Caption: What we know about the gene and its neighbors.

A 1 megabase chromosomal region, centered on the gene of interest (named in red), is shown to scale. Zoom in to view a 200 kilobase region. Click on any gene to navigate.

Knowledge about the gene is summarized in the colored pastilles: G:Gene known to Entrez, D:Disease, C:Conservation, Interactions, Regulation, Publications.
Each arrow represents a gene; it covers the extent of the GenBank/dbEST cDNA sequences belonging specifically to the gene, and points in the direction of transcription (top strand is up, bottom down). The width of the arrow indicates the level of expression. Mouse over gives the name of the gene and the number of accessions from the nucleotide database
The gene is in pink if protein coding, red if spliced and not-protein coding, blue if unspliced but relatively well expressed (putative gene), black if expressed at low level and neither spliced nor obviously coding (what we call “the cloud”).

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Example: A coding gene (pink arrow) covers this area of the chromosome

Above is the gene name, written by default only when there is an official name in Entrez Gene.

Clicking on any arrow in this view opens this gene’s page: the gene called appears in the center and its name is written in red.

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Putatively coding genes (pink) expressed at low level (thin arrow), moderate (medium arrow) or high (wide arrow).

Note: the tiny ones are usually unspliced. When they are under a gene on the same strand, it is possible that they are fragments of this gene, although their available sequence does not overlap. That hypothesis could be tested by sequencing the entire cDNA or by trying RT-PCR.

Spliced genes, apparently non-coding (red).

expressed at low level (thin arrow) or high level (broad arrow)

A “putative” gene, with a high level of expression (broad arrow), but no intron and no obvious coding potential is encoded on the reverse strand of the chromosome (arrow points to the left) .

“Cloud genes”, not spliced, apparently not coding, and expressed at low level (black and always short).

 

The central black line represents the chromosome, at the scale indicated; transcription of the forward strand yields the genes on top of the drawing, while transcription of the reverse strand yields the genes below the line.

This gene has a GeneID and an entry in the current Entrez Gene, but no official name yet.

All genes in Entrez have either this G icon or a name written by default. Other genes are unknown in Entrez.

A disease is proposed to be associated to this gene

Please help us by voting to confirm or infirm the association, send us a short note with your views and how you support those, and we will mention your user’s comment in future releases.

Conserved domain or protein found in another species (most proteins with a Pfam motifs or a BlastP hit with expect <.001 in another species)

Interactions with other genes or proteins are annotated

These are currently third party annotations from HPRD, BioGRID or BIND, collected through Entrez Gene, and only report protein-protein interactions

Regulation is annotated in this gene.

“Regulation” includes alternative splicing, antisense to other spliced gene, complex locus potentially producing unrelated proteins, predicted nonsense mediated RNA decay (NMD), candidate uORF

Publications in PubMed are attached specifically to this gene

This flash diagram is an experimental new development: you may use the right mouse button to zoom, drag and print. We count on you to report any problem