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LOCUS       NP_006588                646 aa            linear   PRI 23-NOV-2008
DEFINITION  heat shock 70kDa protein 8 isoform 1 [Homo sapiens].
VERSION     NP_006588.1  GI:5729877
DBSOURCE    REFSEQ: accession NM_006597.3
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 646)
  AUTHORS   Luciano,M., Lind,P.A., Deary,I.J., Payton,A., Posthuma,D.,
            Butcher,L.M., Bochdanovits,Z., Whalley,L.J., Visscher,P.M.,
            Harris,S.E., Polderman,T.J., Davis,O.S., Wright,M.J., Starr,J.M.,
            de Geus,E.J., Bates,T.C., Montgomery,G.W., Boomsma,D.I.,
            Martin,N.G. and Plomin,R.
  TITLE     Testing replication of a 5-SNP set for general cognitive ability in
            six population samples
  JOURNAL   Eur. J. Hum. Genet. 16 (11), 1388-1395 (2008)
   PUBMED   18493267
  REMARK    GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   2  (residues 1 to 646)
  AUTHORS   Starr,J.M., Shiels,P.G., Harris,S.E., Pattie,A., Pearce,M.S.,
            Relton,C.L. and Deary,I.J.
  TITLE     Oxidative stress, telomere length and biomarkers of physical aging
            in a cohort aged 79 years from the 1932 Scottish Mental Survey
  JOURNAL   Mech. Ageing Dev. (2008) In press
   PUBMED   18977241
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 646)
  AUTHORS   Kato,K., Oguri,M., Kato,N., Hibino,T., Yajima,K., Yoshida,T.,
            Metoki,N., Yoshida,H., Satoh,K., Watanabe,S., Yokoi,K., Murohara,T.
            and Yamada,Y.
  TITLE     Assessment of genetic risk factors for thoracic aortic aneurysm in
            hypertensive patients
  JOURNAL   Am. J. Hypertens. 21 (9), 1023-1027 (2008)
   PUBMED   18600213
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
REFERENCE   4  (residues 1 to 646)
  AUTHORS   Hirasaka,K., Tokuoka,K., Nakao,R., Yamada,C., Oarada,M.,
            Imagawa,T., Ishidoh,K., Okumura,Y., Kishi,K. and Nikawa,T.
  TITLE     Cathepsin C propeptide interacts with intestinal alkaline
            phosphatase and heat shock cognate protein 70 in human Caco-2 cells
  JOURNAL   J Physiol Sci 58 (2), 105-111 (2008)
   PUBMED   18307834
  REMARK    GeneRIF: Cathepsin C propeptide interacts with intestinal alkaline
            phosphatase (IAP) and heat shock cognate protein 70. The propeptide
            of cathepsin C may stimulate the sorting to the lysosome
            contributing to the degradation of IAP in Caco-2 cells.
REFERENCE   5  (residues 1 to 646)
  AUTHORS   Kamiguchi,K., Torigoe,T., Fujiwara,O., Ohshima,S., Hirohashi,Y.,
            Sahara,H., Hirai,I., Kohgo,Y. and Sato,N.
  TITLE     Disruption of the association of 73 kDa heat shock cognate protein
            with transporters associated with antigen processing (TAP)
            decreases TAP-dependent translocation of antigenic peptides into
            the endoplasmic reticulum
  JOURNAL   Microbiol. Immunol. 52 (2), 94-106 (2008)
   PUBMED   18380807
  REMARK    GeneRIF: It was indicated that disruption of the HSC73-TAP
            association resulted in inhibition of TAP-dependent translocation
            of HSC73-bound peptides.
REFERENCE   6  (sites)
  AUTHORS   Matsuoka,S., Ballif,B.A., Smogorzewska,A., McDonald,E.R. III,
            Hurov,K.E., Luo,J., Bakalarski,C.E., Zhao,Z., Solimini,N.,
            Lerenthal,Y., Shiloh,Y., Gygi,S.P. and Elledge,S.J.
  TITLE     ATM and ATR substrate analysis reveals extensive protein networks
            responsive to DNA damage
  JOURNAL   Science 316 (5828), 1160-1166 (2007)
   PUBMED   17525332
REFERENCE   7  (sites)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (residues 1 to 646)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   9  (residues 1 to 646)
  AUTHORS   Hattori,H., Liu,Y.C., Tohnai,I., Ueda,M., Kaneda,T., Kobayashi,T.,
            Tanabe,K. and Ohtsuka,K.
  TITLE     Intracellular localization and partial amino acid sequence of a
            stress-inducible 40-kDa protein in HeLa cells
  JOURNAL   Cell Struct. Funct. 17 (1), 77-86 (1992)
   PUBMED   1586970
REFERENCE   10 (residues 1 to 646)
  AUTHORS   DeLuca-Flaherty,C., McKay,D.B., Parham,P. and Hill,B.L.
