My Bibliography

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Hornemann U, Speedie MK, Kelley KM, Hurley LH, Floss HG. Biosynthesis of indoleisopropionic acid by Claviceps. Biological C-methylation involving an intact methyl group. Arch Biochem Biophys. 1969 May;131(2):430-40. doi: 10.1016/0003-9861(69)90415-9. PubMed PMID: 5787216.

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Hornemann U, Speedie MK, Hurley LH, Floss HG. Demonstration of a C-methylating enzyme in cell free extracts of indolmycin-producing Streptomyces griseus. Biochem Biophys Res Commun. 1970 May 22;39(4):594-9. doi: 10.1016/0006-291x(70)90245-7. PubMed PMID: 5490210.

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Hornemann U, Hurley LH, Speedie MK, Floss HG. Isolation and absolute configuration of indolmycenic acid, an intermediate in the biosynthesis of indolmycin by Streptomyces griseus. Tetrahedron Lett. 1970 Jun;(26):2255-8. doi: 10.1016/s0040-4039(01)98202-4. PubMed PMID: 5447649.

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Hornemann U, Hurley LH, Speedie MK, Floss HG. The biosynthesis of indolmycin. J Am Chem Soc. 1971 Jun 16;93(12):3028-35. doi: 10.1021/ja00741a035. PubMed PMID: 5095271.

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Hurley LH, Bialek D. Regulation of antibiotic production: catabolite inhibition and the dualistic effect of glucose on indolmycin production. J Antibiot (Tokyo). 1974 Jan;27(1):49-56. doi: 10.7164/antibiotics.27.49. PubMed PMID: 4210488.

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Hurley LH, Zmijewski M, Chang CJ. Biosynthesis of anthramycin. Determination of the labeling pattern by the use of radioactive and stable isotope techniques. J Am Chem Soc. 1975 Jul 23;97(15):4372-8. doi: 10.1021/ja00848a040. PubMed PMID: 1141599.

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Chang CJ, Floss HG, Hurley LH, Zmijewski M. Application of long-range spin-spin couplings in biosynthetic studies. J Org Chem. 1976 Aug 20;41(17):2932-4. doi: 10.1021/jo00879a033. PubMed PMID: 956946.

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Hurley LH, Gairola C, Das NV. Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic 11-demethyltomaymycin and its biologically inactive metabolite oxotomaymycin by Streptomyces achromogenes. Biochemistry. 1976 Aug 24;15(17):3760-9. doi: 10.1021/bi00662a019. PubMed PMID: 1085163.

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Hurley LH, Gairola C, Zmijewski M. Pyrrolo(1,4)benzodiazepine antitumor antibiotics. In vitro interaction of anthramycin, sibiromycin and tomaymycin with DNA using specifically radiolabelled molecules. Biochim Biophys Acta. 1977 Apr 4;475(3):521-35. doi: 10.1016/0005-2787(77)90067-3. PubMed PMID: 15599.

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Hurley LH. Pyrrolo(1,4)benzodiazepine antitumor antibiotics. Comparative aspects of anthramycin, tomaymycin and sibiromycin. J Antibiot (Tokyo). 1977 May;30(5):349-70. doi: 10.7164/antibiotics.30.349. Review. PubMed PMID: 328469.

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Hannan MA, Hurley LH, Gairola C. Mutagenic and recombinogenic effects of the antitumor antibiotic anthramycin. Cancer Res. 1978 Sep;38(9):2795-9. PubMed PMID: 354779.

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Hannan MA, Hurley LH. Pathways of DNA repair operating in yeast treated with the pyrrolo(1,4)-benzodiazepine antitumor antibiotics. J Antibiot (Tokyo). 1978 Sep;31(9):911-3. doi: 10.7164/antibiotics.31.911. PubMed PMID: 361666.

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Hurley LH, Gairola C. Pyrrolo (1,4) benzodiazepine antitumor antibiotics: Biosynthetic studies on the conversion of tryptophan to the anthranilic acid moieties of sibiromycin and tomaymycin. Antimicrob Agents Chemother. 1979 Jan;15(1):42-5. doi: 10.1128/AAC.15.1.42. PubMed PMID: 581831; PubMed Central PMCID: PMC352597.

