Conserved Protein Domain Family
COG1754

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COG1754: COG1754 
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]
Statistics
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PSSM-Id: 441360
Aligned: 284 rows
Threshold Bit Score: 327.929
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_599561     32 GNDYIVEASVGHIRDLPRGAADIPAKYKKEPWARLGVDTDRGFAPLYVVSPDKKKKVADLKAKLKLVDELLLATDPDREG 111 
ALM10444       1 --------------MPSHLVIVESPTKAKTIKRFLGKDFDVEASMGHVRDLPEGSLGVDTEDFSVKYVIPKEKAAVVKRL 66  
NP_874826      1 -------------------MPKGFQVIASMGHVRDLPKGASEIPAAMKKEKWSRIGVNTAEDFEPLYVVPKDKKKVVREL 61  
WP_013178849  21 KAKTIRRFLPPSYRVEASMGHVRDLPASAAEIPAEYKNQPWARLGIEVERDFRPLYIVPSKKKRVVSELRAALKDADELL 100 
WP_013629763   9 KALVIVESPLKAKKIGEFLGKDYVVRASLGHVRDLPSKASEIPAAVKKESWSTLGVNTSEKFEPLYVVPPDKKKLIKELK 88  
WP_045089368   1 ---------------------------MEKNLVIVESPAKAKTIEKFLGKDFHVMSSYGHIRDLKKKDFSIDVENNFEPI 53  
WP_049637723   1 -----------MSKLLIVESPSKAKTLKKYLGGDFEVLASYGHVRDLIPKNGAVDPAQQFAMKYDIIDRNSKHVDAIAKA 69  
WP_077026509   6 KALVIVESPAKAKKIQGFLGDQYVVRASVGHVRDLPARAAEIPAALKKESWSNLGVNVDSEFEPLYVVPQDKKKTVKELK 85  
WP_096722373   1 MSTLVIVESPTKARTIRNYLPSGYQVQASMGHVRDLPPSAKEIPPAYKDKQWATLGINVEDDFQPIYVVPEKKKKVVKEL 80  
WP_096687235   1 ------------------------------------MAKNLVIVESPAKAKTIEKILGSNYQVESCYGHICDLVNKNMGI 44  
NP_599561    112 EAIAWHLLEVLKPTVPVRRMVFNEITKPAILAAAENTRELDENLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQ 191 
ALM10444      67 QKSLDSASDLWIATDEDREGEAIGWHLTEILKRKKKQPIRRIVFHEITKEAIEAAVEHPRKIDEKLVDAQHARRILDRLV 146 
NP_874826     62 KSALKDAKEVLLATDEDREGESISWHLLELLKPKVPTKRMVFHEITKQAITKALQKTRDLDMELVHAQETRRILDRLVGY 141 
WP_013178849 101 IATDEDREGESIGWHLLEVLKPKVPVRRMVFHEITEEAIRNALQNTRDIDRHLVDAQETRRVLDRLVGYTLSPLLWKKIA 180 
WP_013629763  89 DLLKDSSELIIATDEDREGESIGWHLVQLLKPKVTVRRMVFSEITKTAIQEAIRNTREINEELVEAQETRRVLDRLYGYT 168 
WP_045089368  54 YEVPDDKKKIVSELKAAVKKANTVWLASDEDREGEAISWHLFETLELKEENTKRIVFHEITKNAILEAIKNPRKIDKNLV 133 
WP_049637723  70 VKNADSIYLATDPDREGEAISWHIAEILAEKKLIKNKLLKRVEFNEITQTAVKHAIDHPRDISMDLVNAQQARRALDYLV 149 
WP_077026509  86 DLLKDAEELLIATDEDREGESIGWHLIQLLNPKVPTKRMVFSEITNEAILEALSNTREMDENLVAAQETRRVVDRLYGYT 165 
