Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Ingalls RR, Golenbock DT. CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide. J Exp Med. 1995 Apr 1;181(4):1473-9. doi: 10.1084/jem.181.4.1473. PubMed PMID: 7535339; PubMed Central PMCID: PMC2191975.
Ingalls RR, Rice PA, Qureshi N, Takayama K, Lin JS, Golenbock DT. The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated. Infect Immun. 1995 Aug;63(8):3125-30. doi: 10.1128/iai.63.8.3125-3130.1995. PubMed PMID: 7542638; PubMed Central PMCID: PMC173426.
Savedra R Jr, Delude RL, Ingalls RR, Fenton MJ, Golenbock DT. Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system. J Immunol. 1996 Sep 15;157(6):2549-54. PubMed PMID: 8805656.
Levitz SM, Tabuni A, Kozel TR, MacGill RS, Ingalls RR, Golenbock DT. Binding of Cryptococcus neoformans to heterologously expressed human complement receptors. Infect Immun. 1997 Mar;65(3):931-5. doi: 10.1128/IAI.65.3.931-935.1997. PubMed PMID: 9038299; PubMed Central PMCID: PMC175071.
Ingalls RR, Arnaout MA, Golenbock DT. Outside-in signaling by lipopolysaccharide through a tailless integrin. J Immunol. 1997 Jul 1;159(1):433-8. PubMed PMID: 9200483.
Flaherty SF, Golenbock DT, Milham FH, Ingalls RR. CD11/CD18 leukocyte integrins: new signaling receptors for bacterial endotoxin. J Surg Res. 1997 Nov;73(1):85-9. doi: 10.1006/jsre.1997.5195. PubMed PMID: 9441798.
Wurfel MM, Monks BG, Ingalls RR, Dedrick RL, Delude R, Zhou D, Lamping N, Schumann RR, Thieringer R, Fenton MJ, Wright SD, Golenbock D. Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact. J Exp Med. 1997 Dec 15;186(12):2051-6. doi: 10.1084/jem.186.12.2051. PubMed PMID: 9396775; PubMed Central PMCID: PMC2199164.
Ingalls RR, Arnaout MA, Delude RL, Flaherty S, Savedra R Jr, Golenbock DT. The CD11/CD18 integrins: characterization of three novel LPS signaling receptors. Prog Clin Biol Res. 1998;397:107-17. PubMed PMID: 9575552.
Medvedev AE, Flo T, Ingalls RR, Golenbock DT, Teti G, Vogel SN, Espevik T. Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls. J Immunol. 1998 May 1;160(9):4535-42. PubMed PMID: 9574560.
Delude RL, Yoshimura A, Ingalls RR, Golenbock DT. Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-alpha, signal transduction. J Immunol. 1998 Sep 15;161(6):3001-9. PubMed PMID: 9743364.
Ingalls RR, Monks BG, Savedra R Jr, Christ WJ, Delude RL, Medvedev AE, Espevik T, Golenbock DT. CD11/CD18 and CD14 share a common lipid A signaling pathway. J Immunol. 1998 Nov 15;161(10):5413-20. PubMed PMID: 9820516.
Ingalls RR, Monks BG, Golenbock DT. Membrane expression of soluble endotoxin-binding proteins permits lipopolysaccharide signaling in Chinese hamster ovary fibroblasts independently of CD14. J Biol Chem. 1999 May 14;274(20):13993-8. doi: 10.1074/jbc.274.20.13993. PubMed PMID: 10318811.
Ingalls RR, Heine H, Lien E, Yoshimura A, Golenbock D. Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors. Infect Dis Clin North Am. 1999 Jun;13(2):341-53, vii. doi: 10.1016/s0891-5520(05)70078-7. Review. PubMed PMID: 10340170.
Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol. 1999 Jul 1;163(1):1-5. PubMed PMID: 10384090.
Ingalls RR, Monks BG, Golenbock DT. Surface presentation of LPS is sufficient for initiation of signaling events. Journal of endotoxin research. 1999 August; 5(4):2244-248.
