My Bibliography

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Barnette BW, Schumacher BT, Armenta RF, Wynn JL, Richardson A, Bradley JS, Lazar S, Lawrence SM. Contribution of Concurrent Comorbidities to Sepsis-Related Mortality in Preterm Infants ≤32 Weeks of Gestation at an Academic Neonatal Intensive Care Network. Am J Perinatol. 2024 Jan;41(2):134-142. doi: 10.1055/a-1675-2899. Epub 2021 Oct 21. PubMed PMID: 34674193; PubMed Central PMCID: PMC10233655.

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Hayes R, Hartnett J, Semova G, Murray C, Murphy K, Carroll L, Plapp H, Hession L, O'Toole J, McCollum D, Roche E, Jenkins E, Mockler D, Hurley T, McGovern M, Allen J, Meehan J, Plötz FB, Strunk T, de Boode WP, Polin R, Wynn JL, Degtyareva M, Küster H, Janota J, Giannoni E, Schlapbach LJ, Keij FM, Reiss IKM, Bliss J, Koenig JM, Turner MA, Gale C, Molloy EJ. Neonatal sepsis definitions from randomised clinical trials. Pediatr Res. 2023 Apr;93(5):1141-1148. doi: 10.1038/s41390-021-01749-3. Epub 2021 Nov 6. PubMed PMID: 34743180; PubMed Central PMCID: PMC10132965.

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Zeigler AC, Ainsworth JE, Fairchild KD, Wynn JL, Sullivan BA. Sepsis and Mortality Prediction in Very Low Birth Weight Infants: Analysis of HeRO and nSOFA. Am J Perinatol. 2023 Mar;40(4):407-414. doi: 10.1055/s-0041-1728829. Epub 2021 May 10. PubMed PMID: 33971672; PubMed Central PMCID: PMC8578589.

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Polcz VE, Rincon JC, Hawkins RB, Barrios EL, Efron PA, Moldawer LL, Larson SD. TRAINED IMMUNITY: A POTENTIAL APPROACH FOR IMPROVING HOST IMMUNITY IN NEONATAL SEPSIS. Shock. 2023 Feb 1;59(2):125-134. doi: 10.1097/SHK.0000000000002054. Epub 2022 Nov 17. PubMed PMID: 36383390; PubMed Central PMCID: PMC9957873.

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Aziz KB, Schles EM, Makker K, Wynn JL. Frequency of Acute Kidney Injury and Association With Mortality Among Extremely Preterm Infants. JAMA Netw Open. 2022 Dec 1;5(12):e2246327. doi: 10.1001/jamanetworkopen.2022.46327. PubMed PMID: 36512358; PubMed Central PMCID: PMC9856227.

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Kerr AW, Efron PA, Larson SD, Rincon JC. T-Cell Activation and LPS: A Dangerous Duo for Organ Dysfunction. J Leukoc Biol. 2022 Aug;112(2):219-220. doi: 10.1002/JLB.3CE0122-019R. Epub 2022 Apr 28. PubMed PMID: 35481682.

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Stevens J, Steinmeyer S, Bonfield M, Peterson L, Wang T, Gray J, Lewkowich I, Xu Y, Du Y, Guo M, Wynn JL, Zacharias W, Salomonis N, Miller L, Chougnet C, O'Connor DH, Deshmukh H. The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota. Sci Transl Med. 2022 Jun 15;14(649):eabl3981. doi: 10.1126/scitranslmed.abl3981. Epub 2022 Jun 15. PubMed PMID: 35704600; PubMed Central PMCID: PMC10032669.

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Lewis AN, de la Cruz D, Wynn JL, Frazer LC, Yakah W, Martin CR, Yang H, Itriago E, Unger J, Hair AB, Miele J, Sullivan BA, Husain A, Good M. Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants with Necrotizing Enterocolitis. Neonatology. 2022;119(3):334-344. doi: 10.1159/000522560. Epub 2022 Mar 21. PubMed PMID: 35313308; PubMed Central PMCID: PMC9117503.

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Henry CJ, Semova G, Barnes E, Cotter I, Devers T, Rafaee A, Slavescu A, Cathain NO, McCollum D, Roche E, Mockler D, Allen J, Meehan J, Klingenberg C, Latour JM, van den Hoogen A, Strunk T, Giannoni E, Schlapbach LJ, Degtyareva M, Plötz FB, de Boode WP, Naver L, Wynn JL, Küster H, Janota J, Keij FM, Reiss IKM, Bliss JM, Polin R, Koenig JM, Turner MA, Gale C, Molloy EJ. Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials. Pediatr Res. 2022 Mar;91(4):735-742. doi: 10.1038/s41390-021-01883-y. Epub 2022 Jan 7. PubMed PMID: 34997225; PubMed Central PMCID: PMC9064797.

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Sakuma M, Wang X, Ellett F, Edd JF, Babatunde KA, Viens A, Mansour MK, Irimia D. Microfluidic capture of chromatin fibres measures neutrophil extracellular traps (NETs) released in a drop of human blood. Lab Chip. 2022 Mar 1;22(5):936-944. doi: 10.1039/d1lc01123e. PubMed PMID: 35084421; PubMed Central PMCID: PMC8978531.

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Squires JE, McKiernan PJ, Squires RH. Acute Liver Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S59-S65. doi: 10.1542/peds.2021-052888I. PubMed PMID: 34970684.

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Schlapbach LJ, Weiss SL, Bembea MM, Carcillo JA, Leclerc F, Leteurtre S, Tissieres P, Wynn JL, Zimmerman J, Lacroix J. Scoring Systems for Organ Dysfunction and Multiple Organ Dysfunction: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S23-S31. doi: 10.1542/peds.2021-052888D. PubMed PMID: 34970683; PubMed Central PMCID: PMC9703039.

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Fitzgerald JC, Basu RK, Fuhrman DY, Gorga SM, Hassinger AB, Sanchez-Pinto LN, Selewski DT, Sutherland SM, Akcan-Arikan A. Renal Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S66-S73. doi: 10.1542/peds.2021-052888J. PubMed PMID: 34970682; PubMed Central PMCID: PMC9722270.

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Wainwright MS, Guilliams K, Kannan S, Simon DW, Tasker RC, Traube C, Pineda J. Acute Neurologic Dysfunction in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S32-S38. doi: 10.1542/peds.2021-052888E. PubMed PMID: 34970681.

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Typpo KV, Irving SY, Prince JM, Pathan N, Brown AM. Gastrointestinal Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S53-S58. doi: 10.1542/peds.2021-052888H. PubMed PMID: 34970680; PubMed Central PMCID: PMC9662164.

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Yehya N, Khemani RG, Erickson S, Smith LS, Rowan CM, Jouvet P, Willson DF, Cheifetz IM, Ward S, Thomas NJ. Respiratory Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S48-S52. doi: 10.1542/peds.2021-052888G. PubMed PMID: 34970679.

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Sanchez-Pinto LN, Bembea MM, Farris RW, Hartman ME, Odetola FO, Spaeder MC, Watson RS, Zimmerman JJ, Bennett TD. Patterns of Organ Dysfunction in Critically Ill Children Based on PODIUM Criteria. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S103-S110. doi: 10.1542/peds.2021-052888P. PubMed PMID: 34970678; PubMed Central PMCID: PMC9271339.

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Alexander PMA, Checchia PA, Ryerson LM, Bohn D, Eckerle M, Gaies M, Laussen P, Jeffries H, Thiagarajan RR, Shekerdemian L, Bembea MM, Zimmerman JJ, Kissoon N. Cardiovascular Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S39-S47. doi: 10.1542/peds.2021-052888F. PubMed PMID: 34970677; PubMed Central PMCID: PMC9745438.

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Pierce RW, Giuliano JS, Whitney JE, Ouellette Y. Endothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S97-S102. doi: 10.1542/peds.2021-052888O. PubMed PMID: 34970676; PubMed Central PMCID: PMC9754809.

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Muszynski JA, Cholette JM, Steiner ME, Tucci M, Doctor A, Parker RI. Hematologic Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S74-S78. doi: 10.1542/peds.2021-052888K. PubMed PMID: 34970675.

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Hall MW, Carcillo JA, Cornell T. Immune System Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S91-S98. doi: 10.1542/peds.2021-052888N. PubMed PMID: 34970674; PubMed Central PMCID: PMC9166150.

