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An Efficient Method for the Isolation of Toxins from Pteridium aquilinum and Evaluation of Ptaquiloside Against Cancer and Non-cancer Cells.
Williams C, Allison SJ, Phillips RM, Linley PA, Wright CW. Williams C, et al. Planta Med. 2021 Aug;87(10-11):892-895. doi: 10.1055/a-1494-3513. Epub 2021 May 21. Planta Med. 2021. PMID: 34020492
The common fern, bracken (Pteridium aquilinum), is well known for its toxic effects on livestock due principally to the carcinogenic constituent ptaquiloside ( 1: ), although other toxins are present including the cyanogenic glycoside, prunasin ( 2: ). Here, we report an i …
The common fern, bracken (Pteridium aquilinum), is well known for its toxic effects on livestock due principally to the carcinogenic constit …
Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer.
Wong K, Abascal F, Ludwig L, Aupperle-Lellbach H, Grassinger J, Wright CW, Allison SJ, Pinder E, Phillips RM, Romero LP, Gal A, Roady PJ, Pires I, Guscetti F, Munday JS, Peleteiro MC, Pinto CA, Carvalho T, Cota J, Du Plessis EC, Constantino-Casas F, Plog S, Moe L, de Brot S, Bemelmans I, Amorim RL, Georgy SR, Prada J, Del Pozo J, Heimann M, de Carvalho Nunes L, Simola O, Pazzi P, Steyl J, Ubukata R, Vajdovich P, Priestnall SL, Suárez-Bonnet A, Roperto F, Millanta F, Palmieri C, Ortiz AL, Barros CSL, Gava A, Söderström ME, O'Donnell M, Klopfleisch R, Manrique-Rincón A, Martincorena I, Ferreira I, Arends MJ, Wood GA, Adams DJ, van der Weyden L. Wong K, et al. Genome Biol. 2023 Aug 28;24(1):191. doi: 10.1186/s13059-023-03026-4. Genome Biol. 2023. PMID: 37635261 Free PMC article.
BACKGROUND: In humans, muscle-invasive bladder cancer (MIBC) is highly aggressive and associated with a poor prognosis. ...We characterize mutational signatures in bovine UC associated with bracken fern and ptaquiloside exposure, a human-linked cancer exposur …
BACKGROUND: In humans, muscle-invasive bladder cancer (MIBC) is highly aggressive and associated with a poor prognosis. ...We charact …
Ptaquiloside and Pterosin B Levels in Mature Green Fronds and Sprouts of Pteridium arachnoideum.
Ribeiro DDSF, Keller KM, Soto-Blanco B. Ribeiro DDSF, et al. Toxins (Basel). 2020 May 1;12(5):288. doi: 10.3390/toxins12050288. Toxins (Basel). 2020. PMID: 32369939 Free PMC article.
A total of 28 mature leaf samples and 23 sprout samples were used. The mean concentrations of ptaquiloside and pterosin B present in the mature green fronds of P. arachnoideum ranged from 2.49 to 2.75 mg/g and 0.68 to 0.88 mg/g, respectively; in P. arachnoideum sprouts, me …
A total of 28 mature leaf samples and 23 sprout samples were used. The mean concentrations of ptaquiloside and pterosin B present in …
Evaluation and Monitoring of the Natural Toxin Ptaquiloside in Bracken Fern, Meat, and Dairy Products.
Park H, Cho Y, Lee J, Lee KM, Kim HJ, Lee J, Bahn YS, Son J. Park H, et al. Toxins (Basel). 2023 Mar 21;15(3):231. doi: 10.3390/toxins15030231. Toxins (Basel). 2023. PMID: 36977122 Free PMC article.
Ptaquiloside, a naturally occurring cancer-causing substance in bracken fern, has been detected in the meat and milk of cows fed a diet containing bracken fern. ...This method was used for the monitoring and exposure assessment of ptaquiloside in all routes o …
Ptaquiloside, a naturally occurring cancer-causing substance in bracken fern, has been detected in the meat and milk of cows f …
Ptaquiloside-induced early-stage urothelial lesions show increased cell proliferation and intact beta-catenin and E-cadherin expression.
Gil da Costa RM, Oliveira PA, Bastos MM, Lopes CC, Lopes C. Gil da Costa RM, et al. Environ Toxicol. 2014 May;29(7):763-9. doi: 10.1002/tox.21803. Epub 2012 Aug 1. Environ Toxicol. 2014. PMID: 22859263
Bracken (Pteridium aquilinum) is a carcinogenic plant whose main toxin, ptaquiloside, causes cancer in farm and laboratory animals. Ptaquiloside contaminates underground waters as well as meat and milk from bracken-grazing animals and is a suspected human car …
Bracken (Pteridium aquilinum) is a carcinogenic plant whose main toxin, ptaquiloside, causes cancer in farm and laboratory ani …
Carcinogenic effects of ptaquiloside in bracken fern and related compounds.
