Biosynthesis of the modified nucleoside Q in transfer RNA

Y Kuchino; H Kasai; K Nihei; S Nishimura

doi:10.1093/nar/3.2.393

Biosynthesis of the modified nucleoside Q in transfer RNA

Nucleic Acids Res. 1976 Feb;3(2):393-8. doi: 10.1093/nar/3.2.393.

Authors

Y Kuchino, H Kasai, K Nihei, S Nishimura

Abstract

During biosynthesis of the modified nucleoside Q, 7-(4,5-DIHYDROXYL-1-1-CYCLOPENTEN-3-YL-AMINOMETHYL)-7-DEAZAGUANOSINE, IN TRNA, the carbon atom at position 8 in precursor molecule guanine was expelled together with the nitrogen atom N-7 in a fashion similar to that in the biosynthesis of the nucleoside antibiotic toyocamycin.

MeSH terms

Chromatography, Thin Layer
Guanosine / analogs & derivatives*
Guanosine / metabolism
Mutation
RNA, Transfer / metabolism*

Substances

Guanosine
RNA, Transfer