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Hurley LH, Chandler C, Garner TF, Petrusek R, Zimmer SG. DNA binding, induction of unscheduled DNA synthesis, and excision of anthramycin from DNA in normal and repair-deficient human fibroblasts. J Biol Chem. 1979 Feb 10;254(3):605-8. PubMed PMID: 762084.

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Lubawy WC, Whaley J, Hurley LH. Coenzyme Q10 or alpha-tocopherol reduce the acute toxicity of anthramycin in mice. Res Commun Chem Pathol Pharmacol. 1979 May;24(2):401-4. PubMed PMID: 461995.

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Hurley LH, Allen CS, Feola JM, Lubawy WC. In vitro and in vivo stability of anthramycin-DNA conjugate and its potential application as an anthramycin prodrug. Cancer Res. 1979 Aug;39(8):3134-40. PubMed PMID: 455297.

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Hurley LH, Lasswell WL, Malhotra RK, Das NV. Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic sibiromycin by Streptosporangium sibiricum. Biochemistry. 1979 Sep 18;18(19):4225-9. doi: 10.1021/bi00586a029. PubMed PMID: 582800.

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Hurley LH, Lasswell WL, Ostrander JM, Parry R. Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthetic conversion of tyrosine to the C2- and C3-proline moieties of anthramycin, tomaymycin, and sibiromycin. Biochemistry. 1979 Sep 18;18(19):4230-7. doi: 10.1021/bi00586a030. PubMed PMID: 582801.

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Hurley LH, Petrusek R. Proposed structure of the anthramycin-DNA adduct. Nature. 1979 Nov 29;282(5738):529-31. doi: 10.1038/282529a0. PubMed PMID: 503235.

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Lubawy WC, Dallam RA, Hurley LH. Protection against anthramycin-induced toxicity in mice by coenzyme Q10. J Natl Cancer Inst. 1980 Jan;64(1):105-9. PubMed PMID: 6928034.

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Hannan MA, Estes RS, Hurley LH. Induction and potentiation of lethal and genetic effects of ultraviolet light by tobacco smoke condensates in yeast. Environ Res. 1980 Feb;21(1):97-107. doi: 10.1016/0013-9351(80)90012-2. PubMed PMID: 6993205.

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Hurley LH, Rokem JS, Petrusek RL. Proposed structures of the pyrrolo(1,4)benzodiazepine antibiotic-deoxyribonucleic acid adducts. Biochem Pharmacol. 1980 May 1;29(9):1307-10. doi: 10.1016/0006-2952(80)90291-9. PubMed PMID: 7397015.

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Ostrander JM, Hurley LH, McInnes AG, Smith DG, Walter JA, Wright JL. Proof for the biosynthetic conversion of L-[indole-15N]tryptophan to [10-15N]anthramycin using (13C, 15N) labelling in conjunction with 13C-NMR and mass spectral analysis. J Antibiot (Tokyo). 1980 Oct;33(10):1167-71. doi: 10.7164/antibiotics.33.1167. PubMed PMID: 7451368.

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Malhotra RK, Ostrander JM, Hurley LH, McInnes AG, Smith DG, Walter JA, Wright JL. Chemical conversion of anthramycin 11-methyl ether to didehydroanhydroanthramycin and its utilization in studies of the biosynthesis and mechanism of action of anthramycin. J Nat Prod. 1981 Jan-Feb;44(1):38-44. doi: 10.1021/np50013a007. PubMed PMID: 7217948.

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Petrusek RL, Anderson GL, Garner TF, Fannin QL, Kaplan DJ, Zimmer SG, Hurley LH. Pyrrol[1,4]benzodiazepine antibiotics. Proposed structures and characteristics of the in vitro deoxyribonucleic acid adducts of anthramycin, tomaymycin, sibiromycin, and neothramycins A and B. Biochemistry. 1981 Mar 3;20(5):1111-9. doi: 10.1021/bi00508a011. PubMed PMID: 6261786.