Lien E, Sellati TJ, Yoshimura A, Flo TH, Rawadi G, Finberg RW, Carroll JD, Espevik T, Ingalls RR, Radolf JD, Golenbock DT. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem. 1999 Nov 19;274(47):33419-25. doi: 10.1074/jbc.274.47.33419. PubMed PMID: 10559223.
Lien E, Means TK, Heine H, Yoshimura A, Kusumoto S, Fukase K, Fenton MJ, Oikawa M, Qureshi N, Monks B, Finberg RW, Ingalls RR, Golenbock DT. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J Clin Invest. 2000 Feb;105(4):497-504. doi: 10.1172/JCI8541. PubMed PMID: 10683379; PubMed Central PMCID: PMC289161.
Moore KJ, Andersson LP, Ingalls RR, Monks BG, Li R, Arnaout MA, Golenbock DT, Freeman MW. Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol. 2000 Oct 15;165(8):4272-80. doi: 10.4049/jimmunol.165.8.4272. PubMed PMID: 11035061.
Flo TH, Ryan L, Kilaas L, Skjâk-Braek G, Ingalls RR, Sundan A, Golenbock DT, Espevik T. Involvement of CD14 and beta2-integrins in activating cells with soluble and particulate lipopolysaccharides and mannuronic acid polymers. Infect Immun. 2000 Dec;68(12):6770-6. doi: 10.1128/IAI.68.12.6770-6776.2000. PubMed PMID: 11083794; PubMed Central PMCID: PMC97779.
Ingalls RR, Lien E, Golenbock DT. Membrane-associated proteins of a lipopolysaccharide-deficient mutant of Neisseria meningitidis activate the inflammatory response through toll-like receptor 2. Infect Immun. 2001 Apr;69(4):2230-6. doi: 10.1128/IAI.69.4.2230-2236.2001. PubMed PMID: 11254578; PubMed Central PMCID: PMC98150.
Medvedev AE, Henneke P, Schromm A, Lien E, Ingalls R, Fenton MJ, Golenbock DT, Vogel SN. Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4. J Immunol. 2001 Aug 15;167(4):2257-67. doi: 10.4049/jimmunol.167.4.2257. PubMed PMID: 11490013.
Lien E, Ingalls RR. Toll-like receptors. Crit Care Med. 2002 Jan;30(1 Suppl):S1-11. Review. PubMed PMID: 11782555.
Lien E, Ingalls RR. Toll-like receptors. Crit Care Med. 2002 Jan;30(1 Supp):S1-S11. PubMed PMID: 11839939.
Fichorova RN, Cronin AO, Lien E, Anderson DJ, Ingalls RR. Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling. J Immunol. 2002 Mar 1;168(5):2424-32. doi: 10.4049/jimmunol.168.5.2424. PubMed PMID: 11859134.
Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT. Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol. 2002 Oct 1;169(7):3970-7. doi: 10.4049/jimmunol.169.7.3970. PubMed PMID: 12244198.
Fisette PL, Ram S, Andersen JM, Guo W, Ingalls RR. The Lip lipoprotein from Neisseria gonorrhoeae stimulates cytokine release and NF-kappaB activation in epithelial cells in a Toll-like receptor 2-dependent manner. J Biol Chem. 2003 Nov 21;278(47):46252-60. doi: 10.1074/jbc.M306587200. Epub 2003 Sep 9. PubMed PMID: 12966099.
O'Connell CM, Ionova IA, Quayle AJ, Visintin A, Ingalls RR. Localization of TLR2 and MyD88 to Chlamydia trachomatis inclusions. Evidence for signaling by intracellular TLR2 during infection with an obligate intracellular pathogen. J Biol Chem. 2006 Jan 20;281(3):1652-9. doi: 10.1074/jbc.M510182200. Epub 2005 Nov 17. PubMed PMID: 16293622.
Andersen JM, Al-Khairy D, Ingalls RR. Innate immunity at the mucosal surface: role of toll-like receptor 3 and toll-like receptor 9 in cervical epithelial cell responses to microbial pathogens. Biol Reprod. 2006 May;74(5):824-31. doi: 10.1095/biolreprod.105.048629. Epub 2006 Jan 18. PubMed PMID: 16421230.
