112195 74 YYWEVCPKYNNDGTMKQEMILACNSFRNDLQHPNEFIRGATLRFLCKLKEPELLDPLIPTVRQCLEHRHAYVRKNAILAV 153 fission yeast 13124070 80 VFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAI 159 house mouse
2506138 162 FSIFKV--SEHLLPDAKEIINSFIVAETDPICKRNAFIGLAELDRENALHYLENNIADIENLDPLLQAVFVQFIRQDAN- 238 baker's yeast 22832491 158 FTIYKN--FDWLVPDGPELIASFLDTQQDMSCKRNAFLMLLHADQERALNYLASCIDQVHTFGDILQLVIVELIYKVCH- 234 fruit fly 15235964 179 MSIYKLpqGDQLFVDAPEMIEKVLSTEQDPSAKRNAFLMLFTCAEERAVNYLLSNVDKVSDWNESLQMVVLELIRSVCK- 257 thale cress 7447851 156 MSIYKLphGDQLFVDAPEMIEKVLSTEQDPSAKRNAFLMLFTCAEERAVNYLLSNVDKVSDWNESLQMVVLELIRSVCK- 234 thale cress 17536967 161 FTIYKN--FEFLIPDAPELVTEYLEQEQDASCKRNAFMMLLHVDQARALDYLSGCIDQVGSFGDILQLVIVELIYKVCH- 237 Caenorhabditis ele... 19173437 151 GEIFLK---MDMYKEVPDLLYHALLRDLDPNCLREAFVSLHLTDPELALKYAGEVSLSIP---SELSTAIVEKIKDERL- 223 Encephalitozoon cu... 19112195 154 FSIYQV--SNHLIPDAASLAEDFLAAESEGTCKRNALIVLFTIDPEKAKAWLLANFEQIPSLNASSLLVIIEFIRKVVLt 231 fission yeast 13124070 160 YTIYRN--FEHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCH- 236 house mouse
2506138 239 RTPALKAQYIELLMELLSTTtSDEVIFETALALTVLSANPNVLVPAVNKLIDLAVKVSDNNIKLIVLDRIQDIN--ANNV 316 baker's yeast 22832491 235 ANPAERSRFIRCIYNLLNSS-SNAVRYESAGTLITLSLAPTAIKAAASCYIELVVKESDNNVKLIVLDRLVAMKehEGME 313 fruit fly 15235964 258 TKPAEKGKYIKIIISLLSAT-SSAVIYECAGTLVSLSSAPTAIRAAANTYCQLLLSQSDNNVKLILLDRLYELK--TLHR 334 thale cress 7447851 235 TKPAEKGKYIKIIISLLSAT-SSAVIYECAGTLVSLSSAPTAIRAAANTYCQLLLSQSDNNVKLILLDRLYELK--TLHR 311 thale cress 17536967 238 NNPNEASRFIRCVYNLLQSS-SPAVRYEAAGTLVTLSNVPAAVKAAASAYIDLIVKESDNNVKLIVLDRLVALRgsSSNE 316 Caenorhabditis ele... 19173437 224 --LER----------FLFSE-DSMTAFEAGMSIHRMSNDEQLLKRSTDTILRCLEDLPRCREYAIDELLLSTYS------ 284 Encephalitozoon cu... 19112195 232 KADGLEKLRFQSLLVSLTATnNSSVVFEAATSVINVFPDAESLKLAASRLLALADREADNNAKLIMLDRISQLA--ARDK 309 fission yeast 13124070 237 ANPSERARFIRCIYNLLQSS-SPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLVELKehPAHE 315 house mouse
2506138 317 GALEELTLDILRVLNAEDLDVRSKALDISMDLATSRNAEDVVQLLKKELQTTVNNpDQDKAMQYRQLLIKTIRTVAVNFV 396 baker's yeast 22832491 314 KVMQDLVMDVLRVLAAPDIEVRRKTLALALDLVYSRNIGEMVLVLKKEVAKTHNV-EHEDTGKYRQLLVRTLHTCSIKFP 392 fruit fly 15235964 335 DIMVELIIDVLRALSSPNLDIRRKTLDISLDLITHHNINEVVQMLKKEVVKTQSG-ELEKNGEYRQMLIQAIHACAVKFP 413 thale cress 7447851 312 DIMVELIIDVLRALSSPNLDIRRKTLDIALDLITHHNINEVVQMLKKEVVKTQSG-ELEKNGEYRQMLIQAIHACAVKFP 390 thale cress 17536967 317 KILQGLVMDILRVLSSPGLEVRKKTLSLALDLVSSRNVEDMVMFLKKEINKTATE-SNDENGKYRQELVKTLHAATIKFP 