Mus musculus gene Itpa, encoding inosine triphosphatase (nucleoside triphosphate pyrophosphatase).
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SUMMARY back to top
RefSeq annotates one representative transcript (NM included in AceView variant.c), but Mus musculus cDNA sequences in GenBank, dbEST, Trace and SRA, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 8 spliced variants.

AceView synopsis, each blue text links to tables and details
Expression: According to AceView, this gene is expressed at high level, 3.4 times the average gene in this release. The sequence of this gene is defined by 362 GenBank accessions from 340 cDNA clones, some from thymus (seen 23 times), cerebellum (12), brain (11), lung (11), visual cortex (10), embryo (9), cortex (8) and 74 other tissues. We annotate structural defects or features in 6 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 11 distinct gt-ag introns. Transcription produces 9 different mRNAs, 8 alternatively spliced variants and 1 unspliced form. There are 3 non overlapping alternative last exons and 3 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by truncation of the 3' end, presence or absence of 5 cassette exons, overlapping exons with different boundaries, splicing versus retention of one intron.
Note that mRNA .fSep07 was found in vivo, although it is a predicted target of nonsense mediated mRNA decay (NMD).
Function: There are 19 articles specifically referring to this gene in PubMed. Functionally, the gene has been proposed to participate in pathways (Purine metabolism, Pyrimidine metabolism) and a process (nucleotide metabolic process). Proteins are expected to have molecular functions (nucleoside-triphosphate diphosphatase activity, hydrolase activity).
Please see the Jackson Laboratory Mouse Genome Database/Informatics site MGI_96622 for in depth functional annotation of this gene.
Protein coding potential: 8 spliced mRNAs putatively encode good proteins, altogether 8 different isoforms (3 complete, 4 COOH complete, 1 partial), some containing Ham1-like protein domain [Pfam]. The remaining mRNA variant (unspliced) appears not to encode a good protein.
Isoform Itpa.eSep07 is annotated using as Met a Kozak-compatible g..CTGg start, thereby gaining 74 amino acids N-terminal to the first AUG.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome 2, links to other databases and other names
Map: This gene Itpa maps on chromosome 2, at 2 F1|2 73.6 cM according to Entrez Gene. In AceView, it covers 14.01 kb, from 130493346 to 130507358 (NCBI 37a, Aug 2007), on the direct strand.
Links to: manual annotations from MGI_96622, KEGG_00230, KEGG_00240, the SNP view, gene overviews from Gene 16434, expression data from Gene 16434, molecular and other annotations from UCSC.
Other names: The gene is also known as Itpa, Itp, AU020102 or 2010016I08Rik, LOC16434.
EC number: This gene encodes protein number: 3.6.1.19.
Closest AceView homologs in other species ?
The closest human gene, according to BlastP, is the AceView gene ITPA (e=2 10-71).
The closest C.elegans gene, according to BlastP, is the AceView/WormGene hap-1 (e=5 10-39), which may contain interesting functional annotation.
The closest A.thaliana gene, according to BlastP, is the AceView gene AT4G13720 (e=3 10-33), which may contain interesting functional annotation
          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene Itpa 5' 3' encoded on plus strand of chromosome 2 from 130,493,346 to 130,507,358 a b c [NM] d e f g i-u h 1 2kb 0 135 bp exon 3463 bp [gt-ag] intron 26 GenBank accessions 58 bp exon 97 bp [gt-ag] intron 127 GenBank accessions 65 bp exon 439 bp [gt-ag] intron 131 GenBank accessions 74 bp exon 2105 bp [gt-ag] intron 124 GenBank accessions 32 bp exon 1358 bp [gt-ag] intron 124 GenBank accessions 1464 bp exon 14 accessions, some from whole body (seen 4 times) visual cortex (3), egg (2) thymus (once) Validated 3' end, 1 accession 1464 bp exon 114 bp exon 3463 bp [gt-ag] intron 26 GenBank accessions 58 bp exon 97 bp [gt-ag] intron 127 GenBank accessions 65 bp exon 439 bp [gt-ag] intron 131 GenBank accessions 74 bp exon 2105 bp [gt-ag] intron 124 GenBank accessions 32 bp exon 1358 bp [gt-ag] intron 124 GenBank accessions 116 bp exon 3590 bp [gt-ag] intron 100 GenBank accessions 77 bp exon 1561 bp [gt-ag] intron 87 GenBank accessions 650 bp exon 11 accessions, some from visual cortex (seen 3 times) brain (2), fetal liver (2) hematopoietic (2), mammary tumor. wap-tag model. 5 months old gross tissue (once) Validated 3' end, 3 accessions 650 bp exon 132 bp exon 132 bp exon 3465 bp [gt-ag] intron 87 GenBank accessions 58 bp exon 97 bp [gt-ag] intron 127 GenBank accessions 65 bp exon 439 bp [gt-ag] intron 131 GenBank accessions 74 bp exon 2105 bp [gt-ag] intron 124 GenBank accessions 32 bp exon 1358 bp [gt-ag] intron 124 GenBank accessions 116 bp exon 3590 bp [gt-ag] intron 100 GenBank accessions 77 bp exon 1561 bp [gt-ag] intron 87 GenBank accessions 644 bp exon 271 accessions, NM_025922 some from cerebellum (seen 12 times) thymus (10), cortex (8) lung (8), brain (7) Validated 3' end, 37 accessions 644 bp exon 326 bp exon 326 bp exon 3465 bp [gt-ag] intron 87 GenBank accessions 58 bp exon 97 bp [gt-ag] intron 127 GenBank accessions 65 bp exon 439 bp [gt-ag] intron 131 GenBank accessions 74 bp exon 2105 bp [gt-ag] intron 124 GenBank accessions 32 bp exon 1358 bp [gt-ag] intron 124 GenBank accessions 2235 bp exon 27 accessions, some from thymus (seen 5 times) inner ear (2), lung (2) adult brain (once), bone marrow (once) 2235 bp exon 110 bp exon 3465 bp [gt-ag] intron 87 GenBank accessions 220 bp exon 439 bp [gt-ag] intron 131 GenBank accessions 74 bp exon 74 bp exon 2105 bp [gt-ag] intron 124 GenBank accessions 32 bp exon 1358 bp [gt-ag] intron 124 GenBank accessions 116 bp exon 3590 bp [gt-ag] intron 100 GenBank accessions 77 bp exon 1561 bp [gt-ag] intron 87 GenBank accessions 517 bp exon 8 accessions, some from embryo (seen 2 times) brain (once), lung (once) mammary gland (once) neural retina (once) 517 bp exon 135 bp exon 3463 bp [gt-ag] intron 26 GenBank accessions 58 bp exon 97 bp [gt-ag] intron 127 GenBank accessions 65 bp exon 439 bp [gt-ag] intron 131 GenBank accessions 279 bp exon 279 bp exon 1900 bp [gt-ag] intron 2 GenBank accessions 32 bp exon 1358 bp [gt-ag] intron 124 GenBank accessions 116 bp exon 3590 bp [gt-ag] intron 100 GenBank accessions 8 accessions, some from thymus (seen 5 times) spleen (3) 1541 bp exon 71 bp exon 3465 bp [gt-ag] intron 87 GenBank accessions 58 bp exon 97 bp [gt-ag] intron 127 GenBank accessions 65 bp exon 65 bp exon 2618 bp [gt-ag] intron 1 GenBank accession 32 bp exon 1358 bp [gt-ag] intron 124 GenBank accessions 116 bp exon 3590 bp [gt-ag] intron 100 GenBank accessions 77 bp exon 1561 bp [gt-ag] intron 87 GenBank accessions 60 bp exon 1 accession from visual cortex 60 bp exon 1264 bp exon 1264 bp exon 5 accessions, some from embryonic body between diaphragm region andneck (seen 3 times) germinal b-cell (once) neural retina (once) 1264 bp exon 77 bp exon 9362 bp [gt-ag] intron 1 GenBank accession 337 bp exon 1 accession 337 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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Sequences: click on the numbers to get the DNA back to top


Click on the headers to reorder the lines
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR uORF Upstream sequence Transcription
unit
pre-mRNA		 Downstream sequence
aSep07 1828 bp 215 aa   1180 bp   2kb 9290 bp 1kb
bSep07 1186 bp 214 aa   541 bp   2kb 13799 bp 1kb
cSep07 1198 bp 198 aa 66 bp 535 bp 594 bp 2kb possibly including promoter 13813 bp 1kb
dSep07 2790 bp 192 aa 260 bp 1951 bp   2kb possibly including promoter 10254 bp 1kb
eSep07 1146 bp 130 aa 345 bp 408 bp   2kb probably including promoter 13664 bp 1kb
fSep07 2226 bp 111 aa   1890 bp   2kb 13073 bp 1kb
gSep07 479 bp 108 aa 153 bp   216 bp 2kb probably including promoter 13168 bp 1kb
hSep07 414 bp 64 aa   219 bp 192 bp 2kb 9776 bp 1kb
iSep07-unspliced 1264 bp 57 aa 24 bp 1066 bp 171 bp 2kb probably including promoter 1264 bp 1kb
Gene neighbors and Navigator on chromosome 2 F1|2 73.6 cM back to top
Tmc2 C P Nol5a C R P R R Ebf4 C R P R G 1700020A23Rik C R 4933425O20Rik C R Vps16 C R P C Ptpra D C R P R Mrps26 C R P Oxt D C P 1700012O15Rik R R R C R P R Itpa C R P R C Atrn D C R P C G R Hspa12b C R P 2310035K24Rik C030014O09Rik C R Idh3b R R G C P C R P A930025D01RikandCpxm1 C R R C R C P Avp C R P Ubox5andFastkd5 C R P 2600009E05RikandProsapip1 C R Slc4a11 C R 4930402H24Rik C R D C R P Gfra4 C R P Adam33 D C R P Siglec1 C R P 1700037H04Rik 100kb 0 Tmc2, 4 accessions, 2 variants Nol5a, 476 accessions 13 variants sakerara, 8 accessions 2 variants sikerara, 15 accessions Ebf4, 45 accessions, 8 variants rihorera, 1 accession LOC100043446, 2 accessions 1700020A23Rik, 8 accessions 2 variants 4933425O20Rik, 15 accessions Vps16, 381 accessions 17 variants mihorera, 6 accessions Ptpra, 270 accessions 11 variants sporsmar, 2 accessions Mrps26, 163 accessions 7 variants Oxt, 14 accessions 1700012O15Rik, 40 accessions gorsly, 1 accession stawsmar, 1 accession swasmar, 3 accessions tahorera, 4 accessions swosmar, 2 accessions tuhorera, 12 accessions Itpa, 350 accessions, 9 variants kehorera, 1 accession kuhorera, 1 accession Atrn, 227 accessions, 8 variants dersmaw, 1 accession LOC100043457, 27 accessions 3 variants Hspa12b, 32 accessions 3 variants snersmar, 4 accessions sneysmar, 3 accessions snoysmar, 3 accessions spasmar, 2 accessions spysmar, 1 accession koherera, 31 accessions rahorera, 3 accessions rehorera, 1 accession yohorera, 1 accession sposmar, 3 accessions muhorera, 5 accessions sparsmar, 1 accession hahorera, 2 accessions huhorera, 3 accessions hehorera, 1 accession speesmar, 1 accession spersmar, 1 accession nihorera, 3 accessions nehorera, 2 accessions nohorera, 1 accession speysmar, 1 accession stasmar, 1 accession stysmar, 1 accession stusmar, 7 accessions swysmar, 1 accession tehorera, 1 accession sweesmar, 2 accessions sihorera, 