Homo sapiens gene KIAA1161, encoding KIAA1161.
SUMMARY back to top
RefSeq annotates one representative transcript.

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is well expressed, 1.1 times the average gene in this release. The sequence of this gene is defined by 135 GenBank accessions from 118 cDNA clones, some from brain (seen 19 times), colon (12), kidney (12), anaplastic oligodendroglioma (8), placenta (8), liver (6), whole brain (5) and 54 other tissues. We annotate structural defects or features in 4 cDNA clones.
The gene contains 1 gt-ag intron. Transcription produces one mRNA. There are 3 validated alternative polyadenylation sites (see the diagram).
Function: There are 3 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to a disease (Glycogen Storage Disease Type II) and proposed to participate in a process (carbohydrate metabolic process). Proteins are expected to have molecular function (hydrolase activity, hydrolyzing O-glycosyl compounds) and to localize in various compartments (endoplasmic reticulum membrane, integral to membrane).
The spliced mRNA putatively encodes a good protein, containing Glycosyl hydrolases family 31 domain [Pfam], some transmembrane domains [Psort2]. Finally proteins from this gene may be modulated by acetylation; phosphorylation; ubiquitination, as detailed at PhosphoSite.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome 9, links to other databases and other names
Map: This gene KIAA1161 maps on chromosome 9, at 9p13.3 according to Entrez Gene. In AceView, it covers 10.23 kb, from 34376896 to 34366664 (NCBI 37, August 2010), on the reverse strand.
Links to: manual annotations from PhosphoSite, the SNP view, gene overviews from Entrez Gene 57462, GeneCards, expression data from ECgene, UniGene, molecular and other annotations from UCSC, or our GOLD analysis.
The previous AceView annotation is here.
Other names: The gene is also known as KIAA1161, RP11-573M23.6 or NET37, LOC57462. It has been described as hypothetical protein LOC57462, OTTHUMP00000021254.
EC number: This gene encodes protein number: 3.2.1.-.
Closest AceView homologs in other species ?
The closest mouse gene, according to BlastP, is the AceView gene AI464131 (e=0.0).
The closest C.elegans gene, according to BlastP, is the AceView/WormGene XB85 (e=5 10-16).
The closest A.thaliana genes, according to BlastP, are the AceView genes AT3G45940 (e=3 10-17), RSW3 (e=8 10-17), AT5G11720 (e=2 10-15)
RNA_seq discoveries back to top
Expression/conservation in primates tissues evaluated by cross-mapping to human. back to top
RNA-seq gene expression profile across 16 selected tissues from the Non-Human Primates Reference Transcriptome Resource (link to NHPRTR project).
- Primates: Apes (HUM: Human (Illumina BodyMap 2), CHP: Chimpanzee), Old World monkeys (PTM: Pig-Tailed Macaque, JMI Japanese Macaque, RMI Rhesus Macaque Indian, RMC Rhesus Macaque Chinese, CMM Cynomolgus Macaque Mauritian, CMC Cynomolgus Macaque Chinese, BAB Olive Baboon, SMY Sooty Mangabey); New World monkeys (MST common Marmoset, SQM Squirrel Monkey, OWL Owl Monkey); and Lemurs (MLM Mouse Lemur, RTL Ring-Tailed Lemur).
- The level for significantly expressed genes is color coded in 8 equal sized bins (light to dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above intergenic background); dark gray for no expression or no sequence conservation (0 read in gene). The plot to the right shows the distribution of measured expression values in all tissues for all genes (blue) and for this gene (green), in Magic index = log2(1000 sFPKM).
You may also examine the strand-specific genome coverage plots on the experimental AceView/Magic hub at UCSC, by tissue or by species. Tracks may be slow to load; please reload if some tracks come up yellow-greenish, and thanks to UCSC for the great work!.
          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the Flash version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR Upstream sequence Transcription
Downstream sequence
aAug10 6447 bp 680 aa 271 bp 4133 bp 2kb possibly including promoter 10233 bp 1kb

Gene neighbors and Navigator on chromosome 9p13.3 back to top
ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications        
Annotated mRNA diagrams back to top
Bibliography:               3 articles in PubMed back to top
? Gene Summary Gene on genome mRNA Expression Tissue Function, regulation, related genes DC

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To see the mRNA diagram, sequence and annotation, click the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

If you know more about this gene, or found errors, please share your knowledge. Thank you !