Conserved Protein Domain Family
Cas12a

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COG5931: Cas12a 
CRISPR-Cas system type-V protein Cas12a [Defense mechanisms]
CRISPR-Cas system type-V protein Cas12a is part of the Pathway/BioSystem: CRISPR-Cas system
Statistics
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PSSM-Id: 444629
Aligned: 6 rows
Threshold Bit Score: 1357.94
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_108604518    1 MSd------RLDVLTNQYPLSKTLRFELKPVGATADWIRKHNVIRyhngklvgKDAIRFQNYKYLKKMLDEMHRLFLQQA 74  
WP_013282991    1 ML-------LYENYTKRNQITKSLRLELRPQGKTLRNIKELNLLE--------QDKAIYALLERLKPVIDEGIKDIARDT 65  
WP_048112740    1 MN-------NYDEFTKLYPIQKTIRFELKPQGRTMEHLETFNFFE--------EDRDRAEKYKILKEAIDEYHKKFIDEH 65  
WP_084710347      --------------------------------------------------------------------------------     
WP_119724936    1 MK-------NFQDFTNLYELSKTLRFELKPIGGTKKLIEEKNILK--------LDKKKRENYEKVKPYFNKIHQEFINFA 65  
WP_122892441    1 MHtggllsmDAKEFTGQYPLSKTLRFELRPIGRTWDNLEASGYLA--------EDRHRAECYPRAKELLDDNHRAFLNRV 72  
WP_108604518   75 LvlepnsnqaqeltallraiennycNNNDLlagdypslstdktikisnglsklttdlfdkkfeDWayqykedmpnfwrQD 154 
WP_013282991   66 L------------------------KNCEL---------------------------------SF-------------EK 75  
WP_048112740   66 L------------------------TNMSL---------------------------------DW-------------NS 75  
WP_084710347      --------------------------------------------------------------------------------     
WP_119724936   66 L------------------------RNPNF---------------------------------DF-------------SQ 75  
WP_122892441   73 L------------------------PQIDM---------------------------------DW-------------HP 82  
WP_108604518  155 IAELEQKLQVSANAKDqkfy--------kgiiKKLKNKIQKSELKA-----ETHKGLYSPTESLQLLEWLVRRGdiklty 221 
WP_013282991   76 LYEHFLSGDKKAYAKEs---------------ERLKKEIVKTLIKNlpegiGKISEINSAKYLNGVLYDFIDKT------ 134 
WP_048112740   76 LKQISEKYYKSREEKDkkvf--------lseqKRMRQEIVSEFKKD-----DRFKDLFSKKLFSELLKEEIYKK------ 136 
WP_084710347      --------------------------------------------------------------------------------     
WP_119724936   76 FEEKYLNWLKDKKNKDllkekesidkiflekiGKLFENSVKDFLKE-----NGFESIV--KEEDQNLKFFRRKEifevlq 148 
