7293054 236 SYEAAAAGTNFNGNG--------NVAGANYKNGYEESIVDIKKEEESFNNLSQASSCDYSMSQFRADEPPF-VVKHEQSY 306 fruit fly 267146 121 DSEDDRPLSSILSGNkg-----pTSSRQVSSPQPEKKNNGDRPLDRASRIIKDESDDETPISSMFRKKIDSgMSGGNQLS 195 thale cress 15240493 130 DSEDDKPLSARLKLDskevtkqpSSSGRGSTQQAVQKSN-MRPQGLSDYTKKKVLDERAPMSSTVQTKTSVgTSSSKPVH 208 thale cress 17508321 1 MSVVSNHHSNGNGNS--------TVYDTNGNDEIKKEVKDEPMASDSEVPFGELMKRDKKEKKQKKRKAES-GSDEDDYK 71 Caenorhabditis ele... 7505887 1 MSVVSNHHSNGNGNS--------TVYDTNGNDEIKKEVKDEPMASDSEVPFGELMKRDKKEKKQKKRKAES-GSDEDDYK 71 Caenorhabditis ele... 12644118 6 LHNDSQIEADFRLND--------SHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKKHKEKEK----TKHKDGS 73 human 20140694 -------------------------------------------------------------------------------- human 13432252 1 -----------MSSS--------DSDSVSLSIRRRQRRGSSKRISMKESDEESDSSENHPLSESLNKKSKS-ESDEDDIP 60 fission yeast 135993 1 -----------MTIA--------DASKVNHELS-------------------SDDDDDVPLSQTLKKRKVA-SMNSASLQ 41 baker's yeast
7293054 307 AEEDSTMnyNDHDDDADEMNDDEEDVPLAMRKRKQEATDRPDGGMDNDDDDDIPLLARKKVKKEKIKKESKEKSK----- 381 fruit fly 267146 196 NDEKKPLvqKLHQNGSTVKNEVPNGKVLGKRPLEKNSSADQSSLKKAKISASPTSVKMKQDS-VKKEIDDKGRVLvspkm 274 thale cress 15240493 209 IEQKRPLvnNIDRNGLKPKTEGHSSQAPAKRPLEKGSSSNQSSVKRPKLSEPARPVKVEQGSHISATQDAKGKNLdaskp 288 thale cress 17508321 72 PEKRKSS--AKNGKKKDVGSDSEDDYKPEKKKSKKNNKKKAQESSEDDDEESEGDVSEEDVKPQIHSDDELEEEDeaptt 149 Caenorhabditis ele... 7505887 72 PEKRKSS--AKNGKKKDVGSDSEDDYKPEKKKSKKNNKKKAQESSEDDDEESEGDVSEEDVKPQ---------------- 133 Caenorhabditis ele... 12644118 74 SEKHKDKh-KDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEPEDDGYFVPPKEDIKPLKRPRDEDDADYk---- 148 human 20140694 1 ------------------------------------------------------------MRVVRLLR------------ 8 human 13432252 61 IRKRRAS----SKKNMSNSSSKKRAKVMGNGGLKNGKKTAVVKEEEDFNEIAKPSPKHKRVSKANGSKNGAKSA------ 130 fission yeast 135993 42 DEAEPYD----SDEAISKISKKKTKKIK----------------TEPVQSSSLPSPPAKKSATSKPKK------------ 89 baker's yeast
7293054 382 ----------------------------------KRVKEEPS------------D---DYGNVKPK--KKKMKKEPEPA- 409 fruit fly 267146 275 ------------------------------kakqLSTREDGTdddddddvpiskRfksDSSNSNTSsaKPKAVKLNSTSs 324 thale cress 15240493 289 -----------------------------lranqATVKEDNSdgddh--vpiasRmksDSSNNKSSsaKPSSSKMIASSs 337 thale cress 17508321 150 