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  Research Group of Ivan Ovcharenko

Ivan Ovcharenko, Ph.D.

Senior Investigator
Computational Biology Branch
Intramural Research Program of the National Library of Medicine (NLM)
National Institutes of Health (NIH)
Building 38A, Room 6S602
8600 Rockville Pike
Bethesda, MD 20894
Email: ovcharen _at_ nih _dot_ gov


Adjunct Professor
Bioinformatics Graduate Program at Boston University

Professional Experience

Sep'14 - present  Senior Investigator, NCBI/NLM, National Institutes of Health (NIH), Bethesda, MD
Jun'07 - Sep'14  Tenure-track Investigator, NCBI/NLM, National Institutes of Health (NIH), Bethesda, MD
Jun'03 - Jun'07Tenure-track Scientist, Lawrence Livermore National Laboratory (LLNL), Livermore, CA
Jan'03 - Jun'07Visiting Scientist, Department of Energy Joint Genome Institute (JGI), Walnut Creek, CA
Jan'01 - Jun'03Staff Scientist, Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA
Oct'99 - Dec'00Postdoctoral Fellow, UC Berkeley, Berkeley, CA

Scientific Community Service

Member of the Editorial Board of Bioinformatics, 2009-present
Associate Editor of BMC Bioinformatics, 2009-present
Ad-hoc Associate Editor of PLoS Genetics and PLoS Computational Biology

Session chair at the Keystone Symposium on Biomolecular Interaction Networks, 2010
Special session organizer at the ISMB/ECCB 2009 Conference; "Regulatory Genome Architecture and Noncoding Mutations in Human Disease"
Committee member of the ISMB/ECCB 2009 program "Sequence Analysis and Alignment"
Committee member of the ISMB 2010, ISMB 2011, ISMB 2012, and ISMB 2013 program "Sequence Analysis" and the ISMB 2012 program "Evolution and Comparative Genomics"
Committee member of the ISMB 2011 and ISMB 2012 Special Interest Group (SIG) review panel
Program committee member of the 2013 ACM Conference on Bioinformatics, Computational Biology and Biomedical Informatics
Technical Program Committee member of the 2012 Brazilian Symposium on Bioinformatics (BSB 2012)
Program Committee member of the ISMB/ECCB 2009 Travel Fellowship

Chair of the NCBI Seminar Series, 2009-present
Co-organizer of the 1st CBB/NCBI Scientific Retreat, 2013. Session chair at the 2nd CBB/ NCBI Scientific Retreat, 2014.

Serving on the NIH Grant Review panel of NHGRI reviewing applications submitted in response to the RFA-HG-11-025 "Computational Analysis of the Encyclopedia of DNA Elements (ENCODE) Data (U01)" (2012), RFA-HG-00-72-34 "The Genomic Resource Grants for Community Resource Projects (U41)" (2012), and RFA-HG-13-012 "Genomics of Gene Regulation (U01)" (2014).
Serving on the NIH Grant Review panel of NINDS reviewing applications submitted in response to the RFA-NS-11-001 call for developing a re-designed and enhanced Parkinson's Disease Data Organizing Center (PD-DOC), 2010
Serving on the grant review panel of Genome Canada for "2010 Large-Scale Applied Research Project Competition", 2011 and Genome Canada Bioinformatics and Computational Biology (2013).
Serving on graduate student thesis committees. Zachary Stine, Johns Hopkins University, 2009-2011. Parsa Hosseini, George Mason University, 2012-2013. Justin Malin, University of Maryland, College Park, 2013-2014.

Member of the NIH-Boston University Graduate Partnership Program search committee, 2010-present
Member of the Earl Stadtman NIH-wide tenure-track Investigator search Systems Biology committee, 2010.
Member of the NIH Tenure-Track committee, 2012-present

Judge for the NIH Fellows Award for Research Excellence (FARE, 2008, 2009, 2010, 2011, 2012, 2013, and 2014) and the NIH National Graduate Student Research Festival (2008)

Reviewer for Genome Research, PLOS Genetics, Nature Genetics, Nature Communications, Human Molecular Genetics, Nucleic Acids Research, Developmental Biology, BMC Bioinformatics, PLOS ONE, Briefings in Bioinformatics, and several other journals.