WP_122892441   83 IAEAFCKVHKNPGNKElaqdy-------nlqlSKRRKEISAYLQDA-----DGYKGLFAKPALDEAMK--IAKE------ 142 
WP_108604518  222 leIGKENEKlNELVplvelkDIHRNfNNFATYLSGFSKNRENVYSTkfdrrsgykatSVIARTFeQNLmfclgniakwhk 301 
WP_013282991  135 --HKDSEEKqNILS------DILET-KGYLALFSKFLTSRITTLEQ-----------SMPKRVI-ENF------------ 181 
WP_048112740  137 ---GNHQEI-----------DALKSfDKFSGYFIGLHENRKNMYSDgde------itAISNRIVnENF------------ 184 
WP_084710347      --------------------------------------------------------------------------------     
WP_119724936  149 ekYGSELET-QMVNkdgeikSIFNGwEKWLGYFDKFFNTRDNFYKTdgt------stAIATRIIkDNL------------ 209 
WP_122892441  143 --NGNESDI-----------EVLEAfNGFSVYFTGYHESRENIYSDed-------mvSVAYRITeDNF------------ 190 
WP_108604518  302 vTEFINQANNYELLQehgidwnkqiAALEHKLDV-CLAEFFALNNFSQTLAQQGIEKYNQVLAGIAEIAGQpKTQGLNEL 380 
WP_013282991  182 -EIYAANIPKMQDAL----------ERGAVSFAI-EYESICSVDYYNQILSQEDIDSYNRLISGIMDEDGA-KEKGINQT 248 
WP_048112740  185 -PKFLDNLQKYQEARkkypewiikaESALVAHNI-KMDEVFSLEYFNKVLNQEGIQRYNLALGGYVTKSGE-KMMGLNDA 261 
WP_084710347    1 ----------------------------------------------------------------------------MNLL 4   
WP_119724936  210 -KIFLENIVAFGKIKnkk----idfSEVEKNFSV-SIDTFFEINNFNNCFLQDGIDFYNKVIGGETLENGE-KLKGLNEI 282 
WP_122892441  191 -PRFVSNALIFDKLNeshp---diiSEVSGNLGVdDIGKYFDVSNYNNFLSQAGIDDYNHIIGGHTTEDG--LIQAFNVV 264 
WP_108604518  381 INLARQKLSAKRSq---LPTLQLLYKQILSKGD-KPFIDD-FKSDQELIAELNEFVSSQIHGEhgaiklinhelESFINE 455 
WP_013282991  249 ISEKNIKIKSEHLeekpFRILKQLHKQILEERE-KAFTIDhIDSDEEVVQVTKEAFEQTKEQW-----------ENIKKI 316 
WP_048112740  262 LNLAHQSEKSSKG----RIHMTPLFKQILSEKEsFSYIPDvFTEDSQLLPSIGGFFAQIENDKdgnif--dralELISSY 335 
WP_084710347    5 INEVNQKYKSK------LNVFNSLYKQILTEEDtKSFVDEiLLTPESVIKTIDNFIDSIIMNDieg------lkEEFLKI 72  
WP_119724936  283 INKYRQDTGEK------IPYFKKLQKQILSEKD-GVFIDK-IEDDGGFYEVLKNFYKNAAEKEgflk----nifENFYTI 350 
WP_122892441  265 LNLRHQKDPGFE-----KIQFKQLYKQILSVRTsKSYIPKqFDNSKEMVDCICDYVSKIEKSEtve-----ralKLVRNI 334 
WP_108604518  456 ARAAQQQ-------IYVPKDKLTELSLLLTGSWQAIN----QWRYKLFDQKQ-LDKQQKQYSFslaqverwlateveqqN 523 
WP_013282991  317 NGFYAKDpgditlfIVVGPNQTHVLSQLIYGEHDRIRllleEYEKNTLEVLP-RRTKSEKARY----------------D 379 