395 Caenorhabditis ele... 19173437 285 --FSGYAMSFLSLIDPYDLSFCSKCFDFVFKISETHEFLQISDFLAFRFMDTHDA--SVQNQSFRVLLLEKMAYFASTYS 360 Encephalitozoon cu... 19112195 310 SILEDLITDVIPFLSSSDFDVCEKAISIIMGLVSSRNVEDILNHFQKELTKSNGEtEKDDGR--RRALTKAIHSCAINFP 387 fission yeast 13124070 316 RVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVsEHEDTDKYRQLLVRTLHSCSVRFP 395 house mouse
2506138 397 EMAASVVSLLLDFIGDLNSVAASGIIAFIKEVIEKYPQLRANILENMVQTLDKVRSAKAYRGALWIMGEYAEGESEIQHC 476 baker's yeast 22832491 393 DVAANVIPVLVEFLSDTNELAAADVLIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHRAAVWILGEYVEGSQ-ILEV 471 fruit fly 15235964 414 EVASTVVHLLMDFLGDSNVASALDVVVFVREIIETNPKLRVSIITRLLDTFYQIRAGKVCPCALWIIGEYCLSLSEVESG 493 thale cress 7447851 391 EVASTVVHLLMDFLGDSNVASALDVVVFVREIIETNPKLRVSIITRLLDTFYQIRAGKVCPCALWIIGEYCLSLSEVESG 470 thale cress 17536967 396 DVASTIVPVLMEFLSDTNEKASSYVLQFVREAVHKLPNLKNAILGALREGIPFIQSPTIFMSALWILATYCEADG-ALDV 474 Caenorhabditis ele... 19173437 361 SYNEEMVSEALKSIASDNPEMSHASLMFLSSCFEIMS-----------------RSSESCEGDAAGHGSYLEVLV---N- 419 Encephalitozoon cu... 19112195 388 HTAATAIQYLLSHISDFQSKSASSVLSFIKEVMEKFPDLRSSNITKLLLSLKELRAGKIFRGVIWIAGEYCLTEDDIRVA 467 fission yeast 13124070 396 DMAANVIPVLMEFLSDSNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYCSTKEDIQSV 475 house mouse
2506138 477 WKHIRNSVGEVPILQSEIKKLTQNQEHTEENEv------------dATAKP-TGPVILPDGTYATESAFDVk-tSQKSVT 542 baker's yeast 22832491 472 IAVIQQTLGEVPMVEAEQRRLAGDQTEEQKQQqgsaggnaagsaaeGSGSGnASNKVTSDGTYATQSAYS----LAPVAK 547 fruit fly 15235964 494 ISTITQCLGELPFYSVSEESEPTETSKKIQPTs-------------sAMVSsRKPVILADGTYATQSAASEttfSSPTVV 560 thale cress 7447851 471 ISTITQCLGELPFYSVSEESEPTETSKKIQPTs-------------sAMVSsRKPVILADGTYATQSAASEttfSSPTVV 537 thale cress 17536967 475 LKLVKNSLGELPLVDSELSGQE-EQKPEEQQPe---------------qQQkQKPKVTADGTYATQTALSS---TVTTSK 535 Caenorhabditis ele... 19173437 420 -KINEVKYGKILRCCFGILRRH--ATKEIFLR-------------------------VVE---VLESSFG---------- 458 Encephalitozoon cu... 19112195 468 WKSIRASLGEVPILASE-EQLLKDVSNVPEDDll----------idISAPAsTSRKVLPDGTYATESAVTSe-aLSAARL 535 fission yeast 13124070 476 MTEVRRSLGEIPIVESEIKKEAGELKPEEEITv---------------gP--VQKLVTEMGTYATQSALSS---SRPTKK 535 house mouse
