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Kawada Y, Khan M, Sharma AK, Ratnayake DB, Dobashi K, Asayama K, Moser HW, Contreras MA, Singh I. Inhibition of peroxisomal functions due to oxidative imbalance induced by mistargeting of catalase to cytoplasm is restored by vitamin E treatment in skin fibroblasts from Zellweger syndrome-like patients. Mol Genet Metab. 2004 Dec;83(4):297-305. doi: 10.1016/j.ymgme.2004.07.012. PubMed PMID: 15589116.
Lohr HR, Kuntchithapautham K, Sharma AK, Rohrer B. Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death. Exp Eye Res. 2006 Aug;83(2):380-9. doi: 10.1016/j.exer.2006.01.014. Epub 2006 Apr 19. PubMed PMID: 16626700.
Zhao M, Fernandez LG, Doctor A, Sharma AK, Zarbock A, Tribble CG, Kron IL, Laubach VE. Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L1018-26. doi: 10.1152/ajplung.00086.2006. Epub 2006 Jul 21. PubMed PMID: 16861385.
Sharma AK, Rohrer B. Sustained elevation of intracellular cGMP causes oxidative stress triggering calpain-mediated apoptosis in photoreceptor degeneration. Curr Eye Res. 2007 Mar;32(3):259-69. doi: 10.1080/02713680601161238. PubMed PMID: 17453946.
Sharma AK, Fernandez LG, Awad AS, Kron IL, Laubach VE. Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L105-13. doi: 10.1152/ajplung.00470.2006. Epub 2007 Apr 6. PubMed PMID: 17416740.
Lisle TC, Gazoni LM, Fernandez LG, Sharma AK, Bellizzi AM, Shifflett GD, Laubach VE, Kron IL. Inflammatory lung injury after cardiopulmonary bypass is attenuated by adenosine A(2A) receptor activation. J Thorac Cardiovasc Surg. 2008 Nov;136(5):1280-7; discussion 1287-8. doi: 10.1016/j.jtcvs.2008.07.010. Epub 2008 Aug 30. PubMed PMID: 19026816; PubMed Central PMCID: PMC2652167.
Yang Z, Sharma AK, Marshall M, Kron IL, Laubach VE. NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury. Am J Respir Cell Mol Biol. 2009 Mar;40(3):375-81. doi: 10.1165/rcmb.2008-0300OC. Epub 2008 Sep 11. PubMed PMID: 18787174; PubMed Central PMCID: PMC2645535.
Yang Z, Sharma AK, Linden J, Kron IL, Laubach VE. CD4+ T lymphocytes mediate acute pulmonary ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2009 Mar;137(3):695-702; discussion 702. doi: 10.1016/j.jtcvs.2008.10.044. PubMed PMID: 19258091; PubMed Central PMCID: PMC2670927.
Lau CL, Zhao Y, Kim J, Kron IL, Sharma A, Yang Z, Laubach VE, Linden J, Ailawadi G, Pinsky DJ. Enhanced fibrinolysis protects against lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2009 May;137(5):1241-8. doi: 10.1016/j.jtcvs.2008.12.029. PubMed PMID: 19379998; PubMed Central PMCID: PMC2752840.
Sharma AK, Linden J, Kron IL, Laubach VE. Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. Respir Res. 2009 Jun 26;10(1):58. doi: 10.1186/1465-9921-10-58. PubMed PMID: 19558673; PubMed Central PMCID: PMC2711962.
Sharma AK, Laubach VE, Ramos SI, Zhao Y, Stukenborg G, Linden J, Kron IL, Yang Z. Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2010 Feb;139(2):474-82. doi: 10.1016/j.jtcvs.2009.08.033. Epub 2009 Nov 11. PubMed PMID: 19909990; PubMed Central PMCID: PMC2813368.
Anvari F, Sharma AK, Fernandez LG, Hranjec T, Ravid K, Kron IL, Laubach VE. Tissue-derived proinflammatory effect of adenosine A2B receptor in lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2010 Oct;140(4):871-7. doi: 10.1016/j.jtcvs.2010.06.051. Epub 2010 Jul 24. PubMed PMID: 20659747; PubMed Central PMCID: PMC2943004.