ddeeeqkrkekerrkkekrekkerkekkrlekenRKIKEEDDedsdd--eddekAkkkKRKSKGAEksKPSTSKKDAGG- 226 Caenorhabditis ele... 7505887 134 ----------------------------------------------------------KRKSKGAEksKPSTSKKDAGG- 154 Caenorhabditis ele... 12644118 149 ---------------------------------pKKIKTEDTk----------kEkkrKLEEEEDGklKKPKNKDKDKK- 184 human 20140694 9 ------------------------------------LRAALT----------------LLGEVP----RRPASRG----- 27 human 13432252 131 ------------------------------------VKKEESd----------tDdsvPLRAVSTVslTPYKSELPSGA- 163 fission yeast 135993 90 ------------------------------------IKKEDGd-------------------VKVKttKKEEQENEKKK- 113 baker's yeast
7293054 410 --------------VSPGKRQKAKAKVEEEEVWRWWEEEKRADGVKWSTLEHKGPVFAPRYERVPRNVRFYYDGKPLELS 475 fruit fly 267146 325 aakpkarnvvsprsRAMTKNTKKVTKDSKYSTSSKSSPSSGDGQKKWTTLVHNGVIFPPPYK--PHGIKILYKGKPVDLT 402 thale cress 15240493 338 --------------RTIAQKPNKWVKDSKYSKSSKSLPS-GDGQKKWKTLQHNGVIFPPPYK--RHGVKILFQGKPVDLT 400 thale cress 17508321 227 --------------KKEPPKKKVKKEEDIEDIWEWWKEEKKPAGVKWNSLQHCGPLFAPPYIPLPSHVHFKYGGEKMKLT 292 Caenorhabditis ele... 7505887 155 --------------KKEPPKKKVKKEEDIEDIWEWWKEEKKPAGVKWNSLQHCGPLFAPPYIPLPSHVHFKYGGEKMKLT 220 Caenorhabditis ele... 12644118 185 --------------VPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLS 250 human 20140694 28 --------------VP---GSRRTQKGSGAR----WEKEKHEDGVKWRQLEHKGPYFAPPYEPLPDGVRFFYEGRPVRLS 86 human 13432252 164 --------------STTQNRSPNDEEDEDED-YKWWTSENIDDTQKWTTLEHNGVIFAPPYEPLPKNVKLIYDGNPVNLP 228 fission yeast 135993 114 --------------REEEEEEDKKAKEEEEE-YKWWEKENEDDTIKWVTLKHNGVIFPPPYQPLPSHIKLYYDGKPVDLP 178 baker's yeast
7293054 476 EETEEAATFYAKMLNHDYCTKEVFNNNFFKDFRKSMTPREREI----IKDFRKCNFQEMFNYFQAESEKRKAASKEEKLI 551 fruit fly 267146 403 IEQEEVATMFAVMRETDYYTKPQFRENFWNDWRRLLG--KKHV----IQKLDDCDFTPIYEWHLEEKEKKKQMSTEEKKA 476 thale cress 15240493 401 PEQEEVATMFAVMRETEYYKKPKFRENFWNDWRKLLG--KNHM----IKSLDDCDFTPIYEWYMQEKETKKQMTAEEKRI 474 thale cress 17508321 293 LETEEIAQFYAGVLDHEYSTKEAFNKNFMKDWRKVMTVEERER----IHDLKKCDFRAIDAYQKEQREIRKAMTKEEKLK 368 Caenorhabditis ele... 7505887 221 LETEEIAQFYAGVLDHEYSTKEAFNKNFMKDWRKVMTVEERER----IHDLKKCDFRAIDAYQKEQREIRKAMTKEEKLK 296 Caenorhabditis ele... 12644118 251 PKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNI----ITNLSKCDFTQMSQYFKAQTEARKQMSKEEKLK 326 human 20140694 87 VAAEEVATFYGRMLDHEYTTKEVFRKNFFNDWRKEMAVEEREV----IKSLDKCDFTEIHRYFVDKAAARKVLSREEKQK 162 human 13432252 229 PEAEEVAGFYAAMLETDHAKNPVFQDNFFRDFLKVCDECNFNHn---IKEFSKCDFTQMFHHFEQKREEKKSMPKEQKKA 305 fission yeast 135993 179 PQAEEVAGFFAALLESDHAKNPVFQKNFFNDFLQVLKESGGPLngieIKEFSRCDFTKMFDYFQLQKEQKKQLTSQEKKQ 258 baker's yeast
