My Bibliography

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Bedenbaugh MN, Brener SC, Maldonado J, Lippert RN, Sweeney P, Cone RD, Simerly RB. Organization of neural systems expressing melanocortin-3 receptors in the mouse brain: Evidence for sexual dimorphism. J Comp Neurol. 2022 Nov;530(16):2835-2851. doi: 10.1002/cne.25379. Epub 2022 Jun 30. PubMed PMID: 35770983; PubMed Central PMCID: PMC9724692.

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Simerly R, DiLeone R. Cerebellar neurons that curb food consumption. Nature. 2021 Dec;600(7888):229-230. doi: 10.1038/d41586-021-03383-9. PubMed PMID: 34789886.

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Lam BYH, Williamson A, Finer S, Day FR, Tadross JA, Gonçalves Soares A, Wade K, Sweeney P, Bedenbaugh MN, Porter DT, Melvin A, Ellacott KLJ, Lippert RN, Buller S, Rosmaninho-Salgado J, Dowsett GKC, Ridley KE, Xu Z, Cimino I, Rimmington D, Rainbow K, Duckett K, Holmqvist S, Khan A, Dai X, Bochukova EG, Trembath RC, Martin HC, Coll AP, Rowitch DH, Wareham NJ, van Heel DA, Timpson N, Simerly RB, Ong KK, Cone RD, Langenberg C, Perry JRB, Yeo GS, O'Rahilly S. MC3R links nutritional state to childhood growth and the timing of puberty. Nature. 2021 Nov;599(7885):436-441. doi: 10.1038/s41586-021-04088-9. Epub 2021 Nov 3. PubMed PMID: 34732894; PubMed Central PMCID: PMC8819628.

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Luchsinger JR, Fetterly TL, Williford KM, Salimando GJ, Doyle MA, Maldonado J, Simerly RB, Winder DG, Centanni SW. Delineation of an insula-BNST circuit engaged by struggling behavior that regulates avoidance in mice. Nat Commun. 2021 Jun 11;12(1):3561. doi: 10.1038/s41467-021-23674-z. PubMed PMID: 34117229; PubMed Central PMCID: PMC8196075.

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Sweeney P, Bedenbaugh MN, Maldonado J, Pan P, Fowler K, Williams SY, Gimenez LE, Ghamari-Langroudi M, Downing G, Gui Y, Hadley CK, Joy ST, Mapp AK, Simerly RB, Cone RD. The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia. Sci Transl Med. 2021 Apr 21;13(590). doi: 10.1126/scitranslmed.abd6434. PubMed PMID: 33883274; PubMed Central PMCID: PMC9022017.

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Biddinger JE, Lazarenko RM, Scott MM, Simerly R. Leptin suppresses development of GLP-1 inputs to the paraventricular nucleus of the hypothalamus. Elife. 2020 Nov 18;9. doi: 10.7554/eLife.59857. PubMed PMID: 33206596; PubMed Central PMCID: PMC7673779.

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MacKay H, Scott CA, Duryea JD, Baker MS, Laritsky E, Elson AE, Garland T Jr, Fiorotto ML, Chen R, Li Y, Coarfa C, Simerly RB, Waterland RA. DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice. Nat Commun. 2019 Dec 2;10(1):5364. doi: 10.1038/s41467-019-13339-3. PubMed PMID: 31792207; PubMed Central PMCID: PMC6889160.

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van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O'Rahilly S, Simerly RB, Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS. Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Cell. 2019 Feb 7;176(4):729-742.e18. doi: 10.1016/j.cell.2018.12.009. Epub 2019 Jan 17. PubMed PMID: 30661757; PubMed Central PMCID: PMC6370916.

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Kamitakahara A, Bouyer K, Wang CH, Simerly R. A critical period for the trophic actions of leptin on AgRP neurons in the arcuate nucleus of the hypothalamus. J Comp Neurol. 2018 Jan 1;526(1):133-145. doi: 10.1002/cne.24327. Epub 2017 Sep 20. PubMed PMID: 28891045; PubMed Central PMCID: PMC6040218.

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Kamitakahara A, Xu B, Simerly R. Ventromedial hypothalamic expression of Bdnf is required to establish normal patterns of afferent GABAergic connectivity and responses to hypoglycemia. Mol Metab. 2016 Feb;5(2):91-101. doi: 10.1016/j.molmet.2015.11.007. eCollection 2016 Feb. PubMed PMID: 26909317; PubMed Central PMCID: PMC4735662.

