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Page 1
Antiviral Polymers: A Review.
Akbari A, Bigham A, Rahimkhoei V, Sharifi S, Jabbari E. Akbari A, et al. Polymers (Basel). 2022 Apr 19;14(9):1634. doi: 10.3390/polym14091634. Polymers (Basel). 2022. PMID: 35566804 Free PMC article. Review.
This review covers natural and synthetic polymers that possess antiviral activity, their mechanism of action, and the effect of material properties like chemical composition, molecular weight, functional groups, and charge density on antiviral activity. Natural polymers like carr …
This review covers natural and synthetic polymers that possess antiviral activity, their mechanism of action, and the effect of material pro …
Fucoidan modulates SIRT1 and NLRP3 to alleviate hypertensive retinopathy: in vivo and in vitro insights.
Li J, Wang X, Bai J, Wei H, Wang W, Wang S. Li J, et al. J Transl Med. 2024 Feb 15;22(1):155. doi: 10.1186/s12967-024-04877-6. J Transl Med. 2024. PMID: 38360728 Free PMC article.
To see if Sirtuin 1 (SIRT1) regulates angiotensin II (Ang II)-induced hypertensive retinopathy and inflammation by modulating NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation and the potential protective effects of fucoidan (FO) …
To see if Sirtuin 1 (SIRT1) regulates angiotensin II (Ang II)-induced hypertensive retinopathy and inflammation by modulating NOD-like recep …
Doxorubicin-fucoidan-gold nanoparticles composite for dual-chemo-photothermal treatment on eye tumors.
Kim H, Nguyen VP, Manivasagan P, Jung MJ, Kim SW, Oh J, Kang HW. Kim H, et al. Oncotarget. 2017 Dec 9;8(69):113719-113733. doi: 10.18632/oncotarget.23092. eCollection 2017 Dec 26. Oncotarget. 2017. PMID: 29371941 Free PMC article.
The current research demonstrates the feasible biomedical application of AuNPs coated with doxorubicin (Dox)-loaded fucoidan (Fu) for dual-chemotherapy and photothermal treatment (PTT) on eye tumors in vitro and in vivo. ...Therefore, the proposed Dox-Fu@AuNPs can b …
The current research demonstrates the feasible biomedical application of AuNPs coated with doxorubicin (Dox)-loaded fucoidan (Fu) for …
Protective Effects of Fucoidan on Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells and Progression of Proliferative Vitreoretinopathy.
Zhang Y, Zhao D, Yang S, Yao H, Li M, Zhao C, Zhang J, Xu GT, Li H, Wang F. Zhang Y, et al. Cell Physiol Biochem. 2018;46(4):1704-1715. doi: 10.1159/000489246. Epub 2018 Apr 23. Cell Physiol Biochem. 2018. PMID: 29698960 Free article.
Moreover, the upregulation of phosphorylated Smad2/3 induced by TGF-beta1 was suppressed by fucoidan. Fucoidan also inhibited the migration and contraction of RPE cells induced by TGF-beta1. In vivo, fucoidan inhibited the progression of experimental PVR in r …
Moreover, the upregulation of phosphorylated Smad2/3 induced by TGF-beta1 was suppressed by fucoidan. Fucoidan also inhibited …
Fucoidan reduces secretion and expression of vascular endothelial growth factor in the retinal pigment epithelium and reduces angiogenesis in vitro.
Dithmer M, Fuchs S, Shi Y, Schmidt H, Richert E, Roider J, Klettner A. Dithmer M, et al. PLoS One. 2014 Feb 18;9(2):e89150. doi: 10.1371/journal.pone.0089150. eCollection 2014. PLoS One. 2014. PMID: 24558482 Free PMC article.
Fucoidan is a polysaccharide isolated from brown algae which is of current interest for anti-tumor therapy. ...Fucoidan decreases VEGF secretion in RPE/choroid explants and RPE cells. ...