Zhao Y, Sharma AK, LaPar DJ, Kron IL, Ailawadi G, Liu Y, Jones DR, Laubach VE, Lau CL. Depletion of tissue plasminogen activator attenuates lung ischemia-reperfusion injury via inhibition of neutrophil extravasation. Am J Physiol Lung Cell Mol Physiol. 2011 May;300(5):L718-29. doi: 10.1152/ajplung.00227.2010. Epub 2011 Mar 4. PubMed PMID: 21378024; PubMed Central PMCID: PMC3094027.
Sharma AK, LaPar DJ, Zhao Y, Li L, Lau CL, Kron IL, Iwakura Y, Okusa MD, Laubach VE. Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury. Am J Respir Crit Care Med. 2011 Jun 1;183(11):1539-49. doi: 10.1164/rccm.201007-1173OC. Epub 2011 Feb 11. PubMed PMID: 21317314; PubMed Central PMCID: PMC3137143.
Sun J, Cardani A, Sharma AK, Laubach VE, Jack RS, Müller W, Braciale TJ. Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus. PLoS Pathog. 2011 Aug;7(8):e1002173. doi: 10.1371/journal.ppat.1002173. Epub 2011 Aug 4. PubMed PMID: 21829368; PubMed Central PMCID: PMC3150291.
LaPar DJ, Laubach VE, Emaminia A, Crosby IK, Hajzus VA, Sharma AK, Sumner HM, Webb DV, Lau CL, Kron IL. Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model. J Thorac Cardiovasc Surg. 2011 Oct;142(4):887-94. doi: 10.1016/j.jtcvs.2011.06.015. Epub 2011 Jul 16. PubMed PMID: 21762933; PubMed Central PMCID: PMC3212732.
Lapar DJ, Hajzus VA, Zhao Y, Lau CL, French BA, Kron IL, Sharma AK, Laubach VE. Acute hyperglycemic exacerbation of lung ischemia-reperfusion injury is mediated by receptor for advanced glycation end-products signaling. Am J Respir Cell Mol Biol. 2012 Mar;46(3):299-305. doi: 10.1165/rcmb.2011-0247OC. Epub 2011 Oct 6. PubMed PMID: 21980055; PubMed Central PMCID: PMC3326427.
Sharma AK, Lu G, Jester A, Johnston WF, Zhao Y, Hajzus VA, Saadatzadeh MR, Su G, Bhamidipati CM, Mehta GS, Kron IL, Laubach VE, Murphy MP, Ailawadi G, Upchurch GR Jr. Experimental abdominal aortic aneurysm formation is mediated by IL-17 and attenuated by mesenchymal stem cell treatment. Circulation. 2012 Sep 11;126(11 Suppl 1):S38-45. doi: 10.1161/CIRCULATIONAHA.111.083451. PubMed PMID: 22965992; PubMed Central PMCID: PMC3448933.
Mulloy DP, Stone ML, Crosby IK, Lapar DJ, Sharma AK, Webb DV, Lau CL, Laubach VE, Kron IL. Ex vivo rehabilitation of non-heart-beating donor lungs in preclinical porcine model: delayed perfusion results in superior lung function. J Thorac Cardiovasc Surg. 2012 Nov;144(5):1208-15. doi: 10.1016/j.jtcvs.2012.07.056. Epub 2012 Aug 31. PubMed PMID: 22944084; PubMed Central PMCID: PMC3477251.
Juncadella IJ, Kadl A, Sharma AK, Shim YM, Hochreiter-Hufford A, Borish L, Ravichandran KS. Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation. Nature. 2013 Jan 24;493(7433):547-51. doi: 10.1038/nature11714. Epub 2012 Dec 12. PubMed PMID: 23235830; PubMed Central PMCID: PMC3662023.
Mulloy DP, Sharma AK, Fernandez LG, Zhao Y, Lau CL, Kron IL, Laubach VE. Adenosine A3 receptor activation attenuates lung ischemia-reperfusion injury. Ann Thorac Surg. 2013 May;95(5):1762-7. doi: 10.1016/j.athoracsur.2013.01.059. Epub 2013 Mar 28. PubMed PMID: 23541429; PubMed Central PMCID: PMC3725313.
Fernandez LG, Sharma AK, LaPar DJ, Kron IL, Laubach VE. Adenosine A1 receptor activation attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2013 Jun;145(6):1654-9. doi: 10.1016/j.jtcvs.2013.01.006. Epub 2013 Feb 8. PubMed PMID: 23398646; PubMed Central PMCID: PMC3657333.
Bhamidipati CM, Mehta GS, Moehle CW, Meher AK, Su G, Vigneshwar NG, Barbery C, Sharma AK, Kron IL, Laubach VE, Owens GK, Upchurch GR Jr, Ailawadi G. Adenosine 2A receptor modulates inflammation and phenotype in experimental abdominal aortic aneurysms. FASEB J. 2013 Jun;27(6):2122-31. doi: 10.1096/fj.12-214197. Epub 2013 Feb 14. PubMed PMID: 23413358; PubMed Central PMCID: PMC3659365.
Sharma AK, LaPar DJ, Stone ML, Zhao Y, Kron IL, Laubach VE. Receptor for advanced glycation end products (RAGE) on iNKT cells mediates lung ischemia-reperfusion injury. Am J Transplant. 2013 Sep;13(9):2255-67. doi: 10.1111/ajt.12368. Epub 2013 Jul 19. PubMed PMID: 23865790; PubMed Central PMCID: PMC3776006.
Sharma AK, Mulloy DP, Le LT, Laubach VE. NADPH oxidase mediates synergistic effects of IL-17 and TNF-α on CXCL1 expression by epithelial cells after lung ischemia-reperfusion. Am J Physiol Lung Cell Mol Physiol. 2014 Jan 1;306(1):L69-79. doi: 10.1152/ajplung.00205.2013. Epub 2013 Nov 1. PubMed PMID: 24186876; PubMed Central PMCID: PMC3920214.
English SJ, Piert MR, Diaz JA, Gordon D, Ghosh A, DʼAlecy LG, Whitesall SE, Sharma AK, DeRoo EP, Watt T, Su G, Henke PK, Eliason JL, Ailawadi G, Upchurch GR Jr. Increased 18F-FDG uptake is predictive of rupture in a novel rat abdominal aortic aneurysm rupture model. Ann Surg. 2015 Feb;261(2):395-404. doi: 10.1097/SLA.0000000000000602. PubMed PMID: 24651130; PubMed Central PMCID: PMC4662083.
Stone ML, Sharma AK, Zhao Y, Charles EJ, Huerter ME, Johnston WF, Kron IL, Lynch KR, Laubach VE. Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 15;308(12):L1245-52. doi: 10.1152/ajplung.00302.2014. Epub 2015 Apr 24. PubMed PMID: 25910934; PubMed Central PMCID: PMC4587601.
Davis JP, Salmon M, Pope NH, Lu G, Su G, Sharma AK, Ailawadi G, Upchurch GR Jr. Attenuation of aortic aneurysms with stem cells from different genders. J Surg Res. 2015 Nov;199(1):249-58. doi: 10.1016/j.jss.2015.04.025. Epub 2015 Apr 14. PubMed PMID: 25958166; PubMed Central PMCID: PMC4604010.
Gehrau RC, Mas VR, Dumur CI, Suh JL, Sharma AK, Cathro HP, Maluf DG. Donor Hepatic Steatosis Induce Exacerbated Ischemia-Reperfusion Injury Through Activation of Innate Immune Response Molecular Pathways. Transplantation. 2015 Dec;99(12):2523-33. doi: 10.1097/TP.0000000000000857. PubMed PMID: 26285018; PubMed Central PMCID: PMC4668234.
Stone ML, Sharma AK, Mas VR, Gehrau RC, Mulloy DP, Zhao Y, Lau CL, Kron IL, Huerter ME, Laubach VE. Ex Vivo Perfusion With Adenosine A2A Receptor Agonist Enhances Rehabilitation of Murine Donor Lungs After Circulatory Death. Transplantation. 2015 Dec;99(12):2494-503. doi: 10.1097/TP.0000000000000830. PubMed PMID: 26262504; PubMed Central PMCID: PMC4668207.
Wagner CE, Pope NH, Charles EJ, Huerter ME, Sharma AK, Salmon MD, Carter BT, Stoler MH, Lau CL, Laubach VE, Kron IL. Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death. J Thorac Cardiovasc Surg. 2016 Feb;151(2):538-45. doi: 10.1016/j.jtcvs.2015.07.075. Epub 2015 Jul 30. PubMed PMID: 26323621; PubMed Central PMCID: PMC4728036.
