PubMed

Competition Between the RNA Transcript and the Nontemplate DNA Strand During R-Loop Formation In Vitro: A Nick Can Serve as a Strong R-loop Initiation Site.

Roy D, Zhang Z, Lu Z, Hsieh CL, Lieber MR.

Mol Cell Biol. 2009 Oct 19. [Epub ahead of print]PMID: 19841062 [PubMed - as supplied by publisher]Related articles

The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia.

Klemm L, Duy C, Iacobucci I, Kuchen S, von Levetzow G, Feldhahn N, Henke N, Li Z, Hoffmann TK, Kim YM, Hofmann WK, Jumaa H, Groffen J, Heisterkamp N, Martinelli G, Lieber MR, Casellas R, Müschen M.

Cancer Cell. 2009 Sep 8;16(3):232-45.PMID: 19732723 [PubMed - indexed for MEDLINE]Related articles

H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations.

Shimazaki N, Tsai AG, Lieber MR.

Mol Cell. 2009 Jun 12;34(5):535-44.PMID: 19524534 [PubMed - indexed for MEDLINE]Related articles

G clustering is important for the initiation of transcription-induced R-loops in vitro, whereas high G density without clustering is sufficient thereafter.

Roy D, Lieber MR.

Mol Cell Biol. 2009 Jun;29(11):3124-33. Epub 2009 Mar 23.PMID: 19307304 [PubMed - indexed for MEDLINE]Related articles

Conformational variants of duplex DNA correlated with cytosine-rich chromosomal fragile sites.

Tsai AG, Engelhart AE, Hatmal MM, Houston SI, Hud NV, Haworth IS, Lieber MR.

J Biol Chem. 2009 Mar 13;284(11):7157-64. Epub 2008 Dec 23.PMID: 19106104 [PubMed - indexed for MEDLINE]Related articles

Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity.

Tsai AG, Lu H, Raghavan SC, Muschen M, Hsieh CL, Lieber MR.

Cell. 2008 Dec 12;135(6):1130-42.PMID: 19070581 [PubMed - indexed for MEDLINE]Related articles

RAGs found "not guilty": cleared by DNA evidence.

Tsai AG, Lieber MR.

Blood. 2008 Feb 15;111(4):1750. No abstract available. PMID: 19048671 [PubMed]Related articlesFree article

A histidine in the beta-CASP domain of Artemis is critical for its full in vitro and in vivo functions.

de Villartay JP, Shimazaki N, Charbonnier JB, Fischer A, Mornon JP, Lieber MR, Callebaut I.

DNA Repair (Amst). 2009 Feb 1;8(2):202-8. Epub 2008 Dec 4.PMID: 19022407 [PubMed - indexed for MEDLINE]Related articles

Turning anti-ageing genes against cancer.

Longo VD, Lieber MR, Vijg J.

Nat Rev Mol Cell Biol. 2008 Nov;9(11):903-10.PMID: 18946478 [PubMed - indexed for MEDLINE]Related articles

Unexpected complexity at breakpoint junctions in phenotypically normal individuals and mechanisms involved in generating balanced translocations t(1;22)(p36;q13).

Gajecka M, Gentles AJ, Tsai A, Chitayat D, Mackay KL, Glotzbach CD, Lieber MR, Shaffer LG.

Genome Res. 2008 Nov;18(11):1733-42. Epub 2008 Sep 2.PMID: 18765821 [PubMed - indexed for MEDLINE]Related articlesFree article

A biochemically defined system for coding joint formation in V(D)J recombination.

Lu H, Shimazaki N, Raval P, Gu J, Watanabe G, Schwarz K, Swanson PC, Lieber MR.

Mol Cell. 2008 Aug 22;31(4):485-97.PMID: 18722175 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanistic aspects of lymphoid chromosomal translocations.

Lieber MR, Raghavan SC, Yu K.

J Natl Cancer Inst Monogr. 2008;(39):8-11.PMID: 18647994 [PubMed - indexed for MEDLINE]Related articles

FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.

Heo K, Kim H, Choi SH, Choi J, Kim K, Gu J, Lieber MR, Yang AS, An W.

Mol Cell. 2008 Apr 11;30(1):86-97.PMID: 18406329 [PubMed - indexed for MEDLINE]Related articles

DNA-PKcs at 7 angstrom: insights for DNA repair.

Shimazaki N, Lieber MR.

Structure. 2008 Mar;16(3):334-6. No abstract available. PMID: 18334206 [PubMed - indexed for MEDLINE]Related articles

Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining.

Gu J, Lieber MR.

Genes Dev. 2008 Feb 15;22(4):411-5. Review. No abstract available. PMID: 18281457 [PubMed - indexed for MEDLINE]Related articlesFree article

Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system.

Lieber MR, Lu H, Gu J, Schwarz K.

Cell Res. 2008 Jan;18(1):125-33. Review.PMID: 18087292 [PubMed - indexed for MEDLINE]Related articlesFree article

The mechanism of human nonhomologous DNA end joining.

