PubMed

Structural basis of the cross-reactivity of genetically related human anti-HIV-1 mAbs: implications for design of V3-based immunogens.

Burke V, Williams C, Sukumaran M, Kim SS, Li H, Wang XH, Gorny MK, Zolla-Pazner S, Kong XP.

Structure. 2009 Nov 11;17(11):1538-46.PMID: 19913488 [PubMed - in process]Related articles

Cross-clade neutralizing antibodies against HIV-1 induced in rabbits by focusing the immune response on a neutralizing epitope.

Zolla-Pazner S, Cohen S, Pinter A, Krachmarov C, Wrin T, Wang S, Lu S.

Virology. 2009 Sep 15;392(1):82-93. Epub 2009 Jul 26.PMID: 19632700 [PubMed - indexed for MEDLINE]Related articlesFree article

Human monoclonal antibody 2909 binds to pseudovirions expressing trimers but not monomeric HIV-1 envelope proteins.

Kimura T, Wang XH, Williams C, Zolla-Pazner S, Gorny MK.

Hum Antibodies. 2009;18(1-2):35-40.PMID: 19478397 [PubMed - indexed for MEDLINE]Related articles

Worldwide distribution of HIV type 1 epitopes recognized by human anti-V3 monoclonal antibodies.

Cardozo T, Swetnam J, Pinter A, Krachmarov C, Nadas A, Almond D, Zolla-Pazner S.

AIDS Res Hum Retroviruses. 2009 Apr;25(4):441-50.PMID: 19320565 [PubMed - indexed for MEDLINE]Related articles

Oligomer-specific conformations of the human immunodeficiency virus (HIV-1) gp41 envelope glycoprotein ectodomain recognized by human monoclonal antibodies.

Yuan W, Li X, Kasterka M, Gorny MK, Zolla-Pazner S, Sodroski J.

AIDS Res Hum Retroviruses. 2009 Mar;25(3):319-28.PMID: 19292593 [PubMed - indexed for MEDLINE]Related articles

International network for comparison of HIV neutralization assays: the NeutNet report.

Fenyö EM, Heath A, Dispinseri S, Holmes H, Lusso P, Zolla-Pazner S, Donners H, Heyndrickx L, Alcami J, Bongertz V, Jassoy C, Malnati M, Montefiori D, Moog C, Morris L, Osmanov S, Polonis V, Sattentau Q, Schuitemaker H, Sutthent R, Wrin T, Scarlatti G.

PLoS One. 2009;4(2):e4505. Epub 2009 Feb 20.PMID: 19229336 [PubMed - indexed for MEDLINE]Related articlesFree article

Preferential use of the VH5-51 gene segment by the human immune response to code for antibodies against the V3 domain of HIV-1.

Gorny MK, Wang XH, Williams C, Volsky B, Revesz K, Witover B, Burda S, Urbanski M, Nyambi P, Krachmarov C, Pinter A, Zolla-Pazner S, Nadas A.

Mol Immunol. 2009 Feb;46(5):917-26. Epub 2008 Oct 25.PMID: 18952295 [PubMed - indexed for MEDLINE]Related articles

Soluble CD4 broadens neutralization of V3-directed monoclonal antibodies and guinea pig vaccine sera against HIV-1 subtype B and C reference viruses.

Wu X, Sambor A, Nason MC, Yang ZY, Wu L, Zolla-Pazner S, Nabel GJ, Mascola JR.

Virology. 2008 Oct 25;380(2):285-95. Epub 2008 Sep 18.PMID: 18804254 [PubMed - indexed for MEDLINE]Related articles

Structure determination of an anti-HIV-1 Fab 447-52D-peptide complex from an epitaxially twinned data set.

Dhillon AK, Stanfield RL, Gorny MK, Williams C, Zolla-Pazner S, Wilson IA.

Acta Crystallogr D Biol Crystallogr. 2008 Jul;D64(Pt 7):792-802. Epub 2008 Jun 18.PMID: 18566514 [PubMed - indexed for MEDLINE]Related articlesFree article

Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccination.

