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SRX077857: GSM742081: RRB-Seq of Apis Mellifera sperm
1 ILLUMINA (Illumina Genome Analyzer IIx) run: 5.1M spots, 455.4M bases, 314.5Mb downloads

Accession: SRX077857
Experiment design: n/a
Submitted by: GEO
Study summary: SRP007214 • Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates • PRJNA140771 • All experiments  • Run Selector (more...)(less...)
Abstract: Here, we demonstrate that Nematostella vectensis, Ciona intestinalis, Apis mellifera, and B. mori, show two distinct populations of genes differentiated by gene-body CpG density. Genome-scale DNA methylation profiles for A. mellifera spermatozoa reveal CpG-poor genes are methylated in the germ line, as predicted by the depletion of CpGs. We find an evolutionarily conserved distinction between CpG-poor and -rich genes: the former are associated with basic biological processes, the latter with more specialized functions. This distinction is strikingly similar to that recently observed between euchromatin-associated genes in Drosophila that contain intragenic histone 3 lysine 36 trimethylation (H3K36me3) and those that do not, even though Drosophila doesnâ??t display CpG density bimodality or methylation. We confirm that a significant number of CpG-poor genes in N. vectensis, C. intestinalis, A. mellifera and B. mori are orthologs of H3K36me3- rich genes in Drosophila. We propose that over evolutionary time, gene-body H3K36me3 has influenced gene-body DNA methylation levels, and consequently the gene-body CpG density bimodality characteristic of invertebrates that harbor CpG methylation. Overall design: Examination of DNA methylation in Apis Mellifera sperm
Center Project: Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates
Sample: SAMN00627828 • RRB-Seq of Apis Mellifera sperm (more...)(less...)
Organism: Apis mellifera
freshly isolated sperm
External link:
Library: GSM742081: RRB-Seq of Apis Mellifera sperm  (more...)(less...)
Strategy: OTHER
Selection: other
Layout: PAIRED, Nominal length: 76
Platform: Illumina  (more...)(less...)
Instrument model: Illumina Genome Analyzer IIx
Spot descriptor:
forward46  reverse

Experiment attributes:
GEO Accession: GSM742081
Total: 1 run, 5.1M spots, 455.4M bases, 314.5Mb 
#Run# of Spots# of BasesSizePublished
1. SRR2850205,059,455455.4M314.5Mb2011-06-29


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