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Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yehya N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S1-S12. doi: 10.1542/peds.2021-052888B. PubMed PMID: 34970673; PubMed Central PMCID: PMC9599725.

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Srinivasan V, Lee JH, Menon K, Zimmerman JJ, Bembea MM, Agus MSD. Endocrine Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S84-S90. doi: 10.1542/peds.2021-052888M. PubMed PMID: 34970672.

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Weiss SL, Carcillo JA, Leclerc F, Leteurtre S, Schlapbach LJ, Tissieres P, Wynn JL, Lacroix J. Refining the Pediatric Multiple Organ Dysfunction Syndrome. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S13-S22. doi: 10.1542/peds.2021-052888C. PubMed PMID: 34970671; PubMed Central PMCID: PMC9084565.

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Faustino EVS, Karam O, Parker RI, Hanson SJ, Brandão LR, Monagle P. Coagulation Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1;149(1 Suppl 1):S79-S83. doi: 10.1542/peds.2021-052888L. PubMed PMID: 34970670.

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Menon K, Schlapbach LJ, Akech S, Argent A, Biban P, Carrol ED, Chiotos K, Jobayer Chisti M, Evans IVR, Inwald DP, Ishimine P, Kissoon N, Lodha R, Nadel S, Oliveira CF, Peters M, Sadeghirad B, Scott HF, de Souza DC, Tissieres P, Watson RS, Wiens MO, Wynn JL, Zimmerman JJ, Sorce LR. Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce. Crit Care Med. 2022 Jan 1;50(1):21-36. doi: 10.1097/CCM.0000000000005294. PubMed PMID: 34612847; PubMed Central PMCID: PMC8670345.

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Lavilla OC, Aziz KB, Lure AC, Gipson D, de la Cruz D, Wynn JL. Hourly Kinetics of Critical Organ Dysfunction in Extremely Preterm Infants. Am J Respir Crit Care Med. 2022 Jan 1;205(1):75-87. doi: 10.1164/rccm.202106-1359OC. PubMed PMID: 34550843; PubMed Central PMCID: PMC8865589.

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Aziz KB, Lavilla OC, Wynn JL, Lure AC, Gipson D, de la Cruz D. Maximum vasoactive-inotropic score and mortality in extremely premature, extremely low birth weight infants. J Perinatol. 2021 Sep;41(9):2337-2344. doi: 10.1038/s41372-021-01030-9. Epub 2021 Mar 12. PubMed PMID: 33712712; PubMed Central PMCID: PMC8435049.

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Wynn JL, Mayampurath A, Carey K, Slattery S, Andrews B, Sanchez-Pinto LN. Multicenter Validation of the Neonatal Sequential Organ Failure Assessment Score for Prognosis in the Neonatal Intensive Care Unit. J Pediatr. 2021 Sep;236:297-300.e1. doi: 10.1016/j.jpeds.2021.05.037. Epub 2021 May 19. PubMed PMID: 34022247; PubMed Central PMCID: PMC9045002.

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Prelipcean I, Wynn JL, Thompson L, Burchfield DJ, James-Woodley L, Chase PB, Barnes CP, Bernier A. Absence of relationship between serum cortisol and critical illness in premature infants. Arch Dis Child Fetal Neonatal Ed. 2021 Jul;106(4):408-412. doi: 10.1136/archdischild-2020-319970. Epub 2021 Feb 4. PubMed PMID: 33541918; PubMed Central PMCID: PMC8852370.

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Fleiss N, Coggins SA, Lewis AN, Zeigler A, Cooksey KE, Walker LA, Husain AN, de Jong BS, Wallman-Stokes A, Alrifai MW, Visser DH, Good M, Sullivan B, Polin RA, Martin CR, Wynn JL. Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection. JAMA Netw Open. 2021 Feb 1;4(2):e2036518. doi: 10.1001/jamanetworkopen.2020.36518. PubMed PMID: 33538825; PubMed Central PMCID: PMC7862993.

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Wynn JL. Application of metabolomics to neonatal meningitis. Pediatr Res. 2020 Aug;88(2):155-156. doi: 10.1038/s41390-020-0954-y. Epub 2020 May 12. PubMed PMID: 32396924; PubMed Central PMCID: PMC7390664.