Polonis VR, Brown BK, Rosa Borges A, Zolla-Pazner S, Dimitrov DS, Zhang MY, Barnett SW, Ruprecht RM, Scarlatti G, Fenyö EM, Montefiori DC, McCutchan FE, Michael NL.

Virology. 2008 Jun 5;375(2):315-20. Epub 2008 Mar 25. Review.PMID: 18367229 [PubMed - indexed for MEDLINE]Related articles

Focusing the immune response on the V3 loop, a neutralizing epitope of the HIV-1 gp120 envelope.

Zolla-Pazner S, Cohen SS, Krachmarov C, Wang S, Pinter A, Lu S.

Virology. 2008 Mar 15;372(2):233-46. Epub 2007 Dec 3.PMID: 18061228 [PubMed - indexed for MEDLINE]Related articles

Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for regulation in acute infection.

Alam SM, Scearce RM, Parks RJ, Plonk K, Plonk SG, Sutherland LL, Gorny MK, Zolla-Pazner S, Vanleeuwen S, Moody MA, Xia SM, Montefiori DC, Tomaras GD, Weinhold KJ, Karim SA, Hicks CB, Liao HX, Robinson J, Shaw GM, Haynes BF.

J Virol. 2008 Jan;82(1):115-25. Epub 2007 Oct 17.PMID: 17942537 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural basis for coreceptor selectivity by the HIV type 1 V3 loop.

Cardozo T, Kimura T, Philpott S, Weiser B, Burger H, Zolla-Pazner S.

AIDS Res Hum Retroviruses. 2007 Mar;23(3):415-26.PMID: 17411375 [PubMed - indexed for MEDLINE]Related articles

Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins.

Dadachova E, Patel MC, Toussi S, Apostolidis C, Morgenstern A, Brechbiel MW, Gorny MK, Zolla-Pazner S, Casadevall A, Goldstein H.

PLoS Med. 2006 Nov;3(11):e427.PMID: 17090209 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel approach for differential diagnosis of HIV infections in the face of vaccine-generated antibodies: utility for detection of diverse HIV-1 subtypes.

Khurana S, Needham J, Park S, Mathieson B, Busch MP, Nemo G, Nyambi P, Zolla-Pazner S, Laal S, Mulenga J, Chomba E, Hunter E, Allen S, McIntyre J, Hewlett I, Lee S, Tang S, Cowan E, Beyrer C, Altfeld M, Yu XG, Tounkara A, Koita O, Kamali A, Nguyen N, Graham BS, Todd D, Mugenyi P, Anzala O, Sanders E, Ketter N, Fast P, Golding H.

J Acquir Immune Defic Syndr. 2006 Nov 1;43(3):304-12.PMID: 17019363 [PubMed - indexed for MEDLINE]Related articlesFree article

The antigenic determinants on HIV p24 for CD4+ T cell inhibiting antibodies as determined by limited proteolysis, chemical modification, and mass spectrometry.

Williams JG, Tomer KB, Hioe CE, Zolla-Pazner S, Norris PJ.

J Am Soc Mass Spectrom. 2006 Nov;17(11):1560-9. Epub 2006 Jul 27.PMID: 16875837 [PubMed - indexed for MEDLINE]Related articles

Immunoprophylaxis against mother-to-child transmission of HIV-1.

Gorny MK, Zolla-Pazner S.

PLoS Med. 2006 Jul;3(7):e259. Epub 2006 Jul 18. No abstract available. PMID: 16842019 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct sequence patterns characterize the V3 region of HIV type 1 gp120 from subtypes A and C.

Felsövályi K, Nádas A, Zolla-Pazner S, Cardozo T.

AIDS Res Hum Retroviruses. 2006 Jul;22(7):703-8.PMID: 16831095 [PubMed - indexed for MEDLINE]Related articlesFree article

Cross-clade neutralizing activity of human anti-V3 monoclonal antibodies derived from the cells of individuals infected with non-B clades of human immunodeficiency virus type 1.

Gorny MK, Williams C, Volsky B, Revesz K, Wang XH, Burda S, Kimura T, Konings FA, Nádas A, Anyangwe CA, Nyambi P, Krachmarov C, Pinter A, Zolla-Pazner S.