WP_048112740  336 AEYDTER-------IYIRQADINRVSNVIFGEWGTLGglmrEYKADSINDIN-LERTCKK-------------------- 387 
WP_084710347   73 SLENFEG-------IYISNKKLNEISNRKFGDYNSINmmikQ----SMNEKGiLSKKEINELIpdl-------------- 127 
WP_119724936  351 SDKNLEK-------IYFNKIAFNTISHKFGSALEFERilyeEMKKEKADGIK-FEKKENKYKFpdfiqiifikrslenyD 422 
WP_122892441  335 SSFDLRG-------IFVNKKNLRILSNKLIGDWDAIEtalmH-SSSSENDKK---------------------------- 378 
WP_108604518  524 FYQTEKERQQHKDTQPANVTTSSDGHSILTafeqqvqtlltnICV------AAEKYRQLSDNL----TAIDKQREsESSK 593 
WP_013282991  380 KFVNAVPKKVAKESHTFDGLQKMTGDDRLF------------ILYrd---eLARNYMRIKEAYgtfeRDILKSRR-GIKG 443 
WP_048112740  388 -VDKWLDSKEFALSDVLEAIKRTGNNDAFNe----------yISKmr---tAREKIDAARKEM----KFISE----KISG 445 
WP_084710347  128 eniNKPKVKSFNLSFIFENLTKEHKELIIDyir-------enICN------VIENVKITIEKY----RNID-NKI-EFKN 188 
WP_119724936  423 SENLFWKERYYKSEENVDGFLEKNNNNLWGqfckilnfeflnILKrriideAGEEYEVGFEIS----KNILGEKLeNFEL 498 
WP_122892441  379 --SVYDSAEAFTLDDIFSSVKKFSDASAEDignr-----aedICR------VISETAPFINDL----RAVDLDSL-NDDG 440 
WP_108604518  594 GFEQIAVIKTLLDACNELNHFLARFTVNk----kDKLPEDrAEFWYEKLQAYIDAF-----PIYELYNKVRNYLSKKPFS 664 
WP_013282991  444 NRDVQESLVSFYDELTKFRSALRIINSG------NDEKAD-PIFYNTFDGIFEKAN-----RTYKAENLCRNYVTKSPAD 511 
WP_048112740  446 DEESIHIIKTLLDSVQQFLHFFNLFKAR------QDIPLD-GAFYAEFDEVHSKLF-----AIVPLYNKVRNYLTKNNLN 513 
WP_084710347  189 NAEKVSKIKEMLESINELCKLIKEFNT-------DEIEKN-NEFYNILNKNFEIFE-----SSYKVLNKVRNFVTKKEVI 255 
WP_119724936  499 NQENKGIIKDFADYSLALYSFGKYFAVEkgrnwdLNIDIS-DDFYGGEDGYIEKFYntgydEIVKPYNLMRNYISKKPWE 577 
WP_122892441  441 YEAAVSKIRESLEPYMDLFHELEIFSVG------DEFPKC-AAFYSELEEVSEQLI-----EIIPLFNKARSFCTRKRYS 508 
WP_108604518  665 TE-KVKINF--DNSHFLSGW---TADYER-HSALLFKFNEN----YLLGVVNENLSSEEEEKLKLVGGEEHAKRFIYDFQ 733 
WP_013282991  512 DA-RIMASClgTPARLRTHWwngEENFAI-NDVAMIRRGDE----YYYFVLTPDVKPVDLKTKDETDAQIFVQRKGAKSF 585 
WP_048112740  514 TK-KIKLNF--KNPTLANGW---DQNKVYdYASLIFLRDGN----YYLGIINPKRK-KNIKFEQGSGNGPFYRKMVYKQI 582 
WP_084710347  256 EN-KMKLNF--SNYQLGNGW---HKNKEKdCSIILFRKRNNerwiYYLGILKHGTKIKENDY--LSSVDTGFYKMDYYAQ 327 
WP_119724936  578 DNkKWKINF--ETSSLLSGW---DKNLES-NGSYIFQKGNK----YYLGIINGSKPAKEILEKLYSGDGEKIKRFIYDFQ 647 
