Abstract
Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction. However, they also play crucial roles in contributing to the innate immune properties of mucus and mucociliary clearance. In this review, we focus on the emerging novel roles for a chloride channel regulator (CLCA1), a calcium-activated chloride channel (TMEM16A), and two chloride exchangers (SLC26A4/pendrin and SLC26A9) in chronic inflammatory airway diseases.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anoctamin-1
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Antiporters / physiology*
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Asthma / etiology*
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Chloride Channels / physiology*
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Cystic Fibrosis Transmembrane Conductance Regulator / physiology
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Humans
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Membrane Transport Proteins / physiology*
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Neoplasm Proteins / physiology*
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Pulmonary Disease, Chronic Obstructive / etiology*
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STAT6 Transcription Factor / physiology
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Sulfate Transporters
Substances
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ANO1 protein, human
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Anoctamin-1
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Antiporters
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CLCA1 protein, human
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Chloride Channels
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Membrane Transport Proteins
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Neoplasm Proteins
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SLC26A4 protein, human
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SLC26A9 protein, human
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STAT6 Transcription Factor
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Sulfate Transporters
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Cystic Fibrosis Transmembrane Conductance Regulator