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BDF2 Bdf2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851488, updated on 11-Apr-2024

Summary

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Gene symbol
BDF2
Gene description
Bdf2p
Primary source
SGD:S000002228
Locus tag
YDL070W
See related
AllianceGenome:SGD:S000002228
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables TFIID-class transcription factor complex binding activity; core promoter sequence-specific DNA binding activity; and lysine-acetylated histone binding activity. Involved in negative regulation of heterochromatin assembly. Located in cell periphery. Human ortholog(s) of this gene implicated in juvenile myoclonic epilepsy; lymphoma (multiple); male infertility (multiple); and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2); BRD3 (bromodomain containing 3); and BRDT (bromodomain testis associated). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (331024..332940)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Ahk1p Neighboring gene Yet3p Neighboring gene Cbs1p Neighboring gene cytochrome c oxidase subunit VIIa

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption and phenotypic analysis of six novel genes from chromosome IV of Saccharomyces cerevisiae reveal YDL060w as an essential gene for vegetative growth. Casalone E, et al. Yeast, 1999 Nov. PMID 10572265
  2. BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae. Donczew R, et al. Elife, 2021 Jun 17. PMID 34137374, Free PMC Article
  3. Interplay between BDF1 and BDF2 and their roles in regulating the yeast salt stress response. Fu J, et al. FEBS J, 2013 May. PMID 23452060
  4. Stress-induced nuclear RNA degradation pathways regulate yeast bromodomain factor 2 to promote cell survival. Roy K, et al. PLoS Genet, 2014 Sep. PMID 25232960, Free PMC Article
  5. NuA4-directed chromatin transactions throughout the Saccharomyces cerevisiae genome. Durant M, et al. Mol Cell Biol, 2007 Aug. PMID 17526728, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitochondrial dysfunctions caused by BDF1 deletion are restored by overexpression of BDF2 under salt stress conditions in yeast.
    Title: Interplay between BDF1 and BDF2 and their roles in regulating the yeast salt stress response.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables TFIID-class transcription factor complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables lysine-acetylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of heterochromatin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bdf2p
NP_010213.1
  • Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress; BDF2 has a paralog, BDF1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    331024..332940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180129.1 → NP_010213.1  TPA: Bdf2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010213.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRS8, Q07442
    UniProtKB/TrEMBL
    A0A8H8UML4, B5VFJ8, N1P468
    Conserved Domains (4) summary
    COG5076
    Location:55 → 378
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam15619
    Location:472 → 537
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    pfam17035
    Location:521 → 576
    BET; Bromodomain extra-terminal - transcription regulation
    cl02556
    Location:344 → 419
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07442.1

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