WP_096722373  81 KTALQTADELILATDEDREGESISWHLLEILKPKVPVKRMVFHEITKEAIQKALKDCREVDQDLVHAQETRRILDRLVGY 160 
WP_096687235  45 DIENNFNPIYEISPDKVKVVSGLKKKSKSAEVIWLASDEDREGEAISWHLARELSLPKEKVKRIVFHEITKKAISKAIEN 124 
NP_599561    192 SVATRVIVERERERMAFVSADYWDLSAEFNARENGKADSDNPSSFTARLSTIDGNRVAQGRDFNDRGELTSEAVVVDKQR 271 
ALM10444     147 GYTLSPFLWKKVYRGLSAGRVQSVAVRIIVDRERAIKAFHAEEYWTVTADLLNGAQQPFSADLKQKDGKKFVPVSDAQAQ 226 
NP_874826    142 TLSPLLWKKVAWGLSAGRVQSVSVRLLVKRERERRAFQRASYWDLKTILEKNNVPIEARLINYADQKIAKGSDFDEKTGK 221 
WP_013178849 181 PKLSAGRVQSVAVRLMVLRERERILFVPASYWDLKASLAKADGAAQAFEAVMTHHGGVRLASGRDFDDATGELKAGLTPG 260 
WP_013629763 169 LSPLLWKKIARGLSAGRVQSVAVRLLVRRELERIAFRSGTYWDLKAELKATEGNPFEAVLSTLGGKRLASGKDFDETTGR 248 
WP_045089368 134 DAQQARRVLDRIVGFELSPVLWRKIKPALSAGRVQSVAVRLIVEREREIQNFNSEASYRVVGVFSKVENGQTYEIKAEYN 213 
WP_049637723 150 GFNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFTSQEYWSIHMSALKHAHGFDAKLIQLNGQKVEQFTVTNHDQ 229 
WP_077026509 166 LSPLLWKKIAPKLSAGRVQSVAVRILVEREIERLKFRSGSFWDLKASLKAKSGQLFDSVLQTVGGQRIATGKDFDENTGQ 245 
WP_096722373 161 TVSPLLWKKISWGLSAGRVQSVAVRLTVARERERRAFQSGGYWDLLAYLEQDKNPFEARLITLDGKKLATGSDFDPDTGK 240 
WP_096687235 125 PREINDDLVNSQKARRVLDRLVGFQLSPVLWQKVKWGLSAGRVQSVAVRLIVEREREISLFSSKSYFKVVAFFINSKGEE 204 
NP_599561    272 AEALAEALEGQEMAVVGVEEKPYTRRPYAPFMTSTLQQESGRKLHYTSERTMRIAQRLYENGHITYMRTDSTSLSEQGMK 351 
ALM10444     227 QVLADLKGASYSVQSLEEKEIKKTPPPPFTTSTLQQEAGRKLGFSVKQTMMVAQQLYEGVDLGKGEGHVGLITYMRTDSV 306 
NP_874826    222 LKVGNKSNLLKEKEAKELVTLLAADKWIVKSVDKKPTIRKPVPPFTTSTLQQEANRKMRLSARETMRCAQGLYERGFITY 301 
WP_013178849 261 KDVLLLSEARARELASRLRTAPWTVKEVETRDGKRTPAAPFTTSTLQQEASRKLGLSAKETMRVAQGLYENGYITYMRTD 340 
WP_013629763 249 LKDGSDVLLLGQDEAERLQAQLLESPWKVSDIEERMSNRKPPAPFITSTLQQEANRKLGMSARQTMQTAQRLYENGHITY 328 
WP_045089368 214 KRLKTKEEALELLEKLKSSVFSIEDVVTRPAKKSPAAPFTTSTLQQEASRKLGFSVGQTMMVAQRLYESGKITYMRTDSV 293 
WP_049637723 230 QADIVGKLLLASAGKTTVTRVEKKQRSRSPAAPFTTSTLQQEAVRKLGFTTSRAMRVAQQLYEGMDVGSGTVGLITYMRT 309 
WP_077026509 246 LKEGSNVLLLEEDAAKELQARIASGDWVVTSVEQKRQTRKPAPPFTTSTLQQEASRKLNMTARQTMQTAQRLYEAGHITY 325 
WP_096722373 241 ITAGRDVVLLNETEANALKTRILNKTWTVANREEKATKRRPSPPFTTSTLQQESNRKLGISARETMSVAQKLYEKGFITY 320 
WP_096687235 205 LKAELSEDFETEKQAESFLKECIDYSFKVDDIQSKEAKRTPSAPFTTSTLQQEASVKLGFSVSQTMRVAQQLYESGHITY 284 
