Conserved Protein Domain Family
Dcm
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COG0270: Dcm (This model is not part of the current CDD release)
DNA-cytosine methylase Dcm or eukaryotic tRNA-C38 C5-methylase, Dcm/DNMT2/TRDMT1 family [Replication, recombination and repair, Translation, ribosomal structure and biogenesis]
Links
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Statistics
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PSSM-Id: 512399
Aligned: 729 rows
Threshold Bit Score: 109.477
Created: 24-Mar-2025
Updated: 26-Mar-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_230398906   1 MMR-MGS---------LFDGIGGFPLAA----VrnG-FTP-V-WASEIEAFP-------IE-VTKiRFP-----Em-RHV 49 
WP_013325610   8 QYKpIVDkdntptigtLFSGGGLFDVGA----MlaG-IKP-V-WGVEFDPNSpslssaiAE-CYEkNLG-----Rh-LIK 73 
WP_121616729 135 RIR-LTS---------ICAGAGIGTSVF----VnsGyFTP-V-MEIEWEEDS-------AE-VLKqNFP-----NscLFN 185
WP_011899376 123 PLS-VCS---------LFHGGGVLDKAIhagfKrsG-IASsIaVAVEMEGSY-------LDsSLAnN-PelwdqNsiAIE 183
WP_136550730 132 KLA-VHS---------HYHGAGILDLAIhsgfAraG-VKTfVqVAIEMERKY-------LDiSLKqN-PelfdeDsiLIE 192
WP_011267012 133 PLA-VCS---------LFHGGGVLDRAIhaglArsG-IDTfVrIGIEVEDQY-------LDaSLRnN-PmlwrdTsfAIC 193
WP_013386305 122 QLR-TIT---------FCAGAGISSECM----KkaG-FEE-V-AAVEWNPKEgse-dkfSD-IYLeNHP-----EsvMF- 176
WP_286241233 136 PMK-EGS---------LCTGVGVSTFGVhqslKqqG-IISqLeWVVDVEQTY-------LEaAARnN-Pal-ndDtqLIV 195
WP_052465121 134 CLS-TAS---------LSHGGGIMDAAAhkglKisG-VETrLgFACEIEPEY-------LEtSLRnN-RvwadkDskFYC 194
WP_159130465 131 RLT-LTS---------VCAGCGIGTAQF----KatNyFVP-V-QEIEIESDS-------CE-VIKhNFP-----NsyLFN 181

WP_230398906  50 GDI--TKlDGaKL-PPVDVICGGSPCQDLSVA--GQRA--------GLA--G---ARSGLFMEQTRIAKEMrksdeqrnv 111
WP_013325610  74 KPV--QDvDFsSLvP-PDFLHCSPPCQKFSLS--NPQR--------GET--D---NDLELALTTRRAIETL--------- 126
WP_121616729 186 GDI--RNc--yEVm-ESDVVLATLPCNEHSNL--GWGD----------E--G---MVNNLVLAAAKLIESS--------- 234
WP_011899376 184 SPI--QAvNLsRQpTQVDLLIGGIPVTGASKS--GRSKn-------KLEfaEsheDAGALFFNFLEFVKAL--------- 243
WP_136550730 193 API--QDvRFdPR-VKADVLVAGLPCTGASLA--GRAKmrdtkgekRTYlpEehdSAGALFYHTLRYVEAS--------- 258
WP_011267012 194 ADV--RDvQRgTGtPECDLVVAGIPCTGASRA--GKAKn-------KLSsaEqhpSAGSLFIDFLDFVRYS--------- 253
WP_013386305 177 -NIpmQQlKAsDL-PHAEVWLATLDCSDFSKAsnGTKK----------Qy-----HTMHLFMHLMRIFWEKpi------- 232
WP_286241233 196 GSI--EEvEPelL-STVDVLSVSLPCTGFSLA--GRAKl-------GLKfgEahpEAATAVFGLMQIVKQT--------- 254
WP_052465121 195 GPM--QDiRPaDIgKEADILIAGLPCVDASSA--GRSKk-------KLKnaEa-gKVGHLFHSFLNVVKWA--------- 253
WP_159130465 182 GDL--RDv--qEVv-ESDVCLVTLPCSQHSEL--GNLE----------Q--N---VMENLVLATAKIIKSA--------- 230

WP_230398906 112 paylvRPRYLVWENVPGAFSSAegEdfRAVIEEIVRikysacdvprpesgrwesAGAillgdefSLAWRVMDAQFWGVAQ 191
WP_013325610 127 -----KPQVFTLENVVPYAKS---LsfQTIKETLEK------------------LGY-------QYRELILDAADFGVPQ 173
WP_121616729 235 -----KAKAVIFENVPQWYKSKs---yQTLKGLLQS-------------------TFp------YWMEKNMESLDYGSLA 281
WP_011899376 244 -----NPAVVLIENVPEYQKT---AsmTVIRSVLSS------------------LGY-------SLQERILDGNEFGVIE 290
WP_136550730 259 -----QPAVIVLENVKAYSTT---AsaAVIRALLSG------------------AGY-------TVSERVLNGNEFGALE 305
WP_011267012 254 -----NPVMAIVENVPDYQTS---TsmEVIRSVLKS------------------LGY-------RLFECILDGAVFGAFE 300
WP_013386305 233 ---heRPLAILIENVTEFEKVAg----iSLELCFKE------------------EGY-------HVSKAKLNSLDYGSRT 280
WP_286241233 255 -----NPGVILSENVKQAKDS---AtyHLIISELER------------------LGY-------TVKETILDGADAGTIE 301
WP_052465121 254 -----NPSIVQLENVPEYQNT---TsmAVIRACLQE------------------WGY-------TLHEQVLNGNDYGALE 300
WP_159130465 231 -----NSSCLIFENVPGFYKSQs---wYQLREILAP-------------------DYp------FISEKQIESWDFGNIS 277

WP_230398906 192 RRRRIFLVADfggttapeilfkqdslfgdiaqsggqrqgaaapaqgcaddtggacltpwdvqsrrifeetgtwpalygge 271
WP_013325610 174 CRKRFFLVATnnlipleltlpkklsitwfeatvdliddlpestlaawqwq------------------------------ 223
WP_121616729 282 RRNRTYAIAAtdkelflnfefptapkslkrrklrnyvdsfkeeny----------------------------------- 326
WP_011899376 291 ARKRLCVVAVshgidgfdleqvqpvrtkescindilepipldsq------------------------------------ 334
WP_136550730 306 NRDRLCIIAVteglediidmseivpltvkperlsdvlqpipldse----------------------------------- 350
WP_011267012 301 SRSRMALVAYtegafepltldqitplrtkerslkdlmdvvpetde----------------------------------- 345
WP_013386305 281 KRERFFMVASvypgflfpeksgvkqtsiaeagiispdelewvsp------------------------------------ 324
WP_286241233 302 DRTRYFFVAVsnglseafdldnlptqervydrmadvmdevpydss----------------------------------- 346
WP_052465121 301 NRDRFFLVAVssglpnlleglspispkpatlgeiletvpedapn------------------------------------ 344
WP_159130465 278 TRNRKYVVCFreedlfeafqwpvppklrrkslkhfldgkngvyd------------------------------------ 321

WP_230398906 272 ggghgyiqteektaiafaanqrdevrnlhdvagaiqaqpgmkqqtfvadiekisafhvnqrdevidldgisgallatrnm 351
WP_013325610     --------------------------------------------------------------------------------    
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WP_013386305     --------------------------------------------------------------------------------    
WP_286241233     --------------------------------------------------------------------------------    
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WP_159130465     --------------------------------------------------------------------------------    

WP_230398906 352 qmqtfvtrqplfclndqggermdvtedvsstlragmgghpplvsqpncmngwdtqqsrvftpegvaptlagadggggrnp 431
WP_013325610     --------------------------------------------------------------------------------    
WP_121616729     --------------------------------------------------------------------------------    
WP_011899376     --------------------------------------------------------------------------------    
WP_136550730     --------------------------------------------------------------------------------    
WP_011267012     --------------------------------------------------------------------------------    
WP_013386305     --------------------------------------------------------------------------------    
WP_286241233     --------------------------------------------------------------------------------    
WP_052465121     --------------------------------------------------------------------------------    
WP_159130465     --------------------------------------------------------------------------------    

WP_230398906 432 agllfaagvvskgdgdcfltpethtsltggggqagqgypcvltagfcgsasaeargigyqaecsptiktgtapsvlclnd 511
WP_013325610     --------------------------------------------------------------------------------    
WP_121616729     --------------------------------------------------------------------------------    
WP_011899376     --------------------------------------------------------------------------------    
WP_136550730     --------------------------------------------------------------------------------    
WP_011267012     --------------------------------------------------------------------------------    
WP_013386305     --------------------------------------------------------------------------------    
WP_286241233     --------------------------------------------------------------------------------    
WP_052465121     --------------------------------------------------------------------------------    
WP_159130465     --------------------------------------------------------------------------------    

WP_230398906 512 qggsqmhcteditgtlraqehghqplvfdnhaqdsrftgpvavsqtvsagfgqggnnqplvmatqqggaeigegicptit 591
WP_013325610     --------------------------------------------------------------------------------    
WP_121616729     --------------------------------------------------------------------------------    
WP_011899376     --------------------------------------------------------------------------------    
WP_136550730     --------------------------------------------------------------------------------    
WP_011267012     --------------------------------------------------------------------------------    
WP_013386305     --------------------------------------------------------------------------------    
WP_286241233     --------------------------------------------------------------------------------    
WP_052465121     --------------------------------------------------------------------------------    
WP_159130465     --------------------------------------------------------------------------------    

