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LOCUS       NP_006588                646 aa            linear   PRI 15-FEB-2009
DEFINITION  heat shock 70kDa protein 8 isoform 1 [Homo sapiens].
ACCESSION   NP_006588
VERSION     NP_006588.1  GI:5729877
DBSOURCE    REFSEQ: accession NM_006597.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 646)
  AUTHORS   Lee,L.C., Chen,C.M., Chen,F.L., Lin,P.Y., Hsiao,Y.C., Wang,P.R.,
            Su,M.T., Hsieh-Li,H.M., Hwang,J.C., Wu,C.H., Lee,G.C., Singh,S.,
            Lin,Y., Hsieh,S.Y., Lee-Chen,G.J. and Lin,J.Y.
  TITLE     Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar
            ataxia type 17 identified by 2-dimensional fluorescence difference
            in gel electrophoresis
  JOURNAL   Clin. Chim. Acta 400 (1-2), 56-62 (2009)
   PUBMED   19014922
  REMARK    GeneRIF: altered expression of proteins that underlie pathogenesis
            of SCA17
REFERENCE   2  (residues 1 to 646)
  AUTHORS   Martins-de-Souza,D., Gattaz,W.F., Schmitt,A., Maccarrone,G.,
            Hunyadi-Gulyas,E., Eberlin,M.N., Souza,G.H., Marangoni,S.,
            Novello,J.C., Turck,C.W. and Dias-Neto,E.
  TITLE     Proteomic analysis of dorsolateral prefrontal cortex indicates the
            involvement of cytoskeleton, oligodendrocyte, energy metabolism and
            new potential markers in schizophrenia
  JOURNAL   J Psychiatr Res (2008) In press
   PUBMED   19110265
  REMARK    GeneRIF: This protein has been found differentially expressed in
            the dorsolateral prefrontal cortex from patients with
            schizophrenia.
            Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 646)
  AUTHORS   Yoshida,T., Kato,K., Fujimaki,T., Yokoi,K., Oguri,M., Watanabe,S.,
            Metoki,N., Yoshida,H., Satoh,K., Aoyagi,Y., Nishigaki,Y.,
            Tanaka,M., Nozawa,Y. and Yamada,Y.
  TITLE     Association of a polymorphism of the apolipoprotein E gene with
            chronic kidney disease in Japanese individuals with metabolic
            syndrome
  JOURNAL   Genomics (2008) In press
   PUBMED   19056482
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Available-Online prior to print
REFERENCE   4  (residues 1 to 646)
  AUTHORS   Starr,J.M., Shiels,P.G., Harris,S.E., Pattie,A., Pearce,M.S.,
            Relton,C.L. and Deary,I.J.
  TITLE     Oxidative stress, telomere length and biomarkers of physical aging
            in a cohort aged 79 years from the 1932 Scottish Mental Survey
  JOURNAL   Mech. Ageing Dev. 129 (12), 745-751 (2008)
   PUBMED   18977241
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (residues 1 to 646)
  AUTHORS   Powers,M.V., Clarke,P.A. and Workman,P.
  TITLE     Dual targeting of HSC70 and HSP72 inhibits HSP90 function and
            induces tumor-specific apoptosis
  JOURNAL   Cancer Cell 14 (3), 250-262 (2008)
   PUBMED   18772114
  REMARK    GeneRIF: Simultaneously reducing the expression of both HSC70 and
            HSP72 induces proteasome-dependent degradation of HSP90 client
            proteins, G1 cell-cycle arrest, and extensive tumor-specific
            apoptosis in human tumor cell lines.
REFERENCE   6  (sites)
  AUTHORS   Matsuoka,S., Ballif,B.A., Smogorzewska,A., McDonald,E.R. III,
            Hurov,K.E., Luo,J., Bakalarski,C.E., Zhao,Z., Solimini,N.,
            Lerenthal,Y., Shiloh,Y., Gygi,S.P. and Elledge,S.J.
  TITLE     ATM and ATR substrate analysis reveals extensive protein networks
            responsive to DNA damage
  JOURNAL   Science 316 (5828), 1160-1166 (2007)
   PUBMED   17525332
REFERENCE   7  (sites)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (residues 1 to 646)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   9  (residues 1 to 646)
  AUTHORS   Hattori,H., Liu,Y.C., Tohnai,I., Ueda,M., Kaneda,T., Kobayashi,T.,
            Tanabe,K. and Ohtsuka,K.
  TITLE     Intracellular localization and partial amino acid sequence of a
            stress-inducible 40-kDa protein in HeLa cells
  JOURNAL   Cell Struct. Funct. 17 (1), 77-86 (1992)
   PUBMED   1586970
REFERENCE   10 (residues 1 to 646)
  AUTHORS   DeLuca-Flaherty,C., McKay,D.B., Parham,P. and Hill,B.L.
  TITLE     Uncoating protein (hsc70) binds a conformationally labile domain of
            clathrin light chain LCa to stimulate ATP hydrolysis
  JOURNAL   Cell 62 (5), 875-887 (1990)
   PUBMED   1975516
REFERENCE   11 (residues 1 to 646)
  AUTHORS   Lim,M.Y., Davis,N., Zhang,J.Y. and Bose,H.R. Jr.