WP_122892441  509 TD-KIKVNL--KFPTLADGW---DLNKERdNKAAILRKDGK----YYLAILDMKKDLSSIRT--SDEDESSFEKMEYKLL 576 
WP_108604518  734 KIDNSNPPRVFIRS-------KGSSFAPA-----------VEKYQLPIGDIIDIYDQGKFKTEHk---kKNEAEFKDSLV 792 
WP_013282991  586 LGLPKALFKCILEPyfespehKNDKNCVIee--------yVSKPLTIDRRAYDIFKNGTFKKTNigidgLTEEKFKDDCR 657 
WP_048112740  583 PGPNKNLPRVFLTS-------TK-----------------GKKEYKPSKEIIEGYEADKHI--------RGDKFDLDFCH 630 
WP_084710347  328 NSLSKMIPKCSITV-------KNVKNAPEdesvilndskkFNEPLEITPEIRKLYGNNEHI--------KGDKFKKESLV 392 
WP_119724936  648 KPDNKNTPRMFIRS-------KKDSFSPA-----------VEKYNLPINDILEIYDNGLFKTEN-----KGNPNYKESLR 704 
WP_122892441  577 PSPVKMLPKIFVKS-------KA-----------------AKEKYGLTDRMLECYDKGMHK--------SGSAFDLGFCH 624 
WP_108604518  793 RLIDYFKLGFSRHDSYKHYP---FKWKASHQYSDIAEFYAHTASFCYTLKEENINFNVLRELSSAGKVYLFEI-----YN 864 
WP_013282991  658 YLIDVYKEFIAVYTRYSCFNm--SGLKRADEYNDIGEFFSDVDTRLCTMEWIPVSFERINDMVDKKEGLLFLVrsmflYN 735 
WP_048112740  631 KLIDFFKESIEKHKDWSKFN---FYFSPTESYGDISEFYLDVEKQGYRMHFENISAETIDEYVEKGDLFLFQI-----YN 702 
WP_084710347  393 KWIDFCKEFLLKYKSFEKAKkeiLKLKESNLYENLEEFYSDAEEKAYFLEFINIDEDKIKKLVKEKNLYLFQI-----YN 467 
WP_119724936  705 KLIDYFKLGFSRHESFKHFN---FVWKDSKSYENIADFYRDVEKSCYKIDFEFLNFEELKKLTFEKHLYLFQI-----YN 776 
WP_122892441  625 ELIDYYKRCIAEYPGWDVFD---FKFRETSDYGSMKEFNEDVAGAGYYMSLRKIPCSEVYRLLDEKSIYLFQI-----YN 696 
WP_108604518  865 KDFsknkr---------gqgrdNLHTSYWKLLFSAENL---KDVVLKLNGQAEIFYRPASlaETKAYTHKKGEVLKHKAY 932 
WP_013282991  736 RPR-------------------KPYERTFIQLFSDSNM---EHTSMLLNSRAMIQYRAAS--LPRRVTHKKGSILVALRD 791 
WP_048112740  703 KDFvkaa-----------tgkkDMHTIYWNAAFSPENL---QDVVVKLNGEAELFYRDKS--DIKEIVHREGEILVNRTY 766 
WP_084710347  468 KDFsays-----------tgnkNLHTMYFEELFTDENL---KKPVFKLNGNTEVFYRIAS--SKPKIVHNKGEKLVNKTY 531 
WP_119724936  777 KDFeldeslqekgynfkgegqkNIHTKYFEALFLEENIsrkSGAVFKLSGGGEVFFRKKSikAKKE-------------- 842 
WP_122892441  697 KDYsena-----------hgnkNMHTMYWEGLFSPQNL---ESPVFKLSGGAELFFRKSSipNDAKTVHPKGSVLVPRND 762 
WP_108604518  933 SkvwealDSpigTRLSwDDALKipSITEK-TNHNNQRVV------QYNGQ--EIGRKAEFAIIKNRRYSVDKFLFHCPIT 1003
WP_013282991  792 S------NG---EHIP-MHIRE--AIYKM-KNNFDISSEdfimakAYLAEhdVAIKKANEDIIRNRRYTEDKFFLSLSYT 858 
WP_048112740  767 N------GR---TPVP-DKIHK--KLTDY--HNGRTKDLge--akEYLDK--VRYFKAHYDITKDRRYLNDKIYFHVPLT 828 
WP_084710347  532 L------DDgiiKTIP-DSVYE--EISEKvKNNEDYSKLle---eNNIKN--LEIKVATHEIVKDKRYFENKFLFYLPIT 597 
WP_119724936  843 -------------------------------------------------------KRNSVEVIKNKRYTECKYFLHFPIQ 867 
WP_122892441  763 V------NG---RRIP-DSIYR--ELTRY-FNRGDCRISde--akSYLDK--VKTKKADHDIVKDRRFTVDKMMFHVPIA 825 
WP_108604518 1004 LNFKANGQ---DNINARVNQFLANNKkiNIIGIDRGEKHLLYISVINQQGEVLHQESFNTITNsyqtang---------- 1070
WP_013282991  859 KNADISARt-lDYINDKVEEDTQDSR--MAVIVTRNLKDLTYVAVVDEKNNVLEEKSLNEIDG----------------- 918 
WP_048112740  829 LNFKANGK---KNLNKMVIEKFLSDEkaHIIGIDRGERNLLYYSIIDRSGKIIDQQSLNVIDG----------------- 888 
WP_084710347  598 LNKKVSNKntnKNINKNVIDEIKDCNeyNVIGIDRGERNLISLCIINQNGEIILQKEMNIIQSsdk-------------- 663 
WP_119724936  868 VNFKEEIS---GNFNQEINKFLANNPdiNVIGIDRGEKHLAYFSVINQKGEILESGSFNKIENynkngekllfpereike 944 
WP_122892441  826 MNFKAISK---PNLNKKVIDGIIDDQdlKIIGIDRGERNLIYVTMVDRKGNILYQDSLNILNG----------------- 885 
WP_108604518 1071 ---------------ekrqvvTDYHQKLDMSED-KRDKARKSWSTIENIKELKAGYLSHVVHRLAQLIIEFNAIVALEDL 1134
WP_013282991  919 ---------------------VNYRELLKERTKiKYHDKTRLWQYDVSSKGLKEAYVELAVTQISKLATKYNAVVVVESM 977 
WP_048112740  889 ---------------------FDYREKLNQREI-EMKDARQSWNAIGKIKDLKEGYLSKAVHEITKMAIQYNAIVVMEEL 946 
WP_084710347  664 -------------------ynVDYNEKLEIKSK-ERDNAKKNWSEIGKIKDLKSGYLSAVVHEIVKLAIEYNAVIILEDL 723 
WP_119724936  945 ihkdgslidlelvetgrkvdyVDYKLLLEYKER-KRLLQRQSWKEVEQIKDLKKGYISALVRKIADLIIKHNAIVIFEDL 1023
WP_122892441  886 ---------------------YDYRKALDVREY-DNKEARRNWTKVEGIRKMKEGYLSLAVSKLADMIIENNAIIVMEDL 943 
WP_108604518 1135 NHGFKRGRFKIEKQVYQKFEKALIDKLSYLAFKDRTScLETGHYLNAFQLTSKfkgfNNLGKQSGILFYVNADYTSTTDP 1214
WP_013282991  978 SSTFKDKFSFLDEQIFKAFEARLCARMSDLSFNTIKE-GEAGSISNPIQVSNN----NGNSYQDGVIYFLNNAYTRTLCP 1052
WP_048112740  947 NYGFKRGRFKVEKQIYQKFENMLIDKMNYLVFKDAPD-ESPGGVLNAYQLTNPlesfAKLGKQTGILFYVPAAYTSKIDP 1025
WP_084710347  724 NNGFKNSRKKVDKQIYQKFERALIEKLQFLIFKNYDK-NEKGGLRNAFQLTPElkniTKVASQQGIIIYTNPAYTSKIDP 802 
WP_119724936 1024 NFRFKQIRGGIEKSIYQQLEKALIDKLNFLVNKNEINlEKAGSILKAYQLTVPvdslKEIGKQTGVIFYTEAAYTSKIDP 1103