Potter DM, Baird MS. Potter DM, et al. Br J Cancer. 2000 Oct;83(7):914-20. doi: 10.1054/bjoc.2000.1368. Br J Cancer. 2000. PMID: 10970694 Free PMC article. Review.
These give anti-tumour activity and similar reactivity with nucleophiles to ptaquiloside. Compound CC-1065, a highly toxic antibiotic also containing a cyclopropane ring, has been isolated from Streptomyces zelensis. The mechanism of its reactivity with DNA has been compar …
These give anti-tumour activity and similar reactivity with nucleophiles to ptaquiloside. Compound CC-1065, a highly toxic antibiotic …
Ptaquiloside from bracken (Pteridium spp.) inhibits tumour-infiltrating CD8(+) T cells in HPV-16 transgenic mice.
Santos C, Ferreirinha P, Sousa H, Ribeiro J, Bastos MM, Neto T, Oliveira PA, Medeiros R, Vilanova M, Gil da Costa RM. Santos C, et al. Food Chem Toxicol. 2016 Nov;97:277-285. doi: 10.1016/j.fct.2016.09.019. Epub 2016 Sep 15. Food Chem Toxicol. 2016. PMID: 27640346
Bracken is a fern with worldwide distribution. Exposure to bracken toxins such as ptaquiloside is hypothesized to increase the risk of papillomavirus-related cancers of the upper digestive tract. Ptaquiloside is thought to be an immunosupressor, thus allowing …
Bracken is a fern with worldwide distribution. Exposure to bracken toxins such as ptaquiloside is hypothesized to increase the risk o …
Pteridium spp. and Bovine Papillomavirus: Partners in Cancer.
Medeiros-Fonseca B, Abreu-Silva AL, Medeiros R, Oliveira PA, Gil da Costa RM. Medeiros-Fonseca B, et al. Front Vet Sci. 2021 Nov 2;8:758720. doi: 10.3389/fvets.2021.758720. eCollection 2021. Front Vet Sci. 2021. PMID: 34796228 Free PMC article. Review.
Those lesions include cutaneous and upper digestive papillomas, multiple histological types of urinary bladder cancers-most often associated with BPV1 and BPV2-and squamous cell carcinomas of the upper digestive system, associated with BPV4. ...This carcinogenic potential …
Those lesions include cutaneous and upper digestive papillomas, multiple histological types of urinary bladder cancers-most often ass …
Ptaquiloside reduces NK cell activities by enhancing metallothionein expression, which is prevented by selenium.
Latorre AO, Caniceiro BD, Fukumasu H, Gardner DR, Lopes FM, Wysochi HL Jr, da Silva TC, Haraguchi M, Bressan FF, Górniak SL. Latorre AO, et al. Toxicology. 2013 Feb 8;304:100-8. doi: 10.1016/j.tox.2012.12.010. Epub 2012 Dec 26. Toxicology. 2013. PMID: 23274088 Free article.
We also verified that this immunosuppression facilitated development of cancer. Here, we performed gene expression microarray analysis in splenic NK cells from mice treated for 14 days with ptaquiloside (5.3 mg/kg) and/or selenium (1.3 mg/kg) to identify gene transc …
We also verified that this immunosuppression facilitated development of cancer. Here, we performed gene expression microarray analysi …
Ptaquiloside from bracken (Pteridium spp.) promotes oral carcinogenesis initiated by HPV16 in transgenic mice.
Gil da Costa RM, Neto T, Estêvão D, Moutinho M, Félix A, Medeiros R, Lopes C, Bastos MMSM, Oliveira PA. Gil da Costa RM, et al. Food Funct. 2020 Apr 30;11(4):3298-3305. doi: 10.1039/d0fo00207k. Food Funct. 2020. PMID: 32222741
This study tested the hypothesis that two bracken compounds, ptaquiloside and rutin, are able to promote head-and-neck and bladder carcinogenesis in HPV16-transgenic mice. ...Also, cancers of unexposed transgenic mice were restricted to the tongue base, while pta …
This study tested the hypothesis that two bracken compounds, ptaquiloside and rutin, are able to promote head-and-neck and bladder ca …
57 results