My Bibliography

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Zebrafish expression reporters and mutants reveal that the IgSF cell adhesion molecule Dscamb is required for feeding and survival. Journal of neurogenetics. . NIHMSID: NIHMS1024006.

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Roayaie K, Crump JG, Sagasti A, Bargmann CI. The G alpha protein ODR-3 mediates olfactory and nociceptive function and controls cilium morphogenesis in C. elegans olfactory neurons. Neuron. 1998 Jan;20(1):55-67. doi: 10.1016/s0896-6273(00)80434-1. PubMed PMID: 9459442.

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Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI. Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes Dev. 1999 Jul 15;13(14):1794-806. doi: 10.1101/gad.13.14.1794. PubMed PMID: 10421632; PubMed Central PMCID: PMC316880.

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Troemel ER, Sagasti A, Bargmann CI. Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans. Cell. 1999 Nov 12;99(4):387-98. doi: 10.1016/s0092-8674(00)81525-1. PubMed PMID: 10571181.

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Sagasti A, Hisamoto N, Hyodo J, Tanaka-Hino M, Matsumoto K, Bargmann CI. The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling decision required for asymmetric olfactory neuron fates. Cell. 2001 Apr 20;105(2):221-32. doi: 10.1016/s0092-8674(01)00313-0. PubMed PMID: 11336672.

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Tanaka-Hino M, Sagasti A, Hisamoto N, Kawasaki M, Nakano S, Ninomiya-Tsuji J, Bargmann CI, Matsumoto K. SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans. EMBO Rep. 2002 Jan;3(1):56-62. doi: 10.1093/embo-reports/kvf001. Epub 2001 Dec 19. PubMed PMID: 11751572; PubMed Central PMCID: PMC1083920.

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Sagasti A, Guido MR, Raible DW, Schier AF. Repulsive interactions shape the morphologies and functional arrangement of zebrafish peripheral sensory arbors. Curr Biol. 2005 May 10;15(9):804-14. doi: 10.1016/j.cub.2005.03.048. PubMed PMID: 15886097.

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Merchant SS, Sagasti A. Precious metal economy. Cell Metab. 2006 Aug;4(2):99-101. doi: 10.1016/j.cmet.2006.07.003. Review. PubMed PMID: 16890535.

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Sagasti A. Three ways to make two sides: genetic models of asymmetric nervous system development. Neuron. 2007 Aug 2;55(3):345-51. doi: 10.1016/j.neuron.2007.07.015. Review. PubMed PMID: 17678849.

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Richler E, Chaumont S, Shigetomi E, Sagasti A, Khakh BS. Tracking transmitter-gated P2X cation channel activation in vitro and in vivo. Nat Methods. 2008 Jan;5(1):87-93. doi: 10.1038/nmeth1144. Epub 2007 Dec 16. PubMed PMID: 18084300; PubMed Central PMCID: PMC3523716.

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O'Brien GS, Rieger S, Martin SM, Cavanaugh AM, Portera-Cailliau C, Sagasti A. Two-photon axotomy and time-lapse confocal imaging in live zebrafish embryos. J Vis Exp. 2009 Feb 16;(24). doi: 10.3791/1129. PubMed PMID: 19229185; PubMed Central PMCID: PMC2726581.

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O'Brien GS, Sagasti A. Fragile axons forge the path to gene discovery: a MAP kinase pathway regulates axon regeneration. Sci Signal. 2009 May 5;2(69):pe30. doi: 10.1126/scisignal.269pe30. PubMed PMID: 19417215.

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O'Brien GS, Martin SM, Söllner C, Wright GJ, Becker CG, Portera-Cailliau C, Sagasti A. Developmentally regulated impediments to skin reinnervation by injured peripheral sensory axon terminals. Curr Biol. 2009 Dec 29;19(24):2086-90. doi: 10.1016/j.cub.2009.10.051. Epub 2009 Dec 3. PubMed PMID: 19962310; PubMed Central PMCID: PMC2805760.

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Grueber WB, Sagasti A. Self-avoidance and tiling: Mechanisms of dendrite and axon spacing. Cold Spring Harb Perspect Biol. 2010 Sep;2(9):a001750. doi: 10.1101/cshperspect.a001750. Epub 2010 Jun 23. Review. PubMed PMID: 20573716; PubMed Central PMCID: PMC2926746.

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Martin SM, O'Brien GS, Portera-Cailliau C, Sagasti A. Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning. Development. 2010 Dec;137(23):3985-94. doi: 10.1242/dev.053611. Epub 2010 Nov 1. PubMed PMID: 21041367; PubMed Central PMCID: PMC2976282.

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Issa FA, O'Brien G, Kettunen P, Sagasti A, Glanzman DL, Papazian DM. Neural circuit activity in freely behaving zebrafish (Danio rerio). J Exp Biol. 2011 Mar 15;214(Pt 6):1028-38. doi: 10.1242/jeb.048876. PubMed PMID: 21346131; PubMed Central PMCID: PMC3044078.

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Rieger S, Sagasti A. Hydrogen peroxide promotes injury-induced peripheral sensory axon regeneration in the zebrafish skin. PLoS Biol. 2011 May;9(5):e1000621. doi: 10.1371/journal.pbio.1000621. Epub 2011 May 24. PubMed PMID: 21629674; PubMed Central PMCID: PMC3101194.

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Rieger S, Wang F, Sagasti A. Time-lapse imaging of neural development: zebrafish lead the way into the fourth dimension. Genesis. 2011 Jul;49(7):534-45. doi: 10.1002/dvg.20729. Epub 2011 Apr 2. Review. PubMed PMID: 21305690; PubMed Central PMCID: PMC3132295.

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O'Brien GS, Rieger S, Wang F, Smolen GA, Gonzalez RE, Buchanan J, Sagasti A. Coordinate development of skin cells and cutaneous sensory axons in zebrafish. J Comp Neurol. 2012 Mar 1;520(4):816-31. doi: 10.1002/cne.22791. PubMed PMID: 22020759; PubMed Central PMCID: PMC4299821.

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Wang F, Wolfson SN, Gharib A, Sagasti A. LAR receptor tyrosine phosphatases and HSPGs guide peripheral sensory axons to the skin. Curr Biol. 2012 Mar 6;22(5):373-82. doi: 10.1016/j.cub.2012.01.040. Epub 2012 Feb 9. PubMed PMID: 22326027; PubMed Central PMCID: PMC3298620.

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Villegas R, Martin SM, O'Donnell KC, Carrillo SA, Sagasti A, Allende ML. Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types. Neural Dev. 2012 Jun 8;7:19. doi: 10.1186/1749-8104-7-19. PubMed PMID: 22681863; PubMed Central PMCID: PMC3780720.

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Issa FA, Mock AF, Sagasti A, Papazian DM. Spinocerebellar ataxia type 13 mutation that is associated with disease onset in infancy disrupts axonal pathfinding during neuronal development. Dis Model Mech. 2012 Nov;5(6):921-9. doi: 10.1242/dmm.010157. Epub 2012 Jun 26. PubMed PMID: 22736459; PubMed Central PMCID: PMC3484873.

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Fitzmaurice AG, Rhodes SL, Lulla A, Murphy NP, Lam HA, O'Donnell KC, Barnhill L, Casida JE, Cockburn M, Sagasti A, Stahl MC, Maidment NT, Ritz B, Bronstein JM. Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):636-41. doi: 10.1073/pnas.1220399110. Epub 2012 Dec 24. PubMed PMID: 23267077; PubMed Central PMCID: PMC3545765.

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Palanca AM, Sagasti A. Optogenetic activation of zebrafish somatosensory neurons using ChEF-tdTomato. J Vis Exp. 2013 Jan 31;(71):e50184. doi: 10.3791/50184. PubMed PMID: 23407374; PubMed Central PMCID: PMC3596911.

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Palanca AM, Lee SL, Yee LE, Joe-Wong C, Trinh le A, Hiroyasu E, Husain M, Fraser SE, Pellegrini M, Sagasti A. New transgenic reporters identify somatosensory neuron subtypes in larval zebrafish. Dev Neurobiol. 2013 Feb;73(2):152-67. doi: 10.1002/dneu.22049. Epub 2012 Sep 27. PubMed PMID: 22865660; PubMed Central PMCID: PMC3541445.

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Wang F, Julien DP, Sagasti A. Journey to the skin: Somatosensory peripheral axon guidance and morphogenesis. Cell Adh Migr. 2013 Jul-Aug;7(4):388-94. doi: 10.4161/cam.25000. Epub 2013 May 13. Review. PubMed PMID: 23670092; PubMed Central PMCID: PMC3739816.

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O'Donnell KC, Vargas ME, Sagasti A. WldS and PGC-1α regulate mitochondrial transport and oxidation state after axonal injury. J Neurosci. 2013 Sep 11;33(37):14778-90. doi: 10.1523/JNEUROSCI.1331-13.2013. PubMed PMID: 24027278; PubMed Central PMCID: PMC3771034.