Ad hoc referee for the National Science Foundation and the Biology and Biological Sciences Research Council, UK

Selected Publications

De novo human brain enhancers created by single-nucleotide mutations.
Li S, Hannenhalli S, Ovcharenko I.
Science Advances, 9(7) 2023 PDF

Enhancer-silencer transitions in the human genome.
Huang D, Ovcharenko I.
Genome Research, 32(3):437-448 (2022) PDF

Comprehensive In Vivo Interrogation Reveals Phenotypic Impact of Human Enhancer Variants.
Kvon EZ, Zhu Y, ... Hudaiberdiev S, Ovcharenko I, ... Pennacchio LA.
Cell, 180(6):1262-1271 (2020) PDF

The first enhancer in an enhancer chain safeguards subsequent enhancer-promoter contacts from a distance.
W. Song, R.Sharan and I. Ovcharenko
Genome Biology, 20(1):197-207 (2019) PDF

Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation.
S. Li, E. Kvon, A. Visel, L. Pennacchio and I. Ovcharenko
Genome Biology, 20(1):140-149 (2019) PDF

Identification of human silencers by correlating cross-tissue epigenetic profiles and gene expression.
D. Huang, H. Petrykowska, B. Miller, L. Elnitski and I. Ovcharenko
Genome Research, 29(4):657-667 (2019) PDF

Integrative analysis of the zinc finger transcription factor Lame duck in the Drosophila myogenic gene regulatory network
Busser BW *, Huang D *, Rogacki KR *, ... Bulyk ML, Ovcharenko I #, Michelson AM #
PNAS, 109(50):20768-73 (2013) (* - co-first, # - co-corresponding authors) PDF

A High-Resolution Enhancer Atlas of the Developing Telencephalon
Visel A, Taher L, ... Ovcharenko I, Pennacchio LA, Rubenstein JL (25 authors)
Cell, (2013) PDF

A machine learning approach for identifying novel cell type-specific transcriptional regulators of myogenesis
B.W. Busser *, L. Taher *, Y. Kim, T. Tansey, M.J. Bloom, I. Ovcharenko #, A.M. Michelson #
PLoS Genetics, 8(3):e1002531 (2012) PDF
(* co-first, # co-corresponding authors)

Genome-wide identification of conserved regulatory function in diverged sequences
L. Taher, D.M. McGaughey, S. Maragh, I. Aneas, S.L. Bessling, W. Miller, M.A. Nobrega, A.S. McCallion, I. Ovcharenko
Genome Research, 21(7), 1139-1149 (2011) PDF

The Genome of the Western Clawed Frog Xenopus tropicalis
U. Hellsten, et al. ... (48 authors)
Science, 328:633-636 (2010) PDF

Genome-wide discovery of human heart enhancers
L. Narlikal, N.J. Sakabe, A.A. Blanski, F.E. Arimura, J.M. Westlund, M.A. Nobrega, I. Ovcharenko
Genome Research, 2010 PDF

Predicting tissue-specific enhancers in the human genome
L.A. Pennacchio, G.G. Loots, M.A. Nobrega, and I. Ovcharenko
Genome Research, 17(2), 201-11 (2007) PDF

Evolution and functional classification of vertebrate gene deserts
I. Ovcharenko, G.G. Loots, M.A. Nobrega, R.C. Hardison, W. Miller, and L. Stubbs
Genome Research, 15, 137-145 (2005) PDF

Scanning Human Gene Deserts for Long-Range Enhancers
M. Nobrega*, I. Ovcharenko*, V. Afzal, E. Rubin
Science 302(5644), 413 (2003) PDF

Search for other articles from the group on PubMed


Current research is funded by the NIH Intramural Research Program.

Previous funding:
DOE/OBER, $305k/18month (FY'04-05)
  Development of computational methods for decoding the transcriptional machinery language of genomes to model novel biological systems. Role: PI.
LLNL LDRD, $750k/3years (FY'04-06)
  De novo identification of regulatory regions in intergenic spaces of prokaryotic genomes. Role: Co-PI.
LLNL LDRD, $1,050k/3years (FY'03-05)
  A coupled computational and experimental approach to determine functions of deeply conserved anonymous human genes. Role: Co-PI.
DOE/OBER, $1,260k/3years (FY'05-07)
  Identification and Validation of Low-Dose Irradiation Responsive Transcription Factor sites. Role: Co-PI.
LLNL LDRD, $250k/year (FY06)
  Development of Computational Techniques For Decoding The Language of Genomes. Role: PI.
NIH R01 (5R01HG003963-02), $450k/year
  Deciphering Principles of Regulatory Genomics; Role: PI

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