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Elson AE, Simerly RB. Developmental specification of metabolic circuitry. Front Neuroendocrinol. 2015 Oct;39:38-51. doi: 10.1016/j.yfrne.2015.09.003. Epub 2015 Sep 25. Review. PubMed PMID: 26407637; PubMed Central PMCID: PMC4681622.

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Liao GY, Bouyer K, Kamitakahara A, Sahibzada N, Wang CH, Rutlin M, Simerly RB, Xu B. Brain-derived neurotrophic factor is required for axonal growth of selective groups of neurons in the arcuate nucleus. Mol Metab. 2015 Jun;4(6):471-82. doi: 10.1016/j.molmet.2015.03.003. eCollection 2015 Jun. PubMed PMID: 26042201; PubMed Central PMCID: PMC4443292.

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Li G, Zhang W, Baker MS, Laritsky E, Mattan-Hung N, Yu D, Kunde-Ramamoorthy G, Simerly RB, Chen R, Shen L, Waterland RA. Major epigenetic development distinguishing neuronal and non-neuronal cells occurs postnatally in the murine hypothalamus. Hum Mol Genet. 2014 Mar 15;23(6):1579-90. doi: 10.1093/hmg/ddt548. Epub 2013 Nov 1. PubMed PMID: 24186871; PubMed Central PMCID: PMC3929094.

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Schipper L, Bouyer K, Oosting A, Simerly RB, van der Beek EM. Postnatal dietary fatty acid composition permanently affects the structure of hypothalamic pathways controlling energy balance in mice. Am J Clin Nutr. 2013 Dec;98(6):1395-401. doi: 10.3945/ajcn.113.069229. Epub 2013 Oct 9. PubMed PMID: 24108786; PubMed Central PMCID: PMC6546223.

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Bouyer K, Simerly RB. Neonatal leptin exposure specifies innervation of presympathetic hypothalamic neurons and improves the metabolic status of leptin-deficient mice. J Neurosci. 2013 Jan 9;33(2):840-51. doi: 10.1523/JNEUROSCI.3215-12.2013. PubMed PMID: 23303959; PubMed Central PMCID: PMC3610601.

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Bouret SG, Bates SH, Chen S, Myers MG Jr, Simerly RB. Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits. J Neurosci. 2012 Jan 25;32(4):1244-52. doi: 10.1523/JNEUROSCI.2277-11.2012. PubMed PMID: 22279209; PubMed Central PMCID: PMC3567460.

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Tang Y, Sharma P, Nelson MD, Simerly R, Moats RA. Automatic abdominal fat assessment in obese mice using a segmental shape model. J Magn Reson Imaging. 2011 Oct;34(4):866-73. doi: 10.1002/jmri.22690. Epub 2011 Jul 18. PubMed PMID: 21769982.

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Cone RD, Simerly RB. Leptin grows up and gets a neural network. Neuron. 2011 Jul 14;71(1):4-6. doi: 10.1016/j.neuron.2011.06.033. PubMed PMID: 21745633; PubMed Central PMCID: PMC3175484.

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Blackshaw S, Scholpp S, Placzek M, Ingraham H, Simerly R, Shimogori T. Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation. J Neurosci. 2010 Nov 10;30(45):14925-30. doi: 10.1523/JNEUROSCI.4499-10.2010. Review. PubMed PMID: 21068293; PubMed Central PMCID: PMC6633850.

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Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM, Nemeroff CB, Reyes TM, Simerly RB, Susser ES, Nestler EJ. Early life programming and neurodevelopmental disorders. Biol Psychiatry. 2010 Aug 15;68(4):314-9. doi: 10.1016/j.biopsych.2010.05.028. Review. PubMed PMID: 20674602; PubMed Central PMCID: PMC3168778.

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Myers MG Jr, Simerly RB. The neuroendocrinology and neuroscience of energy balance. Front Neuroendocrinol. 2010 Jan;31(1):1-3. doi: 10.1016/j.yfrne.2009.10.007. Epub 2009 Oct 23. PubMed PMID: 19854213; PubMed Central PMCID: PMC2813945.

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Waters EM, Simerly RB. Estrogen induces caspase-dependent cell death during hypothalamic development. J Neurosci. 2009 Aug 5;29(31):9714-8. doi: 10.1523/JNEUROSCI.0135-09.2009. PubMed PMID: 19657024; PubMed Central PMCID: PMC6428191.

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Simerly RB. Hypothalamic substrates of metabolic imprinting. Physiol Behav. 2008 Apr 22;94(1):79-89. doi: 10.1016/j.physbeh.2007.11.023. Epub 2007 Nov 22. Review. PubMed PMID: 18262209; PubMed Central PMCID: PMC2430416.

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Bouret SG, Gorski JN, Patterson CM, Chen S, Levin BE, Simerly RB. Hypothalamic neural projections are permanently disrupted in diet-induced obese rats. Cell Metab. 2008 Feb;7(2):179-85. doi: 10.1016/j.cmet.2007.12.001. PubMed PMID: 18249177; PubMed Central PMCID: PMC2442478.

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Bouret SG, Simerly RB. Development of leptin-sensitive circuits. J Neuroendocrinol. 2007 Aug;19(8):575-82. doi: 10.1111/j.1365-2826.2007.01563.x. Review. PubMed PMID: 17620099.

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Simerly R. Feeding signals and drugs meet in the midbrain. Nat Med. 2006 Nov;12(11):1244-6. doi: 10.1038/nm1106-1244. PubMed PMID: 17088890.

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Bouret SG, Simerly RB. Developmental programming of hypothalamic feeding circuits. Clin Genet. 2006 Oct;70(4):295-301. doi: 10.1111/j.1399-0004.2006.00684.x. Review. PubMed PMID: 16965320.

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Cooke BM, Simerly RB. Ontogeny of bidirectional connections between the medial nucleus of the amygdala and the principal bed nucleus of the stria terminalis in the rat. J Comp Neurol. 2005 Aug 15;489(1):42-58. doi: 10.1002/cne.20612. PubMed PMID: 15977169.

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Simerly R. Building neural choice points for love and war. Neuron. 2005 May 19;46(4):525-6. doi: 10.1016/j.neuron.2005.05.001. PubMed PMID: 15944120.

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Simerly RB. Wired on hormones: endocrine regulation of hypothalamic development. Curr Opin Neurobiol. 2005 Feb;15(1):81-5. doi: 10.1016/j.conb.2005.01.013. Review. PubMed PMID: 15721748.

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Forger NG, Rosen GJ, Waters EM, Jacob D, Simerly RB, de Vries GJ. Deletion of Bax eliminates sex differences in the mouse forebrain. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13666-71. doi: 10.1073/pnas.0404644101. Epub 2004 Sep 1. PubMed PMID: 15342910; PubMed Central PMCID: PMC518810.

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Bouret SG, Simerly RB. Minireview: Leptin and development of hypothalamic feeding circuits. Endocrinology. 2004 Jun;145(6):2621-6. doi: 10.1210/en.2004-0231. Epub 2004 Mar 24. Review. PubMed PMID: 15044371.

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Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science. 2004 Apr 2;304(5667):108-10. doi: 10.1126/science.1095004. PubMed PMID: 15064420.

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Bouret SG, Draper SJ, Simerly RB. Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice. J Neurosci. 2004 Mar 17;24(11):2797-805. doi: 10.1523/JNEUROSCI.5369-03.2004. PubMed PMID: 15028773; PubMed Central PMCID: PMC6729527.

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Polston EK, Gu G, Simerly RB. Neurons in the principal nucleus of the bed nuclei of the stria terminalis provide a sexually dimorphic GABAergic input to the anteroventral periventricular nucleus of the hypothalamus. Neuroscience. 2004;123(3):793-803. doi: 10.1016/j.neuroscience.2003.09.034. PubMed PMID: 14706792.

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Polston EK, Simerly RB. Sex-specific patterns of galanin, cholecystokinin, and substance P expression in neurons of the principal bed nucleus of the stria terminalis are differentially reflected within three efferent preoptic pathways in the juvenile rat. J Comp Neurol. 2003 Oct 27;465(4):551-9. doi: 10.1002/cne.10841. PubMed PMID: 12975815.

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Gu G, Cornea A, Simerly RB. Sexual differentiation of projections from the principal nucleus of the bed nuclei of the stria terminalis. J Comp Neurol. 2003 Jun 9;460(4):542-62. doi: 10.1002/cne.10677. PubMed PMID: 12717713.