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O'Donnell KC, Lulla A, Stahl MC, Wheat ND, Bronstein JM, Sagasti A. Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity. Dis Model Mech. 2014 May;7(5):571-82. doi: 10.1242/dmm.013185. Epub 2014 Mar 13. PubMed PMID: 24626988; PubMed Central PMCID: PMC4007408.

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Chun RF, Blatter E, Elliott S, Fitz-Gibbon S, Rieger S, Sagasti A, Adams JS, Hewison M. Cloning of a functional 25-hydroxyvitamin D-1α-hydroxylase in zebrafish (Danio rerio). Cell Biochem Funct. 2014 Dec;32(8):675-82. doi: 10.1002/cbf.3071. Epub 2014 Oct 7. PubMed PMID: 25290078; PubMed Central PMCID: PMC4363119.

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Julien DP, Sagasti A. Synaptic specificity: when the neighbors are away, sensory axons turn promiscuous. Curr Biol. 2014 Dec 15;24(24):R1168-70. doi: 10.1016/j.cub.2014.11.004. PubMed PMID: 25514010.

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Rasmussen JP, Sack GS, Martin SM, Sagasti A. Vertebrate epidermal cells are broad-specificity phagocytes that clear sensory axon debris. J Neurosci. 2015 Jan 14;35(2):559-70. doi: 10.1523/JNEUROSCI.3613-14.2015. PubMed PMID: 25589751; PubMed Central PMCID: PMC4293411.

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Di Stefano M, Nascimento-Ferreira I, Orsomando G, Mori V, Gilley J, Brown R, Janeckova L, Vargas ME, Worrell LA, Loreto A, Tickle J, Patrick J, Webster JR, Marangoni M, Carpi FM, Pucciarelli S, Rossi F, Meng W, Sagasti A, Ribchester RR, Magni G, Coleman MP, Conforti L. A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration. Cell Death Differ. 2015 May;22(5):731-42. doi: 10.1038/cdd.2014.164. Epub 2014 Oct 17. PubMed PMID: 25323584; PubMed Central PMCID: PMC4392071.

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Vargas ME, Yamagishi Y, Tessier-Lavigne M, Sagasti A. Live Imaging of Calcium Dynamics during Axon Degeneration Reveals Two Functionally Distinct Phases of Calcium Influx. J Neurosci. 2015 Nov 11;35(45):15026-38. doi: 10.1523/JNEUROSCI.2484-15.2015. PubMed PMID: 26558774; PubMed Central PMCID: PMC4642236.

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Lulla A, Barnhill L, Bitan G, Ivanova MI, Nguyen B, O'Donnell K, Stahl MC, Yamashiro C, Klärner FG, Schrader T, Sagasti A, Bronstein JM. Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos. Environ Health Perspect. 2016 Nov;124(11):1766-1775. doi: 10.1289/EHP141. Epub 2016 Jun 15. PubMed PMID: 27301718; PubMed Central PMCID: PMC5089875.

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Rasmussen JP, Sagasti A. Learning to swim, again: Axon regeneration in fish. Exp Neurol. 2017 Jan;287(Pt 3):318-330. doi: 10.1016/j.expneurol.2016.02.022. Epub 2016 Mar 3. Review. PubMed PMID: 26940084.

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Madigan CA, Cambier CJ, Kelly-Scumpia KM, Scumpia PO, Cheng TY, Zailaa J, Bloom BR, Moody DB, Smale ST, Sagasti A, Modlin RL, Ramakrishnan L. A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy. Cell. 2017 Aug 24;170(5):973-985.e10. doi: 10.1016/j.cell.2017.07.030. PubMed PMID: 28841420; PubMed Central PMCID: PMC5848073.

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Rasmussen JP, Vo NT, Sagasti A. Fish Scales Dictate the Pattern of Adult Skin Innervation and Vascularization. Dev Cell. 2018 Aug 6;46(3):344-359.e4. doi: 10.1016/j.devcel.2018.06.019. Epub 2018 Jul 19. PubMed PMID: 30032992; PubMed Central PMCID: PMC6561483.

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Julien DP, Chan AW, Barrios J, Mathiaparanam J, Douglass A, Wolman MA, Sagasti A. Zebrafish expression reporters and mutants reveal that the IgSF cell adhesion molecule Dscamb is required for feeding and survival. J Neurogenet. 2018 Dec;32(4):336-352. doi: 10.1080/01677063.2018.1493479. Epub 2018 Sep 11. PubMed PMID: 30204029; PubMed Central PMCID: PMC6464818.

