Homo sapiens gene ZNF582, encoding zinc finger protein 582.
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SUMMARY back to top
RefSeq annotates one representative transcript (NM included in AceView variant.b), but Homo sapiens cDNA sequences in GenBank, dbEST, Trace and SRA, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 4 spliced variants.

AceView synopsis, each blue text links to tables and details
Expression: According to AceView, this gene is well expressed, 0.7 times the average gene in this release. The sequence of this gene is defined by 79 GenBank accessions from 72 cDNA clones, some from brain (seen 7 times), kidney (5), liver and spleen (5), carcinoid (4), lung (4), hippocampus (3), cerebellum (2) and 24 other tissues. We annotate structural defects or features in 3 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 7 distinct gt-ag introns. Transcription produces 4 alternatively spliced mRNAs. There are 2 non overlapping alternative last exons and 2 validated alternative polyadenylation sites (see the diagram). 101 bp of this gene are antisense to spliced gene ZNF583, 1122 to ZNF542, raising the possibility of regulated alternate expression.
Efficacy of translation may be reduced by the presence of a shorter translated product (uORF) initiating at an AUG upstream of the main open reading frame (in variant bAug10).
Function:. Functionally, the gene has been proposed to participate in a process (regulation of transcription, DNA-dependent). Proteins are expected to have molecular functions (DNA binding, metal ion binding, zinc ion binding) and to localize in various compartments (nucleus, intracellular).
Protein coding potential: The 4 spliced mRNAs putatively encode good proteins, altogether 4 different isoforms (2 complete, 1 COOH complete, 1 partial), some containing domains KRAB box, Zinc finger, C2H2 type [Pfam].

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome 19, links to other databases and other names
Map: This gene ZNF582 maps on chromosome 19, at 19q13.43 according to Entrez Gene. In AceView, it covers 17.92 kb, from 56905129 to 56887211 (NCBI 37, August 2010), on the reverse strand.
Links to: the SNP view, gene overviews from Entrez Gene 147948, GeneCards, expression data from ECgene, UniGene, molecular and other annotations from UCSC, or our GOLD analysis.
The previous AceView annotation is here.
Other names: The gene is also known as ZNF582 or FLJ30927, LOC147948. It has been described as zinc finger protein 582.
Closest AceView homologs in other species ?
The closest mouse genes, according to BlastP, are the AceView genes LOC100042459 (e= 10-159), KRAB.51 (e= 10-149).
The closest C.elegans gene, according to BlastP, is the AceView/WormGene 4B812 (e=3 10-42).
The closest A.thaliana genes, according to BlastP, are the AceView genes ELF6 (e=3 10-11), REF6 (e=3 10-10), AT4G06634 (e=10-09)
RNA_seq discoveries back to top
Expression/conservation in primates tissues evaluated by cross-mapping to human. back to top
ZNF582 Gene expression in 15 primates, 16 tissues, from the NHPRTR project in sFPKM BAB SkeletalMuscle WholeBlood CHP Kidney Liver Lung Spleen CMC CMM Cerebellum HUM Brain Colon Heart LymphNode Ovary Testis JMI BoneMarrow MLM OWL PTM RMC RMI Pituitary SQM Thymus MST SMY RTL 0.59 1.26 1.78 0.78 1.02 0.59 1.35 0.29 1.66 2.52 0.72 1.45 1.35 1.78 2.70 0.55 0.59 1.55 0.51 3.33 3.82 1.78 1.55 1.18 2.52 2.05 1.91 0.45 2.90 3.10 1.91 0.68 1.18 2.70 3.82 1.66 0.96 0.72 0.48 0.63 2.52 1.66 1.02 1.26 1.10 0.36 1.45 2.05 0.72 2.90 2.52 0.96 3.33 2.35 1.55 0.96 2.19 1.78 2.90 2.70 3.33 1.35 0.78 2.19 1.26 0.89 1.78 2.90 2.19 2.05 2.05 2.05 0.83 1.91 1.91 1.18 1.26 1.35 1.78 2.35 1.78 0.96 1.78 3.10 4.71 1.91 2.19 2.52 3.57 2.05 4.10 1.91 1.55 2.52 0.72 1.66 1.78 0.68 2.19 1.02 1.02 1.26 1.66 0.89 0.78 2.05 2.05 1.18 0.83 1.10 1.91 2.05 2.70 2.52 4.71 0.68 0.96 2.05 2.70 2.35 3.57 2.19 2.35 2.52 0.78 2.90 0.89 0.72 1.91 0.89 1.18 4.39 1.55 1.78 2.70 1.26 1.66 1.02 1.26 1.26 2.35 1.55 2.35 0.83 1.78 0.83 2.35 1.91 3.57 3.82 2.35 1.55 1.78 0.83 2.19 1.78 Expression quantiles None Weak 1 2 3 4 5 6 7 8 10 20 This gene All genes log2 distributions RNA-seq gene expression profile across 16 selected tissues from the Non-Human Primates Reference Transcriptome Resource (link to NHPRTR project).