2506138 543 DEERDSrp-pIRRFVLSGDFYTAAILANTIIKLVLKFENVSKNK-TVINALKAEALLILVSIVRVGQS--SLVEKKIDED 618 baker's yeast 22832491 548 AEKRPP----LRQYLMDGDFFIGAALSATLTKLALRYAELETEA-RAQNRLTTQVMLIMSSILHLGKS--GFPSKPITND 620 fruit fly 15235964 561 QGSLTSg--nLRALLLTGDFFLGAVVACTLTKLVLRLEEVQSSK-TEVNKTVTQALLIMVSMLQLGQS--PVSPHPIDND 635 thale cress 7447851 538 QGSLTSg--nLRALLLTGDFFLGAVVACTLTKLVLRLEEVQSSK-TEVNKTVSQALLIMVSILQLGQS--PVSPHPIDND 612 thale cress 17536967 536 KNEKPP----LRRFLLDGEFFLGASLATVLTKLAQQFTELNGAAsERANRFRAECMLILSSIIHLAKSglCIVHQQVNED 611 Caenorhabditis ele... 19173437 459 HADRPL----YLRNTQT---FLGAFMCIELSEMCRR---LEGPK-------DR-VIAVMLRFIEHGKE-----SNTIDMS 515 Encephalitozoon cu... 19112195 536 EAVKASkkppLRTQILSGDYYLAAVLASALTKLVMRFARLSFDK-ERLNALKAEACLIMTSIIRVGQS--KFVKYTIDDD 612 fission yeast 13124070 536 EEDRPP----LRGFLLDGDFFVAASLATTLTKIALRYVALVQEK-KKQNSFVAEAMLLMATILHLGKS--SLPKKPITDD 608 house mouse
2506138 619 SLERVMTSISILLDEvnpeekkeeVKLLEVAFLDTTKSSFKRQIEIAKKNKHKRALKDSCKNIEP---------IDTPIS 689 baker's yeast 22832491 621 DTDRIFVCLRTLSER---------TPEAISVFTLYCREALGKMLDAQHDEDQR-MLKEKQKATAKv-------qPDDPVL 683 fruit fly 15235964 636 SYERIVLCIKLLCHR---------NDEMKKIWLESCRQSFVKMISEKQLREMEELKAKTQTTHAQ---------PDDLID 697 thale cress 7447851 613 SYERIMLCIKLLCHR---------NVEMKKIWLESCRQSFVKMISEKQLREMEELKAKTQTTHAQ---------PDDLID 674 thale cress 17536967 612 DLDRMGATIKILAQG---------IPGLDEQYGDDCKKSLELMLGAKSISRLDVTTEKMASTTAAgyrskdfveIDKTIN 682 Caenorhabditis ele... 19173437 516 SQSTIVSCIRSLVS-------------CNSQG--------EVSSDGHKRCREG---------------------VLDPIM 553 Encephalitozoon cu... 19112195 613 SVERIMNCIRAIYSfe-------eLPEFQTVFLDDMRKAFSSLVAQSDKRQKEADLLVNGSDAVQ---------ADELLN 676 fission yeast 13124070 609 DVDRISLCLKVLSEC---------SPLMNDIFNKECRQSLSQMLSAKLEEEKLSQKKESEKRNVTv-------qPDDPIS 672 house mouse
2506138 690 FRQFAG------------VDSTNVQKDSIEEDLQLAMKg--DAIHATSSSS-ISKLKKIVPLCGFSDPVYAEACITNNQF 754 baker's yeast 22832491 684 FAQLSN------------GRDNQLGENVFESSLNQALAgskNAQLSDVASP-NSKLNKVTQLTGFSDPVYAEAYVNVNQY 750 fruit fly 15235964 698 FFHLKSr----------kGMSQLELEDQVQDDLKRATG---EFTK--DEND-ANKLNRILQLTGFSDPVYAEAYVTVHHY 761 thale cress 7447851 675 FFHLKSrkmsllminffqGMSQLELEDQVQDDLKRATG---EFTK--DEND-ANKLNRILQLTGFSDPVYAEAYVTVHHY 748 thale cress 17536967 683 FTQLS-------------ARSNQQGENLFDLSLSQALG---TAPKAQKFDFsSSKLGKVIQLAGFSDPIYAEAYVNVNQY 746 Caenorhabditis ele... 19173437 554 LPGTRS--------------SDERGLNKLNEFLVDSEG----------GS---AEMRNVTQLTGLSDPIYVEATTSYTRY 606 Encephalitozoon cu... 19112195 677 IRQFQR------------VIEE-KQDLNFESDIIQATN---DGMVVEDLA---SKLDHIVQLAGFTDPVYCEAYVKIQQF 737 fission yeast 13124070 673 FMQLTA------------KNEMNCKEDQFQLSLLAAMG---NTQRKEAADPlASKLNKVTQLTGFSDPVYAEAYVHVNQY 737 house mouse