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Jiang N, Rasmussen JP, Clanton JA, Rosenberg MF, Luedke KP, Cronan MR, Parker ED, Kim HJ, Vaughan JC, Sagasti A, Parrish JZ. A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites. Elife. 2019 Mar 11;8. doi: 10.7554/eLife.42455. PubMed PMID: 30855229; PubMed Central PMCID: PMC6450671.

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Rosa JB, Sagasti A. Developmental Neurobiology: It Takes Nrg to Separate Dendrites. Curr Biol. 2019 May 6;29(9):R327-R329. doi: 10.1016/j.cub.2019.03.045. PubMed PMID: 31063725.

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Feng C, Thyagarajan P, Shorey M, Seebold DY, Weiner AT, Albertson RM, Rao KS, Sagasti A, Goetschius DJ, Rolls MM. Patronin-mediated minus end growth is required for dendritic microtubule polarity. J Cell Biol. 2019 Jul 1;218(7):2309-2328. doi: 10.1083/jcb.201810155. Epub 2019 May 10. PubMed PMID: 31076454; PubMed Central PMCID: PMC6605808.

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Cokus SJ, De La Torre M, Medina EF, Rasmussen JP, Ramirez-Gutierrez J, Sagasti A, Wang F. Tissue-Specific Transcriptomes Reveal Gene Expression Trajectories in Two Maturing Skin Epithelial Layers in Zebrafish Embryos. G3 (Bethesda). 2019 Oct 7;9(10):3439-3452. doi: 10.1534/g3.119.400402. PubMed PMID: 31431477; PubMed Central PMCID: PMC6778804.

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van Loon AP, Erofeev IS, Maryshev IV, Goryachev AB, Sagasti A. Cortical contraction drives the 3D patterning of epithelial cell surfaces. J Cell Biol. 2020 Mar 2;219(3). doi: 10.1083/jcb.201904144. PubMed PMID: 32003768; PubMed Central PMCID: PMC7054995.

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Inaba Y, Chauhan V, van Loon AP, Choudhury LS, Sagasti A. Keratins and the plakin family cytolinker proteins control the length of epithelial microridge protrusions. Elife. 2020 Sep 7;9. doi: 10.7554/eLife.58149. PubMed PMID: 32894222; PubMed Central PMCID: PMC7535935.

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van Loon AP, Erofeev IS, Goryachev AB, Sagasti A. Stochastic contraction of myosin minifilaments drives evolution of microridge protrusion patterns in epithelial cells. Mol Biol Cell. 2021 Aug 1;32(16):1501-1513. doi: 10.1091/mbc.E21-05-0258. Epub 2021 Jun 3. PubMed PMID: 34081537; PubMed Central PMCID: PMC8351741.

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Shorey M, Rao K, Stone MC, Mattie FJ, Sagasti A, Rolls MM. Microtubule organization of vertebrate sensory neurons in vivo. Dev Biol. 2021 Oct;478:1-12. doi: 10.1016/j.ydbio.2021.06.007. Epub 2021 Jun 18. PubMed PMID: 34147472; PubMed Central PMCID: PMC8364508.

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Lu TQ, van Loon AP, Sagasti A. How to wrinkle a cell: Emerging mechanisms of microridge morphogenesis. Curr Opin Cell Biol. 2022 Jun;76:102088. doi: 10.1016/j.ceb.2022.102088. Epub 2022 May 12. Review. PubMed PMID: 35569260.

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Adula KP, Shorey M, Chauhan V, Nassman K, Chen SF, Rolls MM, Sagasti A. The MAP3Ks DLK and LZK Direct Diverse Responses to Axon Damage in Zebrafish Peripheral Neurons. J Neurosci. 2022 Aug 10;42(32):6195-6210. doi: 10.1523/JNEUROSCI.1395-21.2022. Epub 2022 Jul 15. PubMed PMID: 35840323; PubMed Central PMCID: PMC9374156.

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Adula KP, Sagasti A. Live Imaging of Axonal Dynamics After Laser Axotomy of Peripheral Neurons in Zebrafish. Methods Mol Biol. 2023;2636:247-261. doi: 10.1007/978-1-0716-3012-9_14. PubMed PMID: 36881305.

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Rosa JB, Nassman KY, Sagasti A. Sensory axons induce epithelial lipid microdomain remodeling and determine the distribution of junctions in the epidermis. Mol Biol Cell. 2023 Jan 1;34(1):ar5. doi: 10.1091/mbc.E22-09-0396. Epub 2022 Nov 2. PubMed PMID: 36322392; PubMed Central PMCID: PMC9816649.