O'Connell CM, Ingalls RR, Andrews CW Jr, Scurlock AM, Darville T. Plasmid-deficient Chlamydia muridarum fail to induce immune pathology and protect against oviduct disease. J Immunol. 2007 Sep 15;179(6):4027-34. doi: 10.4049/jimmunol.179.6.4027. PubMed PMID: 17785841.
Packiam M, Veit SJ, Anderson DJ, Ingalls RR, Jerse AE. Mouse strain-dependent differences in susceptibility to Neisseria gonorrhoeae infection and induction of innate immune responses. Infect Immun. 2010 Jan;78(1):433-40. doi: 10.1128/IAI.00711-09. Epub 2009 Nov 9. PubMed PMID: 19901062; PubMed Central PMCID: PMC2798183.
Han ES, Mekasha S, Ingalls RR. Fibroblast growth factor-inducible 14 (Fn14) is expressed in the lower genital tract and may play a role in amplifying inflammation during infection. J Reprod Immunol. 2010 Jan;84(1):16-23. doi: 10.1016/j.jri.2009.09.009. Epub 2009 Dec 5. PubMed PMID: 19963275; PubMed Central PMCID: PMC2814934.
He X, Mekasha S, Mavrogiorgos N, Fitzgerald KA, Lien E, Ingalls RR. Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome. J Immunol. 2010 May 15;184(10):5743-54. doi: 10.4049/jimmunol.0903937. Epub 2010 Apr 14. PubMed PMID: 20393140; PubMed Central PMCID: PMC3156096.
He X, Nair A, Mekasha S, Alroy J, O'Connell CM, Ingalls RR. Enhanced virulence of Chlamydia muridarum respiratory infections in the absence of TLR2 activation. PLoS One. 2011;6(6):e20846. doi: 10.1371/journal.pone.0020846. Epub 2011 Jun 14. PubMed PMID: 21695078; PubMed Central PMCID: PMC3114860.
Packiam M, Wu H, Veit SJ, Mavrogiorgos N, Jerse AE, Ingalls RR. Protective role of Toll-like receptor 4 in experimental gonococcal infection of female mice. Mucosal Immunol. 2012 Jan;5(1):19-29. doi: 10.1038/mi.2011.38. Epub 2011 Sep 21. PubMed PMID: 21937985; PubMed Central PMCID: PMC3240729.
Frazer LC, Darville T, Chandra-Kuntal K, Andrews CW Jr, Zurenski M, Mintus M, AbdelRahman YM, Belland RJ, Ingalls RR, O'Connell CM. Plasmid-cured Chlamydia caviae activates TLR2-dependent signaling and retains virulence in the guinea pig model of genital tract infection. PLoS One. 2012;7(1):e30747. doi: 10.1371/journal.pone.0030747. Epub 2012 Jan 24. PubMed PMID: 22292031; PubMed Central PMCID: PMC3265510.
Hawley KL, Olson CM Jr, Iglesias-Pedraz JM, Navasa N, Cervantes JL, Caimano MJ, Izadi H, Ingalls RR, Pal U, Salazar JC, Radolf JD, Anguita J. CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1228-32. doi: 10.1073/pnas.1112078109. Epub 2012 Jan 9. PubMed PMID: 22232682; PubMed Central PMCID: PMC3268315.
He X, Berland R, Mekasha S, Christensen TG, Alroy J, Kramnik I, Ingalls RR. The sst1 resistance locus regulates evasion of type I interferon signaling by Chlamydia pneumoniae as a disease tolerance mechanism. PLoS Pathog. 2013;9(8):e1003569. doi: 10.1371/journal.ppat.1003569. Epub 2013 Aug 29. PubMed PMID: 24009502; PubMed Central PMCID: PMC3757055.
Roseman DA, Kabbani D, Kwah J, Bird D, Ingalls R, Gautam A, Nuhn M, Francis JM. Strongyloides stercoralis transmission by kidney transplantation in two recipients from a common donor. Am J Transplant. 2013 Sep;13(9):2483-6. doi: 10.1111/ajt.12390. Epub 2013 Aug 6. PubMed PMID: 23919410; PubMed Central PMCID: PMC3785548.