- Primates: Apes (HUM: Human (Illumina BodyMap 2), CHP: Chimpanzee), Old World monkeys (PTM: Pig-Tailed Macaque, JMI Japanese Macaque, RMI Rhesus Macaque Indian, RMC Rhesus Macaque Chinese, CMM Cynomolgus Macaque Mauritian, CMC Cynomolgus Macaque Chinese, BAB Olive Baboon, SMY Sooty Mangabey); New World monkeys (MST common Marmoset, SQM Squirrel Monkey, OWL Owl Monkey); and Lemurs (MLM Mouse Lemur, RTL Ring-Tailed Lemur).
- The level for significantly expressed genes is color coded in 8 equal sized bins (light to dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above intergenic background); dark gray for no expression or no sequence conservation (0 read in gene). The plot to the right shows the distribution of measured expression values in all tissues for all genes (blue) and for this gene (green), in Magic index = log2(1000 sFPKM).
You may also examine the strand-specific genome coverage plots on the experimental AceView/Magic hub at UCSC, by tissue or by species. Tracks may be slow to load; please reload if some tracks come up yellow-greenish, and thanks to UCSC for the great work!.
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          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene ZNF582 5' 3' encoded on minus strand of chromosome 19 from 56,905,129 to 56,887,211 4164 5423 5892 4806 a 898 5423 5892 4806 b [NM] 76 5423 5892 c 898 5423 5892 1699 d 1kb 0 326 bp exon 326 bp exon 1387 bp [gt-ag] intron 19 GenBank accessions 4145 RNA-seq supporting reads 384 UHR pooled cells 776 Brain 412 Blood 2535 Neuroblastoma 38 Other (also 401 Primates bodymap) 89 bp exon 1242 bp [gt-ag] intron 35 GenBank accessions 5388 RNA-seq supporting reads 540 UHR pooled cells 1089 Brain 532 Blood 3180 Neuroblastoma 47 Other (also 679 Primates bodymap) 127 bp exon 278 bp [gt-ag] intron 37 GenBank accessions 5855 RNA-seq supporting reads 733 UHR pooled cells 1196 Brain 623 Blood 3260 Neuroblastoma 43 Other (also 516 Primates bodymap) 96 bp exon 4816 bp [gt-ag] intron 21 GenBank accessions 4785 RNA-seq supporting reads 581 UHR pooled cells 808 Brain 478 Blood 2867 Neuroblastoma 51 Other (also 774 Primates bodymap) 1906 bp exon 21 accessions, some from brain (seen 5 times) liver and spleen (3) carcinoid (2), lung (2) anaplastic oligodendroglioma (once) 1906 bp exon 319 bp exon 319 bp exon 243 bp uORF 1609 bp [gt-ag] intron 10 GenBank accessions 888 RNA-seq supporting reads 77 UHR pooled cells 148 Brain 98 Blood 557 Neuroblastoma 8 Other (also 32 Primates bodymap) 243 bp uORF 89 bp exon 89 bp exon 89 bp exon 1242 bp [gt-ag] intron 35 GenBank accessions 5388 RNA-seq supporting reads 540 UHR pooled cells 1089 Brain 532 Blood 3180 Neuroblastoma 47 Other (also 679 Primates bodymap) 127 bp exon 127 bp exon 278 bp [gt-ag] intron 37 GenBank accessions 5855 RNA-seq supporting reads 733 UHR pooled cells 1196 Brain 623 Blood 3260 Neuroblastoma 43 Other (also 516 Primates bodymap) 96 bp exon 96 bp exon 4816 bp [gt-ag] intron 21 GenBank accessions 4785 RNA-seq supporting reads 581 UHR pooled cells 808 Brain 478 Blood 2867 Neuroblastoma 51 Other (also 774 Primates bodymap) 2436 bp exon 2436 bp exon 36 accessions, NM_144690.1 some from kidney (seen 3 times) brain (2), liver and spleen (2) pooled germ cell tumors (2) breast cancer (once) Validated 3' end, 1 accession Validated 3' end, 1 accession 2436 bp exon 241 bp exon 1404 bp [gt-ag] intron 2 GenBank accessions 74 RNA-seq supporting reads 11 UHR pooled cells 9 Brain 8 Blood 45 Neuroblastoma 1 Other (also 1 Primates bodymap) 89 bp exon 1242 bp [gt-ag] intron 35 GenBank accessions 5388 RNA-seq supporting reads 540 UHR pooled cells 1089 Brain 532 Blood 3180 Neuroblastoma 47 Other (also 679 Primates bodymap) 127 bp exon 278 bp [gt-ag] intron 37 GenBank accessions 5855 RNA-seq supporting reads 733 UHR pooled cells 1196 Brain 623 Blood 3260 Neuroblastoma 43 Other (also 516 Primates bodymap) 96 bp exon 2 accessions, some from carcinoid (seen once) lung (once) 96 bp exon 37 bp exon 1609 bp [gt-ag] intron 10 GenBank accessions 888 RNA-seq supporting reads 77 UHR pooled cells 148 Brain 98 Blood 557 Neuroblastoma 8 Other (also 32 Primates bodymap) 89 bp exon 1242 bp [gt-ag] intron 35 GenBank accessions 5388 RNA-seq supporting reads 540 UHR pooled cells 1089 Brain 532 Blood 3180 Neuroblastoma 47 Other (also 679 Primates bodymap) 127 bp exon 278 bp [gt-ag] intron 37 GenBank accessions 5855 RNA-seq supporting reads 733 UHR pooled cells 1196 Brain 623 Blood 3260 Neuroblastoma 43 Other (also 516 Primates bodymap) 96 bp exon 13879 bp [gt-ag] intron 4 GenBank accessions 1695 RNA-seq supporting reads 163 UHR pooled cells 496 Brain 39 Blood 982 Neuroblastoma 15 Other (also 1 Primates bodymap) 276 bp exon 5 accessions, some from carcinoid (seen once) hippocampus (once), islets of langerhans (once) kidney (once), lung (once) 276 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR uORF Upstream sequence Transcription
unit
pre-mRNA
Downstream sequence
aAug10 2544 bp 548 aa 313 bp 584 bp 2kb probably including promoter 10267 bp 1kb
bAug10 3067 bp 517 aa 399 bp 1114 bp 240 bp 2kb possibly including promoter 11012 bp 1kb
cAug10 553 bp 184 aa 2kb probably including promoter 3477 bp 1kb
dAug10 625 bp 153 aa 163 bp 2kb probably including promoter 17633 bp 1kb

Gene neighbors and Navigator on chromosome 19q13.43 back to top
NLRP8 C R P NLRP5 C P ZNF444 D C R P GALP C R P R R ZNF542 C R ZNF583 C R C MGC9913 R ZNF471 C I R P ZFP28 C R P ZNF470 C R P ZNF71 C R P G R OR5AH1P R PEG3AS P MIMT1 P C P C R ZNF787 C C P ZSCAN5B C R ZSCAN5A G C R ZNF582 R P C R P ZNF667 R R C R ZNF835 D C I R P ZIM2andPEG3 100kb 0 NLRP8, 4 accessions, 2 variants NLRP5, 9 accessions ZNF444, 300 accessions 18 variants GALP, 6 accessions, 2 variants rimare, 22 accessions 5 variants chasaw, 15 accessions 4 variants ZNF542, 155 accessions 16 variants ZNF583, 129 accessions 16 variants gawjaw, 1 accession MGC9913, 239 accessions 14 variants ZNF471, 62 accessions 4 variants ZFP28, 83 accessions, 7 variants ZNF470, 72 accessions 6 variants ZNF71, 91 accessions, 4 variants LOC147670, 51 accessions 2 variants OR5AH1P, 22 accessions 7 variants PEG3AS, 1 accession MIMT1, 14 accessions, 3 variants storblar, 1 accession swyblar, 1 accession foyjaw, 2 accessions bawblaw, 1 accession beyblaw, 1 accession dyblaw, 4 accessions teeky, 1 accession sporza, 1 accession jyblaw, 1 accession kawblaw, 4 accessions sloysarbo, 1 accession waner, 2 accessions steyza, 1 accession gleytabu, 1 accession loblaw, 1 accession leyblaw, 1 accession yureri, 6 accessions klotabu, 1 accession mublaw, 1 accession klortabu, 1 accession mawblaw, 1 accession kozy, 1 accession merblaw, 1 accession meyblaw, 1 accession morblaw, 1 accession terky, 2 accessions nublaw, 3 accessions peeblaw, 1 accession porblaw, 1 accession ryblaw, 1 accession plotabu, 3 accessions plartabu, 1 accession plawtabu, 1 accession pleetabu, 3 accessions perzy, 1 accession mireri, 2 accessions pleytabu, 1 accession chysaw, 2 accessions moreri, 1 accession hareri, 1 accession kiyuro, 1 accession mawvoy, 2 accessions tuzy, 1 accession skutabu, 1 accession vorzy, 1 accession zerblaw, 1 accession skartabu, 1 accession skawtabu, 1 accession fleener, 4 accessions charblaw, 2 accessions smosarbo, 6 accessions voyzy, 1 accession slober, 5 accessions smarsarbo, 1 accession warzy, 1 accession shawblaw, 1 accession bleeblaw, 1 accession glablaw, 1 accession glyblaw, 1 accession woyzy, 1 accession gleeblaw, 1 accession glerblaw, 5 accessions skoner, 5 accessions smawsarbo, 1 accession sloblaw, 1 accession slatabu, 1 accession sloyblaw, 1 accession slotabu, 1 accession snyblaw, 1 accession keyuro, 1 accession vorky, 1 accession styblaw, 2 accessions shawzy, 1 accession slawtabu, 1 accession swyblaw, 1 accession fleezy, 1 accession wawsaw, 1 accession toky, 1 accession slorsarbo, 1 accession snoyza, 1 accession glutabu, 1 accession borblaw, 1 accession spuza, 1 accession spoza, 1 accession doblaw, 1 accession gublaw, 1 accession vyner, 1 accession gorblaw, 4 accessions woysaw, 2 accessions keyblaw, 2 accessions stuza, 3 accessions larblaw, 1 accession lerblaw, 2 accessions swoza, 1 accession lorblaw, 3 accessions loyblaw, 1 accession klartabu, 2 accessions deezy, 1 accession mablaw, 2 accessions klawtabu, 2 accessions kleetabu, 2 accessions myblaw, 1 accession moblaw, 2 accessions marblaw, 3 accessions sunuru, 2 accessions kleytabu, 1 accession zawsaw, 3 accessions kloytabu, 2 accessions ployber, 4 accessions platabu, 1 accession moyblaw, 1 accession mareri, 1 accession neyblaw, 1 accession korzy, 2 accessions plutabu, 5 accessions pablaw, 1 accession lazy, 1 accession myzy, 1 accession mawzy, 1 accession nozy, 2 accessions nawzy, 1 accession pazy, 1 accession pawzy, 3 accessions toblaw, 1 accession toyblaw, 1 accession rerzy, 1 accession toyky, 3 accessions mereri, 1 accession tayuro, 2 accessions, 2 variants tyzy, 1 accession ploytabu, 1 accession veeblaw, 1 accession chawsaw, 2 accessions skytabu, 2 accessions skotabu, 1 accession zeeblaw, 1 accession skeetabu, 1 accession smysarbo, 1 accession choblaw, 1 accession vyky, 1 accession skeyber, 4 accessions shoblaw, 1 accession sharblaw, 2 accessions floyblaw, 2 accessions glublaw, 1 accession gloyblaw, 4 accessions skublaw, 1 accession slarblaw, 1 accession slytabu, 1 accession vuky, 1 accession snablaw, 5 accessions chuzy, 2 accessions chozy, 1 accession snoblaw, 3 accessions speyblaw, 1 accession waky, 1 accession slartabu, 1 accession bluzy, 1 accession stawblaw, 1 accession blozy, 1 accession smeesarbo, 1 accession meyvoy, 2 accessions slertabu, 1 accession NLRP13, 2 accessions ZNF787, 118 accessions 3 variants boblaw, 1 accession ZSCAN5B, 7 accessions ZSCAN5A, 141 accessions 25 variants LOC729999, 1 accession ZNF582, 72 accessions 4 variants plortabu, 2 accessions hireri, 1 accession ZNF667, 111 accessions 10 variants cheysaw, 8 accessions 5 variants chorsaw, 22 accessions 2 variants ZNF835, 29 accessions 7 variants ZIM2andPEG3, 422 accessions 20 variants borblee, 2 accessions ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         Read more...
Annotated mRNA diagrams back to top
? Gene Summary Gene on genome mRNA:.a, .b, .c, .d Alternative mRNAs features, proteins, introns, exons, sequences Expression Tissue Function, regulation, related genes C

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To compare alternative variants, their summarized annotations, predicted proteins, introns and exons, or to access any sequence, click the 'Alternative mRNAs features' tab. To see a specific mRNA variant diagram, sequence and annotation, click the variant name in the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !