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Page 1
XPO7 is a tumor suppressor regulating p21(CIP1)-dependent senescence.
Innes AJ, Sun B, Wagner V, Brookes S, McHugh D, Pombo J, Porreca RM, Dharmalingam G, Vernia S, Zuber J, Vannier JB, García-Escudero R, Gil J. Innes AJ, et al. Genes Dev. 2021 Mar 1;35(5-6):379-391. doi: 10.1101/gad.343269.120. Epub 2021 Feb 18. Genes Dev. 2021. PMID: 33602872 Free PMC article.
Deletion of XPO7 correlates with poorer overall survival in several cancer types. Moreover, depletion of XPO7 alleviated OIS and increased tumor formation in a mouse model of liver cancer. ...
Deletion of XPO7 correlates with poorer overall survival in several cancer types. Moreover, depletion of XPO7 alleviated OIS a …
Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
Lin Y, Zhan M, Xu B. Lin Y, et al. J Cancer Res Clin Oncol. 2023 Aug;149(10):7663-7677. doi: 10.1007/s00432-023-04705-2. Epub 2023 Mar 31. J Cancer Res Clin Oncol. 2023. PMID: 37000263
To investigate the functions of XPO7 in vitro and in vivo, we knocked down XPO7 in PCa cell lines and established xenograft mice models. ...CONCLUSIONS: These findings indicate that XPO7 promotes PCa initiation and progression and that targeting XPO7 m …
To investigate the functions of XPO7 in vitro and in vivo, we knocked down XPO7 in PCa cell lines and established xenograft mi …
Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus.
Markiewicz Ł, Uśpieński T, Baran B, Niedziółka SM, Niewiadomski P. Markiewicz Ł, et al. Cell Signal. 2021 Apr;80:109907. doi: 10.1016/j.cellsig.2020.109907. Epub 2020 Dec 28. Cell Signal. 2021. PMID: 33383157
The nuclear export machinery prevents the unchecked nuclear accumulation of Gli proteins, but the mechanistic insight into this process is limited. We show that the atypical exportin Xpo7 functions as a major nuclear export receptor that actively excludes Gli2 from the nuc …
The nuclear export machinery prevents the unchecked nuclear accumulation of Gli proteins, but the mechanistic insight into this process is l …
Xpo7 is a broad-spectrum exportin and a nuclear import receptor.
Aksu M, Pleiner T, Karaca S, Kappert C, Dehne HJ, Seibel K, Urlaub H, Bohnsack MT, Görlich D. Aksu M, et al. J Cell Biol. 2018 Jul 2;217(7):2329-2340. doi: 10.1083/jcb.201712013. Epub 2018 May 10. J Cell Biol. 2018. PMID: 29748336 Free PMC article.
Moreover, we developed anti-Xpo7 nanobodies that acutely block Xpo7 function when transfected into cultured cells. ...This establishes Xpo7 as a broad-spectrum bidirectional transporter and paves the way for a much deeper analysis of exportin and importin fun …
Moreover, we developed anti-Xpo7 nanobodies that acutely block Xpo7 function when transfected into cultured cells. ...This est …
KPNB1, XPO7 and IPO8 mediate the translocation ofNF-kappaB/p65 into the nucleus.
Liang P, Zhang H, Wang G, Li S, Cong S, Luo Y, Zhang B. Liang P, et al. Traffic. 2013 Nov;14(11):1132-43. doi: 10.1111/tra.12097. Epub 2013 Aug 19. Traffic. 2013. PMID: 23906023 Free article.
In this study, using high-content siRNA screening, we identified three of 17 importin beta family members that are involved in the nuclear import of p65. Our data showed that knockdown of KPNB1, XPO7 and IPO8 reduced the amount of nuclear p65 following tumor necrosis facto …
In this study, using high-content siRNA screening, we identified three of 17 importin beta family members that are involved in the nuclear i …
An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis.
Modepalli S, Martinez-Morilla S, Venkatesan S, Fasano J, Paulsen K, Görlich D, Hattangadi S, Kupfer GM. Modepalli S, et al. Exp Hematol. 2022 Oct;114:22-32. doi: 10.1016/j.exphem.2022.08.001. Epub 2022 Aug 13. Exp Hematol. 2022. PMID: 35973480 Free PMC article.
We also identified a previously unannotated, erythroid-specific isoform of Xpo7 (Xpo7B) containing a novel first exon Xpo7-1b expressed only in late Ter119(+) erythroblasts. To better understand the functional difference between the erythroid Xpo7B isoform and the u …
We also identified a previously unannotated, erythroid-specific isoform of Xpo7 (Xpo7B) containing a novel first exon Xpo7-1b …
The molecular pathology of schizophrenia: an overview of existing knowledge and new directions for future research.
Nakamura T, Takata A. Nakamura T, et al. Mol Psychiatry. 2023 May;28(5):1868-1889. doi: 10.1038/s41380-023-02005-2. Epub 2023 Mar 6. Mol Psychiatry. 2023. PMID: 36878965 Free PMC article. Review.
Also, a large-scale exome sequencing study identified single genes whose rare mutations substantially increase the risk for schizophrenia, of which six genes (SETD1A, CUL1, XPO7, GRIA3, GRIN2A, and RB1CC1) showed odds ratios larger than ten. ...
Also, a large-scale exome sequencing study identified single genes whose rare mutations substantially increase the risk for schizophrenia, o …
RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 are new prognostic biomarkers in serous epithelial ovarian cancer.
Cáceres-Gorriti KY, Carmona E, Barrès V, Rahimi K, Létourneau IJ, Tonin PN, Provencher D, Mes-Masson AM. Cáceres-Gorriti KY, et al. PLoS One. 2014 Mar 13;9(3):e91000. doi: 10.1371/journal.pone.0091000. eCollection 2014. PLoS One. 2014. PMID: 24625450 Free PMC article.
The RAN GDP/GTP cycle was evaluated by the expression of RANBP1 and RCC1, the mitotic function by TPX2 and IMPbeta, and the nucleo-cytoplasmic trafficking function by XPO7, XPOT and IMPbeta. RESULTS: Based on Kaplan-Meier analyses, RAN, cytoplasmic XPO7 and TPX2 wer …
The RAN GDP/GTP cycle was evaluated by the expression of RANBP1 and RCC1, the mitotic function by TPX2 and IMPbeta, and the nucleo-cytoplasm …
22 results