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Wynn JL, Polin RA. A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants. Pediatr Res. 2020 Jul;88(1):85-90. doi: 10.1038/s41390-019-0517-2. Epub 2019 Aug 8. PubMed PMID: 31394566; PubMed Central PMCID: PMC7007331.

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Molloy EJ, Wynn JL, Bliss J, Koenig JM, Keij FM, McGovern M, Kuester H, Turner MA, Giannoni E, Mazela J, Degtyareva M, Strunk T, Simons SHP, Janota J, Plotz FB, van den Hoogen A, de Boode W, Schlapbach LJ, Reiss IKM. Neonatal sepsis: need for consensus definition, collaboration and core outcomes. Pediatr Res. 2020 Jul;88(1):2-4. doi: 10.1038/s41390-020-0850-5. Epub 2020 Mar 19. PubMed PMID: 32193517.

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McGovern M, Giannoni E, Kuester H, Turner MA, van den Hoogen A, Bliss JM, Koenig JM, Keij FM, Mazela J, Finnegan R, Degtyareva M, Simons SHP, de Boode WP, Strunk T, Reiss IKM, Wynn JL, Molloy EJ. Challenges in developing a consensus definition of neonatal sepsis. Pediatr Res. 2020 Jul;88(1):14-26. doi: 10.1038/s41390-020-0785-x. Epub 2020 Mar 3. Review. PubMed PMID: 32126571.

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Menon K, Schlapbach LJ, Akech S, Argent A, Chiotos K, Chisti MJ, Hamid J, Ishimine P, Kissoon N, Lodha R, Oliveira CF, Peters M, Tissieres P, Watson RS, Wiens MO, Wynn JL, Sorce LR. Pediatric Sepsis Definition-A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce. Crit Care Explor. 2020 Jun;2(6):e0123. doi: 10.1097/CCE.0000000000000123. eCollection 2020 Jun. Review. PubMed PMID: 32695992; PubMed Central PMCID: PMC7314341.

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Brook B, Harbeson DJ, Shannon CP, Cai B, He D, Ben-Othman R, Francis F, Huang J, Varankovich N, Liu A, Bao W, Bjerregaard-Andersen M, Schaltz-Buchholzer F, Sanca L, Golding CN, Larsen KL, Levy O, Kampmann B, Tan R, Charles A, Wynn JL, Shann F, Aaby P, Benn CS, Tebbutt SJ, Kollmann TR, Amenyogbe N. BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis. Sci Transl Med. 2020 May 6;12(542). doi: 10.1126/scitranslmed.aax4517. PubMed PMID: 32376769; PubMed Central PMCID: PMC8008103.

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Nolan LS, Wynn JL, Good M. Exploring Clinically-Relevant Experimental Models of Neonatal Shock and Necrotizing Enterocolitis. Shock. 2020 May;53(5):596-604. doi: 10.1097/SHK.0000000000001507. Review. PubMed PMID: 31977960; PubMed Central PMCID: PMC7376956.

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Meegan JE, Shaver CM, Putz ND, Jesse JJ, Landstreet SR, Lee HNR, Sidorova TN, McNeil JB, Wynn JL, Cheung-Flynn J, Komalavilas P, Brophy CM, Ware LB, Bastarache JA. Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis. PLoS One. 2020;15(2):e0228727. doi: 10.1371/journal.pone.0228727. eCollection 2020. PubMed PMID: 32012200; PubMed Central PMCID: PMC6996826.

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Bearer C, Agostoni C, Anand KJS, Ambalavanan N, Bhandari V, Bliss JM, Bloomfield F, Bonifacio SL, Buhimschi I, Cilio MR, Coppes M, Czinn SJ, El-Khuffash A, Embleton N, Felderhoff-Müser U, Ferriero DM, Florin T, Fuentes-Afflick E, Gardner W, Gospe SM Jr, Gunn A, Gressens P, Guissani D, Haiden N, Hauptman M, Kim KS, Klebanoff M, Lachman P, Lanphear B, Ozen S, Roehr C, Roland D, Rosenblum N, Schwarz M, Staiano A, Stroustrup A, Valente EM, Wilson-Costello D, Wynn J, Molloy E. Toward the elimination of bias in Pediatric Research. Pediatr Res. 2019 Dec;86(6):680-681. doi: 10.1038/s41390-019-0583-5. Epub 2019 Sep 18. PubMed PMID: 31533126.