J Virol. 2006 Jul;80(14):6865-72.PMID: 16809292 [PubMed - indexed for MEDLINE]Related articlesFree article

Nonneutralizing antibodies are able to inhibit human immunodeficiency virus type 1 replication in macrophages and immature dendritic cells.

Holl V, Peressin M, Decoville T, Schmidt S, Zolla-Pazner S, Aubertin AM, Moog C.

J Virol. 2006 Jun;80(12):6177-81.PMID: 16731957 [PubMed - indexed for MEDLINE]Related articlesFree article

Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity.

Stanfield RL, Gorny MK, Zolla-Pazner S, Wilson IA.

J Virol. 2006 Jun;80(12):6093-105.PMID: 16731948 [PubMed - indexed for MEDLINE]Related articlesFree article

Improving on nature: focusing the immune response on the V3 loop.

Zolla-Pazner S.

Hum Antibodies. 2005;14(3-4):69-72. Review.PMID: 16720976 [PubMed - indexed for MEDLINE]Related articles

Efficient inhibition of HIV-1 replication in human immature monocyte-derived dendritic cells by purified anti-HIV-1 IgG without induction of maturation.

Holl V, Peressin M, Schmidt S, Decoville T, Zolla-Pazner S, Aubertin AM, Moog C.

Blood. 2006 Jun 1;107(11):4466-74. Epub 2006 Feb 9.PMID: 16469871 [PubMed - indexed for MEDLINE]Related articlesFree article

A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs.

de Parseval A, Bobardt MD, Chatterji A, Chatterji U, Elder JH, David G, Zolla-Pazner S, Farzan M, Lee TH, Gallay PA.

J Biol Chem. 2005 Nov 25;280(47):39493-504. Epub 2005 Sep 12.PMID: 16157597 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV-1 envelope pseudotyped viral vectors and infectious molecular clones expressing the same envelope glycoprotein have a similar neutralization phenotype, but culture in peripheral blood mononuclear cells is associated with decreased neutralization sensitivity.

Louder MK, Sambor A, Chertova E, Hunte T, Barrett S, Ojong F, Sanders-Buell E, Zolla-Pazner S, McCutchan FE, Roser JD, Gabuzda D, Lifson JD, Mascola JR.

Virology. 2005 Sep 1;339(2):226-38.PMID: 16005039 [PubMed - indexed for MEDLINE]Related articles

The C108g epitope in the V2 domain of gp120 functions as a potent neutralization target when introduced into envelope proteins derived from human immunodeficiency virus type 1 primary isolates.

Pinter A, Honnen WJ, D'Agostino P, Gorny MK, Zolla-Pazner S, Kayman SC.

J Virol. 2005 Jun;79(11):6909-17.PMID: 15890930 [PubMed - indexed for MEDLINE]Related articlesFree article

Induced fit in HIV-neutralizing antibody complexes: evidence for alternative conformations of the gp120 V3 loop and the molecular basis for broad neutralization.

Rosen O, Chill J, Sharon M, Kessler N, Mester B, Zolla-Pazner S, Anglister J.

Biochemistry. 2005 May 17;44(19):7250-8.PMID: 15882063 [PubMed - indexed for MEDLINE]Related articles

Identification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particles.

Gorny MK, Stamatatos L, Volsky B, Revesz K, Williams C, Wang XH, Cohen S, Staudinger R, Zolla-Pazner S.

J Virol. 2005 Apr;79(8):5232-7.PMID: 15795308 [PubMed - indexed for MEDLINE]Related articlesFree article

Remembrance: G. Jeanette Thorbecke.

Tsiagbe VK, Coico R, Ponzio NM, Zolla-Pazner S.

Autoimmunity. 2002 Mar;35(2):75-78. No abstract available. PMID: 15729784 [PubMed - indexed for MEDLINE]Related articles

Vaccination of rhesus macaques with recombinant Mycobacterium bovis bacillus Calmette-Guérin Env V3 elicits neutralizing antibody-mediated protection against simian-human immunodeficiency virus with a homologous but not a heterologous V3 motif.

Someya K, Cecilia D, Ami Y, Nakasone T, Matsuo K, Burda S, Yamamoto H, Yoshino N, Kaizu M, Ando S, Okuda K, Zolla-Pazner S, Yamazaki S, Yamamoto N, Honda M.

