Arch Dis Child. 2001 May;84(5):432-3.

Bronchoconstriction following nebulised colistin in cystic fibrosis.

Cunningham S, Prasad A, Collyer L, Carr S, Lynn IB, Wallis C.

Source

Portex Anaesthesia, Intensive Care and Respiratory Medicine, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK. steve.cunningham@talk21.com

Abstract

Nebulised colistin is regularly used as antipseudomonal therapy in children with cystic fibrosis. We assessed bronchoconstriction in response to nebulised colistin in 58 children. Nebulised colistin significantly reduced FEV(1), MEF(25%), and SaO(2) for 15 minutes. In 20 children the reduction was greater than 10% from baseline FEV(1), and was still at that level in five at 30 minutes. Subjective assessment, baseline FEV(1), and serum IgE were unable to identify susceptible children. It is recommended that children receiving colistin should be carefully assessed for bronchoconstriction.

PMID:: 11316693; [PubMed - indexed for MEDLINE]
PMCID:: PMC1718770

Free PMC Article

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Molecular Biology Databases

COLISTIN - HSDB

Supplemental Content

Save items

Related citations in PubMed

Bronchial constriction and inhaled colistin in cystic fibrosis. [Chest. 2005]
Bronchial constriction and inhaled colistin in cystic fibrosis.
Alothman GA, Ho B, Alsaadi MM, Ho SL, O'Drowsky L, Louca E, Coates AL. Chest. 2005 Feb; 127(2):522-9.
A randomised clinical trial of nebulised tobramycin or colistin in cystic fibrosis. [Eur Respir J. 2002]
A randomised clinical trial of nebulised tobramycin or colistin in cystic fibrosis.
Hodson ME, Gallagher CG, Govan JR. Eur Respir J. 2002 Sep; 20(3):658-64.
Effect of tonicity of nebulised colistin on chest tightness and pulmonary function in adults with cystic fibrosis. [Thorax. 1997]
Effect of tonicity of nebulised colistin on chest tightness and pulmonary function in adults with cystic fibrosis.
Dodd ME, Abbott J, Maddison J, Moorcroft AJ, Webb AK. Thorax. 1997 Jul; 52(7):656-8.
Review Systemic colistin use in children without cystic fibrosis: a systematic review of the literature. [Int J Antimicrob Agents. 2009]
Review Systemic colistin use in children without cystic fibrosis: a systematic review of the literature.
Falagas ME, Vouloumanou EK, Rafailidis PI. Int J Antimicrob Agents. 2009 Jun; 33(6):503.e1-503.e13. Epub 2009 Jan 24.
Review [Anti-Pseudomonas aerosol therapy in cystic fibrosis: improvement with tobramycin]. [Rev Pneumol Clin. 2002]
Review [Anti-Pseudomonas aerosol therapy in cystic fibrosis: improvement with tobramycin].
Foucaud P, Borel B, Charara O, Nathanson S, Petitprez P, Pin I. Rev Pneumol Clin. 2002 Jun; 58(3 Pt 1):131-8.

See reviews... See all...

Cited by 7 PubMed Central articles

Review Polymyxins revisited. [Clin Microbiol Rev. 2008]
Review Polymyxins revisited.
Landman D, Georgescu C, Martin DA, Quale J. Clin Microbiol Rev. 2008 Jul; 21(3):449-65.
Stability of colistin methanesulfonate in pharmaceutical products and solutions for administration to patients. [Antimicrob Agents Chemother. 2...]
Stability of colistin methanesulfonate in pharmaceutical products and solutions for administration to patients.
Wallace SJ, Li J, Rayner CR, Coulthard K, Nation RL. Antimicrob Agents Chemother. 2008 Sep; 52(9):3047-51. Epub 2008 Jul 7.
Colistin: the phoenix arises. [Can J Infect Dis Med Microbiol...]
Colistin: the phoenix arises.
Conly J, Johnston B. Can J Infect Dis Med Microbiol. 2006 Sep; 17(5):267-9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Search details

Recent activity

Clear Turn Off Turn On

11316693[uid] (1)
PubMed
Bronchoconstriction following nebulised colistin in cystic fibrosis.
Bronchoconstriction following nebulised colistin in cystic fibrosis.
Arch Dis Child. 2001 May ;84(5):432-3.

PubMed
Long-term prospective study of the effect of ursodeoxycholic acid on cystic fibr...
Long-term prospective study of the effect of ursodeoxycholic acid on cystic fibrosis-related liver disease.
J Clin Gastroenterol. 2001 Apr ;32(4):324-8.

PubMed
11276276[uid] (1)
PubMed
Normal bone mineral density in cystic fibrosis.
Normal bone mineral density in cystic fibrosis.
Arch Dis Child. 2001 Apr ;84(4):363-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: