PIP: This article discusses some of the public health practice needs that would be met by the Guide to Clinical Preventive Services (GCPS) and highlights some of the challenges that lie ahead in using the recommendations to actually improve the health of the population and communities. Overall, the discussions indicate that the Guide would be useful across public health settings from academia to health departments. It is noted that it would be the first comprehensive, evidence-based evaluation of community preventive services. In addition, the focus of the Guide on economic evaluation would prove to be extremely helpful to decision-makers in both public health and managed care settings in which fixed (or shrinking) budgets have become the norm. However, in terms of challenges, the implementation of the Guide is seen as the most difficult process, despite its clear and compelling recommendations. A number of initiatives are being developed and carried out that would support the dissemination and implementation of the Guide.