WP_230398906 592 stagtsgnnqpvlfenhgidsrytgphavaptmsarmgtggnnvplvgsavafsldskesnsmksanphsgcretdvart 671
WP_013325610     --------------------------------------------------------------------------------    
WP_121616729     --------------------------------------------------------------------------------    
WP_011899376     --------------------------------------------------------------------------------    
WP_136550730     --------------------------------------------------------------------------------    
WP_011267012     --------------------------------------------------------------------------------    
WP_013386305     --------------------------------------------------------------------------------    
WP_286241233     --------------------------------------------------------------------------------    
WP_052465121     --------------------------------------------------------------------------------    
WP_159130465     --------------------------------------------------------------------------------    

WP_230398906 672 idttnpdpsknqggiailqeticiagntidrepenggnglgcqpdisYTITTSdrhavcepyqevvgalcrgdekgIGSq 751
WP_013325610 224 -------rlpfdvvqefkneadtayliersgarndrplhlrtanqpaWTIKAG-----------------------LGSd 273
WP_121616729 327 ------------ewkslkrwsdsfatrgawkgrnldktfvsldvkeiQCIPKRyr------------------------s 370
WP_011899376 335 -------------rwksfdylaekelrdkaagkgfarqllagaetfcGTVGKGy-------------------------- 375
WP_136550730 351 -------------rwksfdylrlkeerdiaagkgfrrqlftgeeghiATVTRQy-------------------------- 391
WP_011267012 346 -------------swkcydylgrkeerdiasgkgfrrqlltpeatscGCIGRGy-------------------------- 386
WP_013386305 325 -------------eesgtlryflereskgishnhhmtvfdvtkdaylGTITKNhfki----------------------- 368
WP_286241233 347 -------------mwkandhlnekairdkaagkgferqfitavstkvGVIGRHy-------------------------- 387
WP_052465121 345 --------------wrtfdylhkkeqrdkaagkgfmmqifaadspriATLRAGy-------------------------- 384
WP_159130465 322 -------------wkpvgkwmesfnsrkawidrsldktfvtedtkqiSCVPARyr------------------------s 364

WP_230398906 752 yVSQN--KCIv-eRR-N---L-IR--RLTPLECERLQGFPD-GWTliPg-A-SDSA-RYKALGNSVAIPCVDFVLRGIAY 817
WP_013325610 274 gKGGNr------lDPiNlyvKg-KilRPTPRFLARIMSVPD-WYEl-P--T-AMSI-ATTILGNGVCPLVAQQLLTALIP 340
WP_121616729 371 hCASN--SYVlngNK-D---Kw-R--FLTISEIKKILSIPD-WFEf-SphT-TFSR-QFEMLGQGVDGRILSSIANNLTA 437
WP_011899376 376 sKCRStePFIv--hP-Eq-sElSR--LFTPVEHCRIKGIPE-ELId----GlSDTT-AHEILGQSVVYPAFEALASSLgN 443
WP_136550730 392 mKCRStdPFIq--hP-Es-eElSR--LLTPVEHARVKGIPE-KLIsd--sDiADTT-AHEVLGQSIVFPMFEAVGFALgK 461
WP_011267012 387 aKARStePFIr--hP-Rn-pAlSR--LLTVSEHARVKTIPV-EIVe----GvSNTT-AHEILGQSVIYAAFEAIAATVgK 454
WP_013386305 369 ----qpeNWIk--hP-T---EeNKyaYLKGEQIRALHQI-DkQYYl----GnS-NKmVVECIGQSVCTQSFTAIAEALFT 432
WP_286241233 388 mKGRStePFWk--rE-Dg---mER--LMTVSEHAKVKLIPE-KLVd----GlSATV-AHQGLGQSVLLPHITAIMDRVaE 453
WP_052465121 385 hKGGStdPLLa--hP-Nn-pRlKR--LLTPREHAAVKGINP-KLVe----GcSNTL-AHQILGQSVISKVVEALYATIgL 452
WP_159130465 365 hSASS--SYVlseDK-T---Mw-R--FLTESELFRIMDIPE-FFSf-PdhT-PITR-RYEMIGLSVCGKVFKALANNIAA 431

WP_230398906 818 FL 819
WP_013325610 341 YL 342
WP_121616729 438 AF 439
WP_011899376 444 SL 445
WP_136550730 462 QL 463
WP_011267012 455 LI 456
WP_013386305 433 FL 434
WP_286241233 454 GL 455
WP_052465121 453 NL 454
WP_159130465 432 SF 433
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