NP_599561    352 AARDQALELYGAEYVSPSPRTYDRKVKNSQEAHEAIRPAGETFATPGQLHGQLDAEEFKLYELIWQRTVASQMADAKGTS 431 
ALM10444     307 NLSDKALADARETIQQHYGREYILSSPRKYKTKSKGAQEAHEAIRPTEMARVPESLKDVLDHQQLKLYTLIWERAVATQM 386 
NP_874826    302 MRTDSVNLSEQAIRASRKCVELRYGKDYLSEAPRQFASSTRNAQEAHEAIRPAGETFRAPNDTGLNGRDLALYELIWKRT 381 
WP_013178849 341 STNLSREAIEGARRAVRTRYGAEYLSPAPRTYASKAKNAQEAHEAIRPAGSEMKTQAEHGLSGVEGRLYDLIWKRTVATQ 420 
WP_013629763 329 MRTDSVTLSNEAVQAARGRIEDLYGGDYLSPSPRQYASKSKNAQEAHEAIRPSGTEMKTPEELNLSGPEFKLYSLIWKRT 408 
WP_045089368 294 NLSGLAIGTAKTEVIDQYGEKYHKSRQYSTKSKGAQEAHEAIRPTYISEHEIEGTAQEKKLYNLIWKRTIASQMADVELE 373 
WP_049637723 310 DSFSLATEAVMQIRDYVKKHFDADYLPKAPIMYKTKAKNAQEAHEAIRPTDITRTPASVRQYLNDEQFKLYEMIWKRTLA 389 
WP_077026509 326 MRTDSVNLSAEAMDAARGRIDKLYGGDYLSPSPRQFTNKNKGAQEAHEAIRPAGKKMMTAEEIGVDGPQSRLYDLIWKRT 405 
WP_096722373 321 MRTDSVHLSQQAIAAARSCVEQMYGKEYLSPKARQYSTKSKGAQEAHEAIRPAGETFRTPQETGLKDQEFKLYDLIWKRT 400 
WP_096687235 285 MRTDSVNLSVDAVDEMREVIVAKYGDKYSQPRSYTTKSKTAQEAHEAIRPTSVKQESAGSDNNQKRLYSLIWKRALSSQM 364 
NP_599561    432 MKVTIGGTAKTGEKTEFNATGRTLTFPGFLRAYVETTRTADGRDVADNAEKRLPLLSEGDLLKVLSIEADGHSTNPPARY 511 
ALM10444     387 AEAQLKRVGADIRAGAYTFRATGQTIAFDGYLRVYLEGRDEPESQQSAEEEEDAGMLPPLQEGETLECKSLLPEQHFTKP 466 
NP_874826    382 VASQMAEARLTMLSVDISVRDAIFRASGKNIDFPGFFRAYVEGSDDPEVALEGQEIVLPVLNVGDVLSPKSVDAMGHETK 461 
WP_013178849 421 MADARLRFVTARITVGEGEDASEFRASGRTTLFPGFFRAYVEGSDDPEAALDDQEQPLPELARGDALRCRALEALGHETK 500 
WP_013629763 409 MASQMAEARLKFLNVTIAVGEAEFKATGRQVVFPGFFRAYVEGSDDPEAALDDRDAMLPPLSQEESLDCKQLDPVAHETK 488 
WP_045089368 374 RTTANISVSNTDGKFVANGEVIKFDGFLRVYLEGTDDENGEKEDGILPPVKKGEVLEMQEVSATERFSQRPARYSEASLV 453 
WP_049637723 390 CQMTQAKYDAVSVDLSVGSEANLFRASGQTLIFPGFIAVYMEGKDDDKDDEDAEAKLPHLETGEILTVEKIFGEQHFTEP 469 
WP_077026509 406 MATQMADAKLRFDNVTITAGDADFRSSGRTVEFPGFFRAYVEGSDDPDAALDDQDSPLPPLAENDKVGCEDVEAIPHETK 485 
WP_096722373 401 VACQMADADLTQIAVDVKVENAVFRANGKRIEFPGYFRAYVEGSDNPDAAIEDQEILLPPLKVGDKPKCKKLEVVGHETQ 480 
WP_096687235 365 SDAKLERTKVKIGYSSSETKFISKGEVLLFDGFLRLSLEDKEDNKDNMLPLVKKGEALKYETITATQKFTRPPSRFTEAS 444 
NP_599561    512 TEASLVKKMEDLGIGRPSTYASIIKTIQDRGYVYSRGNALVPSWVAFAVVGLLEANFTSLVDYDFTSSMEDELDNIAAGR 591 
ALM10444     467 PPRYTEASLVKKLEEEGIGRPSTYAPTISTVQQRGYIKKEGKQLIPEDIAFTVTDLLTEHFPDIVDLTFTAKMEQSLDDI 546 