7293054 552 KKNENEALMKEFGFCMIDGHKEKIGNFRLEPPGLFRGRGEHPKMGMIKRRIQASDVSINCGKDSKVPS-PPPGSRWKEVR 630 fruit fly 267146 477 LKEEKMKQEEKYMWAVVDGVKEKIGNFRVEPPGLFRGRGEHPKMGKLKKRIHPCEITLNIGKGAPIPEcPIAGERWKEVK 556 thale cress 15240493 475 VKEEKLKQEEKYMWAVLDGVRERIGNFRVEPPGLFRGRGEHPKMGKLKKRIRPCDITINIGKEAPIPEcPIPGERWKEVK 554 thale cress 17508321 369 IKEEKEAEVKIYGIAIIDGHRQKVANFRIEPPGVFRGRGGHPKMGLIKKRIMPEDVIINCGKDTEIPK-PPPGHKWKEVR 447 Caenorhabditis ele... 7505887 297 IKEEKEAEVKIYGIAIIDGHRQKVANFRIEPPGVFRGRGGHPKMGLIKKRIMPEDVIINCGKDTEIPK-PPPGHKWKEVR 375 Caenorhabditis ele... 12644118 327 IKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPS-PPPGHKWKEVR 405 human 20140694 163 LKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIPE-PPAGHQWKEVR 241 human 13432252 306 IKQKKDEEEEKYKWCILDGRKEKVGNFRIEPPGLFRGRGSHPKTGSLKRRVYPEQITINIGEGVPVPE-PLPGHQWAEVK 384 fission yeast 135993 259 IRLEREKFEEDYKFCELDGRREQVGNFKVEPPDLFRGRGAHPKTGKLKRRVNPEDIVLNLSKDAPVPP-APEGHKWGEIR 337 baker's yeast
7293054 631 HDNTVTWLASWIENVQG-QVKYIMLNPSSKLKGEKDHIKYETARRLDKVIDKIRATYRDEWKSKEMRVRQRAVALYFIDK 709 fruit fly 267146 557 HDNTVTWLAFWADPINPkEFKYVFLGAGSSLKGLSDKEKYEKARNLTDHIDNIRTTYTKNFTAKDVKMRQIAVATYLIDK 636 thale cress 15240493 555 HDNTVTWLAFWSDPINPkEFKYVFLAASSSLKGQSDKEKYEKARKLHNHIGSIRAAYTKDFNNKDVTKRQIAVATYLIDK 634 thale cress 17508321 448 HDNTVTWLCSWTESVLG-QNKYIMLNPSSKIKGEKDFEKYETARRLKKKIGGIRERYTDDFKSKEMRVRQRATALYFIDK 526 Caenorhabditis ele... 7505887 376 HDNTVTWLCSWTESVLG-QNKYIMLNPSSKIKGEKDFEKYETARRLKKKIGGIRERYTDDFKSKEMRVRQRATALYFIDK 454 Caenorhabditis ele... 12644118 406 HDNKVTWLVSWTENIQG-SIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDK 484 human 20140694 242 SDNTVTWLAAWTESVQN-SIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDK 320 human 13432252 385 HDNTVTWLATWHENINN-NVKYVFLAAGSSLKGQSDLKKYEKSRKLKDYIDDIRKGYRKDLKSELTVERQRGTAMYLIDV 463 fission yeast 135993 338 HDNTVQWLAMWRENIFN-SFKYVRLAANSSLKGQSDYKKFEKARQLKSYIDAIRRDYTRNLKSKVMLERQKAVAIYLIDV 416 baker's yeast