Mavrogiorgos N, Mekasha S, Yang Y, Kelliher MA, Ingalls RR. Activation of NOD receptors by Neisseria gonorrhoeae modulates the innate immune response. Innate Immun. 2014 May;20(4):377-89. doi: 10.1177/1753425913493453. Epub 2013 Jul 24. PubMed PMID: 23884094; PubMed Central PMCID: PMC3880408.
Kramer CD, Weinberg EO, Gower AC, He X, Mekasha S, Slocum C, Beaulieu LM, Wetzler L, Alekseyev Y, Gibson FC 3rd, Freedman JE, Ingalls RR, Genco CA. Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet. BMC Genomics. 2014 Dec 24;15(1):1176. doi: 10.1186/1471-2164-15-1176. PubMed PMID: 25540039; PubMed Central PMCID: PMC4367889.
Beaulieu LM, Clancy L, Tanriverdi K, Benjamin EJ, Kramer CD, Weinberg EO, He X, Mekasha S, Mick E, Ingalls RR, Genco CA, Freedman JE. Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans. PLoS One. 2015;10(7):e0131688. doi: 10.1371/journal.pone.0131688. eCollection 2015. PubMed PMID: 26148065; PubMed Central PMCID: PMC4493099.
He X, Liang Y, LaValley MP, Lai J, Ingalls RR. Comparative analysis of the growth and biological activity of a respiratory and atheroma isolate of Chlamydia pneumoniae reveals strain-dependent differences in inflammatory activity and innate immune evasion. BMC Microbiol. 2015 Oct 23;15:228. doi: 10.1186/s12866-015-0569-3. PubMed PMID: 26494400; PubMed Central PMCID: PMC4619265.
Shaik-Dasthagirisaheb YB, Mekasha S, He X, Gibson FC 3rd, Ingalls RR. Signaling events in pathogen-induced macrophage foam cell formation. Pathog Dis. 2016 Aug;74(6). doi: 10.1093/femspd/ftw074. Epub 2016 Jul 31. PubMed PMID: 27481727; PubMed Central PMCID: PMC5985511.
Pudney J, He X, Masheeb Z, Kindelberger DW, Kuohung W, Ingalls RR. Differential expression of toll-like receptors in the human placenta across early gestation. Placenta. 2016 Oct;46:1-10. doi: 10.1016/j.placenta.2016.07.005. Epub 2016 Jul 26. PubMed PMID: 27697215; PubMed Central PMCID: PMC5119647.
Aqeel Y, Rodriguez R, Chatterjee A, Ingalls RR, Samuelson J. Killing of diverse eye pathogens (Acanthamoeba spp., Fusarium solani, and Chlamydia trachomatis) with alcohols. PLoS Negl Trop Dis. 2017 Feb;11(2):e0005382. doi: 10.1371/journal.pntd.0005382. eCollection 2017 Feb. PubMed PMID: 28182670; PubMed Central PMCID: PMC5321442.
Kramer CD, Simas AM, He X, Ingalls RR, Weinberg EO, Genco CA. Distinct roles for dietary lipids and Porphyromonas gingivalis infection on atherosclerosis progression and the gut microbiota. Anaerobe. 2017 Jun;45:19-30. doi: 10.1016/j.anaerobe.2017.04.011. Epub 2017 Apr 23. PubMed PMID: 28442421; PubMed Central PMCID: PMC5521207.
Ray TD, Mekasha S, Liang Y, Lu B, Ram S, Ingalls RR. Species-specific differences in regulation of macrophage inflammation by the C3a-C3a receptor axis. Innate Immun. 2018 Jan;24(1):66-78. doi: 10.1177/1753425917747044. Epub 2018 Jan 3. PubMed PMID: 29297237; PubMed Central PMCID: PMC6818254.
Mostaghim A, Dhanani M, Ingalls RR. Fournier's gangrene as an initial manifestation of acute promyelocytic leukemia: A case report and review of the literature. SAGE Open Med Case Rep. 2019;7:2050313X19834425. doi: 10.1177/2050313X19834425. eCollection 2019. PubMed PMID: 30854206; PubMed Central PMCID: PMC6399751.
What would you like to do?