NP_874826    462 PPARYSEASLVKTLEKEGIGRPSTYASIIGTIVDRGYASLSANSLAPTFTAFAVTSLLEEHFPDLVDTTFTARMESSLDE 541 
WP_013178849 501 PPARFTEASLVKLLESEGIGRPSTYASIIDTVISRGYARKNGAQLVPTFTAFATNNLLEARFAQLVDTGFTAQMEGVLDD 580 
WP_013629763 489 PPARYTEASLVRMLESEGIGRPSTYASILSTIQDRGYVRKDGNQLTPTFTAMAVTRLLEDNFPNLVDTQFTAGMEQTLDD 568 
WP_045089368 454 RKMEELGIGRPSTYAPTISTIINREYVEKKSIDGEKRNFNVLLLKKGKIKDSEKTETTGADKNKLFPTDIGIVVNDFLVE 533 
WP_049637723 470 PPRYSEASLVKALEEYGIGRPSTYASIISTLQDREYVLLDKKRFTPTDVGRVVNKFLTEHFTQYVDYDFTAKLENELDEI 549 
WP_077026509 486 PPARYTEASLVRKLEAEGIGRPSTYASIIGTIQDREYVNKNGSQLVPTFKGLAVTKLLEKHFPKLVDFGFTAGMEQTLDD 565 
WP_096722373 481 PPARYTEASLVKTLEKEGIGRPSTYATVISTIIDRGYVQMRGKALIPTFTAFAVTALLEEHFPDLVDTEFTSKMEQTLDE 560 
WP_096687235 445 LVKKLEELGIGRPSTYAPTISTIQSRQYVKKSELEGDKRTSHELVLKEKAISLNVKEETFGADKNKLIPEDIGVVVNDFL 524 
NP_599561    592 EGRTEWLNGFYFGDAEADQSMAESVARQGGlkalvdanleHIDARSVNSLKL-FDdaegrAVNVRVGRYG-PYIERivgt 669 
ALM10444     547 AESDLKSVTFLRGFYKPFHKLIESKTVEVK--------------------------------------KG-EVLKd---- 583 
NP_874826    542 ISSGTVQWLPYLESFYKGRKGLAAQVDKREg---------DIDGKAYRKVDL-EGi----PCTVRIGSNG-PWLEGkrin 606 
WP_013178849 581 IAAGEQEAGPYLERFYRGQEGLAARTQRSLg---------DVDAKAISTLSF-PKw---gEFVVRVGRFG-PYAEGvi-- 644 
WP_013629763 569 ISNGQAERLPYLDRFYSGSDGLETQVKSREe---------QIDPRKACTLEL-SGl----QSNVRVGRYG-PYLEKdn-- 631 
WP_045089368 534 YFPSIIDYNFTAKVEEGFDKIAEGKAKWNK----------SI------------------------SDFYdVFHP----- 574 
WP_049637723 550 AEGNLEWVPVMDKFWQGFNQQIQVKADVERpgn-------elIDE---FCPKcGR-----QLQKQLSRYG-SFIGCtg-- 611 
WP_077026509 566 IATGNADRLPYLREFYAGDEGINEQVKKHEs---------EIDPREACTLKL-DGi----DADVRVGRYG-PYFEKmd-- 628 
WP_096722373 561 IARGGADWIPYLKQFYQGETGLKTQIDVKSe---------EIEPALAKTIYL-ENl----DATVRIGKYG-PYIEMptdq 625 
WP_096687235 525 VKNFEKILDYEFTAKVEGDFDNIAKGKECW-------------------VEM-------------IKLFYtDFKS----- 567 
NP_599561    670 taegepEFQRANLPEETTPDELTLEVAEKLFATPQGG-RELGINPANGRMVVAKEGRFGPYVIEQVTdseragaeaqaee 748 
ALM10444     584 --------------------------------------RVIGIDPDTKLEVLARTGRFGPYIQLGRIelkp--------- 616 
NP_874826    607 e-egeeVDAKGNLPIDITPGDLDEEKVKQIL----DGpSDLGNHPDTGEKVYLRFGPWGPFVQLGEA------------- 668 
WP_013178849 645 ----ggEVKTASLPAELAPDEVTRELLEKALVAGNADdNVIGTFPETHQPMLLKSGPYGPYLQLGD-------------- 706 
