Advanced Workshop for Bioinformatics Specialists
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Molecular Evolution Tips

  • Rule Of Functional Constraint: As the biological (functional) importance of a gene or protein increases, the selective constraints on it increase, thereby lowering its evolutionary rate. Thus genes, proteins, and subsections thereof of greatest functional importance will evolve slowest and exhibit least polymorphism.
  • Molecular Clock: Rate of sequence change is roughly proportional to time since last common ancestor of two species or genes.

Phylogenetic Resources
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Revised 07/19/2004