Fucoidan is a polysaccharide isolated from brown algae which is of current interest for anti-tumor therapy. ...Fucoidan decrea …
Fucoidans as Potential Therapeutics for Age-Related Macular Degeneration-Current Evidence from In Vitro Research.
Dörschmann P, Klettner A. Dörschmann P, et al. Int J Mol Sci. 2020 Dec 4;21(23):9272. doi: 10.3390/ijms21239272. Int J Mol Sci. 2020. PMID: 33291752 Free PMC article. Review.
Fucoidans from Saccharina latissima and Laminaria hyperborea were identified as the most promising candidates for further development. Further research is warranted to establish fucoidans as potential therapeutics for AMD....
Fucoidans from Saccharina latissima and Laminaria hyperborea were identified as the most promising candidates for further development …
Fucoidan protects ARPE-19 cells from oxidative stress via normalization of reactive oxygen species generation through the Ca2+-dependent ERK signaling pathway.
Li X, Zhao H, Wang Q, Liang H, Jiang X. Li X, et al. Mol Med Rep. 2015 May;11(5):3746-52. doi: 10.3892/mmr.2015.3224. Epub 2015 Jan 19. Mol Med Rep. 2015. PMID: 25606812
Therefore, the aim of the present study was to evaluate the role of fucoidan in DR. The human retinal pigment epithelial cell line ARPE-19 was exposed to high D-glucose in the presence or absence of fucoidan. ...Fucoidan also inhibited high glucose-induced ce …
Therefore, the aim of the present study was to evaluate the role of fucoidan in DR. The human retinal pigment epithelial cell line AR …
The Effects of Sargassum horneri Extract and Fucoidan on Tear Hyposecretion and Ocular Surface Injury in Rats with Dry Eye Diseases.
Park SB, Jung WK, Yu HY, Kim J. Park SB, et al. Curr Issues Mol Biol. 2023 Aug 8;45(8):6583-6592. doi: 10.3390/cimb45080415. Curr Issues Mol Biol. 2023. PMID: 37623234 Free PMC article.
Hyperosmotic stress caused by tear hyposection is a leading cause of dry eye disease. We investigated the prevention of dry eye disease in corneal epithelial cells and in rats that were induced to develop dry eye disease via unilateral excision of their exorb …
Hyperosmotic stress caused by tear hyposection is a leading cause of dry eye disease. We investigated the prevention of dry eye …
Comparison of Fucoidans from Saccharina latissima Regarding Age-Related Macular Degeneration Relevant Pathomechanisms in Retinal Pigment Epithelium.
Dörschmann P, Thalenhorst T, Seeba C, Tischhöfer MT, Neupane S, Roider J, Alban S, Klettner A. Dörschmann P, et al. Int J Mol Sci. 2023 Apr 27;24(9):7939. doi: 10.3390/ijms24097939. Int J Mol Sci. 2023. PMID: 37175646 Free PMC article.
Fucoidans from brown algae are described as anti-inflammatory, antioxidative, and antiangiogenic. ...VEGF secretion was reduced in ARPE-19 by SL-FRO and in RPE by both fucoidans. Polyinosinic:polycytidylic acid induced interleukin 6 and interleukin 8 secretion was r …
Fucoidans from brown algae are described as anti-inflammatory, antioxidative, and antiangiogenic. ...VEGF secretion was reduced in AR …
Interaction of High-Molecular Weight Fucoidan from Laminaria hyperborea with Natural Functions of the Retinal Pigment Epithelium.
Dörschmann P, Kopplin G, Roider J, Klettner A. Dörschmann P, et al. Int J Mol Sci. 2023 Jan 23;24(3):2232. doi: 10.3390/ijms24032232. Int J Mol Sci. 2023. PMID: 36768552 Free PMC article.
Fucoidans are polysaccharides and constituents of cell walls of brown algae such as Laminaria hyperborea (LH). ...However, the safety of this compound needs to be assured. The focus of this study lies on influences of an LH fucoidan on the retinal pigment epithelium …
Fucoidans are polysaccharides and constituents of cell walls of brown algae such as Laminaria hyperborea (LH). ...However, the safety …
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