J Virol. 2005 Feb;79(3):1452-62.PMID: 15650171 [PubMed - indexed for MEDLINE]Related articlesFree article

Antibodies that are cross-reactive for human immunodeficiency virus type 1 clade a and clade B v3 domains are common in patient sera from Cameroon, but their neutralization activity is usually restricted by epitope masking.

Krachmarov C, Pinter A, Honnen WJ, Gorny MK, Nyambi PN, Zolla-Pazner S, Kayman SC.

J Virol. 2005 Jan;79(2):780-90.PMID: 15613306 [PubMed - indexed for MEDLINE]Related articlesFree article

The cross-clade neutralizing activity of a human monoclonal antibody is determined by the GPGR V3 motif of HIV type 1.

Zolla-Pazner S, Zhong P, Revesz K, Volsky B, Williams C, Nyambi P, Gorny MK.

AIDS Res Hum Retroviruses. 2004 Nov;20(11):1254-8.PMID: 15588347 [PubMed - indexed for MEDLINE]Related articles

Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies.

Binley JM, Wrin T, Korber B, Zwick MB, Wang M, Chappey C, Stiegler G, Kunert R, Zolla-Pazner S, Katinger H, Petropoulos CJ, Burton DR.

J Virol. 2004 Dec;78(23):13232-52.PMID: 15542675 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the outer domain of the gp120 glycoprotein from human immunodeficiency virus type 1.

Yang X, Tomov V, Kurteva S, Wang L, Ren X, Gorny MK, Zolla-Pazner S, Sodroski J.

J Virol. 2004 Dec;78(23):12975-86.PMID: 15542649 [PubMed - indexed for MEDLINE]Related articlesFree article

Infection with HIV type 1 group M non-B subtypes in individuals living in New York City.

Achkar JM, Burda ST, Konings FA, Urbanski MM, Williams CA, Seifen D, Kahirimbanyi MN, Vogler M, Parta M, Lupatkin HC, Zolla-Pazner S, Nyambi PN.

J Acquir Immune Defic Syndr. 2004 Jul 1;36(3):835-44.PMID: 15213568 [PubMed - indexed for MEDLINE]Related articles

The V1/V2 domain of gp120 is a global regulator of the sensitivity of primary human immunodeficiency virus type 1 isolates to neutralization by antibodies commonly induced upon infection.

Pinter A, Honnen WJ, He Y, Gorny MK, Zolla-Pazner S, Kayman SC.

J Virol. 2004 May;78(10):5205-15.PMID: 15113902 [PubMed - indexed for MEDLINE]Related articlesFree article

Identifying epitopes of HIV-1 that induce protective antibodies.

Zolla-Pazner S.

Nat Rev Immunol. 2004 Mar;4(3):199-210. Review. No abstract available. PMID: 15039757 [PubMed - indexed for MEDLINE]Related articles

Defining human immunodeficiency virus (HIV) type 1 immunotypes with six human monoclonal antibodies.

Nádas A, Zhong P, Burda S, Zekeng L, Urbanski M, Gorny MK, Zolla-Pazner S, Nyambi PN.

AIDS Res Hum Retroviruses. 2004 Jan;20(1):55-65.PMID: 15000699 [PubMed - indexed for MEDLINE]Related articles

The v3 loop is accessible on the surface of most human immunodeficiency virus type 1 primary isolates and serves as a neutralization epitope.

Gorny MK, Revesz K, Williams C, Volsky B, Louder MK, Anyangwe CA, Krachmarov C, Kayman SC, Pinter A, Nadas A, Nyambi PN, Mascola JR, Zolla-Pazner S.

J Virol. 2004 Mar;78(5):2394-404.PMID: 14963135 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D.

Stanfield RL, Gorny MK, Williams C, Zolla-Pazner S, Wilson IA.

Structure. 2004 Feb;12(2):193-204.PMID: 14962380 [PubMed - indexed for MEDLINE]Related articles

Genetic and biological properties of HIV type 1 isolates prevalent in villagers of the Cameroon equatorial rain forests and grass fields: further evidence of broad HIV type 1 genetic diversity.

