Scheduled Seminars on 6/11/2012

Sayantani Basu Roy at 14:00  Edit  Reschedule  Delete
Affiliation: UMR de Génétique Végétale, INRA -- Université Paris-Sud -- CNRS, Ferme du Moulon, Gif-sur-Yvette, France
Host: John Spouge

Interference between Crossovers during Meiosis
Crossovers (COs) form during meiosis and are responsible for shuffling alleles, a major driver of adaptation and evolution. Each pair of homologous chromosomes will form at least one crossover (in the great majority of species), and when multiple crossovers arise, they typically exhibit "interference", occurring rarely in close proximity. To model this phenomenon, statistical and mechanistic approaches have been used based mainly on the "Gamma" stationary renewal process and the “beam-film” model. We found the co-existence of two different pathways, one interfering and the other non-interfering, among COs in maize. More recently, we found significant differences between male and female meiosis in Arabdopsis thaliana using both, statistical and mechanistic approaches. Significant trends were also observed in interference heterogeneity between distinct regions of the same chromosome. This takes us towards a new class of models that incorporate intra-chromosomal variation of interference strength.

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