Abstract
Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Active Transport, Cell Nucleus / physiology
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Animals
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Cell Communication
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Cell Nucleus / metabolism*
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Cysteine Endopeptidases / metabolism
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Cytoplasm / physiology
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Endopeptidases / metabolism*
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Evolution, Molecular*
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Humans
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Intracellular Membranes / metabolism*
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Multienzyme Complexes / metabolism
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Proteasome Endopeptidase Complex
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Signal Transduction*
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Transcription Factors / genetics
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Transcription Factors / metabolism*
Substances
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Multienzyme Complexes
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Transcription Factors
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Endopeptidases
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Cysteine Endopeptidases
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Proteasome Endopeptidase Complex