  TITLE     The v-rel oncogene product is complexed with cellular proteins
            including its proto-oncogene product and heat shock protein 70
  JOURNAL   Virology 175 (1), 149-160 (1990)
   PUBMED   2155506
REFERENCE   12 (residues 1 to 646)
  AUTHORS   Welch,W.J. and Mizzen,L.A.
  TITLE     Characterization of the thermotolerant cell. II. Effects on the
            intracellular distribution of heat-shock protein 70, intermediate
            filaments, and small nuclear ribonucleoprotein complexes
  JOURNAL   J. Cell Biol. 106 (4), 1117-1130 (1988)
   PUBMED   2966179
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC019816.2 and AK096100.1.
            
            Summary: The product encoded by this gene belongs to the heat shock
            protein 70 family which contains both heat-inducible and
            constitutively expressed members. The latter are called heat-shock
            cognate proteins. This gene encodes a heat-shock cognate protein.
            This protein binds to nascent polypeptides to facilitate correct
            folding. It also functions as an ATPase in the disassembly of
            clathrin-coated vesicles during transport of membrane components
            through the cell. Two alternatively spliced variants have been
            characterized to date. [provided by RefSeq].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..646
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.1"
     Protein         1..646
                     /product="heat shock 70kDa protein 8 isoform 1"
                     /note="heat shock cognate protein, 71-kDa; heat shock 70kD
                     protein 8; heat shock 70kd protein 10; heat shock cognate
                     protein 54; constitutive heat shock protein 70;
                     lipopolysaccharide-associated protein 1; LPS-associated
                     protein 1; N-myristoyltransferase inhibitor protein 71"
                     /calculated_mol_wt=70767
     Region          1..613
                     /region_name="PTZ00009"
                     /note="heat shock 70 kDa protein; Provisional"
                     /db_xref="CDD:240227"
     Region          6..381
                     /region_name="HSPA1-2_6-8-like_NBD"
                     /note="Nucleotide-binding domain of HSPA1-A, -B, -L,
                     HSPA-2, -6, -7, -8, and similar proteins; cd10233"
                     /db_xref="CDD:212675"
     Site            order(10,12..15,71,147,175,199..204,206,230..231,268,
                     271..272,275,338..340,342..343,366)
                     /site_type="other"
                     /note="nucleotide binding site [chemical binding]"
                     /db_xref="CDD:212675"
     Site            order(23,25,27,32..34,36,50,54,57,133..134,258,262,269,
                     272..273,276,281,283,285..286,290,342)
                     /site_type="other"
                     /note="NEF/HSP70 interaction site [polypeptide binding]"
                     /db_xref="CDD:212675"
     Site            order(33,35,57,60..61,257..258,261..262,265..266,269,
                     283..286,292,294)
                     /site_type="other"
                     /note="BAG/HSP70 interaction site [polypeptide binding]"
                     /db_xref="CDD:212675"
     Site            order(152,192,213,215..217,219..220,325)
                     /site_type="other"
                     /note="SBD interface [polypeptide binding]"
                     /db_xref="CDD:212675"
     Site            153
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /citation=[6]
     Site            477
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /citation=[7]
     CDS             1..646
                     /gene="HSPA8"
                     /gene_synonym="HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10;
                     LAP1; MGC131511; MGC29929; NIP71"
                     /coded_by="NM_006597.3:79..2019"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS8440.1"
                     /db_xref="GeneID:3312"
                     /db_xref="HGNC:HGNC:5241"
                     /db_xref="HPRD:07205"
                     /db_xref="MIM:600816"
ORIGIN      
        1 mskgpavgid lgttyscvgv fqhgkveiia ndqgnrttps yvaftdterl igdaaknqva
       61 mnptntvfda krligrrfdd avvqsdmkhw pfmvvndagr pkvqveykge tksfypeevs
      121 smvltkmkei aeaylgktvt navvtvpayf ndsqrqatkd agtiaglnvl riineptaaa
      181 iaygldkkvg aernvlifdl gggtfdvsil tiedgifevk stagdthlgg edfdnrmvnh
      241 fiaefkrkhk kdisenkrav rrlrtacera krtlssstqa sieidslyeg idfytsitra
      301 rfeelnadlf rgtldpveka lrdakldksq ihdivlvggs tripkiqkll qdffngkeln
      361 ksinpdeava ygaavqaail sgdksenvqd lllldvtpls lgietaggvm tvlikrntti
      421 ptkqtqtftt ysdnqpgvli qvyegeramt kdnnllgkfe ltgippaprg vpqievtfdi
      481 dangilnvsa vdkstgkenk ititndkgrl skediermvq eaekykaede kqrdkvsskn
      541 slesyafnmk atvedeklqg kindedkqki ldkcneiinw ldknqtaeke efehqqkele
      601 kvcnpiitkl yqsaggmpgg mpggfpggga ppsggassgp tieevd
//