Scheduled Seminars on 10/23/2012

Qingliang Li at 11:00  Edit  Reschedule  Delete

Understanding the promiscuous interactions of drugs on molecular level
Many marketed drugs are found to bind multiple targets in vivo, despite that some of them were originally designed as single-target drugs. The promiscuous interactions between a drug and their targets are usually responsible for the drug efficacy, as well as the side effects. To identify potential targets for drugs are important for drug repurposing and drug safety. However, there is still no a systematical way to identify potential targets for a drug in the field. Here, we reported a computational strategy for drug target identification guided by a protein domain network, which was constructed in a chemical-centric way based on the capability of small-molecule binding. The network can not only facilitate drug target identification, but also provide an novel relationship between protein domain with respect to small-molecule binding.

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