Sharma AK, LaPar DJ, Stone ML, Zhao Y, Mehta CK, Kron IL, Laubach VE. NOX2 Activation of Natural Killer T Cells Is Blocked by the Adenosine A2A Receptor to Inhibit Lung Ischemia-Reperfusion Injury. Am J Respir Crit Care Med. 2016 May 1;193(9):988-99. doi: 10.1164/rccm.201506-1253OC. PubMed PMID: 26757359; PubMed Central PMCID: PMC4872653.
Sharma AK, Salmon MD, Lu G, Su G, Pope NH, Smith JR, Weiss ML, Upchurch GR Jr. Mesenchymal Stem Cells Attenuate NADPH Oxidase-Dependent High Mobility Group Box 1 Production and Inhibit Abdominal Aortic Aneurysms. Arterioscler Thromb Vasc Biol. 2016 May;36(5):908-18. doi: 10.1161/ATVBAHA.116.307373. Epub 2016 Mar 17. PubMed PMID: 26988591; PubMed Central PMCID: PMC4861899.
Laubach VE, Sharma AK. Mechanisms of lung ischemia-reperfusion injury. Curr Opin Organ Transplant. 2016 Jun;21(3):246-52. doi: 10.1097/MOT.0000000000000304. Review. PubMed PMID: 26945320; PubMed Central PMCID: PMC4861054.
Huerter ME, Sharma AK, Zhao Y, Charles EJ, Kron IL, Laubach VE. Attenuation of Pulmonary Ischemia-Reperfusion Injury by Adenosine A2B Receptor Antagonism. Ann Thorac Surg. 2016 Aug;102(2):385-393. doi: 10.1016/j.athoracsur.2016.02.060. Epub 2016 Apr 22. PubMed PMID: 27109193; PubMed Central PMCID: PMC4958568.
Charles EJ, Huerter ME, Wagner CE, Sharma AK, Zhao Y, Stoler MH, Mehaffey JH, Isbell JM, Lau CL, Tribble CG, Laubach VE, Kron IL. Donation After Circulatory Death Lungs Transplantable Up to Six Hours After Ex Vivo Lung Perfusion. Ann Thorac Surg. 2016 Dec;102(6):1845-1853. doi: 10.1016/j.athoracsur.2016.06.043. Epub 2016 Sep 7. PubMed PMID: 27614736; PubMed Central PMCID: PMC5112144.
Mehaffey JH, Charles EJ, Sharma AK, Money DT, Zhao Y, Stoler MH, Lau CL, Tribble CG, Laubach VE, Roeser ME, Kron IL. Airway pressure release ventilation during ex vivo lung perfusion attenuates injury. J Thorac Cardiovasc Surg. 2017 Jan;153(1):197-204. doi: 10.1016/j.jtcvs.2016.09.029. Epub 2016 Sep 22. PubMed PMID: 27742245; PubMed Central PMCID: PMC5164862.
Cronk JC, Herz J, Kim TS, Louveau A, Moser EK, Sharma AK, Smirnov I, Tung KS, Braciale TJ, Kipnis J. Influenza A induces dysfunctional immunity and death in MeCP2-overexpressing mice. JCI Insight. 2017 Jan 26;2(2):e88257. doi: 10.1172/jci.insight.88257. PubMed PMID: 28138553; PubMed Central PMCID: PMC5256138.
Mehaffey JH, Charles EJ, Sharma AK, Salmon M, Money D, Schubert S, Stoler MH, Tribble CG, Laubach VE, Roeser ME, Kron IL. Ex Vivo Lung Perfusion Rehabilitates Sepsis-Induced Lung Injury. Ann Thorac Surg. 2017 Jun;103(6):1723-1729. doi: 10.1016/j.athoracsur.2017.01.018. Epub 2017 Apr 21. PubMed PMID: 28434548; PubMed Central PMCID: PMC5438908.