4 accessions suhorera, 1 accession sohorera, 1 accession kahorera, 1 accession kihorera, 13 accessions C030014O09Rik, 3 accessions ranarera, 2 accessions renarera, 1 accession yanarera, 1 accession yonarera, 1 accession manarera, 2 accessions dysmaw, 1 accession dusmaw, 1 accession munarera, 1 accession monarera, 1 accession darsmaw, 1 accession hinarera, 3 accessions deesmaw, 1 accession dorsmaw, 1 accession doysmaw, 1 accession fasmaw, 1 accession fosmaw, 1 accession henarera, 4 accessions nanarera, 3 accessions jasly, 1 accession farsmaw, 1 accession ninarera, 2 accessions fawsmaw, 1 accession geysly, 4 accessions sneesmar, 2 accessions kiherera, 3 accessions kuherera, 1 accession spusmar, 1 accession wahorera, 2 accessions ruhorera, 4 accessions yahorera, 1 accession yuhorera, 4 accessions mahorera, 8 accessions mohorera, 1 accession spawsmar, 1 accession hihorera, 2 accessions nahorera, 1 accession nuhorera, 1 accession spoysmar, 1 accession stosmar, 1 accession starsmar, 1 accession steesmar, 1 accession stersmar, 3 accessions steysmar, 2 accessions storsmar, 1 accession stoysmar, 1 accession tihorera, 3 accessions swusmar, 1 accession tohorera, 1 accession swarsmar, 5 accessions swawsmar, 5 accessions 2 variants sahorera, 7 accessions swersmar, 3 accessions sweysmar, 1 accession sworsmar, 3 accessions swoysmar, 3 accessions sehorera, 2 accessions basmaw, 1 accession bysmaw, 2 accessions busmaw, 2 accessions bosmaw, 1 accession barsmaw, 1 accession bawsmaw, 1 accession beesmaw, 1 accession bersmaw, 1 accession kohorera, 1 accession wanarera, 2 accessions rinarera, 1 accession runarera, 1 accession beysmaw, 1 accession borsmaw, 4 accessions boysmaw, 1 accession dasmaw, 1 accession ronarera, 2 accessions yunarera, 1 accession dosmaw, 1 accession minarera, 1 accession menarera, 1 accession dawsmaw, 3 accessions 2 variants hanarera, 1 accession deysmaw, 1 accession fusmaw, 1 accession hunarera, 3 accessions honarera, 2 accessions feesmaw, 1 accession nunarera, 1 accession Snrpb, 377 accessions 7 variants Idh3b, 362 accessions 11 variants keherera, 3 accessions snorsmar, 1 accession LOC668899, 69 accessions A930025D01RikandCpxm1 272 accessions, 12 variants rohorera, 4 accessions mehorera, 41 accessions hohorera, 1 accession sukerara, 8 accessions 3 variants Avp, 20 accessions Ubox5andFastkd5, 237 accessions 13 variants 2600009E05RikandProsapip1 328 accessions, 18 variants Slc4a11, 235 accessions 9 variants 4930402H24Rik, 387 accessions 23 variants fysmaw, 1 accession goysly, 2 accessions, 2 variants Gfra4, 36 accessions, 6 variants Adam33, 62 accessions 11 variants Siglec1, 17 accessions 3 variants 1700037H04Rik, 291 accessions 16 variants ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography:               19 articles in PubMed back to top
? Gene Summary Gene on genome mRNA:.a, .b, .c, .d, .e, .f, .g, .h, .i-u Alternative mRNAs features, proteins, introns, exons, sequences Expression Tissue Function, regulation, related genes C

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To compare alternative variants, their summarized annotations, predicted proteins, introns and exons, or to access any sequence, click the 'Alternative mRNAs features' tab. To see a specific mRNA variant diagram, sequence and annotation, click the variant name in the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

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