7293054 710 LALRAGNEKDE-DQADTVGCCSLRVEHVQLHKELNG-------KENVVVFDFPGKDSIRYYNEVEVEKRVFKNLELFMEH 781 fruit fly 267146 637 LALRAGNEKDD-DEADTVGCCTLKVGNVECIPPNKI------------KFDFLGKDSIQYVNTVEVEPLVYKAIGQFQAG 703 thale cress 15240493 635 LALRAGNEKDD-DEADTVGCCTLKVGNVECIPPNKL------------KFDFLGKDSIQYVNTVEVEPLVYKAIGQFQAG 701 thale cress 17508321 527 LALRAGNEKDVdEAADTVGCCSLRVEHIKLFDSAKLneddkkeKEFVVEFDFLGKDSIRYFNRVSVEKRVYKNLKIFMEG 606 Caenorhabditis ele... 7505887 455 LALRAGNEKDVdEAADTVGCCSLRVEHIKLFDSAKLneddkkeKEFVVEFDFLGKDSIRYFNRVSVEKRVYKNLKIFMEG 534 Caenorhabditis ele... 12644118 485 LALRAGNEKEEgETADTVGCCSLRVEHINLHPELDG-------QEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMEN 557 human 20140694 321 LALRAGNEKEDgEAADTVGCCSLRVEHVQLHPEADG-------CQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMEN 393 human 13432252 464 FALRAGNEKGE-DEADTVGCCSLRYEHVTLKPPRTV------------VFDFLGKDSIRYYNEVEVDPQVFKNLKIFKRP 530 fission yeast 135993 417 FALRAGGEKSE-DEADTVGCCSLRYEHVTLKPPNTV------------IFDFLGKDSIRFYQEVEVDKQVFKNLTIFKRP 483 baker's yeast
7293054 782 -KKEGDDLFDRLNTQVLNEHLKELMEGLTAKVFRTYNASKTLQSQLDLLTDPSATVPEKLLAYNRANRAVAILCNHQRSV 860 fruit fly 267146 704 -KSKTDDLFDELDTSKLNAHLKELVPGLTAKVFRTYNASITLDEMLSQETK-DGDVTQKIVVYQKANKEVAIICNHQRTV 781 thale cress 15240493 702 -KSKTDDLFDELDTSKLNTHLKELMAGLTAKVFRTYNASITLDLMLSKETR-DGDVPEKVVVYQQANKEVAIICNHQRTV 779 thale cress 17508321 607 -KAPSDDLFDRLDTATLNDHLRSLMDGLTVKVFRTYNASITLQEQLIKLTNPKDNVAAKILSYNRANRQVAILCNHQRAV 685 Caenorhabditis ele... 7505887 535 -KAPSDDLFDRLDTATLNDHLRSLMDGLTVKVFRTYNASITLQEQLIKLTNPKDNVAAKILSYNRANRQVAILCNHQRAV 613 Caenorhabditis ele... 12644118 558 -KQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAP 636 human 20140694 394 -KDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRAT 472 human 13432252 531 pKKEGDLIFDRLSTNSLNKYLTSLMDGLSAKVFRTYNASYTMAEELKKMPK-NLTLADKILFYNRANRTVAILCNHQRSV 609 fission yeast 135993 484 pKQPGHQLFDRLDPSILNKYLQNYMPGLTAKVFRTYNASKTMQDQLDLIPN-KGSVAEKILKYNAANRTVAILCNHQRTV 562 baker's yeast
7293054 861 PKSHEKSMENLKEKIKAKREA----------------------------------------------------------- 881 fruit fly 267146 782 SKTHGAQIEKLTARIEELKEV----------------------------------------------------------- 802 thale cress 15240493 780 SKSHGAQVEKLAVKIEELREQ----------------------------------------------------------- 800 thale cress 17508321 686 SKGFDESMQKLEQKIKDKKKE----------------------------------------------------------- 706 Caenorhabditis ele... 7505887 614 