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Rokem JS, Hurley LH. Sensitivity and permeability of the anthramycin producing organism Streptomyces refuineus to anthramycin and structurally related antibiotics. J Antibiot (Tokyo). 1981 Sep;34(9):1171-4. doi: 10.7164/antibiotics.34.1171. PubMed PMID: 6895748.

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Kaplan DJ, Hurley LH. Anthramycin binding to deoxyribonucleic acid-mitomycin C complexes. Evidence for drug-induced deoxyribonucleic acid conformational change and cooperativity in mitomycin C binding. Biochemistry. 1981 Dec 22;20(26):7572-80. doi: 10.1021/bi00529a036. PubMed PMID: 6798992.

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Petrusek RL, Uhlenhopp EL, Duteau N, Hurley LH. Reaction of anthramycin with DNA. Biological consequences of DNA damage in normal and xeroderma pigmentosum cell. J Biol Chem. 1982 Jun 10;257(11):6207-16. PubMed PMID: 7076670.

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Swenson DH, Li LH, Hurley LH, Rokem JS, Petzold GL, Dayton BD, Wallace TL, Lin AH, Krueger WC. Mechanism of interaction of CC-1065 (NSC 298223) with DNA. Cancer Res. 1982 Jul;42(7):2821-8. PubMed PMID: 7083173.

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Reynolds VL, Hurley LH. Comparison of properties of the in vitro and cellular anthramycin-DNA adducts and characterization of the reaction of anthramycin with chromatin. Chem Biol Interact. 1982 Nov;42(2):141-51. doi: 10.1016/0009-2797(82)90128-4. PubMed PMID: 7151226.

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Hurley LH, Rokem JS. Biosynthesis of the antitumor antibiotic CC-1065 by Streptomyces zelensis. J Antibiot (Tokyo). 1983 Apr;36(4):383-90. doi: 10.7164/antibiotics.36.383. PubMed PMID: 6406412.

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Hurley LH, Thurston DE. Pyrrolo(l ,4)benzodiazepine Antitumor Antibiotics: Chemistry, Interaction with DNA, and Biological Implications. Pharm Res. 1984 Mar;1(2):52-9. doi: 10.1023/A:1016395113085. PubMed PMID: 24277212.

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Graves DE, Pattaroni C, Krishnan BS, Ostrander JM, Hurley LH, Krugh TR. The reaction of anthramycin with DNA. Proton and carbon nuclear magnetic resonance studies on the structure of the anthramycin-DNA adduct. J Biol Chem. 1984 Jul 10;259(13):8202-9. PubMed PMID: 6736032.

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Needham-VanDevanter DR, Hurley LH, Reynolds VL, Theriault NY, Krueger WC, Wierenga W. Characterization of an adduct between CC-1065 and a defined oligodeoxynucleotide duplex. Nucleic Acids Res. 1984 Aug 10;12(15):6159-68. doi: 10.1093/nar/12.15.6159. PubMed PMID: 6473105; PubMed Central PMCID: PMC320064.

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Hurley LH, Reynolds VL, Swenson DH, Petzold GL, Scahill TA. Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity. Science. 1984 Nov 16;226(4676):843-4. doi: 10.1126/science.6494915. PubMed PMID: 6494915.

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Reynolds VL, Molineux IJ, Kaplan DJ, Swenson DH, Hurley LH. Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity. Biochemistry. 1985 Oct 22;24(22):6228-37. doi: 10.1021/bi00343a029. PubMed PMID: 3002434.

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Hurley LH, Needham-VanDevanter DR. Sequence specificity and biological consequences of drugs that bind covalently in the minor groove of DNA. Basic Life Sci. 1986;38:203-10. doi: 10.1007/978-1-4615-9462-8_21. PubMed PMID: 3741332.

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Reynolds VL, McGovren JP, Hurley LH. The chemistry, mechanism of action and biological properties of CC-1065, a potent antitumor antibiotic. J Antibiot (Tokyo). 1986 Mar;39(3):319-34. doi: 10.7164/antibiotics.39.319. Review. PubMed PMID: 3516958.