Lieber MR.

J Biol Chem. 2008 Jan 4;283(1):1-5. Epub 2007 Nov 12. Review.PMID: 17999957 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of R-loop formation at immunoglobulin class switch sequences.

Roy D, Yu K, Lieber MR.

Mol Cell Biol. 2008 Jan;28(1):50-60. Epub 2007 Oct 22.PMID: 17954560 [PubMed - indexed for MEDLINE]Related articlesFree article

Extent to which hairpin opening by the Artemis:DNA-PKcs complex can contribute to junctional diversity in V(D)J recombination.

Lu H, Schwarz K, Lieber MR.

Nucleic Acids Res. 2007;35(20):6917-23. Epub 2007 Oct 11.PMID: 17932067 [PubMed - indexed for MEDLINE]Related articlesFree article

Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence.

Gu J, Lu H, Tsai AG, Schwarz K, Lieber MR.

Nucleic Acids Res. 2007;35(17):5755-62. Epub 2007 Aug 23.PMID: 17717001 [PubMed - indexed for MEDLINE]Related articlesFree article

Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region.

Huang FT, Yu K, Balter BB, Selsing E, Oruc Z, Khamlichi AA, Hsieh CL, Lieber MR.

Mol Cell Biol. 2007 Aug;27(16):5921-32. Epub 2007 Jun 11.PMID: 17562862 [PubMed - indexed for MEDLINE]Related articlesFree article

DNA structure and human diseases.

Raghavan SC, Lieber MR.

Front Biosci. 2007 May 1;12:4402-8. Review.PMID: 17485384 [PubMed - indexed for MEDLINE]Related articles

Length-dependent binding of human XLF to DNA and stimulation of XRCC4.DNA ligase IV activity.

Lu H, Pannicke U, Schwarz K, Lieber MR.

J Biol Chem. 2007 Apr 13;282(15):11155-62. Epub 2007 Feb 21.PMID: 17317666 [PubMed - indexed for MEDLINE]Related articlesFree article

The structure-specific nicking of small heteroduplexes by the RAG complex: implications for lymphoid chromosomal translocations.

Raghavan SC, Gu J, Swanson PC, Lieber MR.

DNA Repair (Amst). 2007 Jun 1;6(6):751-9. Epub 2007 Feb 20.PMID: 17307402 [PubMed - indexed for MEDLINE]Related articlesFree article

XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps.

Gu J, Lu H, Tippin B, Shimazaki N, Goodman MF, Lieber MR.

EMBO J. 2007 Feb 21;26(4):1010-23. Epub 2007 Feb 8. Erratum in: EMBO J. 2007 Jul 25;26(14):3506-7. PMID: 17290226 [PubMed - indexed for MEDLINE]Related articlesFree article

DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs.

Niewolik D, Pannicke U, Lu H, Ma Y, Wang LC, Kulesza P, Zandi E, Lieber MR, Schwarz K.

J Biol Chem. 2006 Nov 10;281(45):33900-9. Epub 2006 Aug 16.PMID: 16914548 [PubMed - indexed for MEDLINE]Related articlesFree article

The polymerases for V(D)J recombination.

Lieber MR.

Immunity. 2006 Jul;25(1):7-9.PMID: 16860749 [PubMed - indexed for MEDLINE]Related articles

Detection and structural analysis of R-loops.

Yu K, Roy D, Huang FT, Lieber MR.

Methods Enzymol. 2006;409:316-29.PMID: 16793409 [PubMed - indexed for MEDLINE]Related articles

Analysis of non-B DNA structure at chromosomal sites in the mammalian genome.

Raghavan SC, Tsai A, Hsieh CL, Lieber MR.

Methods Enzymol. 2006;409:301-16.PMID: 16793408 [PubMed - indexed for MEDLINE]Related articles

In vitro nonhomologous DNA end joining system.

Ma Y, Lieber MR.

Methods Enzymol. 2006;408:502-10.PMID: 16793389 [PubMed - indexed for MEDLINE]Related articles

Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations.

Lieber MR, Yu K, Raghavan SC.

DNA Repair (Amst). 2006 Sep 8;5(9-10):1234-45. Epub 2006 Jun 21. Review.PMID: 16793349 [PubMed - indexed for MEDLINE]Related articles

DNA structures at chromosomal translocation sites.

Raghavan SC, Lieber MR.

Bioessays. 2006 May;28(5):480-94. Review.PMID: 16615081 [PubMed - indexed for MEDLINE]Related articles

Downstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination.

Huang FT, Yu K, Hsieh CL, Lieber MR.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5030-5. Epub 2006 Mar 17.PMID: 16547142 [PubMed - indexed for MEDLINE]Related articlesFree article

Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV.

Buck D, Moshous D, de Chasseval R, Ma Y, le Deist F, Cavazzana-Calvo M, Fischer A, Casanova JL, Lieber MR, de Villartay JP.

