CBB Seminars

Computational Biology Branch (CBB) is the research branch of the National Center for Biotechnology Information (NCBI), National Library of Medicine (NLM), National Institutes of Health (NIH).

We hold weekly seminars by CBB members each Tuesday at 11 AM and select Thursdays at 3 PM in the B2 Library, Building 38A. Visitors' presentations usually take place in the same room, but are scheduled on a different day of the week. If scheduling a visitor's presentation, please don't forget to book a seminar room.

To schedule a seminar, please click on the appropriate date in the calendar.

Contact Ivan Ovcharenko with questions or if you need help scheduling a seminar.

Upcoming Seminars

Aleksandra GalitsynaOctober 23, 2018 at 11:00
Affiliation: Skolkovo Institute of Science and Technology, Moscow
Chromatin folding patterns of human and Drosophila
“Chromatin topology affects the functioning and regulation of a eukaryotic cell. Multiple physical models and mechanisms have been proposed to describe the chromatin folding patterns. For a long time validation of these models had been limited by the lack of high-throughput experimental techniques for the detection of nuclear DNA-DNA contacts. Recent advances in single-cell Hi-C (scHi-C) allowed for mapping of chromatin topology in individual cells. ScHi-C in humans demonstrated the presence of compartments and contact domains in accordance with the model of loop extrusion, but with high levels of stochasticity. We aim to compare the chromatin folding principles in a variety of distantly related species. For this, we developed and performed scHi-C in Drosophila melanogaster and detected much lower levels of intercellular stochasticity than had been reported for human. We discovered the presence of stable domains and their boundaries characterized by specific epigenetic pattern. We further applied polymer modelling and domain detection techniques to characterize possible mechanisms of chromatin folding in Drosophila, and demonstrated the presence of compartments in single nuclei and the action of the loop extrusion mechanism during formation of chromatin.“

Jessica SeverinNovember 1, 2018 at 15:00
Alexis AllotNovember 6, 2018 at 11:00