WP_013629763 632 ----dgEPMTASLPQEISPADVNNEMAEKLFELKAKGpESIGMHPEEGLPIFVLSGPFGPYLQLGEQ------------- 694 
WP_045089368 575 ---------------------IVEEt-ANMRMEHKAGeRVLGVDPKSGRQVSVKIGRYGAMAQIGTP------------- 619 
WP_049637723 612 ---------ynATPKCDYKRNLDGEV-NN-----ASEpTVIGLDAETQKEIYLMNGPYGPYLQVGQPv------------ 664 
WP_077026509 629 ----geEKLTASIPLSVAPADLNNELAERLIEEKQKGpTALGMHPEEGQPVYQLNGPFGPYLQLGEV------------- 691 
WP_096722373 626 ---getEAIKISIPDELTPADLNPDQIAALIRQKQDGpEKVGIHPETGEPIYFKVGKYGPYVQLGDK------------- 689 
WP_096687235 568 ---------------------TVDNV-KD-KAERTVGeRILGKEEKTGKTILVRIGKFGPIAQIGDS------------- 611 
NP_599561    749 vvaaerkaedeqratdgmrpknwetktaanqKekrinqlvEENLKPATASLFS-----GMEPATVTLEEALKLLSLPREV 823 
ALM10444     617 ----------------------------gekM--------KNVPKPKSASIPK-----TIGKDAITLEQALSLLAFPRVL 655 
NP_874826    669 -------------------------------L--------DKKEKPRRASLPK-----NIKTQELSLDEAVKLLSLPRLL 704 
WP_013178849 707 ----------------------------------------DDQEKPKRVSLPR-----GLEPSAVTYEQAVGLLSLPRTL 741 
WP_013629763 695 -------------------------------Q--------EDGPKPKRVSIPK-----NYDPTKVDLDLAVKLMELPRTV 730 
WP_045089368 620 ----------------------------------------EEDEKPLFASLQK-----SQSIESITLEETLKLFELPRNI 654 
WP_049637723 665 -------------------------------E--------GEKKKPKRVSIPK-----EIPLSQINIDTANMLLSLPRDL 700 
WP_077026509 692 -------------------------------T--------EEQPKPKRCSIPN-----CFDPLNIDLETAIQLLALPRRI 727 
WP_096722373 690 -------------------------------T--------EDNPKPKMSSIPKkdnkeNLGIEDVSLDMAVGLLSLPRLL 730 
WP_096687235 612 ----------------------------------------SDEEKPKYASLLV-----SKHIETITLEEALDLFKLPREL 646 
NP_599561    824 GVDPSDNEVITAQNGRYGPYLKKG----------S-DSRSLNSEE----------QIFTVTLDEARRIYAEPKR-RGRAA 881 
ALM10444     656 GEK--DGQTIEVHLGRFGPYIKWG----------K-ATTSLGKDQ----------EPAQITKEEAIAYLASAKD-RKAQ- 710 
NP_874826    705 GEHPD-GGTIEARTGQFGPYVVWDkgn-----geKpDNRSLKKED----------DVYEIDLKRAIELLAIPKLgRGG-- 766 
WP_013178849 742 GAHPETGEAVTAAIGRFGPYVKHQ----------S-TFASLPKDE----------DVLRVGLQRALELLAKKAA-R---- 795 
WP_013629763 731 GQHPEDGKVVKAGIGRFGPYVQHD----------G-KYKSLGKDN----------DVLTVGLEEAVELLKQART-K---Q 785 
WP_045089368 655 GEF--RDKDVVIGIGRFGPYIRHN----------N-KFVSIPKGV----------DPLEIQLEEAIELIEDKER----KD 707 