WP_122892441  944 NHGFKAGRSKIEKQVYQKFESMLINKLGYMVLKDKSI-DQSGGALHGYQLANHvttlASVGKQCGVIFYIPAAFTSKIDP 1022
WP_108604518 1215 LTGYIKNVYKTY-SSVKDSTEFWQRFNSIRYIASEn-rFEFSYDLadlkqKSLEskTKQTpLAKTQWTVSSHVTRSYYNQ 1292
WP_013282991 1053 DTGFVDVFDKTRlITMQSKRQFFAKMKDIRIDDGE---MLFTFNL-----EEYP--TKRL-LDRKEWTVKIAGDGSYFDK 1121
WP_048112740 1026 TTGFVNLFNTSSkTNAQERKEFLQKFESISYSAKDggiFAFAFDY-----RKFG--TSKT-DHKNVWTAYTNGERMRYIK 1097
WP_084710347  803 TTGYANIIKKSN----NNEESIVKAIDKISYDKEKd-mFYFDINLs---nSSFNl-TVKN-VLKKEWRIYTNGERIIYK- 871 
WP_119724936 1104 ITGWRPNLYLKK-NNSKINKENILKFDNIVFNSKEn-rFEFTYDL-----KKFFgkDSKF-PAKTVNTVCSCVERFKWNR 1175
WP_122892441 1023 TTGFADLFALSNvKNVASMREFFSKMKSVIYDKAEg-kFAFTFDY-----LDYN--VKSE-CGRTLWTVYTVGERFTYSR 1093
WP_108604518 1293 ----QTKQHELFE---------VTAR------IQQLLSKAEISYQHQndL---IPALASCQsKALHKELIWLFNSILTMR 1350
WP_013282991 1122 ----DKGEYVYVNd-------iVREQ------IIPALLEDKAVFDGN--MaekFLDKTAIS-GKSVELIYKWFANALYGI 1181
WP_048112740 1098 ----EKKRNELFD---------PSKE------IKEALTSSGIKYDGGqnI---LPDILRSNnNGLIYTMYSSFIAAIQMR 1155
WP_084710347  872 -----DRKYITLN---------ITQE------MKDILSKCGIDYLNIdnL---KQDILK---NKLHKKVYYIFELANKMR 925 
WP_119724936 1176 nlnnNKGGYIHYEnltdgklanKEQKedefsnFKELFEKYFIDINGN--IleqIKNLDTKNnEKFFSSFIDLFTLVCQIR 1253
WP_122892441 1094 ----VNREYVRKV---------PTDI------IYDALQKAGISVEGD------LRDRIAESdGDTLKSIFYAFKYALDMR 1148
WP_108604518 1351 VTDSSkpsatSENDFiLSPVapyfdsr----nlnkqlPENGDANGAYNIARKGIMLLERIGDfvpegnkkyPDLLirnND 1426
WP_013282991 1182 ITKKD-----GEKIY-RSPItg--------------tEIDVSKNTTYNFGKKFMFKQEYRGD---------GDFL---DA 1229
WP_048112740 1156 VYD-------GKEDYiISPIknskgeffrtdpkrrelPIDADANGAYNIALRGELTMRAIAEkfdpdsekmAKLElkhKD 1228
WP_084710347  926 NEN-------KDVDYiISPVlnkdgkffmtqeineltPKDADLNGAYNIALKGKLMIDNLnk-------keKFVFlsnED 991 
WP_119724936 1254 NTNQNak--gDENDFiLSPVepffdsrk-sqnfgkslPKNGDENGAFNIARKGLIILNRISEnp-----ekPDLLifnAD 1325
WP_122892441 1149 VEN-------REEDYiQSPVknasgeffcsknagkslPQDSDANGAYNIALKGILQLRMLSEqydpnaesiRLPLitnKA 1221
WP_108604518 1427 WQNFVQRP 1434
WP_013282991 1230 FLNYMQAQ 1237
WP_048112740 1229 WFEFMQTR 1236
WP_084710347  992 WLNFIQGR 999 
WP_119724936 1326 WDNFARNI 1333
WP_122892441 1222 WLTFMQSG 1229
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