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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1991 4
1992 2
1993 5
1994 7
1995 17
1996 6
1997 7
1998 10
1999 6
2000 8
2001 5
2002 4
2003 8
2004 11
2005 7
2006 7
2007 8
2008 12
2009 14
2010 16
2011 19
2012 19
2013 27
2014 17
2015 36
2016 23
2017 26
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2019 36
2020 27
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2022 24
2023 28
2024 11

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491 results

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Page 1
The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m(6)A recognition.
Li L, Krasnykov K, Homolka D, Gos P, Mendel M, Fish RJ, Pandey RR, Pillai RS. Li L, et al. Mol Cell. 2022 May 5;82(9):1678-1690.e12. doi: 10.1016/j.molcel.2022.02.034. Epub 2022 Mar 18. Mol Cell. 2022. PMID: 35305312 Free article.
Biochemical studies reveal that the weak helicase activity of YTHDC2 is enhanced by its interaction with the 5'3' exoribonuclease XRN1. Single-cell transcriptomics indicate that Ythdc2 mutant mitotic germ cells transition into meiosis but accumulate a transcriptome with mi …
Biochemical studies reveal that the weak helicase activity of YTHDC2 is enhanced by its interaction with the 5'3' exoribonuclease XRN1 …
Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy.
Ran XB, Ding LW, Sun QY, Yang H, Said JW, Zhentang L, Madan V, Dakle P, Xiao JF, Loh X, Li Y, Xu L, Xiang XQ, Wang LZ, Goh BC, Lin DC, Chng WJ, Tan SY, Jha S, Koeffler HP. Ran XB, et al. Cancer Res. 2023 Mar 15;83(6):922-938. doi: 10.1158/0008-5472.CAN-21-3052. Cancer Res. 2023. PMID: 36638333
Silencing of XRN1 suppressed tumor growth in syngeneic immunocompetent mice and potentiated immunotherapy efficacy, while silencing of XRN1 alone did not affect tumor growth in immunodeficient mice. ...Aberrant RNA-sensing signaling proteins (RIG-I/MAVS) mediated th …
Silencing of XRN1 suppressed tumor growth in syngeneic immunocompetent mice and potentiated immunotherapy efficacy, while silencing o …
The 5' 3' exoribonuclease XRN1/Pacman and its functions in cellular processes and development.
Jones CI, Zabolotskaya MV, Newbury SF. Jones CI, et al. Wiley Interdiscip Rev RNA. 2012 Jul-Aug;3(4):455-68. doi: 10.1002/wrna.1109. Epub 2012 Mar 1. Wiley Interdiscip Rev RNA. 2012. PMID: 22383165 Review.
XRN1 is a 5' 3' processive exoribonuclease that degrades mRNAs after they have been decapped. ...Although XRN1 shows little specificity to particular 5' monophosphorylated RNAs in vitro, mutations in XRN1 in vivo have specific phenotypes suggesting that it sp …
XRN1 is a 5' 3' processive exoribonuclease that degrades mRNAs after they have been decapped. ...Although XRN1 shows little sp …
Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA.
Sharma S, Yang J, Grudzien-Nogalska E, Shivas J, Kwan KY, Kiledjian M. Sharma S, et al. Nat Commun. 2022 Feb 16;13(1):889. doi: 10.1038/s41467-022-28555-7. Nat Commun. 2022. PMID: 35173156 Free PMC article.
The significance of Xrn1 deNADding is evident in a deNADding deficient Xrn1 mutant that predominantly still retains its 5'-monophosphate exonuclease activity. ...Our findings uncover a contribution of mitochondrial NAD-capped RNAs in overall NAD regulation with the …
The significance of Xrn1 deNADding is evident in a deNADding deficient Xrn1 mutant that predominantly still retains its 5'-mon …
XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells.
Zou T, Zhou M, Gupta A, Zhuang P, Fishbein AR, Wei HY, Zhang Z, Cherniack AD, Meyerson M. Zou T, et al. bioRxiv [Preprint]. 2023 Aug 3:2023.08.01.551488. doi: 10.1101/2023.08.01.551488. bioRxiv. 2023. PMID: 37577567 Free PMC article. Updated. Preprint.