SKGFDESMQKLEQKIKDKKKE----------------------------------------------------------- 634 Caenorhabditis ele... 12644118 637 PKTFEKSMMNLQTKIDAKKEQ----------------------------------------------------------- 657 human 20140694 473 PSTFEKSMQNLQTKIQAKKEQ----------------------------------------------------------- 493 human 13432252 610 TKNHDVQMERFAERIKALQYQrmrlrkmmlnlepklakskpellakeegitdswivkhhetlyelekekikkkfdrenek 689 fission yeast 135993 563 TKGHAQTVEKANNRIQELEWQkirckrailqldkdllkkepkyfeeiddltkede-atihkriidreiekyqrkfvrend 641 baker's yeast
7293054 882 ---------IEKCESEYHSR-----------D---------------EKKGKQLERLRDQLKKLELQETDRDENKTIALG 926 fruit fly 267146 803 ---------LKELKTNLDRAkkgkpplegsdGkkir-------slepNAWEKKIAQQSAKIEKMERDMHTKEDLKTVALG 866 thale cress 15240493 801 ---------IKELNIDLDRAkkgrtplmgsdGkrkr-------nltpEALEKKIMQTQGKIEKMERDMQTKEDMKTVALG 864 thale cress 17508321 707 ---------VKEAEAALKSArga----------------------ekEKAQKKYDRLKEQLKKLKISRTDKDENKQIALG 755 Caenorhabditis ele... 7505887 635 ---------VKEAEAALKSArga----------------------ekEKAQKKYDRLKEQLKKLKISRTDKDENKQIALG 683 Caenorhabditis ele... 12644118 658 ---------LADARRDLKSAkadakvmkdakTkk-----------vvESKKKAVQRLEEQLMKLEVQATDREENKQIALG 717 human 20140694 494 ---------VAEARAELRRAraehkaqgdgkSrs-----------vlEKKRRLLEKLQEQLAQLSVQATDKEENKQVALG 553 human 13432252 690 laaedpksvLPESELEVRLKaadelkkaldaElkskkvd--pgrssmEQLEKRLNKLNERINVMRTQMIDKDENKTTALG 767 fission yeast 135993 642 krkfekeelLPESQLKEWLEkvdekkqefekElktgevelksswnsvEKIKAQVEKLEQRIQTSSIQLKDKEENSQVSLG 721 baker's yeast
7293054 927 TSKLNYLDPRISVAWCKKHDVPIEKIFNKTQRTKFLWAVHMA---DENYRF 974 fruit fly 267146 867 TSKINYLDPRITVAWCKRHEVPIEKIFTKSLLEKFAWAMDVE----PEYRF 913 thale cress 15240493 865 TSKINYMDPRITVAWCKRHDVPIEKIFNKSLLAKFAWAMDVD----PEFRF 911 thale cress 17508321 756 TSKLNYIDPRITVAWCKKFEVPLEKVFTKTHREKFRWAIDMTnssDEEYVF 806 Caenorhabditis elegans 7505887 684 TSKLNYIDPRITVAWCKKFEVPLEKVFTKTHREKFRWAIDMTnssDEEYVF 734 Caenorhabditis elegans 12644118 718 TSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMA---DEDYEF 765 human 20140694 554 TSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFAWALAMA---GEDFEF 601 human 13432252 768 TSKINYIDPRLTYSFSKREDVPIEKLFSKTIRDKFNWAADTP----PDWKW 814 fission yeast 135993 722 TSKINYIDPRLSVVFCKKYDVPIEKIFTKTLREKFKWAIESVd---ENWRF 769 baker's yeast
Jiyao W et al.(2023). "The conserved domain database in 2023.",