Genetics Review
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Course Description

Schedule

Introduction

Genetics Review

Types of Databases

Format of Sequence Record

Entrez

BLAST

3-D Structures

Genomes and Maps

Librarian Roles

WWW Sites

Glossaries and Dictionaries

 

Brief Key to Basic Genetics back to top

Blazing a Genetic Trail, by the Howard Hughes Medical Institute (HHMI), provides an excellent introduction to genetics, gene discovery, and genetic disorders, using cystic fibrosis as an example. The left sidebar also includes a link to a "Brief Key to Basic Genetics," which discusses the cell, nucleus, chromosome, gene, and protein.

Central Dogma of Biology back to top

DNA transcription RNA translation PROTEIN

A more detailed explanation of the central dogma is provided by the MIT Biology Hypertextbook

Terms and Illustrations back to top

References:  WWW Resources back to top

Access Excellence Graphics Gallery. Provides labeled illustrations of genetic concepts.

Biology Project, by the University of Arizona, features brief tutorials and corresponding problem sets on a variety of biology topics, including cell biology, human biology, Mendelian Genetics, molecular biology, and others. A sample problem in the Human Biology section is 'Web Karyotyping,' in which you play the role of a cytogenetic technician and complete three patient karyotypes, then evaluate and diagnose each patient. Another example of a feature that will be of interest is "The Cell Cycle & Mitosis Tutorial."

Blazing a Genetic Trail, by the Howard Hughes Medical Institute (HHMI), illustrates the significance of genetic research by recounting the discovery of the gene for cystic fibrosis. It also includes a link to a Brief Key to Basic Genetics.

Dolan DNA Learning Center is a unit of Cold Spring Harbor Laboratory, serving to provide public genetics education to college, pre-college, and the public. The Center serves as both a clearinghouse for information on DNA science, genetic medicine and biotechnology; and provides an interactive learning environment for students. These goals are reflected in the wealth of information provided at their web site.

Genes and Disease web site discusses how genetic factors contribute to human disease, and provides summary information for ~60 genetic diseases with links to related databases and organizations.

MIT Biology Hypertextbook is designed to supplement the course materials of MIT Introductory Biology 7.01. It contains a variety of components designed to be used independently or together to facilitate your understanding of introductory molecular biology.

National Human Genome Research Institute (NHGRI) provides Educational Resources for students, teachers, and the general public. It includes an introduction to the human genome project, a talking glossary, fact sheets, and multimedia educational kits on "Exploring Our Molecular Selves".

Science Primer, an NCBI resource that explains the science behind the molecular databases at the National Center for Biotechnology Information (NCBI). Topics include bioinformatics, genome mapping, molecular modeling, SNPs, ESTs, microarray technology, molecular genetics, pharmacogenomics, and phylogenetics.

Understanding Gene Testing, by Access Excellence, explores how genes are linked to disease and discusses the nature and uses of genetic testing.

US Department of Energy's Human Genome Project Information site includes links to a wide variety of educational resources, including a glossary, science primer, and wide variety publications, teaching aids, and online animations.

References:  Articles and Chapters back to top

Shreeve, J. 1999. Secrets of the Gene. National Geographic, 196(4): 44-75 (October).

Green, E.D. Forthcoming. The Human Genome Project and Its Impact on the Study of Human Disease. Chapter 9 IN Metabolic and Molecular Bases of Inherited Disease, 8th edition, edited by Scriver, C.R., Beaudet, A.l., Sly, W.S., Valle, D., Childs, B., and Vogelstein B. New York: McGraw-Hill.

References:  Texts back to top

Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K., Watson, J. 1994. Molecular Biology of the Cell. 3rd ed. New York: Garland Publishing.

Lewin, B. 1997. Genes VI. New York: Oxford University Press.

Lodish, H., Berk, A., Zipursky, S.L., Matsudaira, P. 1999. Molecular Cell Biology. 4th ed. New York: W.H. Freeman and Company.

Strachan, T. and Read, A.P. 1999. Human Molecular Genetics, 2nd ed. New York: John Wiley & Sons.

Watson, J.D., M. Gilman, J. Witkowski, M. Zoller. 1992. Recombinant DNA. 2d ed. New York: W.H. Freeman and Company, Scientific American Books.

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  Revised September 13, 2002
Comments/questions about course to Renata Geer renata@ncbi.nlm.nih.gov
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