XRN1 deletion causes PKR activation and consequent cancer cell lethality. ...Our data demonstrate how XRN1 regulates PKR and nominate XRN1 as a potential therapeutic target in cancer cells with an activated interferon cell state....
XRN1 deletion causes PKR activation and consequent cancer cell lethality. ...Our data demonstrate how XRN1 regulates PKR and n …
The roles of the exoribonucleases DIS3L2 and XRN1 in human disease.
Pashler AL, Towler BP, Jones CI, Newbury SF. Pashler AL, et al. Biochem Soc Trans. 2016 Oct 15;44(5):1377-1384. doi: 10.1042/BST20160107. Biochem Soc Trans. 2016. PMID: 27911720 Review.
This review focusses on the roles of DIS3L2 and XRN1 in the pathogenesis of human disease, particularly in relation to phenotypes seen in model organisms. The known diseases associated with loss of activity of DIS3L2 and XRN1 are discussed, together with possible me …
This review focusses on the roles of DIS3L2 and XRN1 in the pathogenesis of human disease, particularly in relation to phenotypes see …
XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells.
Zou T, Zhou M, Gupta A, Zhuang P, Fishbein AR, Wei HY, Capcha-Rodriguez D, Zhang Z, Cherniack AD, Meyerson M. Zou T, et al. Cell Rep. 2024 Feb 27;43(2):113600. doi: 10.1016/j.celrep.2023.113600. Epub 2024 Jan 22. Cell Rep. 2024. PMID: 38261514 Free PMC article.
XRN1 deletion causes PKR pathway activation and consequent cancer cell lethality. Disruption of interferon signaling with the JAK1/2 inhibitor ruxolitinib can decrease cellular PKR levels and rescue sensitivity to XRN1 deletion. Conversely, interferon-beta stimulati …
XRN1 deletion causes PKR pathway activation and consequent cancer cell lethality. Disruption of interferon signaling with the JAK1/2 …
Mn-XRN1 Has an Inhibitory Effect on Ovarian Reproduction in Macrobrachium nipponense.
Chen T, Yuan H, Qiao H, Jiang S, Zhang W, Xiong Y, Fu H, Jin S. Chen T, et al. Genes (Basel). 2023 Jul 16;14(7):1454. doi: 10.3390/genes14071454. Genes (Basel). 2023. PMID: 37510358 Free PMC article.
Quantitative real-time PCR was used to detect the spatiotemporal expression pattern of Mn-XRN1. At the tissue level, Mn-XRN1 was significantly expressed in the ovary. ...The in situ hybridization results showed the location of Mn-XRN1 in the ovary. The expres …
Quantitative real-time PCR was used to detect the spatiotemporal expression pattern of Mn-XRN1. At the tissue level, Mn-XRN1 w …
The EDC4-XRN1 interaction controls P-body dynamics to link mRNA decapping with decay.
Brothers WR, Ali F, Kajjo S, Fabian MR. Brothers WR, et al. EMBO J. 2023 Nov 2;42(21):e113933. doi: 10.15252/embj.2023113933. Epub 2023 Aug 25. EMBO J. 2023. PMID: 37621215 Free PMC article.
Here, we show that disrupting the EDC4-XRN1 interaction or altering their stoichiometry inhibits mRNA decapping, with microRNA-targeted mRNAs being stabilized in a translationally repressed state. ...Finally, we demonstrate that P-bodies support cell viability and prevent …
Here, we show that disrupting the EDC4-XRN1 interaction or altering their stoichiometry inhibits mRNA decapping, with microRNA-target …
Xrn1-resistant RNA structures are well-conserved within the genus flavivirus.
Dilweg IW, Bouabda A, Dalebout T, Gultyaev AP, Bredenbeek PJ, Olsthoorn RCL. Dilweg IW, et al. RNA Biol. 2021 May;18(5):709-717. doi: 10.1080/15476286.2020.1830238. Epub 2020 Oct 16. RNA Biol. 2021. PMID: 33064973 Free PMC article.
Subgenomic RNAs are produced by several RNA viruses through incomplete degradation of their genomic RNA by the exoribonuclease Xrn1, and have been shown to be essential for viral growth and pathogenicity. ...For the no-known-vector flavivirus Modoc virus, we show that in v …
Subgenomic RNAs are produced by several RNA viruses through incomplete degradation of their genomic RNA by the exoribonuclease Xrn1, …
491 results