Myopia disease mouse models: a missense point mutation (S673G) and a protein-truncating mutation of the Zfp644 mimic human disease phenotype.
Szczerkowska KI, Petrezselyova S, Lindovsky J, Palkova M, Dvorak J, Makovicky P, Fang M, Jiang C, Chen L, Shi M, Liu X, Zhang J, Kubik-Zahorodna A, Schuster B, Beck IM, Novosadova V, Prochazka J, Sedlacek R.
Szczerkowska KI, et al.
Cell Biosci. 2019 Feb 21;9:21. doi: 10.1186/s13578-019-0280-4. eCollection 2019.
Cell Biosci. 2019.
PMID: 30834109
Free PMC article.
Employing TALEN technology, two mice mutants were generated, either with the disease-carrying mutation (Zfp644 (S673G) ) or with a truncated form of Zfp644 (Zfp644 (delta8) ). Eye morphology and visual functions were analysed in both mutants, revealing a sign …
Employing TALEN technology, two mice mutants were generated, either with the disease-carrying mutation (Zfp644 (S673G) ) or with a tr …