Zhong P, BUrda S, Konings F, Urbanski M, Ma L, Zekeng L, Ewane L, Agyingi L, Agwara M, Saa, Afane ZE, Kinge T, Zolla-Pazner S, Nyambi P.

AIDS Res Hum Retroviruses. 2003 Dec;19(12):1167-78.PMID: 14717120 [PubMed - indexed for MEDLINE]Related articles

Combined use of serum and urinary antibody for diagnosis of tuberculosis.

Singh KK, Dong Y, Hinds L, Keen MA, Belisle JT, Zolla-Pazner S, Achkar JM, Nadas AJ, Arora VK, Laal S.

J Infect Dis. 2003 Aug 1;188(3):371-7. Epub 2003 Jul 15.PMID: 12870118 [PubMed - indexed for MEDLINE]Related articles

Chronic lymphocytic leukemia with prostate infiltration mediated by specific clonal membrane-bound IgM.

Bogdan CA, Alexander AA, Gorny MK, Matute R, Marjanovic N, Zolla-Pazner S, Walden PD, Furneaux HM, Sidhu GS, Jacobson DR.

Cancer Res. 2003 May 1;63(9):2067-71.PMID: 12727821 [PubMed - indexed for MEDLINE]Related articlesFree article

Alternative conformations of HIV-1 V3 loops mimic beta hairpins in chemokines, suggesting a mechanism for coreceptor selectivity.

Sharon M, Kessler N, Levy R, Zolla-Pazner S, Görlach M, Anglister J.

Structure. 2003 Feb;11(2):225-36.PMID: 12575942 [PubMed - indexed for MEDLINE]Related articles

Evidence for CD4-enchanced signaling through the chemokine receptor CCR5.

Staudinger R, Phogat SK, Xiao X, Wang X, Dimitrov DS, Zolla-Pazner S.

J Biol Chem. 2003 Mar 21;278(12):10389-92. Epub 2003 Jan 15.PMID: 12531905 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV infection in rural villages of Cameroon.

Nyambi P, Zekeng L, Kenfack H, Tongo M, Nanfack A, Nkombe I, Ndonko F, Shang J, Burda S, Mbah H, Agyingi L, Zhong P, Nádas A, Zolla-Pazner S, Marmor M.

J Acquir Immune Defic Syndr. 2002 Dec 15;31(5):506-13.PMID: 12473839 [PubMed - indexed for MEDLINE]Related articles

HIV type 1 group M clades infecting subjects from rural villages in equatorial rain forests of Cameroon.

Zhong P, Burda S, Urbanski M, Kenfack H, Tongo M, Heyndrickx L, Nanfack A, Shang J, Agyingi L, Zolla-Pazner S, Zekeng L, Nyambi P.

J Acquir Immune Defic Syndr. 2002 Dec 15;31(5):495-505.PMID: 12473838 [PubMed - indexed for MEDLINE]Related articles

Human monoclonal antibodies specific for conformation-sensitive epitopes of V3 neutralize human immunodeficiency virus type 1 primary isolates from various clades.

Gorny MK, Williams C, Volsky B, Revesz K, Cohen S, Polonis VR, Honnen WJ, Kayman SC, Krachmarov C, Pinter A, Zolla-Pazner S.

J Virol. 2002 Sep;76(18):9035-45.PMID: 12186887 [PubMed - indexed for MEDLINE]Related articlesFree article

High levels of antibodies to the CD4 binding domain of human immunodeficiency virus type 1 glycoprotein 120 are associated with faster disease progression.

Chien PC Jr, Cohen S, Kleeberger C, Giorgi J, Phair J, Zolla-Pazner S, Hioe CE.

J Infect Dis. 2002 Jul 15;186(2):205-13. Epub 2002 Jul 3.PMID: 12134256 [PubMed - indexed for MEDLINE]Related articles

In memorium G. Jeanette Thorbecke, 1929-2001.

Tsiagbe VK, Zolla-Pazner S, Coico R, Ponzio NM.

Am J Pathol. 2002 Jun;160(6):1917-20. No abstract available. PMID: 12057894 [PubMed - indexed for MEDLINE]Related articlesFree article