Caption:
What we know about the gene and its neighbors.
A 1
megabase chromosomal region, centered on the gene of interest (named in red),
is shown to scale. Zoom in to view a 200 kilobase region. Click on any gene to
navigate.
Knowledge
about the gene is summarized in the colored pastilles: G:Gene known to
Entrez, D:Disease, C:Conservation, Interactions,
Regulation, Publications.
Each arrow represents a gene; it covers the extent of the GenBank/dbEST cDNA sequences
belonging specifically to the gene, and points in the direction of
transcription (top strand is up, bottom down). The width
of the arrow indicates the level of expression.
Mouse over gives the name of the gene and the number of accessions from the
nucleotide database
The gene is in pink if protein coding, red if spliced and not-protein coding, blue if unspliced but relatively well expressed
(putative gene), black if expressed at low level and neither spliced nor
obviously coding (what we call “the cloud”).
.
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Example:
A coding gene (pink arrow) covers this area of the chromosome Above is
the gene name, written by default only when there is an official name in
Entrez Gene. Clicking on any arrow in this view opens this gene’s
page: the gene called appears in the center and its name is written in red. |
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Putatively
coding genes (pink) expressed at low level (thin arrow), moderate (medium
arrow) or high (wide arrow). Note: the tiny ones are usually unspliced. When they are
under a gene on the same strand, it is possible that they are fragments of
this gene, although their available sequence does not overlap. That
hypothesis could be tested by sequencing the entire cDNA or by trying RT-PCR. |
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Spliced
genes, apparently non-coding (red). expressed
at low level (thin arrow) or high level (broad arrow) |
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A
“putative” gene, with a high level of expression (broad arrow),
but no intron and no obvious coding potential is encoded on the reverse
strand of the chromosome (arrow points to the left) . |
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“Cloud
genes”, not spliced, apparently not coding, and expressed at low level
(black and always short). |
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The central
black line represents the chromosome, at the scale indicated; transcription
of the forward strand yields the genes on top of the drawing, while
transcription of the reverse strand yields the genes below the line. |
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This gene
has a GeneID and an entry in the current Entrez Gene, but no official name
yet. All genes in Entrez have either this G icon or a name written by default. Other genes
are unknown in Entrez. |
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A disease is proposed to be associated to this gene Please help us by voting to confirm or infirm the
association, send us a short note with your views and how you support those,
and we will mention your user’s comment in future releases. |
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Conserved domain or protein found in another species (most proteins with a
Pfam motifs or a BlastP hit with expect <.001 in another species) |
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Interactions with other genes or proteins are annotated These are currently third party annotations from HPRD, BioGRID or BIND, collected through Entrez Gene, and only report
protein-protein interactions |
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Regulation
is annotated in this gene. “Regulation” includes alternative splicing,
antisense to other spliced gene, complex locus potentially producing
unrelated proteins, predicted nonsense mediated RNA decay (NMD), candidate uORF |
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Publications in PubMed are attached specifically to this gene |
This
flash diagram is an experimental new development: you may use the right mouse
button to zoom, drag and print. We count on you to report any problem