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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, also known as 2019 novel coronavirus (2019-nCoV)) is the strain of coronavirus that causes coronavirus disease 2019 (COVID-19), a contagious respiratory illness. Coronaviruses possess the largest genomes among any RNA viruses.
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SARS-CoV-2-related data provided by the Protein Domains resource

ORF name CDD model Model name (mouse-over name for description) SARS Cov-2 structure SARSr-CoV structure Other coronavirus structure RefSeq protein Length
Non-structural proteins encoded by orf1ab:
orf1ab YP_009724389 [domain architecture] 7096
Nsp1 cd21796 SARS-CoV-like_Nsp1_N Molecular structure image for 7K3N
7K3N
[all]
Molecular structure image for 2HSX
2HSX
[all]
- YP_009725297 [domain architecture] 180
Nsp2 cd21516 cv_beta_Nsp2_SARS-like - - - YP_009725298 [domain architecture] 638
Nsp3 cd21467 Ubl1_cv_Nsp3_N-like Molecular structure image for 7KAG
7KAG
Molecular structure image for 2IDY
2IDY
[all]
Molecular structure image for 2M0A
2M0A
YP_009725299 [domain architecture] 1945
pfam12379 DUF3655 - Molecular structure image for 2K87
2K87
-
cd21557 Macro_X_Nsp3-like Molecular structure image for 6WEY
6WEY
[all]
Molecular structure image for 2FAV
2FAV
[all]
Molecular structure image for 2VRI
2VRI
[all]
cd21562 Macro_cv_SUD-N_Nsp3-like - Molecular structure image for 2W2G
2W2G
[all]
-
cd21563 Macro_cv_SUD-M_Nsp3-like - Molecular structure image for 2W2G
2W2G
[all]
-
cd21525 SUD_C_SARS-CoV_Nsp3 - Molecular structure image for 2KAF
2KAF
[all]
-
cd21466 Ubl2_cv_PLpro_N_Nsp3-like Molecular structure image for 6W9C
6W9C
[all]
Molecular structure image for 2FE8
2FE8
[all]
Molecular structure image for 4X2Z
4X2Z
[all]
cd21732 betaCoV_PLPro Molecular structure image for 6W9C
6W9C
[all]
Molecular structure image for 2FE8
2FE8
[all]
Molecular structure image for 5WFI
5WFI
[all]
cd21822 SARS-CoV-like_Nsp3_NAB Molecular structure image for 7LGO
7LGO
Molecular structure image for 2K87
2K87
-
cd21814 SARS-CoV-like_Nsp3_betaSM - - -
cd21717 TM_Y_SARS-CoV-like_Nsp3_C - - -
Nsp4 cd21473 cv_Nsp4_TM - - - YP_009725300 [domain architecture] 500
pfam16348 Corona_NSP4_C - - Molecular structure image for 3GZF
3GZF
[all]
Nsp5 cd21666 betaCoV_Nsp5_Mpro Molecular structure image for 7BQY
7BQY
[all]
Molecular structure image for 1WOF
1WOF
[all]
Molecular structure image for 3D23
3D23
[all]
YP_009725301 [domain architecture] 306
Nsp6 cd21560 betaCoV-Nsp6 - - - YP_009725302 [domain architecture] 290
Nsp7 cd21827 betaCoV_Nsp7 Molecular structure image for 7BV2
7BV2
[all]
Molecular structure image for 2AHM
2AHM
[all]
- YP_009725303 [domain architecture] 83
Nsp8 cd21831 betaCoV_Nsp8 Molecular structure image for 7BV2
7BV2
[all]
Molecular structure image for 2AHM
2AHM
[all]
- YP_009725304 [domain architecture] 198
Nsp9 cd21898 betaCoV_Nsp9 Molecular structure image for 6W9Q
6W9Q
[all]
Molecular structure image for 1QZ8
1QZ8
[all]
- YP_009725305 [domain architecture] 113
Nsp10 cd21901 alpha_betaCoV_Nsp10 Molecular structure image for 6W4H
6W4H
[all]
Molecular structure image for 5C8S
5C8S
[all]
Molecular structure image for 5YN5
5YN5
[all]
YP_009725306 [domain architecture] 139
Nsp12 cd21591 SARS-CoV-like_RdRp Molecular structure image for 7BV2
7BV2
[all]
Molecular structure image for 6NUR
6NUR
[all]
- YP_009725307 [domain architecture] 932
Nsp13 cd21401 ZBD_cv_Nsp13-like Molecular structure image for 6XEZ
6XEZ
[all]
Molecular structure image for 6JYT
6JYT
Molecular structure image for 5WWP
5WWP