Eur J Immunol. 2006 Jan;36(1):224-35.PMID: 16358361 [PubMed - indexed for MEDLINE]Related articles

Hybrid joint formation in human V(D)J recombination requires nonhomologous DNA end joining.

Raghavan SC, Tong J, Lieber MR.

DNA Repair (Amst). 2006 Feb 3;5(2):278-85. Epub 2005 Nov 7.PMID: 16275127 [PubMed - indexed for MEDLINE]Related articles

The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis.

Ma Y, Pannicke U, Lu H, Niewolik D, Schwarz K, Lieber MR.

J Biol Chem. 2005 Oct 7;280(40):33839-46. Epub 2005 Aug 10.PMID: 16093244 [PubMed - indexed for MEDLINE]Related articlesFree article

Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: the iterative processing model.

Ma Y, Lu H, Schwarz K, Lieber MR.

Cell Cycle. 2005 Sep;4(9):1193-200. Epub 2005 Sep 27. Review.PMID: 16082219 [PubMed - indexed for MEDLINE]Related articlesFree article

Both V(D)J coding ends but neither signal end can recombine at the bcl-2 major breakpoint region, and the rejoining is ligase IV dependent.

Raghavan SC, Hsieh CL, Lieber MR.

Mol Cell Biol. 2005 Aug;25(15):6475-84.PMID: 16024785 [PubMed - indexed for MEDLINE]Related articlesFree article

Double-strand break formation by the RAG complex at the bcl-2 major breakpoint region and at other non-B DNA structures in vitro.

Raghavan SC, Swanson PC, Ma Y, Lieber MR.

Mol Cell Biol. 2005 Jul;25(14):5904-19.PMID: 15988007 [PubMed - indexed for MEDLINE]Related articlesFree article

The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps.

Ma Y, Schwarz K, Lieber MR.

DNA Repair (Amst). 2005 Jul 12;4(7):845-51.PMID: 15936993 [PubMed - indexed for MEDLINE]Related articles

Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation.

Raghavan SC, Chastain P, Lee JS, Hegde BG, Houston S, Langen R, Hsieh CL, Haworth IS, Lieber MR.

J Biol Chem. 2005 Jun 17;280(24):22749-60. Epub 2005 Apr 18.PMID: 15840562 [PubMed - indexed for MEDLINE]Related articlesFree article

Omenn syndrome due to ARTEMIS mutations.

Ege M, Ma Y, Manfras B, Kalwak K, Lu H, Lieber MR, Schwarz K, Pannicke U.

Blood. 2005 Jun 1;105(11):4179-86. Epub 2005 Feb 24.PMID: 15731174 [PubMed - indexed for MEDLINE]Related articlesFree article

Fine-structure analysis of activation-induced deaminase accessibility to class switch region R-loops.

Yu K, Roy D, Bayramyan M, Haworth IS, Lieber MR.

Mol Cell Biol. 2005 Mar;25(5):1730-6.PMID: 15713630 [PubMed - indexed for MEDLINE]Related articlesFree article

Generation and characterization of endonuclease G null mice.

Irvine RA, Adachi N, Shibata DK, Cassell GD, Yu K, Karanjawala ZE, Hsieh CL, Lieber MR.

Mol Cell Biol. 2005 Jan;25(1):294-302.PMID: 15601850 [PubMed - indexed for MEDLINE]Related articlesFree article

A biochemically defined system for mammalian nonhomologous DNA end joining.

Ma Y, Lu H, Tippin B, Goodman MF, Shimazaki N, Koiwai O, Hsieh CL, Schwarz K, Lieber MR.

Mol Cell. 2004 Dec 3;16(5):701-13.PMID: 15574326 [PubMed - indexed for MEDLINE]Related articles

Genetic interactions between BLM and DNA ligase IV in human cells.

So S, Adachi N, Lieber MR, Koyama H.

J Biol Chem. 2004 Dec 31;279(53):55433-42. Epub 2004 Oct 26.PMID: 15509577 [PubMed - indexed for MEDLINE]Related articlesFree article

Stability and strand asymmetry in the non-B DNA structure at the bcl-2 major breakpoint region.

Raghavan SC, Houston S, Hegde BG, Langen R, Haworth IS, Lieber MR.

J Biol Chem. 2004 Oct 29;279(44):46213-25. Epub 2004 Aug 23.PMID: 15328356 [PubMed - indexed for MEDLINE]Related articlesFree article

The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination.

Lieber MR, Ma Y, Pannicke U, Schwarz K.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):817-26. Review.PMID: 15279766 [PubMed - indexed for MEDLINE]Related articles

DNA damage and aging.

Karanjawala ZE, Lieber MR.

Mech Ageing Dev. 2004 Jun;125(6):405-16. Review.PMID: 15272504 [PubMed - indexed for MEDLINE]Related articles

Chromosomal translocations and non-B DNA structures in the human genome.

Raghavan SC, Lieber MR.

Cell Cycle. 2004 Jun;3(6):762-8. Epub 2004 Jun 21. Review.PMID: 15254430 [PubMed - indexed for MEDLINE]Related articlesFree article