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Hertzberg RP, Hecht SM, Reynolds VL, Molineux IJ, Hurley LH. DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs. Biochemistry. 1986 Mar 25;25(6):1249-58. doi: 10.1021/bi00354a009. PubMed PMID: 3008824.

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Barkley MD, Cheatham S, Thurston DE, Hurley LH. Pyrrolo[1,4]benzodiazepine antitumor antibiotics: evidence for two forms of tomaymycin bound to DNA. Biochemistry. 1986 May 20;25(10):3021-31. doi: 10.1021/bi00358a043. PubMed PMID: 3718937.

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Jacobson MK, Twehous D, Hurley LH. Depletion of nicotinamide adenine dinucleotide in normal and xeroderma pigmentosum fibroblast cells by the antitumor drug CC-1065. Biochemistry. 1986 Oct 7;25(20):5929-32. doi: 10.1021/bi00368a014. PubMed PMID: 3790494.

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Needham-VanDevanter DR, Hurley LH. Construction and characterization of a site-directed CC-1065-N3-adenine adduct within a 117 base pair DNA restriction fragment. Biochemistry. 1986 Dec 30;25(26):8430-6. doi: 10.1021/bi00374a016. PubMed PMID: 3030397.

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Hurley LH, Needham-VanDevanter DR, Lee CS. Demonstration of the asymmetric effect of CC-1065 on local DNA structure using a site-directed adduct in a 117-base-pair fragment from M13mp1. Proc Natl Acad Sci U S A. 1987 Sep;84(18):6412-6. doi: 10.1073/pnas.84.18.6412. PubMed PMID: 2819875; PubMed Central PMCID: PMC299086.

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Hurley LH. Molecular biology and medicinal chemistry. J Med Chem. 1987 Oct;30(10):7A-8A. PubMed PMID: 3656367.

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Tang MS, Lee CS, Doisy R, Ross L, Needham-VanDevanter DR, Hurley LH. Recognition and repair of the CC-1065-(N3-adenine)-DNA adduct by the UVRABC nucleases. Biochemistry. 1988 Feb 9;27(3):893-901. doi: 10.1021/bi00403a009. PubMed PMID: 2966637.

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Cheatham S, Kook A, Hurley LH, Barkley MD, Remers W. One- and two-dimensional 1H NMR, fluorescence, and molecular modeling studies on the tomaymycin-d(ATGCAT)2 adduct. Evidence for two covalent adducts with opposite orientations and stereochemistries at the covalent linkage site. J Med Chem. 1988 Mar;31(3):583-90. doi: 10.1021/jm00398a016. PubMed PMID: 3346874.

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Hurley LH, Lee CS, McGovren JP, Warpehoski MA, Mitchell MA, Kelly RC, Aristoff PA. Reaction of CC-1065 and select synthetic analogs with DNA. Biochem Pharmacol. 1988 May 1;37(9):1795-6. doi: 10.1016/0006-2952(88)90450-9. PubMed PMID: 3377837.

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Hurley LH, Lee CS, McGovren JP, Warpehoski MA, Mitchell MA, Kelly RC, Aristoff PA. Molecular basis for sequence-specific DNA alkylation by CC-1065. Biochemistry. 1988 May 17;27(10):3886-92. doi: 10.1021/bi00410a054. PubMed PMID: 3408734.

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Hurley LH, Reck T, Thurston DE, Langley DR, Holden KG, Hertzberg RP, Hoover JR, Gallagher G Jr, Faucette LF, Mong SM. Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds. Chem Res Toxicol. 1988 Sep-Oct;1(5):258-68. doi: 10.1021/tx00005a002. PubMed PMID: 2979741.

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Hurley LH, Boyd FL. DNA as a target for drug action. Trends Pharmacol Sci. 1988 Nov;9(11):402-7. doi: 10.1016/0165-6147(88)90067-3. Review. PubMed PMID: 3078076.