  TITLE     Uncoating protein (hsc70) binds a conformationally labile domain of
            clathrin light chain LCa to stimulate ATP hydrolysis
  JOURNAL   Cell 62 (5), 875-887 (1990)
   PUBMED   1975516
REFERENCE   11 (residues 1 to 646)
  AUTHORS   Lim,M.Y., Davis,N., Zhang,J.Y. and Bose,H.R. Jr.
  TITLE     The v-rel oncogene product is complexed with cellular proteins
            including its proto-oncogene product and heat shock protein 70
  JOURNAL   Virology 175 (1), 149-160 (1990)
   PUBMED   2155506
REFERENCE   12 (residues 1 to 646)
  AUTHORS   Welch,W.J. and Mizzen,L.A.
  TITLE     Characterization of the thermotolerant cell. II. Effects on the
            intracellular distribution of heat-shock protein 70, intermediate
            filaments, and small nuclear ribonucleoprotein complexes
  JOURNAL   J. Cell Biol. 106 (4), 1117-1130 (1988)
   PUBMED   2966179
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC019816.2 and AK096100.1.
            Summary: The product encoded by this gene belongs to the heat shock
            protein 70 family which contains both heat-inducible and
            constitutively expressed members. The latter are called heat-shock
            cognate proteins. This gene encodes a heat-shock cognate protein.
            This protein binds to nascent polypeptides to facilitate correct
            folding. It also functions as an ATPase in the disassembly of
            clathrin-coated vesicles during transport of membrane components
            through the cell. Two alternatively spliced variants have been
            characterized to date. [provided by RefSeq].
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform.
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the
            Entrez Gene record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..646
                     /organism="Homo sapiens"
     Protein         1..646
                     /product="heat shock 70kDa protein 8 isoform 1"
                     /note="heat shock cognate protein, 71-kDa; heat shock 70kD
                     protein 8; heat shock 70kd protein 10; heat shock cognate
                     protein 54; constitutive heat shock protein 70;
                     lipopolysaccharide-associated protein 1; LPS-associated
                     protein 1; N-myristoyltransferase inhibitor protein 71"
     Region          1..613
                     /note="heat shock 70 kDa protein; Provisional"
     Region          6..381
                     /note="Nucleotide-binding domain of HSPA1-A, -B, -L,
                     HSPA-2, -6, -7, -8, and similar proteins; cd10233"
     Site            order(10,12..15,71,147,175,199..204,206,230..231,268,
                     /note="nucleotide binding site [chemical binding]"
     Site            order(23,25,27,32..34,36,50,54,57,133..134,258,262,269,
                     /note="NEF/HSP70 interaction site [polypeptide binding]"
     Site            order(33,35,57,60..61,257..258,261..262,265..266,269,
                     /note="BAG/HSP70 interaction site [polypeptide binding]"
     Site            order(152,192,213,215..217,219..220,325)
                     /note="SBD interface [polypeptide binding]"
     Site            153
                     /experiment="experimental evidence, no additional details
     Site            477
                     /experiment="experimental evidence, no additional details
     CDS             1..646
                     /gene_synonym="HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10;
                     LAP1; MGC131511; MGC29929; NIP71"
                     /note="isoform 1 is encoded by transcript variant 1"
        1 mskgpavgid lgttyscvgv fqhgkveiia ndqgnrttps yvaftdterl igdaaknqva
       61 mnptntvfda krligrrfdd avvqsdmkhw pfmvvndagr pkvqveykge tksfypeevs
      121 smvltkmkei aeaylgktvt navvtvpayf ndsqrqatkd agtiaglnvl riineptaaa
      181 iaygldkkvg aernvlifdl gggtfdvsil tiedgifevk stagdthlgg edfdnrmvnh
      241 fiaefkrkhk kdisenkrav rrlrtacera krtlssstqa sieidslyeg idfytsitra
      301 rfeelnadlf rgtldpveka lrdakldksq ihdivlvggs tripkiqkll qdffngkeln
      361 ksinpdeava ygaavqaail sgdksenvqd lllldvtpls lgietaggvm tvlikrntti
      421 ptkqtqtftt ysdnqpgvli qvyegeramt kdnnllgkfe ltgippaprg vpqievtfdi
      481 dangilnvsa vdkstgkenk ititndkgrl skediermvq eaekykaede kqrdkvsskn
      541 slesyafnmk atvedeklqg kindedkqki ldkcneiinw ldknqtaeke efehqqkele
      601 kvcnpiitkl yqsaggmpgg mpggfpggga ppsggassgp tieevd