WP_049637723 701 GQHPETGKKIVANIGRFGPYVNHD----------G-KFKSIPKTE----------SVFSIDLEGAVKLLAAAG--G---- 753 
WP_077026509 728 GKHPLTDKVVNTGIGRFGPYVLHN----------K-VYGSYDRKThtyeyngetyNVLNMTMDAAVELLKNTKK-R---A 792 
WP_096722373 731 GCHPATEGKIKAALGRFGPYVVHEfkgpedtklqR-DYRSLKKED----------DVLTVTLDRALELLAEPKRsRG-AS 798 
WP_096687235 647 GEF--EGKVITVAIGRFGPYIKFD----------G-KFISIKKASg--------dDPMTIQKSRAIELIEEKRK----AD 701 
NP_599561    882 AQPPLKQLGDNDVSGKPMTVKDGRFGPYVTDGTTNASLRKGDVPESLTDARANELLSERRAK--EAAD-G--GAP--AKk 954 
ALM10444     711 AAEPLRSLGQDAATGAEVQVKTGRYGPYVTDGKTNCSLPKRFTPEAVTLEEASDLLAKKRAR--GPSK-W--KGRg---- 781 
NP_874826    767 -RMALRDLGVPKGGEENIHVYNGPYGLYVKQGKINASLPKGKGAEEITIEEAIQLLEVKKSS--KTSStT--KKK--STt 839 
WP_013178849 796 -NRPLRVLGAHPETGDPVELHDGRYGLYVKHGKTNASLASGQSPDELTLEGALALLAEREGG--ARKAaKp-KRAp-AK- 869 
WP_013629763 786 APKPLREIGKHPEDESVIAVFEGRYGPYIKFGKLNVTVPKDTDIHSITVEEAVQWIDEKAAK--KGVK----KKS--AKk 857 
WP_045089368 708 KEKTIKLFE----EDSDLQVLNGRYGPYIKYQNSNYKIPKTTDPKKLTLEECKRIIEDSAKD--KKSKsKktKKSesAEs 781 
WP_049637723 754 -PAPLADLGEHPSGEGRIEVFSGRFGPYVQHNGIRATLPKSVTPEELTVEQALELLAEKAAK--EGGK----Ta---GKk 823 
WP_077026509 793 APEPIREIGKHPEDESVIGVFEGRYGMYVKHGKINATIPKDTDINSITLEQALEWIDEKAAK--KGIK----KKS--AKk 864 
WP_096722373 799 KKVPLRELGLHPGDQEPINIYKGPYGNYVQHGKVNAGLPQEQEVETVTLAQALELLASKAAT--KKKTtR--KTT--ATs 872 
WP_096687235 702 IDKYINVFK---NGDITLEVLNGRFGPYIRIDKKNYKIPKEIDAKLLTLEDCLKIKDEVEEKkgKSQPqQ--KKSt-NKk 775 
NP_599561    955 tST-K---KTAAK--KTTAKKTTak--ktVRK--ApPKTTknvvkagAKKK 995 
ALM10444     782 -WG-K---K------------------------------------------ 785 
NP_874826    840 -TK-K---KST-----TTKKKSt------TTKtgR-L-RAs------QVKV 866 
WP_013178849 870 -AA-KgagKAAGKapKG--SKAPa----kASK--G-RPKTk-----gATKA 904 
WP_013629763 858 kAA-K---KST-K--KKAAKKKAt-----KKKaaE---------------- 880 
WP_045089368 782 sTTkKgtsKTADKg-KTKTAKATstkktaGKRs---TKK------------ 816 
WP_049637723 824 tTA-K---KSAAKk--------------pAAGktT-ATKTaas--krAKKT 853 
WP_077026509 865 kAA-K---KKTAK--KKAAKKAAs-----GKKktA-KKKSgges------- 896 
WP_096722373 873 -KK-T---KTT-------KRKTt------TAKkaN-S-KSt------E--- 894 
WP_096687235 776 ---sK---------------------------------------------- 777 
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