2506138 755 DVVLDVLLVNQTKETLKNLHVQFATLGDLKIIDTPQKTNVIPHGFHKFTVTVKVSSADTGVIFGNIIYDG-----AHGED 829 baker's yeast 22832491 751 DIVLDVLIVNQTNDTLQNCTLELATLGDLKLVERPHPVVLAPHDFCNIKANVKVSSTENGIIFGNIVYET-------ALN 823 fruit fly 15235964 762 DIALEVTVINRTKETLQNLCLELATMGDLKLVERPQNYSLAPERSMQIKANIKVSSTETGVIFGNIVYETs----N-VME 836 thale cress 7447851 749 DIALEVTVINRTKETLQNLCLELATMGDLKLVERPQNYSLAPERSMQIKANIKVSSTETGVIFGNIVYETs----N-VME 823 thale cress 17536967 747 DIVLDVLIVNQTSDTLQNVSLELATVGDLKLVDKPTPVTLAPNDFSNIKATVKVASTENGVIFSTISYDVt----GSTSD 822 Caenorhabditis ele... 19173437 607 EIVVDMLFINQTPSYLQNILLDFVTSQGLSATFISTPFSLSSRSVVTKRFTFRIIDASNGFISGSITFRYpdecgEYANT 686 Encephalitozoon cu... 19112195 738 DIILDILLVNRTDTTLQNLSVDLATLGDLKVVERPPPMNLGPHAFKSVQATVKVSSTESAVIFGNIVYGG-----KASDE 812 fission yeast 13124070 738 DIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDVs----GAASD 813 house mouse
2506138 830 ARYVILNDVHVDIMDYIKPATADDEHFRTMWNAFEWENKISVKS-QLPTLHAYLRELVKGTNMGILTPSESLGeDDCRFL 908 baker's yeast 22832491 824 TNVVVLNTIHIDIMDYIIPASCTDTEFRQMWQDFEWENKVTVNT-SFTDLHEYLKHLLKSTNMKCLTPEKALS-GQCGFM 901 fruit fly 15235964 837 RNVVVLNDIHIDIMDYISPAVCSEVAFRTMWAEFEWENKVAVNT-TIQNEREFLDHIIKSTNMKCLTAPSAIE-GECGFL 914 thale cress 7447851 824 RNVVVLNDIHIDIMDYISPAVCSEVAFRTMWAEFEWENKVAVNT-TIQNEREFLDHIIKSTNMKCLTAPSAIA-GECGFL 901 thale cress 17536967 823 RNCVYLQDIKIDIMDYIVPGNVTDTEFRTMWSDFEWENKVNVMT-PIRDLRDFLNHLSTSTNMKVLTGDAAIE-GDCGFL 900 Caenorhabditis ele... 19173437 687 VYTINLSEVKTSVSEFLEPRKMDPDGFRETWKELEWENTYTLKFiTKKTLEEIFGEVSRALNGETLDIECDED-----YA 761 Encephalitozoon cu... 19112195 813 DKIVVLNGIPVNIIDYIKPAFIPESQFRSMWTEFEWENKVDISSnEDISLYDFLHKIMKKTNMNCLTPDASLR-GDCGFL 891 fission yeast 13124070 814 RNCVVLSDIHIDIMDYIQPATCTDAEFRQMWAEFEWENKVTVNT-NMTDLNDYLQHILKSTNMKCLTPEKALS-GYCGFM 891 house mouse
2506138 909 SCNLYAKSSFGEDALANLCIEKDSKTN---DVIGYVRIRSKGQGLALSLGDRVALIAKKTNKL 968 baker's yeast 22832491 902 AANMYAKSIFGENALANLSIEKPVDDpd-sKVTGHIRIRAKSqGMALSLGDKISSSQKQSVQA 963 fruit fly 15235964 915 AANLYAKSVFGEDALVNVSIEKQTDG----ALSGYIRIRSKTQGIALSLGDKITLKQKGSS-- 971 thale cress 7447851 902 AANLYAKSVFGEDALVNLSIEKQTDG----TLSGYIRIRSKTQGIALSLGDKITLKQKGGS-- 958 thale cress 17536967 901 AANLCAHSIFGEDALANVSVEKALPMDdssPIVGHIRIRAKSQGMCLTLGDKLSSAMRSRRDG 963 Caenorhabditis elegans 19173437 762 VGNIACSTLQNVCVLVNVCLRRSE------HVHFESRIRSRKEGIVKSVSAVVGDVLRSLKNK 818 Encephalitozoon cuniculi 19112195 892 SANLYACSIFGEDALMSLSVEK-SVSG---PISGHVRIRSKTQGIALSLGAFV---------- 940 fission yeast 13124070 892 AANLYARSIFGEDALANVSIEKPVHQGpdaAVTGHIRIRAKSQGMALSLGDKINLSQKKTSL- 953 house mouse
Jiyao W et al.(2023). "The conserved domain database in 2023.",