Charles EJ, Mehaffey JH, Sharma AK, Zhao Y, Stoler MH, Isbell JM, Lau CL, Tribble CG, Laubach VE, Kron IL. Lungs donated after circulatory death and prolonged warm ischemia are transplanted successfully after enhanced ex vivo lung perfusion using adenosine A2B receptor antagonism. J Thorac Cardiovasc Surg. 2017 Nov;154(5):1811-1820. doi: 10.1016/j.jtcvs.2017.02.072. Epub 2017 Apr 12. PubMed PMID: 28483262; PubMed Central PMCID: PMC6743073.
Call JA, Donet J, Martin KS, Sharma AK, Chen X, Zhang J, Cai J, Galarreta CA, Okutsu M, Du Z, Lira VA, Zhang M, Mehrad B, Annex BH, Klibanov AL, Bowler RP, Laubach VE, Peirce SM, Yan Z. Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice. Free Radic Biol Med. 2017 Dec;113:212-223. doi: 10.1016/j.freeradbiomed.2017.09.029. Epub 2017 Oct 2. PubMed PMID: 28982599; PubMed Central PMCID: PMC5740866.
Stone ML, Zhao Y, Robert Smith J, Weiss ML, Kron IL, Laubach VE, Sharma AK. Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death. Respir Res. 2017 Dec 21;18(1):212. doi: 10.1186/s12931-017-0704-9. PubMed PMID: 29268735; PubMed Central PMCID: PMC5740880.
Mehaffey JH, Charles EJ, Schubert S, Salmon M, Sharma AK, Money D, Stoler MH, Laubach VE, Tribble CG, Roeser ME, Kron IL. In vivo lung perfusion rehabilitates sepsis-induced lung injury. J Thorac Cardiovasc Surg. 2018 Jan;155(1):440-448.e2. doi: 10.1016/j.jtcvs.2017.08.124. Epub 2017 Sep 14. PubMed PMID: 29033043; PubMed Central PMCID: PMC5744259.
Sharma AK, Upchurch GR Jr. Invited commentary. J Vasc Surg. 2018 Mar;67(3):909. doi: 10.1016/j.jvs.2016.12.064. PubMed PMID: 29477203.
Chancellor WZ, Charles EJ, Mehaffey JH, Hawkins RB, Foster CA, Sharma AK, Laubach VE, Kron IL, Tribble CG. Expanding the donor lung pool: how many donations after circulatory death organs are we missing?. J Surg Res. 2018 Mar;223:58-63. doi: 10.1016/j.jss.2017.09.029. Epub 2017 Nov 11. PubMed PMID: 29433886; PubMed Central PMCID: PMC6475907.
Sharma AK, Laubach VE. Protecting Donor Livers During Normothermic Machine Perfusion With Stem Cell Extracellular Vesicles. Transplantation. 2018 May;102(5):725-726. doi: 10.1097/TP.0000000000002124. PubMed PMID: 29406445; PubMed Central PMCID: PMC5930115.
Spinosa M, Lu G, Su G, Bontha SV, Gehrau R, Salmon MD, Smith JR, Weiss ML, Mas VR, Upchurch GR Jr, Sharma AK. Human mesenchymal stromal cell-derived extracellular vesicles attenuate aortic aneurysm formation and macrophage activation via microRNA-147. FASEB J. 2018 May 29;32(11):fj201701138RR. doi: 10.1096/fj.201701138RR. [Epub ahead of print] PubMed PMID: 29812968; PubMed Central PMCID: PMC6181641.
Sharma AK, Charles EJ, Zhao Y, Narahari AK, Baderdinni PK, Good ME, Lorenz UM, Kron IL, Bayliss DA, Ravichandran KS, Isakson BE, Laubach VE. Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L301-L312. doi: 10.1152/ajplung.00004.2018. Epub 2018 May 10. PubMed PMID: 29745255; PubMed Central PMCID: PMC6139659.
Mehaffey JH, Charles EJ, Narahari AK, Schubert S, Laubach VE, Teman NR, Lynch KR, Kron IL, Sharma AK. Increasing circulating sphingosine-1-phosphate attenuates lung injury during ex vivo lung perfusion. J Thorac Cardiovasc Surg. 2018 Aug;156(2):910-917. doi: 10.1016/j.jtcvs.2018.02.090. Epub 2018 Mar 11. PubMed PMID: 29609890; PubMed Central PMCID: PMC6056006.
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