Lancet. 2001 Sep 8;358(9284):812-3.

Combined transplantation of the heart, lung, and liver.

Praseedom RK, McNeil KD, Watson CJ, Alexander GJ, Calne RY, Wallwork J, Friend PJ.

Abstract

Combined transplantation of the heart, lung, and liver may be indicated in patients with either end-stage respiratory failure complicated by advanced liver disease or end-stage liver failure complicated by advanced lung disease. A retrospective review of nine patients who underwent combined heart-lung-liver transplantation in Cambridge (1986-99) was carried out. The 1-year and 5-year actuarial survival was 56% and 42%, respectively. Combined heart-lung-liver transplantation is a feasible option for a few patients and has a 5-year survival similar to heart-lung transplantation but with a lower incidence of acute and chronic rejection.

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