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Zup SL, Carrier H, Waters EM, Tabor A, Bengston L, Rosen GJ, Simerly RB, Forger NG. Overexpression of bcl-2 reduces sex differences in neuron number in the brain and spinal cord. J Neurosci. 2003 Mar 15;23(6):2357-62. doi: 10.1523/JNEUROSCI.23-06-02357.2003. PubMed PMID: 12657695; PubMed Central PMCID: PMC6742046.

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Soderling SH, Langeberg LK, Soderling JA, Davee SM, Simerly R, Raber J, Scott JD. Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1723-8. doi: 10.1073/pnas.0438033100. Epub 2003 Feb 10. PubMed PMID: 12578964; PubMed Central PMCID: PMC149900.

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De Vries GJ, Rissman EF, Simerly RB, Yang LY, Scordalakes EM, Auger CJ, Swain A, Lovell-Badge R, Burgoyne PS, Arnold AP. A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. J Neurosci. 2002 Oct 15;22(20):9005-14. doi: 10.1523/JNEUROSCI.22-20-09005.2002. PubMed PMID: 12388607; PubMed Central PMCID: PMC6757680.

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Simerly RB. Wired for reproduction: organization and development of sexually dimorphic circuits in the mammalian forebrain. Annu Rev Neurosci. 2002;25:507-36. doi: 10.1146/annurev.neuro.25.112701.142745. Epub 2002 Mar 27. Review. PubMed PMID: 12052919.

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Ibanez MA, Gu G, Simerly RB. Target-dependent sexual differentiation of a limbic-hypothalamic neural pathway. J Neurosci. 2001 Aug 1;21(15):5652-9. doi: 10.1523/JNEUROSCI.21-15-05652.2001. PubMed PMID: 11466436; PubMed Central PMCID: PMC6762657.

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Leng N, Gu G, Simerly RB, Spindel ER. Molecular cloning and characterization of two putative G protein-coupled receptors which are highly expressed in the central nervous system. Brain Res Mol Brain Res. 1999 May 21;69(1):73-83. doi: 10.1016/s0169-328x(99)00092-3. PubMed PMID: 10350639.

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Gu G, Varoqueaux F, Simerly RB. Hormonal regulation of glutamate receptor gene expression in the anteroventral periventricular nucleus of the hypothalamus. J Neurosci. 1999 Apr 15;19(8):3213-22. doi: 10.1523/JNEUROSCI.19-08-03213.1999. PubMed PMID: 10191334; PubMed Central PMCID: PMC6782292.

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Simerly RB. Organization and regulation of sexually dimorphic neuroendocrine pathways. Behav Brain Res. 1998 May;92(2):195-203. doi: 10.1016/s0166-4328(97)00191-5. Review. PubMed PMID: 9638961.

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Hutton LA, Gu G, Simerly RB. Development of a sexually dimorphic projection from the bed nuclei of the stria terminalis to the anteroventral periventricular nucleus in the rat. J Neurosci. 1998 Apr 15;18(8):3003-13. doi: 10.1523/JNEUROSCI.18-08-03003.1998. PubMed PMID: 9526017; PubMed Central PMCID: PMC6792590.

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Simerly RB, Zee MC, Pendleton JW, Lubahn DB, Korach KS. Estrogen receptor-dependent sexual differentiation of dopaminergic neurons in the preoptic region of the mouse. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14077-82. doi: 10.1073/pnas.94.25.14077. PubMed PMID: 9391155; PubMed Central PMCID: PMC28435.

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Gu GB, Simerly RB. Projections of the sexually dimorphic anteroventral periventricular nucleus in the female rat. J Comp Neurol. 1997 Jul 21;384(1):142-64. PubMed PMID: 9214545.

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Kesterson RA, Huszar D, Lynch CA, Simerly RB, Cone RD. Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome. Mol Endocrinol. 1997 May;11(5):630-7. doi: 10.1210/mend.11.5.9921. PubMed PMID: 9139806.

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Simerly RB, Young BJ, Carr AM. Co-expression of steroid hormone receptors in opioid peptide-containing neurons correlates with patterns of gene expression during the estrous cycle. Brain Res Mol Brain Res. 1996 Sep 1;40(2):275-84. doi: 10.1016/0169-328x(96)00057-5. PubMed PMID: 8872312.