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Lavoie PM, Popescu CR, Molyneux EM, Wynn JL, Chiume M, Keitel K, Lufesi N, Levine GA, Ansermino JM, Kissoon N. Rethinking management of neonates at risk of sepsis. Lancet. 2019 Jul 27;394(10195):279-281. doi: 10.1016/S0140-6736(19)31627-7. PubMed PMID: 31354128; PubMed Central PMCID: PMC6675455.

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Wynn JL. Prolonged early antimicrobials in ELBWs: too much for too little. Pediatr Res. 2019 Jun;85(7):929-930. doi: 10.1038/s41390-019-0360-5. Epub 2019 Mar 5. PubMed PMID: 30836378; PubMed Central PMCID: PMC6531327.

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Ellett F, Jalali F, Marand AL, Jorgensen J, Mutlu BR, Lee J, Raff AB, Irimia D. Microfluidic arenas for war games between neutrophils and microbes. Lab Chip. 2019 Mar 27;19(7):1205-1216. doi: 10.1039/c8lc01263f. PubMed PMID: 30865740; PubMed Central PMCID: PMC6544356.

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Brook B, Amenyogbe N, Ben-Othman R, Cai B, Harbeson D, Francis F, Liu AC, Varankovich N, Wynn J, Kollmann TR. A Controlled Mouse Model for Neonatal Polymicrobial Sepsis. J Vis Exp. 2019 Jan 27;(143). doi: 10.3791/58574. PubMed PMID: 30741260.

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Wynn JL. Early onset and hospital acquired neonatal sepsis associated with high mortality. J Pediatr. 2019 Jan;204:320-323. doi: 10.1016/j.jpeds.2018.10.075. PubMed PMID: 30579470.

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Wang X, Jodoin E, Jorgensen J, Lee J, Markmann JJ, Cataltepe S, Irimia D. Progressive mechanical confinement of chemotactic neutrophils induces arrest, oscillations, and retrotaxis. J Leukoc Biol. 2018 Dec;104(6):1253-1261. doi: 10.1002/JLB.5TA0318-110RRR. Epub 2018 Aug 21. PubMed PMID: 30129679; PubMed Central PMCID: PMC6258301.

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Benjamin JT, Moore DJ, Bennett C, van der Meer R, Royce A, Loveland R, Wynn JL. Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality. J Immunol. 2018 Nov 15;201(10):2873-2878. doi: 10.4049/jimmunol.1801089. Epub 2018 Oct 10. PubMed PMID: 30305325; PubMed Central PMCID: PMC6219910.

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Raymond SL, Hawkins RB, Stortz JA, Murphy TJ, Ungaro R, Dirain ML, Nacionales DC, Hollen MK, Rincon JC, Larson SD, Brakenridge SC, Moore FA, Irimia D, Efron PA, Moldawer LL. Sepsis is associated with reduced spontaneous neutrophil migration velocity in human adults. PLoS One. 2018;13(10):e0205327. doi: 10.1371/journal.pone.0205327. eCollection 2018. PubMed PMID: 30300408; PubMed Central PMCID: PMC6177179.

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Good M, McElroy SJ, Berger JN, Moore DJ, Wynn JL. Limited achievement of NIH research independence by pediatric K award recipients. Pediatr Res. 2018 Oct;84(4):479-480. doi: 10.1038/s41390-018-0056-2. Epub 2018 Jun 14. PubMed PMID: 29904137; PubMed Central PMCID: PMC6289685.

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Nielsen DW, Ricker N, Barbieri NL, Wynn JL, Gómez-Duarte OG, Iqbal J, Nolan LK, Allen HK, Logue CM. Complete Genome Sequence of the Multidrug-Resistant Neonatal Meningitis Escherichia coli Serotype O75:H5:K1 Strain mcjchv-1 (NMEC-O75). Microbiol Resour Announc. 2018 Sep;7(10). doi: 10.1128/MRA.01043-18. eCollection 2018 Sep. PubMed PMID: 30533615; PubMed Central PMCID: PMC6256591.