YP_009725308 [domain architecture] 601
cd21689 stalk_CoV_Nsp13-like Molecular structure image for 6XEZ
6XEZ
[all]
Molecular structure image for 6JYT
6JYT
Molecular structure image for 5WWP
5WWP
cd21409 1B_cv_Nsp13-like Molecular structure image for 6XEZ
6XEZ
[all]
Molecular structure image for 6JYT
6JYT
Molecular structure image for 5WWP
5WWP
cd21722 betaCoV_Nsp13-helicase Molecular structure image for 6XEZ
6XEZ
[all]
Molecular structure image for 6JYT
6JYT
Molecular structure image for 5WWP
5WWP
cd17934 DEXXQc_Upf1-like Molecular structure image for 6XEZ
6XEZ
[all]
Molecular structure image for 6JYT
6JYT
Molecular structure image for 5WWP
5WWP
[all]
cd18808 SF1_C_Upf1 Molecular structure image for 6XEZ
6XEZ
[all]
Molecular structure image for 6JYT
6JYT
Molecular structure image for 5WWP
5WWP
Nsp14 cd21659 betaCoV_Nsp14 - Molecular structure image for 5C8T
5C8T
[all]
- YP_009725309 [domain architecture] 527
Nsp15 cd21171 NTD_alpha_beta_cv_Nsp15-like Molecular structure image for 6WLC
6WLC
[all]
Molecular structure image for 2H85
2H85
[all]
Molecular structure image for 5YVD
5YVD
[all]
YP_009725310 [domain architecture] 346
cd21167 M_alpha_beta_cv_Nsp15-like Molecular structure image for 6WLC
6WLC
[all]
Molecular structure image for 2H85
2H85
[all]
Molecular structure image for 5YVD
5YVD
[all]
cd21161 NendoU_cv_Nsp15-like Molecular structure image for 6WLC
6WLC
[all]
Molecular structure image for 2H85
2H85
[all]
Molecular structure image for 5YVD
5YVD
[all]
Nsp16 cd20762 capping_2-OMTase_Nidovirales Molecular structure image for 6W4H
6W4H
[all]
Molecular structure image for 2XYQ
2XYQ
[all]
Molecular structure image for 5YN5
5YN5
[all]
YP_009725311 [domain architecture] 298
Accessory proteins:
ORF3a cd21648 SARS-CoV-like_ORF3a Molecular structure image for 6XDC
6XDC
[all]
- - YP_009724391 [domain architecture]275
ORF6 pfam12133 Sars6 - - - YP_009724394 [domain architecture]61
ORF7a cd21663 ORF7a_SARS-CoV-like Molecular structure image for 6W37
6W37
[all]
Molecular structure image for 1XAK
1XAK
[all]
- YP_009724395 [domain architecture]121
ORF7b cd21623 ORF7b_SARS-CoV-2 - - - YP_009725318 [domain architecture] 43
ORF8 cd21641 ORF8-Ig_SARS-CoV-2-like Molecular structure image for 7JX6
7JX6
[all]
- - YP_009724396 [domain architecture] 121
ORF10 cd21597 SARS-CoV-2_Orf10 - - - YP_009725255 [domain architecture]38
Structural proteins:
(S)pike cd21624 SARS-CoV-like_Spike_S1_NTD Molecular structure image for 6VXX
6VXX
[all]
Molecular structure image for 6ACC
6ACC
[all]
Molecular structure image for 7BBH
7BBH
YP_009724390 [domain architecture] 1273
cd21480 SARS-CoV-2_Spike_S1_RBD Molecular structure image for 6VXX
6VXX
[all]
- -
cd21698 CoV_Spike_S1-S2_S2 Molecular structure image for 6VXX
6VXX
[all]
Molecular structure image for 6ACC
6ACC
[all]
Molecular structure image for 3JCL
3JCL
[all]
cd22378 SARS-CoV-like_Spike_SD1-2_S1-S2_S2 Molecular structure image for 6VSB
6VSB
[all]
Molecular structure image for 5WRG
5WRG
[all]
-
(E)nvelope cd21531 SARS-like-CoV_E Molecular structure image for 7K3G
7K3G
[all]
Molecular structure image for 5X29
5X29
[all]
- YP_009724392 [domain architecture]75
(M)embrane cd21529 SARS-like-CoV_M - - - YP_009724393 [domain architecture]222
(N)ucleocapsid cd21554 CoV_N-NTD Molecular structure image for 6VYO
6VYO
[all]
Molecular structure image for 1SSK
1SSK
[all]
Molecular structure image for 4UD1
4UD1
[all]
YP_009724397 [domain architecture]419
cd21595 CoV_N-CTD Molecular structure image for 6WJI
6WJI
[all]
Molecular structure image for 2GIB
2GIB
[all]
Molecular structure image for 6G13
6G13
[all]
Revised 8 April 2021