Dumbbell-like Au-Fe3O4 nanoparticles for target-specific platin delivery

J Am Chem Soc. 2009 Apr 1;131(12):4216-7. doi: 10.1021/ja900790v.

Abstract

Dumbbell-like Au-Fe(3)O(4) nanoparticles (NPs) were made and coupled with Herceptin and a platin complex. The platin-Au-Fe(3)O(4)-Herceptin NPs act as a target-specific nanocarriers for delivery of platin into Her2-positive breast cancer cells (Sk-Br3) with strong therapeutic effects. The conjugate has a half-maximal inhibitory concentration (IC(50)) toward Sk-Br3 cells of 1.76 microg of Pt/mL, which is lower than that needed for cisplatin (3.5 microg/mL). The work demonstrates that the dumbbell-like Au-Fe(3)O(4) NPs are promising nanocarriers for highly sensitive diagnostic and therapeutic applications.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Cell Line, Tumor
  • Cisplatin / administration & dosage*
  • Drug Carriers
  • Drug Delivery Systems*
  • Drug Screening Assays, Antitumor
  • Gold / chemistry*
  • Humans
  • Inhibitory Concentration 50
  • Iron / chemistry*
  • Materials Testing
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / therapeutic use
  • Nanostructures
  • Nanotechnology
  • Solubility

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Gold
  • Iron
  • Cisplatin